Sida Cordifolia + Esomeprazole
Esomeprazole brand name: Nexium.
We found no known interaction between Sida Cordifolia and Esomeprazole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Esomeprazole states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Sida Cordifolia and Esomeprazole
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Esomeprazole and Sida Cordifolia in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Sida Cordifolia safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Esomeprazole
Interactions in our licensed database are recorded against drug classes, not just single drug names. Esomeprazole is filed under 6 classifications — including proton pump inhibitors (ppis), cytochrome p450 2c19 (cyp2c19) inhibitors, cytochrome p450 1a2 (cyp1a2) inducers. Sida Cordifolia has documented interactions with 7 drug classes — the most serious being methylxanthines (major), qt interval-prolonging drugs (major) and stimulant drugs (major) — and none of Esomeprazole’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Sida Cordifolia Does Interact With Other Medications
Sida Cordifolia has 337 major, 108 moderate known drug interactions in our database — Esomeprazole isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Sida Cordifolia
We haven’t checked that one against Sida Cordifolia yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Sida Cordifolia. Pick one to open its full report.
Sida Cordifolia in Pregnancy & Breastfeeding
When used orally. The ephedrine constituent of Sida cordifolia has been linked to several cases of severe side effects.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Esomeprazole Products Have a Food Rule — Sida Cordifolia Should Not Break It
At least one FDA label for a product containing Esomeprazole says to take it on an empty stomach. Most supplements — Sida Cordifolia included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Esomeprazole on its own and move Sida Cordifolia to a meal later in the day.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Esomeprazole products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Table 2: Recommended Dosage of Esomeprazole Magnesium Delayed-Release Capsules in Pediatric Patients by Indication Indication Patient Age Recommended Dosage Duration Healing of EE 12 years to 17 years Esomeprazole magnesium delayed-release capsules: 20 mg or 40 mg once daily 4 to 8 Weeks Treatment of Symptomatic GERD 12 years to 17 years Esomeprazole magnesium delayed-release capsules: 20 mg once
From the Dosage and Administration section of the FDA label we read for Esomeprazole — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
Questions About Sida Cordifolia or Esomeprazole
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Sida Cordifolia or Esomeprazole, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Can You Take Xarelto And Nexium Together? ›
- Can You Take Zyrtec And Xyzal Together? ›
- Taking Nexium With Ibuprofen ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Esomeprazole
This page covers Sida Cordifolia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Esomeprazole page lists 154 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).
By severity: 3 major · 102 moderate · 49 minor.
From our pharmacist’s overview on the Esomeprazole page
“St. John's wort can lower the amount of esomeprazole (Nexium) in your blood by speeding up how the liver clears it, which can leave heartburn or ulcer treatment falling short.”
Reviewed by 2 · Jul 18, 2026
Taking Sida Cordifolia as Part of a Dietary Supplement Product? Check It for Interactions
We hold 48 real supplement products containing Sida Cordifolia, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Sida Cordifolia. Even though Sida Cordifolia itself has no known interaction with Esomeprazole, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Sida Cordifolia and Esomeprazole Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#444 of 1,452 supplements looked up here in the last 7 days
#471 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Sida Cordifolia reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Sida Cordifolia and Esomeprazole records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Sida Cordifolia
What is Sida Cordifolia?
- Weight loss and energy
- Asthma and breathing problems
- Joint and muscle pain
- Fever and cough
- General fatigue or 'tonic'
Sida cordifolia (bala or country mallow) is a traditional Ayurvedic plant that naturally contains ephedrine, a powerful stimulant. Because of this, many supplements containing it have been banned or restricted, and it carries real risks to the heart and blood pressure. There is little reliable human evidence that it works, so most people should avoid it and talk with a pharmacist or doctor first.
Sida cordifolia · Malvaceae · Whole plant, including roots, seeds, leaves, and stems · Capsules, powders, dried herb, teas, and traditional Ayurvedic preparations
An interaction check asks whether these two react with each other — it does not ask whether Sida Cordifolia is a good idea for someone in your situation. Here is what our Sida Cordifolia record says about it on its own.
