Drug & supplement interaction

Chromium + Hydrochlorothiazide, Losartan Potassium

Hydrochlorothiazide, Losartan Potassium brand name: Hyzaar.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Chromium and Hydrochlorothiazide, Losartan Potassium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Chromium and Hydrochlorothiazide, Losartan Potassium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Hydrochlorothiazide, Losartan Potassium and Chromium in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Chromium safety at a glance

Chromium overall Use caution Usually well tolerated at typical supplement doses, but high or long-term doses may pose risks for some people.

Pregnancy Likely Safe When used orally and appropriately in amounts not exceeding adequate intake (AI) levels. The AI for pregnancy is 28 mcg daily for those 14-18 years of age and 3... Read the full pregnancy detail

Breastfeeding Likely Safe When used orally and appropriately in amounts not exceeding adequate intake (AI) levels. The AI for lactation is 44 mcg daily for those 14-18 years of age and 4... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Hydrochlorothiazide, Losartan Potassium and Chromium? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Hydrochlorothiazide, Losartan Potassium

Interactions in our licensed database are recorded against drug classes, not just single drug names. Hydrochlorothiazide, Losartan Potassium is filed under 11 classifications — including angiotensin receptor blockers (arbs), thiazide diuretics, diuretic drugs. Chromium has documented interactions with 5 drug classes — the most serious being antidiabetes drugs (moderate), insulin (moderate) and levothyroxine (synthroid, others) (moderate) — and none of Hydrochlorothiazide, Losartan Potassium’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Chromium Does Interact With Other Medications

Chromium has 89 moderate, 89 minor known drug interactions in our database — Hydrochlorothiazide, Losartan Potassium isn’t one of them. If you take anything else, check it against the full list below.

Moderate 89 Minor 89 No known interaction 2,652 (incl. Hydrochlorothiazide, Losartan Potassium)

Taking anything else?

Check Another of Your Medications Against Chromium

Covers the 2,830 medications we’ve checked against Chromium. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Chromium and Hydrochlorothiazide, Losartan Potassium May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 8 of them are worth acting on rather than waiting out — marked below.

Severe muscle breakdown Worth acting on Additional detail
Chromium
“Acute rhabdomyolysis has been reported for a previously healthy 24-year-old female who ingested chromium picolinate 1200 mcg over a 48-hour time period. Also, chromium polynicotinate has been associated with leg pain and paresthesia in patients taking the supplement to prevent weight gain during smoking cessation.”

Chromium · Natural Medicines adverse-effect record, reported in muscle breakdown.
2 sources cited

42786. Martin, W. R. and Fuller, R. E. Suspected chromium picolinate-induced rhabdomyolysis. Pharmacotherapy 1998;18(4):860-862. DOI

42643. Parsons, A., Ingram, J., Inglis, J., Aveyard, P., Johnstone, E., Brown, K., Franklin, M., and Bermudez, I. A proof of concept randomised placebo controlled factorial trial to examine the efficacy of St John's wort for smoking cessation and chromium to pr
Hydrochlorothiazide, Losartan Potassium

Listed in the ADVERSE REACTIONS section of the FDA label for Hydrochlorothiazide, Losartan Potassium. Read the label on DailyMed ›
A low platelet count Worth acting on Additional detail
Chromium
“Anemia, hemolysis, and thrombocytopenia were reported in a 33 year-old female taking chromium picolinate 1200-2400 mcg daily for 4-5 months. The patient received supportive care, blood product transfusions, and hemodialysis and was stabilized and discharged a few days later. Lab values were normal at a one-year follow-up.”

Chromium · Natural Medicines adverse-effect record, reported in anemia.
1 source cited

554. Cerulli J, Grabe DW, Gauthier I, et al. Chromium picolinate toxicity. Ann Pharmacother 1998;32:428-31. PubMed
Hydrochlorothiazide, Losartan Potassium

Listed in the ADVERSE REACTIONS section of the FDA label for Hydrochlorothiazide, Losartan Potassium. Read the label on DailyMed ›
Kidney problems Worth acting on Additional detail
Chromium
“Orally, chromium picolinate has been associated with at least one report of chronic interstitial nephritis and two reports of acute tubular necrosis. Laboratory evidence suggests that chromium does not cause kidney tissue damage even after long-term, high-dose exposure; however, patient- or product-specific factors could potentially increase the risk of chromium-related kidney damage.”

