Drug & supplement interaction

Moringa + Tepotinib

Tepotinib brand name: Tepmetko.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Tepotinib falls into 2 drug categories that Moringa can interact with; the most serious is rated moderate. Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Moringa and Tepotinib

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Moringa interacts with whole categories of medication. Tepotinib falls into 2 of those categories, so it can interact with Moringa in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES

1 of 2

Why this applies to Tepotinib

Tepotinib falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES — the group Moringa interacts with.

Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.
Some in vitro research suggests that moringa inhibits cytochrome P450 3A4 (CYP3A4). However, other in vitro research suggests that moringa extract induces CYP3A4 enzymes. A pharmacokinetic study in patients with HIV shows no change in the pharmacokinetics of nevirapine, which is partially metabolized by CYP3A4, when administered concomitantly with moringa leaf powder 1.85 grams daily for 14 days.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the short version on combining moringa with tepotinib (Tepmetko). Your body clears tepotinib using a liver enzyme called CYP3A4, and moringa might nudge that enzyme one way or the other. The catch is that the lab studies disagree: some hint moringa slows the enzyme (which could let tepotinib build up and raise the chance of side effects like nausea, swelling, diarrhea, or liver irritation), while others suggest it speeds the enzyme up (which could lower tepotinib levels and make it work less well against the cancer).

Honestly, this is theoretical and based only on test-tube data, with no real human study on tepotinib itself. A small human study with another drug showed no change at all. Food amounts in cooking are unlikely to matter, but concentrated supplements are a bigger unknown. Because tepotinib is a cancer medicine, please check with your oncologist or pharmacist before adding moringa.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Monera TG, Wolfe AR, Maponga CC, et al. Moringa oleifera leaf extracts inhibit 6beta-hydroxylation of testosterone by CYP3A4. J Infect Dev Ctries 2008;2:379-83.
  2. Monera-Penduka TG, Maponga CC, Wolfe AR, Wiesner L, Morse GD, Nhachi CF. Effect of Moringa oleifera Lam. leaf powder on the pharmacokinetics of nevirapine in HIV-infected adults: a one sequence cross-over study. AIDS Res Ther. 2017;14:12. doi: 10.1186/s1 PubMed
  3. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
Moderate

P-GLYCOPROTEIN SUBSTRATES

2 of 2

Tepotinib also falls under P-GLYCOPROTEIN SUBSTRATES.

Theoretically, moringa leaf extract might increase the levels and clinical effects of P-glycoprotein substrates.
In vitro research shows that moringa leaf extract inhibits renal P-glycoprotein transport activity. So far, this reaction has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for your lung cancer pill, tepotinib (Tepmetko). Your body uses a little 'pump' called P-glycoprotein to help move this drug around and clear some of it. Lab studies (in test tubes, not in people) suggest moringa leaf extract may slow that pump down. If the pump works less, more tepotinib could stay in your system, which in theory could mean stronger effects and a higher chance of side effects like swelling in your legs, nausea, diarrhea, tiredness, or liver irritation.

I want to be honest: this is theoretical. It has never actually been reported in humans, and a sprinkle of moringa in food is very different from a concentrated capsule. Still, because cancer drugs leave little room for surprises, please run any moringa supplement by your oncologist or pharmacist first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Amaeze O, Marques ES, Wei W, et al. Evaluation of Nigerian Medicinal Plants Extract on Human P-glycoprotein and Cytochrome P450 Enzyme Induction: Implications for Herb-drug Interaction. Curr Drug Metab. 2021;22(14):1103-1113. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Moringa Also Interacts With Other Medications

Moringa has 716 moderate, 152 minor known drug interactions in our database — the Tepotinib one above is among them. If you take anything else, check it against the full list below.

Moderate 716 Minor 152 No known interaction 1,962 (incl. Tepotinib)
Taking anything else?

Check Another of Your Medications Against Moringa

Covers the 2,830 medications we’ve checked against Moringa. Pick one to open its full report.

From our Q&A

Questions About Moringa or Tepotinib

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Moringa or Tepotinib, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Tepotinib

This page covers Moringa only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tepotinib page lists 144 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 103 moderate · 38 minor.

From our pharmacist’s overview on the Tepotinib page

“The supplement list for tepotinib (Tepmetko), a targeted lung cancer drug, is one I would treat carefully rather than skim. Nearly everything on it touches the same liver enzyme, CYP3A4, that clears tepotinib from the body, so some products can raise its level and its side effects while others quietly lower it and weaken the treatment…”

Reviewed by 2 · Jul 18, 2026

Open the Tepotinib interaction page

One more smart check

Taking Moringa as Part of a Dietary Supplement Product? Check It for Interactions

We hold 738 real supplement products containing Moringa, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Moringa. Your product may carry other ingredients that interact with Tepotinib too, on top of Moringa — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Moringa and Tepotinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Moringa
Top 25%

#199 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tepotinib
Top half

#748 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Moringa

What is Moringa?

  • Nutritional supplement
  • Blood sugar support
  • Cholesterol support
  • Inflammation
  • Skin conditions

Moringa is a nutrient-rich plant whose leaves are widely used as a food and supplement, especially in parts of the world where malnutrition is common. Early research hints at possible benefits for blood sugar, cholesterol, and inflammation, but the human evidence is limited and not strong enough to recommend it as a treatment. Talk with your pharmacist or doctor before using moringa, especially if you are pregnant, breastfeeding, or taking medications.

Read the full Moringa monograph & all interactions
Medication

About Tepotinib

What Is Tepotinib Used For?

Brand name: Tepmetko

Tepmetko (tepotinib) is used to treat adults with metastatic non-small cell lung cancer (NSCLC) — lung cancer that has spread — whose tumors carry a specific genetic alteration called a MET exon 14 skipping mutation. A test on tumor tissue or blood is required to confirm this mutation before treatment begins.

This is a targeted therapy, meaning it works against a specific molecular driver of cancer growth rather than attacking all rapidly dividing cells.

See full Tepotinib drug information
Keep checking

Other Drugs & Moringa

Browse every other medication we’ve checked against Moringa — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
716Moderate
152Minor
1,961No known interaction
716 Moderate 152 Minor 1,961 No interaction
Moderate

716 interactions

Showing 60 of 716 moderate interactions — see all 716 on the Moringa page.

Minor

152 interactions

Showing 60 of 152 minor interactions — see all 152 on the Moringa page.

No interaction 1,961 drugs checked — show the list

We also checked Moringa against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,961 medications checked with no known interaction — see the full Moringa list.

See the full Moringa interactions page
See every supplement checked against Tepotinib, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Moringa monograph › Uses, safety, and every drug interaction in one place Tepotinib supplement interactions › Every supplement checked against Tepotinib, ranked by severity Tepotinib drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Moringa and Tepotinib Together: Common Questions

Can you take Moringa with Tepotinib?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Moringa and Tepotinib?
Tepotinib belongs to more than one drug category, and Moringa interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Moringa and Tepotinib interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Tepotinib and Moringa?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.