Sida Cordifolia: dosing
There is no established safe or standardized dose for Sida cordifolia, and the amount of ephedrine in a product can vary widely and unpredictably. Many health authorities recommend avoiding ephedrine-containing supplements entirely.
From our Sida Cordifolia monograph — the full record covers uses, side effects and every documented interaction.
About Esomeprazole
What Is Esomeprazole Used For?
Brand name: Nexium
Esomeprazole treats problems caused by excess stomach acid. It's used to heal erosive esophagitis (damage to the esophagus from acid), control GERD (gastroesophageal reflux disease) symptoms like heartburn, and protect the stomach lining in people at risk for ulcers caused by NSAIDs (anti-inflammatory pain relievers like ibuprofen).
It's also used as part of a three-drug combination to wipe out H. pylori — a stomach bacteria linked to ulcers — and for people with rare conditions that cause the stomach to overproduce acid, such as Zollinger-Ellison syndrome.
Most-Reported Side Effects for Esomeprazole
From FAERS, the FDA’s public side-effect reporting system (235,235 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Sida Cordifolia
Browse every other medication we’ve checked against Sida Cordifolia — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
337 interactions
- Theophylline ›
- Metronidazole ›
- Phentermine ›
- Methylphenidate ›
- Erythromycin ›
- Phenylpropanolamine ›
- Quinidine ›
- Dyphylline ›
- Nicotine ›
- Tacrolimus ›
- Phenylephrine ›
- Procainamide ›
- Pseudoephedrine ›
- Trimipramine ›
- Amphetamine ›
- Diethylpropion ›
- Lofepramine ›
- Sotalol ›
- Sumatriptan Succinate ›
- Aripiprazole ›
- Azithromycin ›
- Caffeine (otc Drug) ›
- Desipramine ›
- Doxepin ›
- Erythromycin Ethylsuccinate ›
- Erythromycin Stearate ›
- Levofloxacin ›
- Modafinil ›
- Nicardipine ›
- Oxymetazoline Hydrochloride ›
- Amiodarone ›
- Amphetamine Sulfate ›
- Aripiprazole Lauroxil ›
- Artemether ›
- Asenapine ›
- Caffeine (prescription Drug) ›
- Chlorpromazine ›
- Clarithromycin ›
- Cocaine Hydrochloride (prescription Drug) ›
- Dasatinib ›
- Desvenlafaxine ›
- Dexmedetomidine ›
- Disopyramide Phosphate ›
- Ephedrine Sulfate ›
- Fluoxetine ›
- Gatifloxacin ›
- Imipramine ›
- Indacaterol ›
- Indapamide ›
- Methylphenidate Hydrochloride ›
- Mifepristone ›
- Oxtriphylline ›
- Pemoline ›
- Pseudoephedrine Sulfate ›
- Quetiapine ›
- Ranolazine ›
- Rilpivirine ›
- Risperidone ›
- Tamoxifen Citrate ›
- Tizanidine ›
Showing 60 of 337 major interactions — see all 337 on the Sida Cordifolia page.
108 interactions
- Insulin (rdna) ›
- Dexamethasone ›
- Glyburide ›
- Insulin (pork) ›
- Insulin (human) ›
- Selegiline ›
- Acarbose ›
- Insulin Glargine ›
- Semaglutide ›
- Chlorpropamide ›
- Dihydroergotamine ›
- Ergotamine Tartrate (prescription Drug) ›
- Exenatide ›
- Glipizide ›
- Glucagon ›
- Insulin Lispro ›
- Metformin ›
- Moclobemide ›
- Pergolide Mesylate ›
- Repaglinide ›
- Sitagliptin ›
- Tirzepatide ›
- Acetohexamide ›
- Albiglutide ›
- Alogliptin ›
- Bromocriptine ›
- Canagliflozin ›
- Dapagliflozin ›
- Dasiglucagon Hydrochloride ›
- Dihydroergotamine Mesylate ›
- Dulaglutide ›
- Empagliflozin ›
- Ergoloid Mesylates ›
- Ergonovine Maleate (prescription Drug) ›
- Ertugliflozin ›
- Exenatide Synthetic ›
- Gliclazide ›
- Glimepiride ›
- Glucose ›
- Inhaled Insulin ›
- Insulin ›
- Insulin (bovine) ›
- Insulin Aspart ›
- Insulin Degludec ›
- Insulin Determir ›
- Insulin Glargine (rdna) ›
- Insulin Glargine Recombinant ›
- Insulin Glulisine (rdna) ›
- Insulin Lispro Recombinant ›
- Insulin Lispro-aabc ›
- Isocarboxazid ›
- Linagliptin ›
- Liraglutide ›
- Liraglutide Recombinant ›
- Lixisenatide ›
- Metformin Hydrochloride ›
- Metformin Xr ›
- Methylergonovine Maleate ›
- Methysergide Maleate ›
- Miglitol ›
Showing 60 of 108 moderate interactions — see all 108 on the Sida Cordifolia page.