Chromium · Natural Medicines adverse-effect record, reported in burns.
6 sources cited

554. Cerulli J, Grabe DW, Gauthier I, et al. Chromium picolinate toxicity. Ann Pharmacother 1998;32:428-31. PubMed

1951. Wasser WG, Feldman NS, D'Agati VD. Chronic renal failure after ingestion of over-the-counter chromium picolinate. [letter]. Ann Intern Med 1997;126:410. PubMed

14312. Wani S, Weskamp C, Marple J, Spry L. Acute tubular necrosis associated with chromium picolinate-containing dietary supplement. Ann Pharmacother 2006;40:563-6. PubMed

7135. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.

11787. Mouser JF, Hak EB, Helms RA, et al. Chromium and zinc concentrations in pediatric patients receiving long-term parenteral nutrition. Am J Health Syst Pharm 1999;56:1950-6. PubMed

42699. Xiang, J., Sun, Z., and Huan, J. N. Intensive chromic acid burns and acute chromium poisoning with acute renal failure. Chin Med.J.(Engl.) 7-5-2011;124(13):2071-2073.
Hydrochlorothiazide, Losartan Potassium

Listed in the ADVERSE REACTIONS section of the FDA label for Hydrochlorothiazide, Losartan Potassium. Read the label on DailyMed ›
Anemia Worth acting on Additional detail
Chromium
“Another form of chromium, called hexavalent chromium, is unsafe. This type of chromium is a by-product of some manufacturing processes. Chronic exposure can cause liver, kidney, or cardiac failure, pulmonary complications, anemia, and hemolysis.”

Chromium · Natural Medicines adverse-effect record, reported in anemia.
6 sources cited

9141. Lanca S, Alves A, Vieira AI, et al. Chromium-induced toxic hepatitis. Eur J Intern Med 2002;13:518-20. PubMed

11786. Food Standards Agency. Medicines and Healthcare products Regulatory Agency (MHRA). Expert Group on Vitamins and Minerals. Available at: http://cot.food.gov.uk/sites/default/files/vitmin2003.pdf.

42572. Gibb, H. J., Lees, P. S., Pinsky, P. F., and Rooney, B. C. Lung cancer among workers in chromium chemical production. Am J Ind.Med 2000;38(2):115-126. DOI

42573. Gibb, H. J., Lees, P. S., Pinsky, P. F., and Rooney, B. C. Clinical findings of irritation among chromium chemical production workers. Am J Ind.Med 2000;38(2):127-131. PubMed

42699. Xiang, J., Sun, Z., and Huan, J. N. Intensive chromic acid burns and acute chromium poisoning with acute renal failure. Chin Med.J.(Engl.) 7-5-2011;124(13):2071-2073.

42614. Hisatomi, K., Ishii, H., Hashiguchi, K., Seki, M., Ide, M., Sugiyama, K., Ishimoto, H., Nakayama, S., Mukae, H., and Kohno, S. Interstitial pneumonia caused by inhalation of fumes of nickel and chrome. Respirology. 2006;11(6):814-817. PubMed
Hydrochlorothiazide, Losartan Potassium

Listed in the ADVERSE REACTIONS section of the FDA label for Hydrochlorothiazide, Losartan Potassium. Read the label on DailyMed ›
Shortness of breath / A higher chance of infection Worth acting on Additional detail

Chromium

Recorded for Chromium in the same Natural Medicines adverse-effect record shown under Anemia above.

Hydrochlorothiazide, Losartan Potassium

Listed in the ADVERSE REACTIONS section of the FDA label for Hydrochlorothiazide, Losartan Potassium. Read the label on DailyMed ›
Hives Worth acting on Additional detail
Chromium
“Orally, chromium-containing supplements may cause acute generalized exanthematous pustulosis, skin rashes, and urticaria. Also, chromium picolinate or chromium chloride may cause systemic contact dermatitis when taken orally, especially in patients with contact allergy to chromium.”

