Medication interaction hub

What Supplements Interact with Hydrochlorothiazide, Losartan Potassium?

Hydrochlorothiazide, Losartan Potassium brand name: Hyzaar. Every interaction below applies to the brands too.

314 Interactions 12 Major 259 Moderate 43 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Hydrochlorothiazide, Losartan Potassium? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Hydrochlorothiazide, Losartan Potassium against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Grapefruit is the everyday item to know first if you take hydrochlorothiazide with losartan (Hyzaar). It blocks the enzyme that clears losartan, raising drug levels, and it is one of 12 major-rated entries on a list of 314 supplements and herbs, enough serious risk to warrant genuine care. Most of the list follows the pill's own logic, with over a hundred ingredients that can push blood pressure too low or undercut its control, and dozens more that compound the diuretic, shifting potassium and fluid.

Potassium needs watching, since the losartan half holds it back and supplements can tip levels too high, while a few herbs deepen the thiazide's potassium loss instead. St. John's wort works opposite to grapefruit, speeding the drug's clearance so it protects you less. Of the rest, 259 rate moderate and 43 minor, including 20 that raise sun sensitivity, a side effect hydrochlorothiazide can already cause on its own.

— , Clinical Pharmacist · July 18, 2026

Major 12 Moderate 259 Minor 43 No known interaction 1,138

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Hydrochlorothiazide, Losartan Potassium: Top Interactions at a Glance

The Hydrochlorothiazide, Losartan Potassium supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 314 interacting ingredients — plus 1,138 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Hydrochlorothiazide, Losartan Potassium Combinations Today

The Hydrochlorothiazide, Losartan Potassium + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Hops + Hydrochlorothiazide, Losartan Potassiumi

Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.

Read the full interaction Moderate Likelihood Possible Nattokinase + Hydrochlorothiazide, Losartan Potassiumi

Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.

Read the full interaction Moderate Likelihood Possible Ginkgo + Hydrochlorothiazide, Losartan Potassiumi

Theoretically, ginkgo might decrease levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Black Tea + Hydrochlorothiazide, Losartan Potassiumi

Theoretically, using black tea with diuretic drugs might increase the risk of hypokalemia.

Read the full interaction Moderate Likelihood Possible Niacin + Hydrochlorothiazide, Losartan Potassiumi

Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.

Read the full interaction Moderate Likelihood Possible Pomegranate + Hydrochlorothiazide, Losartan Potassiumi

Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction
The complete list

Every Supplement Checked Against Hydrochlorothiazide, Losartan Potassium

All 1,452 ingredients in our database, ranked by severity — 314 with a Hydrochlorothiazide, Losartan Potassium interaction on file and 1,138 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Hydrochlorothiazide, Losartan Potassium?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Hops with Hydrochlorothiazide, Losartan Potassium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.

Full Hops + Hydrochlorothiazide, Losartan Potassium answer

Can you take Nattokinase with Hydrochlorothiazide, Losartan Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.

Full Nattokinase + Hydrochlorothiazide, Losartan Potassium answer

Can you take Ginkgo with Hydrochlorothiazide, Losartan Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ginkgo might decrease levels of drugs metabolized by CYP3A4.

Full Ginkgo + Hydrochlorothiazide, Losartan Potassium answer

Can you take Black Tea with Hydrochlorothiazide, Losartan Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using black tea with diuretic drugs might increase the risk of hypokalemia.

Full Black Tea + Hydrochlorothiazide, Losartan Potassium answer

Can you take Niacin with Hydrochlorothiazide, Losartan Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.

Full Niacin + Hydrochlorothiazide, Losartan Potassium answer

Can you take Tragacanth with Hydrochlorothiazide, Losartan Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Hydrochlorothiazide, Losartan Potassium answer

Can you take Tribulus with Hydrochlorothiazide, Losartan Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Full Tribulus + Hydrochlorothiazide, Losartan Potassium answer

Can you take Turmeric with Hydrochlorothiazide, Losartan Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Turmeric might increase or decrease levels of drugs metabolized by CYP3A4.

Full Turmeric + Hydrochlorothiazide, Losartan Potassium answer

Can you take Uva Ursi with Hydrochlorothiazide, Losartan Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.

Full Uva Ursi + Hydrochlorothiazide, Losartan Potassium answer

Can you take Uzara with Hydrochlorothiazide, Losartan Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics and uzara can increase the risk of cardiac glycoside toxicity due to potassi...

Full Uzara + Hydrochlorothiazide, Losartan Potassium answer

Can you take Vitamin B6 with Hydrochlorothiazide, Losartan Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.

Full Vitamin B6 + Hydrochlorothiazide, Losartan Potassium answer

Can you take Vitamin E with Hydrochlorothiazide, Losartan Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.

