Medication interaction hub

What Supplements Interact with Dextromethorphan, Guaifenesin, Pseudophedrine?

Dextromethorphan, Guaifenesin, Pseudophedrine brand names: Organidin NR, Anatuss DM. Every interaction below applies to the brands too.

171 Interactions 4 Major 125 Moderate 42 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Dextromethorphan, Guaifenesin, Pseudophedrine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Dextromethorphan, Guaifenesin, Pseudophedrine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

171 supplements and herbal ingredients have interactions with Dextromethorphan, Guaifenesin, Pseudophedrine on file in the HelloPharmacist interaction database — 4 rated major, 125 moderate, and 42 minor. The most serious involve Grapefruit, Activated Charcoal, Lithium and St. John's Wort.

Our assessment: with 4 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Dextromethorphan, Guaifenesin, Pseudophedrine.

Major 4 Moderate 125 Minor 42 No known interaction 1,281

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Dextromethorphan, Guaifenesin, Pseudophedrine: Top Interactions at a Glance

The Dextromethorphan, Guaifenesin, Pseudophedrine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 171 interacting ingredients — plus 1,281 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Dextromethorphan, Guaifenesin, Pseudophedrine Combinations Today

The Dextromethorphan, Guaifenesin, Pseudophedrine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Cranberry + Dextromethorphan, Guaifenesin, Pseudophedrinei

Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.

Read the full interaction Minor Likelihood Possible Fucus Vesiculosus + Dextromethorphan, Guaifenesin, Pseudophedrinei

Theoretically, concomitant use of Fucus vesiculosus with CYP2D6 substrates might alter the effects of these substrates.

Read the full interaction Major Likelihood Probable Activated Charcoal + Dextromethorphan, Guaifenesin, Pseudophedrinei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Moderate Likelihood Possible Hu Zhang + Dextromethorphan, Guaifenesin, Pseudophedrinei

Theoretically, hu zhang might increase levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Sulforaphane + Dextromethorphan, Guaifenesin, Pseudophedrinei

Theoretically, sulforaphane might increase the levels and effects of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Diosmin + Dextromethorphan, Guaifenesin, Pseudophedrinei

Theoretically, diosmin might inhibit the metabolism of CYP3A4 substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Dextromethorphan, Guaifenesin, Pseudophedrine

All 1,452 ingredients in our database, ranked by severity — 171 with a Dextromethorphan, Guaifenesin, Pseudophedrine interaction on file and 1,281 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Dextromethorphan, Guaifenesin, Pseudophedrine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Cranberry with Dextromethorphan, Guaifenesin, Pseudophedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.

Full Cranberry + Dextromethorphan, Guaifenesin, Pseudophedrine answer

Can you take Fucus Vesiculosus with Dextromethorphan, Guaifenesin, Pseudophedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of Fucus vesiculosus with CYP2D6 substrates might alter the effects of these substrates.

Full Fucus Vesiculosus + Dextromethorphan, Guaifenesin, Pseudophedrine answer

Can you take Activated Charcoal with Dextromethorphan, Guaifenesin, Pseudophedrine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Dextromethorphan, Guaifenesin, Pseudophedrine answer

Can you take Hu Zhang with Dextromethorphan, Guaifenesin, Pseudophedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hu zhang might increase levels of drugs metabolized by CYP3A4.

Full Hu Zhang + Dextromethorphan, Guaifenesin, Pseudophedrine answer

Can you take Sulforaphane with Dextromethorphan, Guaifenesin, Pseudophedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sulforaphane might increase the levels and effects of CYP3A4 substrates.

Full Sulforaphane + Dextromethorphan, Guaifenesin, Pseudophedrine answer

Can you take Hordenine with Dextromethorphan, Guaifenesin, Pseudophedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Hordenine weakly inhibits cytochrome P450 2D6 (CYP2D6) enzymes in vitro.

Full Hordenine + Dextromethorphan, Guaifenesin, Pseudophedrine answer

Can you take Karaya Gum with Dextromethorphan, Guaifenesin, Pseudophedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Dextromethorphan, Guaifenesin, Pseudophedrine answer

Can you take Marshmallow with Dextromethorphan, Guaifenesin, Pseudophedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Dextromethorphan, Guaifenesin, Pseudophedrine answer

Can you take Melatonin with Dextromethorphan, Guaifenesin, Pseudophedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, melatonin might increase levels of drugs metabolized by CYP2D6.