Chromium · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).
6 sources cited

42561. Young P, Turiansky G, Bonner M, and et al. Acute generalized exanthematous pustulosis induced by chromium picolinate. J.Am Acad.Dermatol. 1999;41(5 Pt 2):820-823. PubMed

42679. Krol, E., Krejpcio, Z., Byks, H., Bogdanski, P., and Pupek-Musialik, D. Effects of chromium brewer's yeast supplementation on body mass, blood carbohydrates, and lipids and minerals in type 2 diabetic patients. Biol.Trace Elem.Res. 2011;143(2):726-737.

17224. Yazaki Y, Faridi Z, Ma Y, et al. A pilot study of chromium picolinate for weight loss. J Altern Complement Med 2010;16:291-9. PubMed

6624. Fowler JF Jr. Systemic contact dermatitis caused by oral chromium picolinate. Cutis 2000;65:116. DOI

90058. De Marchi S, Cecchin E, De Marchi SU. Systemic allergic dermatitis resulting from oral administration of chromium with a food supplement. Contact Dermatitis 2014;70(2):123-5. PubMed

95096. Guimarães MM, Carvalho AC, Silva MS. Effect of chromium supplementation on the glucose homeostasis and anthropometry of type 2 diabetic patients: Double blind, randomized clinical trial: Chromium, glucose homeostasis and anthropometry. J Trace Elem Med Bi PubMed
Hydrochlorothiazide, Losartan Potassium

Listed in the ADVERSE REACTIONS section of the FDA label for Hydrochlorothiazide, Losartan Potassium. Read the label on DailyMed ›
Liver problems Worth acting on Additional detail
Chromium
“Liver damage has been reported for a 33-year-old female taking chromium picolinate 1200 mcg daily for 4-5 months. Also, acute hepatitis has been reported in a patient taking chromium polynicotinate 200 mcg daily for 5 months. Symptoms resolved when the product was discontinued.”

Chromium · Natural Medicines adverse-effect record, reported in hepatitis.
3 sources cited

554. Cerulli J, Grabe DW, Gauthier I, et al. Chromium picolinate toxicity. Ann Pharmacother 1998;32:428-31. PubMed

9141. Lanca S, Alves A, Vieira AI, et al. Chromium-induced toxic hepatitis. Eur J Intern Med 2002;13:518-20. PubMed

13037. Stevens T, Qadri A, Zein NN. Two patients with acute liver injury associated with use of the herbal weight-loss supplement hydroxycut. Ann Intern Med 2005;142:477-8. PubMed
Hydrochlorothiazide, Losartan Potassium

Listed in the ADVERSE REACTIONS section of the FDA label for Hydrochlorothiazide, Losartan Potassium. Read the label on DailyMed ›
Pain in an arm or leg Additional detail

Chromium

Recorded for Chromium in the same Natural Medicines adverse-effect record shown under Severe muscle breakdown above.

Hydrochlorothiazide, Losartan Potassium

Listed in the ADVERSE REACTIONS section of the FDA label for Hydrochlorothiazide, Losartan Potassium. Read the label on DailyMed ›
Bloating or gas Additional detail
Chromium
“Orally, chromium in the form of chromium picolinate, chromium polynicotinate, chromium-containing brewer's yeast, or chromium-containing milk powder may cause nausea, vomiting, diarrhea, decreased appetite, constipation, flatulence, or gastrointestinal upset.

Long-term exposure to heavy metals, including chromium, has been associated with increased risk of gallbladder disease and cancer.”