Full Vitamin E + Hydrochlorothiazide, Losartan Potassium answer

Can you take Wahoo with Hydrochlorothiazide, Losartan Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics with wahoo can increase the risk of cardiac glycoside toxicity due to potass...

Full Wahoo + Hydrochlorothiazide, Losartan Potassium answer

Can you take Wallflower with Hydrochlorothiazide, Losartan Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics and wallflower can increase the risk of cardiac glycoside toxicity due to po...

Full Wallflower + Hydrochlorothiazide, Losartan Potassium answer

Can you take White Horehound with Hydrochlorothiazide, Losartan Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that taking white horehound extract lowers blood pressure.

Full White Horehound + Hydrochlorothiazide, Losartan Potassium answer

Can you take White Pepper with Hydrochlorothiazide, Losartan Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that piperine, a constituent of white pepper, inhibits cytochrome P450 3A4 (CYP3A4).

Full White Pepper + Hydrochlorothiazide, Losartan Potassium answer

Can you take Wild Cherry with Hydrochlorothiazide, Losartan Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that wild cherry can inhibit cytochrome P450 3A4 (CYP3A4) enzymes.

Full Wild Cherry + Hydrochlorothiazide, Losartan Potassium answer

Can you take Yerba Mate with Hydrochlorothiazide, Losartan Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the caffeine in yerba mate might increase the risk of hypokalemia when used concomitantly with other diuretics.

Full Yerba Mate + Hydrochlorothiazide, Losartan Potassium answer

Can you take Zedoary with Hydrochlorothiazide, Losartan Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zedoary might increase levels of drugs metabolized by CYP3A4.

Full Zedoary + Hydrochlorothiazide, Losartan Potassium answer

Can you take American Ivy with Hydrochlorothiazide, Losartan Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. The berries of American ivy contain up to 2% oxalic acid, which can be toxic because it has the potential to cause kidney failure by precipi...

Full American Ivy + Hydrochlorothiazide, Losartan Potassium answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Hydrochlorothiazide, Losartan Potassium is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Hydrochlorothiazide, Losartan Potassium, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Hydrochlorothiazide, Losartan Potassium sits in 11 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Hydrochlorothiazide, Losartan Potassium through this category.

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Hydrochlorothiazide, Losartan Potassium through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Hydrochlorothiazide, Losartan Potassium through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Hydrochlorothiazide, Losartan Potassium through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Hydrochlorothiazide, Losartan Potassium through this category.

Losartan (Cozaar) 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Hydrochlorothiazide, Losartan Potassium through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Hydrochlorothiazide, Losartan Potassium through this category.

Thiazide Diuretics 5 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

5 of the supplement ingredients on this page reach Hydrochlorothiazide, Losartan Potassium through this category.

Angiotensin Receptor Blockers (Arbs) 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydrochlorothiazide, Losartan Potassium through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydrochlorothiazide, Losartan Potassium through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydrochlorothiazide, Losartan Potassium through this category.

Related: does Hydrochlorothiazide, Losartan Potassium deplete any nutrients?

Hydrochlorothiazide, Losartan Potassium has 9 reported nutrient associations in the research literature — see the Hydrochlorothiazide, Losartan Potassium nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Hydrochlorothiazide, Losartan Potassium

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Hydrochlorothiazide, Losartan Potassium.

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Pharmacist Counseling Corner

Hydrochlorothiazide, Losartan Potassium & Supplements: Common Questions

What supplements interact with Hydrochlorothiazide, Losartan Potassium?
Our database currently documents 314 ingredients with a known Hydrochlorothiazide, Losartan Potassium interaction (12 major, 259 moderate, 43 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 314. The highest-ranked right now: American Hellebore, Grapefruit, Siberian Cocklebur.
Which Hydrochlorothiazide, Losartan Potassium supplement interactions are the most serious?
Focus on the major group: American Hellebore, Grapefruit, Siberian Cocklebur, Tyramine and Activated Charcoal, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Hydrochlorothiazide, Losartan Potassium?
Plenty of supplements coexist fine with Hydrochlorothiazide, Losartan Potassium; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Hyzaar have the same supplement interactions as Hydrochlorothiazide, Losartan Potassium?
Yes — Hyzaar all contain Hydrochlorothiazide, Losartan Potassium, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Hydrochlorothiazide, Losartan Potassium deplete any vitamins or nutrients?
It might — Hydrochlorothiazide, Losartan Potassium has 9 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Hydrochlorothiazide, Losartan Potassium nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Hydrochlorothiazide, Losartan Potassium and my other medications?
This page covers Hydrochlorothiazide, Losartan Potassium against supplements and herbal ingredients. Checking Hydrochlorothiazide, Losartan Potassium against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.