Full Melatonin + Dextromethorphan, Guaifenesin, Pseudophedrine answer

Can you take Passion Flower with Dextromethorphan, Guaifenesin, Pseudophedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, passion flower might decrease the effects of CYP3A4 substrates.

Full Passion Flower + Dextromethorphan, Guaifenesin, Pseudophedrine answer

Can you take Puravive with Dextromethorphan, Guaifenesin, Pseudophedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Puravive contains Panax ginseng.

Full Puravive + Dextromethorphan, Guaifenesin, Pseudophedrine answer

Can you take Rhodiola with Dextromethorphan, Guaifenesin, Pseudophedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.

Full Rhodiola + Dextromethorphan, Guaifenesin, Pseudophedrine answer

Can you take Valerian with Dextromethorphan, Guaifenesin, Pseudophedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.

Full Valerian + Dextromethorphan, Guaifenesin, Pseudophedrine answer

Can you take Vitamin D with Dextromethorphan, Guaifenesin, Pseudophedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Full Vitamin D + Dextromethorphan, Guaifenesin, Pseudophedrine answer

Can you take Xanthan Gum with Dextromethorphan, Guaifenesin, Pseudophedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Dextromethorphan, Guaifenesin, Pseudophedrine answer

Can you take Yerba Mate with Dextromethorphan, Guaifenesin, Pseudophedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, yerba mate might increase the levels and clinical effects of CYP3A4 substrates.

Full Yerba Mate + Dextromethorphan, Guaifenesin, Pseudophedrine answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Dextromethorphan, Guaifenesin, Pseudophedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, THC may increase the levels and clinical effects of CYP3A4 substrates.

Full Delta-9-tetrahydrocannabinol (thc) + Dextromethorphan, Guaifenesin, Pseudophedrine answer

Can you take Eleuthero with Dextromethorphan, Guaifenesin, Pseudophedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.

Full Eleuthero + Dextromethorphan, Guaifenesin, Pseudophedrine answer

Can you take Green Tea with Dextromethorphan, Guaifenesin, Pseudophedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Green tea is unlikely to produce clinically significant changes in the levels and clinical effects of CYP3A4 substrates.

Full Green Tea + Dextromethorphan, Guaifenesin, Pseudophedrine answer

Can you take Gymnema with Dextromethorphan, Guaifenesin, Pseudophedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.

Full Gymnema + Dextromethorphan, Guaifenesin, Pseudophedrine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Dextromethorphan, Guaifenesin, Pseudophedrine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Dextromethorphan, Guaifenesin, Pseudophedrine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Dextromethorphan, Guaifenesin, Pseudophedrine sits in 6 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Dextromethorphan, Guaifenesin, Pseudophedrine through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Dextromethorphan, Guaifenesin, Pseudophedrine through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Dextromethorphan, Guaifenesin, Pseudophedrine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Dextromethorphan, Guaifenesin, Pseudophedrine through this category.

Dextromethorphan (Robitussin Dm, Others) 9 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

9 of the supplement ingredients on this page reach Dextromethorphan, Guaifenesin, Pseudophedrine through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Dextromethorphan, Guaifenesin, Pseudophedrine through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Dextromethorphan, Guaifenesin, Pseudophedrine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Dextromethorphan, Guaifenesin, Pseudophedrine.

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Pharmacist Counseling Corner

Dextromethorphan, Guaifenesin, Pseudophedrine & Supplements: Common Questions

What supplements interact with Dextromethorphan, Guaifenesin, Pseudophedrine?
More than you might expect — 171 in total, though they are far from equal: 4 are rated major, 125 moderate, and 42 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Activated Charcoal, Lithium.
Which Dextromethorphan, Guaifenesin, Pseudophedrine supplement interactions are the most serious?
The 4 major-rated combinations — led by Grapefruit, Activated Charcoal, Lithium and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Dextromethorphan, Guaifenesin, Pseudophedrine?
Usually yes — most people on Dextromethorphan, Guaifenesin, Pseudophedrine can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Organidin NR have the same supplement interactions as Dextromethorphan, Guaifenesin, Pseudophedrine?
Yes — Organidin NR, Anatuss DM all contain Dextromethorphan, Guaifenesin, Pseudophedrine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Dextromethorphan, Guaifenesin, Pseudophedrine and my other medications?
This page covers Dextromethorphan, Guaifenesin, Pseudophedrine against supplements and herbal ingredients. Checking Dextromethorphan, Guaifenesin, Pseudophedrine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.