Chromium · Natural Medicines adverse-effect record, reported in cancer.
6 sources cited

14325. Kleefstra N, Houweling ST, Jansman FG, et al. Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial. Diabetes Care 2006;29: PubMed

42594. Pittler, M. H. and Ernst, E. Dietary supplements for body-weight reduction: a systematic review. Am.J.Clin Nutr. 2004;79(4):529-536. PubMed

42607. Pei, D., Hsieh, C. H., Hung, Y. J., Li, J. C., Lee, C. H., and Kuo, S. W. The influence of chromium chloride-containing milk to glycemic control of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial. Metabolism 2 PubMed

42622. Kleefstra, N., Houweling, S. T., Bakker, S. J., Verhoeven, S., Gans, R. O., Meyboom-de Jong, B., and Bilo, H. J. Chromium treatment has no effect in patients with type 2 diabetes in a Western population: a randomized, double-blind, placebo-controlled tri DOI

42643. Parsons, A., Ingram, J., Inglis, J., Aveyard, P., Johnstone, E., Brown, K., Franklin, M., and Bermudez, I. A proof of concept randomised placebo controlled factorial trial to examine the efficacy of St John's wort for smoking cessation and chromium to pr

42679. Krol, E., Krejpcio, Z., Byks, H., Bogdanski, P., and Pupek-Musialik, D. Effects of chromium brewer's yeast supplementation on body mass, blood carbohydrates, and lipids and minerals in type 2 diabetic patients. Biol.Trace Elem.Res. 2011;143(2):726-737.
Hydrochlorothiazide, Losartan Potassium

Listed in the ADVERSE REACTIONS section of the FDA label for Hydrochlorothiazide, Losartan Potassium. Read the label on DailyMed ›

Showing the 10 most notable of 23 shared effects — ranked by how unusual each one is, not just whether both lists mention it.

Reported for Chromium but not commonly for Hydrochlorothiazide, Losartan Potassium: heart failure, mood changes or irritability, low blood sugar and weight gain.

Effects for Hydrochlorothiazide, Losartan Potassium come from the ADVERSE REACTIONS section of its FDA label; effects for Chromium come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Chromium in Pregnancy & Breastfeeding

Pregnancy Likely Safe

When used orally and appropriately in amounts not exceeding adequate intake (AI) levels. The AI for pregnancy is 28 mcg daily for those 14-18 years of age and 30 mcg daily for those 19-50 years of age.

Pregnancy Possibly Safe

When used orally in amounts exceeding the adequate intake (AI) levels. There is some evidence that patients with gestational diabetes can safely use chromium in doses of 4-8 mcg/kg; however, patients should not take chromium supplements during pregnancy without medical supervision.

Lactation Likely Safe

When used orally and appropriately in amounts not exceeding adequate intake (AI) levels. The AI for lactation is 44 mcg daily for those 14-18 years of age and 45 mcg daily for those 19-50 years of age. Chromium supplements do not seem to increase normal chromium concentration in human breast milk. There is insufficient reliable information available about the safety of chromium when used in higher amounts while breast-feeding.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Hydrochlorothiazide, Losartan Potassium

This page covers Chromium only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hydrochlorothiazide, Losartan Potassium page lists 314 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).

By severity: 12 major · 259 moderate · 43 minor.

From our pharmacist’s overview on the Hydrochlorothiazide, Losartan Potassium page

“Grapefruit is the everyday item to know first if you take hydrochlorothiazide with losartan (Hyzaar). It blocks the enzyme that clears losartan, raising drug levels, and it is one of 12 major-rated entries on a list of 314 supplements and herbs, enough serious risk to warrant genuine care.”

Reviewed by 2 · Jul 18, 2026

Open the Hydrochlorothiazide, Losartan Potassium interaction page

One more smart check

Taking Chromium as Part of a Dietary Supplement Product? Check It for Interactions

We hold 16,728 real supplement products containing Chromium, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chromium. Even though Chromium itself has no known interaction with Hydrochlorothiazide, Losartan Potassium, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chromium and Hydrochlorothiazide, Losartan Potassium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chromium

Top 5%

#17 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Hydrochlorothiazide, Losartan Potassium

Top 25%

#414 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chromium reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Chromium and Hydrochlorothiazide, Losartan Potassium records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Chromium

What is Chromium?

Blood sugar support in type 2 diabetes
Weight loss and appetite control
Insulin sensitivity
Cholesterol and lipid support
General nutritional supplement

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, but results are mixed and the effect on weight loss is small and uncertain. For most healthy people who eat a varied diet, supplements are not needed; check with your pharmacist or doctor before starting.

