Drug Interactions Directory

2,618 drugs with documented interactions.

2,618Drugs
67,117Interactions
53,805Serious (major+)
PharmacistReviewed
1Look up a drugSearch by generic or brand name, or browse A-Z.
2Scan the severityInteractions are grouped and color-coded by how much they matter.
3Read the write-upPlain-English and clinical explanations, with cited evidence.
Popular: Buprenorphine 633 Hydroxychloroquine 631 Ketoconazole Topical 546 Cyclosporine Injection 545 Cyclosporine Ophthalmic 545 Sertraline 532 Amitriptyline 525 Fentanyl Transdermal Patch 493

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

I
Isatuximab-Irfc Injection 15 Isavuconazole 38 Isavuconazonium 39 Isavuconazonium Sulfate 2 Isepamicin 7 Islatravir 10 Isocarboxazid 57 Isoconazole 4 Isoetharine 1 Isoetharine Oral Inhalation 5 Isoflurane 85 Isoflurophate 1 Isoniazid 25 Isopropamide 1 Isoproterenol 5 Isoproterenol Hydrochloride 1 Isosorbide 1 Isosorbide Dinitrate 7 Isosorbide Mononitrate 1 Isotretinoin 44 Isradipine 113 Istradefylline 87 Itraconazole 206 Ivabradine 275 Ivacaftor 46 Ivosidenib 130 Ixabepilone 5 Ixabepilone Injection 46 Ixazomib 45 Ixekizumab 4 Ixekizumab Injection 21
J
Japanese Encephalitis Virus Vaccine 2 Josamycin 7
K
Kanamycin 20 Kaolin 7 Kava 29 Kelp 2 Ketamine 28 Ketanserin 1 Ketazolam 22 Ketobemidone 30 Ketoconazole 186 Ketoconazole Topical 546 Ketoprofen 289 Ketorolac 277 Ketorolac Injection 246 Ketorolac Nasal Spray 246 Ketorolac Ophthalmic 246 Ketotifen 8 Ketotifen Ophthalmic 8 Khat 3 Khella 1 Kratom 134 Kyushin 1
L
L-Methylfolate 30 Labetalol 215 Lacosamide 49 Lacosamide Injection 234 Lactated Ringer's Solution 1 Lactulose 9 Lamifiban 4 Lamivudine 8 Lamotrigine 22 Landiolol 29 Lanreotide 26 Lanreotide Acetate 19 Lanreotide Injection 92 Lansoprazole 94 Lanthanum 74 Lanthanum Carbonate 36 Lapatinib 86 Laropiprant 2 Larotrectinib 42 Lasmiditan 27 Latanoprost Ophthalmic 6 Lazabemide 1 Lazertinib 38 Lecanemab-Irmb 19 Lecanemab-Irmb Injection 51 Ledipasvir 13 Lefamulin 443 Leflunomide 58 Lemborexant 67 Lenacapavir 75 Lenacapavir Injection 213 Lenacapavir Oral 213 Lenalidomide 16 Leniolisib 133 Lenvatinib 254 Lepirudin 53 Lercanidipine 12 Lesinurad 36 Letermovir 114 Letermovir Injection 346 Letibotulinumtoxina-Wlbg 15 Letrozole 20 Leucovorin 13 Leucovorin Injection 11 Leuprolide 63 Levacetylleucine 23 Levalbuterol 16 Levalbuterol Hydrochloride 1 Levalbuterol Tartrate 1 Levamisole 4 Levamlodipine 5 Levetiracetam 19 Levetiracetam Injection 16 Levobunolol 58 Levobunolol Ophthalmic 160 Levocabastine 1 Levocarnitine 2 Levocetirizine 21 Levodopa 26 Levodopa Oral Inhalation 208 Levofloxacin 406 Levofloxacin Injection 354 Levoketoconazole 185 Levoleucovorin 5 Levomethadyl 31 Levomethadyl Acetate 1