No interaction 2,384 drugs checked — show the list
We also checked Sida Cordifolia against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Ivermectin ›
- Aspirin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Tadalafil ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Abemaciclib ›
- Ibuprofen ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Bupropion ›
- Amoxicillin ›
- Acyclovir ›
- Lisinopril ›
- Bendamustine ›
- Doxycycline ›
- Methotrexate ›
- Lamotrigine ›
- Gabapentin ›
- Pregabalin ›
- Acetaminophen, Codeine ›
- Isotretinoin ›
- Clonazepam ›
- Omeprazole ›
- Methylene Blue ›
- Amlodipine Besylate ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Naproxen ›
- Ciprofloxacin ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
- Acetaminophen, Oxycodone ›
- Dapsone ›
- Diazepam ›
- Cyclopentolate ›
- Candesartan Cilexetil ›
- Cephalexin ›
- Mannitol ›
- Roxithromycin ›
- Atorvastatin Calcium ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Pegunigalsidase Alfa-iwxj ›
- Daptomycin ›
Showing the 60 most looked-up of 2,384 medications checked with no known interaction — see the full Sida Cordifolia list.
Sida Cordifolia References
The 29 references that drive our Sida Cordifolia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Okada S, Rohan PJ, Miller FW, et al. Myopathies following ingestion of special nutritional products. Arthritis Rheum 1996;39:349.
- Zaacks SM, Klein L, Tan CD, et al. Hypersensitivity myocarditis associated with ephedra use. J Toxicol Clin Toxicol 1999;37:485-9. PubMed
- Powell T, Hsu FF, Turk J, Hruska K. Ma-huang strikes again: ephedrine nephrolithiasis. Am J Kidney Dis 1998;32:153-9. PubMed
- Theoharides TC. Sudden death of a healthy college student related to ephedrine toxicity from a ma-huang containing drink. J Clin Psychopharmacol 1997;17:437-9. PubMed
- Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3.
- Doyle H, Kargin M. Herbal stimulant containing ephedrine has also caused psychosis. BMJ 1996;313:756. PubMed
- For Dieter, Nearly the Ultimate Loss. The Washington Post. Available at: http://www.washingtonpost.com/archive/politics/2000/03/19/for-dieter-nearly-the-ultimate-loss/c0f07474-489d-4f44-bc17-1f1367c956ae/ (Accessed 19 March 2000).
- FDA Takes Aim at Ephedra. The Washington Post. Available at: http://www.washingtonpost.com/archive/politics/2000/03/19/fda-takes-aim-at-ephedra/4ce534a7-d291-44ec-88a8-38e97ff27e3b/ (Accessed 19 March 2000).
- FDA. Proposed rule: dietary supplements containing ephedrine alkaloids. Available at: www.verity.fda.gov (Accessed 25 January 2000).
- Boozer CN, Nasser JA, Heymsfield SB, et al. An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial. Int J Obes Relat Metab Disord 2001;25:316-24. PubMed
- Anon. Sida Cordifolia. Metro Marketing, Inc. Available at: http://metromkt.net/viable/1sidacor.shtml (Accessed 9 March 2000).