Trace mineral (not a plant) · Capsules, tablets, gummies; common salt forms include chromium picolinate, chromium chloride, and chromium polynicotinate

An interaction check asks whether these two react with each other — it does not ask whether Chromium is a good idea for someone in your situation. Here is what our Chromium record says about it on its own.

Chromium: dosing

There is no single agreed-upon "best" dose of chromium as a supplement, and needs vary from person to person. Health authorities describe general daily intake amounts for adults to prevent deficiency, but these are not the same as the higher doses sometimes used in studies.Because products and strengths differ, it is best to follow the directions on the product label and not exceed the recommended amount. They can help you decide if it is appropriate and at what dose.

From our Chromium monograph — the full record covers uses, side effects and every documented interaction.

Read the full Chromium monograph & all interactions

Keep checking

Other Drugs & Chromium

Browse every other medication we’ve checked against Chromium — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

89Moderate

89Minor

2,651No known interaction

89 Moderate 89 Minor 2,651 No interaction

Moderate

89 interactions

Showing 60 of 89 moderate interactions — see all 89 on the Chromium page.

Minor

89 interactions

Showing 60 of 89 minor interactions — see all 89 on the Chromium page.

No interaction 2,651 drugs checked — show the list

We also checked Chromium against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,651 medications checked with no known interaction — see the full Chromium list.

See the full Chromium interactions page

See every supplement checked against Hydrochlorothiazide, Losartan Potassium, ranked by severity

Evidence & sources

Chromium References

The 53 references that drive our Chromium monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Cerulli J, Grabe DW, Gauthier I, et al. Chromium picolinate toxicity. Ann Pharmacother 1998;32:428-31. PubMed
Urberg M, Zemel MB. Evidence for synergism between chromium and nicotinic acid in the control of glucose tolerance in elderly humans. Metabolism 1987;36:896-9. PubMed
Mohamedshah FY, Moser-Veillon PB, Yamini S, et al. Distribution of a stable isotope of chromium (53Cr) in serum, urine, and breast milk in lactating women. Am J Clin Nutr 1998;67:1250-5. PubMed
Wasser WG, Feldman NS, D'Agati VD. Chronic renal failure after ingestion of over-the-counter chromium picolinate. [letter]. Ann Intern Med 1997;126:410. PubMed
Mertz W. Interaction of chromium with insulin: a progress report. Nutr Rev 1998;56:174-7. PubMed
Anderson RA. Chromium, glucose intolerance and diabetes. J Am Coll Nutr 1998;17:548-55. PubMed
McLeod MN, Gaynes BN, Golden RN. Chromium potentiation of antidepressant pharmacotherapy for dysthymic disorder in 5 patients. J Clin Psych 1999;60:237-40. PubMed
Fowler JF Jr. Systemic contact dermatitis caused by oral chromium picolinate. Cutis 2000;65:116. DOI
Trent LK, Thieding-Cancel D. Effects of chromium picolinate on body composition. J Sports Med Phys Fitness 1995;35:273-80.
Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
Rabinovitz H, Friedensohn A, Leibovitz A, et al. Effect of chromium supplementation on blood glucose and lipid levels in type 2 diabetes mellitus elderly patients. Int J Vitam Nutr Res 2004;74:178-82. PubMed
Lanca S, Alves A, Vieira AI, et al. Chromium-induced toxic hepatitis. Eur J Intern Med 2002;13:518-20. PubMed
Kockler DR, McCarthy MW, Lawson CL. Seizure activity and unresponsiveness after hydroxycut ingestion. Pharmacotherapy 2001;21:647-51.. PubMed
Davidson JR, Abraham K, Connor KM, McLeod MN. Effectiveness of chromium in atypical depression: a placebo-controlled trial. Biol Psychiatry 2003;53:261-4.. PubMed
Food Standards Agency. Medicines and Healthcare products Regulatory Agency (MHRA). Expert Group on Vitamins and Minerals. Available at: http://cot.food.gov.uk/sites/default/files/vitmin2003.pdf.
Mouser JF, Hak EB, Helms RA, et al. Chromium and zinc concentrations in pediatric patients receiving long-term parenteral nutrition. Am J Health Syst Pharm 1999;56:1950-6. PubMed
Stevens T, Qadri A, Zein NN. Two patients with acute liver injury associated with use of the herbal weight-loss supplement hydroxycut. Ann Intern Med 2005;142:477-8. PubMed
Wani S, Weskamp C, Marple J, Spry L. Acute tubular necrosis associated with chromium picolinate-containing dietary supplement. Ann Pharmacother 2006;40:563-6. PubMed
Kleefstra N, Houweling ST, Jansman FG, et al. Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial. Diabetes Care 2006;29: PubMed
Martin J, Wang ZQ, Zhang XH, et al. Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care 2006;29:1826-32. PubMed
Singer GM, Geohas J. The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized trial. Diabetes Technol Ther 2006;8:636-43. PubMed
John-Kalarickal J, Pearlman G, Carlson HE. New medications which decrease levothyroxine absorption. Thyroid 2007;17:763-5. PubMed
Yazaki Y, Faridi Z, Ma Y, et al. A pilot study of chromium picolinate for weight loss. J Altern Complement Med 2010;16:291-9. PubMed
Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
Young P, Turiansky G, Bonner M, and et al. Acute generalized exanthematous pustulosis induced by chromium picolinate. J.Am Acad.Dermatol. 1999;41(5 Pt 2):820-823. PubMed
Gibb, H. J., Lees, P. S., Pinsky, P. F., and Rooney, B. C. Lung cancer among workers in chromium chemical production. Am J Ind.Med 2000;38(2):115-126. DOI
Gibb, H. J., Lees, P. S., Pinsky, P. F., and Rooney, B. C. Clinical findings of irritation among chromium chemical production workers. Am J Ind.Med 2000;38(2):127-131. PubMed
Pittler, M. H. and Ernst, E. Dietary supplements for body-weight reduction: a systematic review. Am.J.Clin Nutr. 2004;79(4):529-536. PubMed
Pei, D., Hsieh, C. H., Hung, Y. J., Li, J. C., Lee, C. H., and Kuo, S. W. The influence of chromium chloride-containing milk to glycemic control of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial. Metabolism 2 PubMed
Hisatomi, K., Ishii, H., Hashiguchi, K., Seki, M., Ide, M., Sugiyama, K., Ishimoto, H., Nakayama, S., Mukae, H., and Kohno, S. Interstitial pneumonia caused by inhalation of fumes of nickel and chrome. Respirology. 2006;11(6):814-817. PubMed