- Gurley BJ, Gardner SF, Hubbard MA. Content versus label claims in ephedra-containing dietary supplements. Am J Health Syst Pharm 2000;57:963-9. PubMed
- White LM, Gardner SF, Gurley BJ, et al. Pharmacokinetics and Cardiovascular Effects of Ma-Huang (Ephedra sinica) in Normotensive Adults. J Clin Pharmacol 1997;37:116-22.
- Haller CA, Benowitz NL. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 2000;343:1833-8. PubMed
- Leikin JB, Klein L. Ephedra causes myocarditis. Clin Toxicol 2000;38:353-4.
- Jacobs KM, Hirsch KA. Psychiatric complications of Ma-huang. Psychosomatics 2000;41:58-62. PubMed
- Dulloo AG. Herbal simulation of ephedrine and caffeine in treatment of obesity. Int J Obes Relat Metab Disord 2002;26:590-2. PubMed
- Samenuk D, Link MS, Homoud MK, et al. Adverse cardiovascular events temporally associated with ma huang, an herbal source of ephedrine. Mayo Clin Proc 2002;77:12-6. PubMed
- Boozer CN, Daly PA, Homel P, et al. Herbal ephedra/caffeine for weight loss: a 6-month randomized safety and efficacy trial. Int J Obes Relat Metab Disord 2002;26:593-604. PubMed
- Morgenstern LB, Viscoli CM, Kernan WN, et al. Use of Ephedra-containing products and risk for hemorrhagic stroke. Neurology 2003;60:132-5. .
- Kalman D, Incledon T, Gaunaurd I, et al. An acute clinical trial evaluating the cardiovascular effects of an herbal ephedra-caffeine weight loss product in healthy overweight adults. Int J Obes 2002;26:1363-66.. PubMed
- Kockler DR, McCarthy MW, Lawson CL. Seizure activity and unresponsiveness after hydroxycut ingestion. Pharmacotherapy 2001;21:647-51.. PubMed
- Yates KM, O'Connor A, Horsley CA. "Herbal Ecstasy": a case series of adverse reactions. N Z Med J 2000;113:315-7..
- Walton R, Manos GH. Psychosis related to ephedra-containing herbal supplement use. South Med J 2003;96:718-20.. PubMed
- Jenkins DJ, Wesson V, Wolever TM, et al. Wholemeal versus wholegrain breads: proportion of whole or cracked grain and the glycaemic response. BMJ 1988;297:958-60. PubMed
- McBride BF, Karapanos AK, Krudysz A, et al. Electrocardiographic and hemodynamic effects of a multicomponent dietary supplement containing ephedra and caffeine: a randomized controlled trial. JAMA 2004;291:216-21. PubMed
- Brooks SM, Sholiton LJ, Werk EE Jr, Altenau P. The effects of ephedrine and theophylline on dexamethasone metabolism in bronchial asthma. J Clin Pharmacol 1977;17:308-18. PubMed
- Gardner SF, Franks AM, Gurley BJ, et al. Effect of a multicomponent, ephedra-containing dietary supplement (Metabolife 356) on Holter monitoring and hemostatic parameters in healthy volunteers. Am J Cardiol 2003;91:1510-3, A9. PubMed
- Haller CA, Jacob P 3rd, Benowitz NL. Enhanced stimulant and metabolic effects of combined ephedrine and caffeine. Clin Pharmacol Ther 2004;75:259-73.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Esomeprazole Is Linked to Lower Levels of 9 Nutrients
Natural Medicines records Esomeprazole as a medicine that can lower these. This is not an interaction with Sida Cordifolia — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Esomeprazole nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Sida Cordifolia and Esomeprazole Together: Common Questions
Is it safe to take Sida Cordifolia with Esomeprazole?
Do Sida Cordifolia and Esomeprazole have any of the same side effects?
Should I take Sida Cordifolia and Esomeprazole at the same time of day?
How was the Sida Cordifolia and Esomeprazole combination checked?
Does Sida Cordifolia interact with any other medications?
Does Esomeprazole interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.