Kleefstra, N., Houweling, S. T., Bakker, S. J., Verhoeven, S., Gans, R. O., Meyboom-de Jong, B., and Bilo, H. J. Chromium treatment has no effect in patients with type 2 diabetes in a Western population: a randomized, double-blind, placebo-controlled tri DOI
Parsons, A., Ingram, J., Inglis, J., Aveyard, P., Johnstone, E., Brown, K., Franklin, M., and Bermudez, I. A proof of concept randomised placebo controlled factorial trial to examine the efficacy of St John's wort for smoking cessation and chromium to pr
Bagdon RE and Hazen RE. Skin permeation and cutaneous hypersensitivity as a basis for making risk assessments of chromium as a soil contaminant. Environ.Health Perspect. 1991;92:111-119. PubMed
Bharmal, S. V., Moyes, V., Ahmed, S., and Grossman, A. Hypoglycaemia: possible mediation by chromium salt medication. Hormones.(Athens.) 2010;9(2):181-183. PubMed
Krol, E., Krejpcio, Z., Byks, H., Bogdanski, P., and Pupek-Musialik, D. Effects of chromium brewer's yeast supplementation on body mass, blood carbohydrates, and lipids and minerals in type 2 diabetic patients. Biol.Trace Elem.Res. 2011;143(2):726-737.
Unisa, S., Jagannath, P., Dhir, V., Khandelwal, C., Sarangi, L., and Roy, T. K. Population-based study to estimate prevalence and determine risk factors of gallbladder diseases in the rural Gangetic basin of North India. HPB (Oxford) 2011;13(2):117-125. PubMed
Noda, S., Asano, Y., and Sato, S. Lichen planus in a patient with long-term exposure to chrome. Eur.J.Dermatol. 2011;21(3):417-418. PubMed
Xiang, J., Sun, Z., and Huan, J. N. Intensive chromic acid burns and acute chromium poisoning with acute renal failure. Chin Med.J.(Engl.) 7-5-2011;124(13):2071-2073.
Chhabra, D., Oda, K., Jagannath, P., Utsunomiya, H., Takekoshi, S., and Nimura, Y. Chronic heavy metal exposure and gallbladder cancer risk in India, a comparative study with Japan. Asian Pac.J.Cancer Prev. 2012;13(1):187-190. PubMed
Huszonek, J. Over-the-counter chromium picolinate. Am J Psychiatry 1993;150(10):1560-1561. PubMed
Bunner S and McGinnis R. Chromium-induced hypoglycemia. Psychosomatics 1998;39(3):298-299. PubMed
Martin, W. R. and Fuller, R. E. Suspected chromium picolinate-induced rhabdomyolysis. Pharmacotherapy 1998;18(4):860-862. DOI
Proctor, D. M., Fredrick, M. M., Scott, P. K., Paustenbach, D. J., and Finley, B. L. The prevalence of chromium allergy in the United States and its implications for setting soil cleanup: a cost-effectiveness case study. Regul.Toxicol Pharmacol 1998;28(1 PubMed
De Marchi S, Cecchin E, De Marchi SU. Systemic allergic dermatitis resulting from oral administration of chromium with a food supplement. Contact Dermatitis 2014;70(2):123-5. PubMed
Hedberg YS, Gumulka M, Lind ML, Matura M, Lidén C. Severe occupational chromium allergy despite cement legislation. Contact Dermatitis. 2014;70(5):321-3. PubMed
Thyssen JP, Jellesen MS, Møller P, Menné T, Johansen JD. Allergic chromium dermatitis from wearing 'chromium-free' footwear. Contact Dermatitis 2014;70(3):185-7. PubMed
Liu Y, Cotillard A, Vatier C, et al. A Dietary Supplement Containing Cinnamon, Chromium and Carnosine Decreases Fasting Plasma Glucose and Increases Lean Mass in Overweight or Obese Pre-Diabetic Subjects: A Randomized, Placebo-Controlled Trial. PLoS One.
Jamilian M, Asemi Z. Chromium Supplementation and the Effects on Metabolic Status in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Ann Nutr Metab. 2015;67(1):42-8. PubMed
Guimarães MM, Carvalho AC, Silva MS. Effect of chromium supplementation on the glucose homeostasis and anthropometry of type 2 diabetic patients: Double blind, randomized clinical trial: Chromium, glucose homeostasis and anthropometry. J Trace Elem Med Bi PubMed
Paiva AN, Lima JG, Medeiros AC, et al. Beneficial effects of oral chromium picolinate supplementation on glycemic control in patients with type 2 diabetes: A randomized clinical study. J Trace Elem Med Biol. 2015;32:66-72. PubMed
Yin RV, Phung OJ. Effect of chromium supplementation on glycated hemoglobin and fasting plasma glucose in patients with diabetes mellitus. Nutr J. 2015;14:14. PubMed
Jamilian M, Zadeh Modarres S, Amiri Siavashani M, et al. The influences of chromium supplementation on glycemic control, markers of cardio-metabolic risk, and oxidative stress in infertile polycystic ovary syndrome women candidate for in vitro fertilizati
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Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Related: nutrient depletion

Hydrochlorothiazide, Losartan Potassium Is Linked to Lower Levels of 8 Nutrients

Natural Medicines records Hydrochlorothiazide, Losartan Potassium as a medicine that can lower these. This is not an interaction with Chromium — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:

Read the full Hydrochlorothiazide, Losartan Potassium nutrient depletion report ›

Chromium is itself a nutrient we track — see which medications may deplete CHROMIUM.

Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.

Pharmacist Counseling Corner

Taking Chromium and Hydrochlorothiazide, Losartan Potassium Together: Common Questions

Is it safe to take Chromium with Hydrochlorothiazide, Losartan Potassium?

We do not list a known interaction between Chromium and Hydrochlorothiazide, Losartan Potassium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Chromium and Hydrochlorothiazide, Losartan Potassium have any of the same side effects?

Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

How was the Chromium and Hydrochlorothiazide, Losartan Potassium combination checked?

Interactions in our licensed database are recorded against drug classes. Hydrochlorothiazide, Losartan Potassium is filed under 11 classifications, and Chromium has documented interactions with 5 drug classes — none of Hydrochlorothiazide, Losartan Potassium's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Chromium interact with any other medications?

Yes. Chromium has 178 documented drug interactions in our database — Hydrochlorothiazide, Losartan Potassium is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Hydrochlorothiazide, Losartan Potassium interact with any supplements?

Yes. Hydrochlorothiazide, Losartan Potassium has documented interactions with 314 supplements in our database — Chromium is not one of them. The Hydrochlorothiazide, Losartan Potassium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

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Still Have a Question About Hydrochlorothiazide, Losartan Potassium and Chromium?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

anemia: A low level of red blood cells or the oxygen-carrying protein inside them, which can cause tiredness, weakness, and paleness.

constipation: Having bowel movements less often than usual, or passing stools that are hard, dry, and difficult to move.

contact dermatitis: A skin rash caused by touching something that irritates the skin or triggers an allergy.

dermatitis: Inflammation of the skin, causing redness, itching, and sometimes swelling or blisters.

diarrhea: Loose, watery bowel movements that happen more often than normal.

Drug Interactions: The label section listing other medicines, foods, or substances that can change how a medicine works or raise the chance of side effects.

flatulence: Passing gas from the bowel; feeling bloated or gassy.

hemodialysis: A treatment that uses a machine to filter waste and extra fluid from the blood when the kidneys cannot.

hemolysis: The breaking apart of red blood cells, which can lower the number of cells available to carry oxygen.

hepatitis: Inflammation of the liver, which can be caused by infections, alcohol, or certain medicines.

insomnia: Trouble falling asleep, staying asleep, or getting restful sleep.

interstitial nephritis: Inflammation of the tissue between the kidney's tiny filtering tubes, sometimes triggered by a medicine, that can reduce kidney function.

irritability: Getting annoyed, frustrated, or angry more easily than usual.

Metabolism: How the body chemically changes a medicine, usually in the liver, into other substances.

paresthesia: A tingling, prickling, or "pins and needles" feeling in the skin, often in the hands or feet.

rhabdomyolysis: A serious condition where damaged muscle breaks down and releases material into the blood that can harm the kidneys.

thrombocytopenia: A low level of platelets, the blood cells that help form clots, which can lead to easier bruising or bleeding.

urticaria: Raised, itchy welts on the skin, commonly called hives.

Chromium + Hydrochlorothiazide, Losartan Potassium

Chromium and Hydrochlorothiazide, Losartan Potassium

No Known Interaction Found

Chromium safety at a glance

Why No Interaction Is Listed for Hydrochlorothiazide, Losartan Potassium

Chromium Does Interact With Other Medications

Check Another of Your Medications Against Chromium

No Interaction Found — But Data Suggests Chromium and Hydrochlorothiazide, Losartan Potassium May Share Several of the Same Side Effects

Chromium in Pregnancy & Breastfeeding

See Every Supplement That Interacts With Hydrochlorothiazide, Losartan Potassium

Taking Chromium as Part of a Dietary Supplement Product? Check It for Interactions

Where Chromium and Hydrochlorothiazide, Losartan Potassium Sit Against Everything Else

About Chromium

What is Chromium?

Chromium: dosing

Other Drugs & Chromium

89 interactions

89 interactions

Chromium References

Hydrochlorothiazide, Losartan Potassium Is Linked to Lower Levels of 8 Nutrients

Taking Chromium and Hydrochlorothiazide, Losartan Potassium Together: Common Questions

Related Supplements & Herbs

Keep Exploring

Still Have a Question About Hydrochlorothiazide, Losartan Potassium and Chromium?