Medication interaction hub

What Supplements Interact with Dorzolamide, Timolol?

Dorzolamide, Timolol brand name: Cosopt. Every interaction below applies to the brands too.

71 Interactions 1 Major 59 Moderate 11 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Dorzolamide, Timolol? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Dorzolamide, Timolol against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Indian snakeroot is the one entry here I would treat as a genuine hazard with Cosopt (dorzolamide and timolol), the glaucoma eye drop. Its reserpine content plus a beta-blocker like timolol could slow the heart or drop blood pressure too far, and it holds the only major rating among the 71 supplements and herbs on file. Enough timolol from an eye drop reaches the bloodstream to act like an oral beta-blocker, so this page deserves careful reading.

The 59 moderate and 11 minor entries mostly share one mechanism: sixty ingredients, goldenseal among them, can slow the enzyme (CYP2D6) that clears timolol from the body, letting levels creep up. A few others, policosanol with actual human evidence behind it, add their own blood-pressure-lowering push, and six may raise seizure risk. Start with the major entry, then check the list for anything you already take.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 59 Minor 11 No known interaction 1,381

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Dorzolamide, Timolol: Top Interactions at a Glance

The Dorzolamide, Timolol supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 71 interacting ingredients — plus 1,381 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Dorzolamide, Timolol Combinations Today

The Dorzolamide, Timolol + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Terminalia + Dorzolamide, Timololi

Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.

Read the full interaction Moderate Likelihood Possible Hawthorn + Dorzolamide, Timololi

Theoretically, concomitant use might cause additive effects on blood pressure and heart rate.

Read the full interaction Moderate Likelihood Possible Rooibos + Dorzolamide, Timololi

Theoretically, taking rooibos with CYP2D6 substrates may increase the effects of CYP2D6 substrates.

Read the full interaction Moderate Likelihood Possible 1,3-dmaa + Dorzolamide, Timololi

1,3-DMAA strongly inhibits cytochrome P450 2D6 (CYP2D6) enzymes in vitro.

Read the full interaction Moderate Likelihood Possible Active Hexose Correlated Compound (ahcc) + Dorzolamide, Timololi

Theoretically, AHCC might increase levels of drugs metabolized by CYP2D6.

Read the full interaction Major Likelihood Probable Indian Snakeroot + Dorzolamide, Timololi

Theoretically, taking Indian snakeroot with beta-blockers might increase the risk of bradycardia and/or hypotension.

Read the full interaction
The complete list

Every Supplement Checked Against Dorzolamide, Timolol

All 1,452 ingredients in our database, ranked by severity — 71 with a Dorzolamide, Timolol interaction on file and 1,381 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Dorzolamide, Timolol?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Terminalia with Dorzolamide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.

Full Terminalia + Dorzolamide, Timolol answer

Can you take Hawthorn with Dorzolamide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might cause additive effects on blood pressure and heart rate.

Full Hawthorn + Dorzolamide, Timolol answer

Can you take Rooibos with Dorzolamide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rooibos with CYP2D6 substrates may increase the effects of CYP2D6 substrates.

Full Rooibos + Dorzolamide, Timolol answer

Can you take 1,3-dmaa with Dorzolamide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. 1,3-DMAA strongly inhibits cytochrome P450 2D6 (CYP2D6) enzymes in vitro.

Full 1,3-dmaa + Dorzolamide, Timolol answer

Can you take Active Hexose Correlated Compound (ahcc) with Dorzolamide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, AHCC might increase levels of drugs metabolized by CYP2D6.

Full Active Hexose Correlated Compound (ahcc) + Dorzolamide, Timolol answer

Can you take Indian Snakeroot with Dorzolamide, Timolol?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, taking Indian snakeroot with beta-blockers might increase the risk of bradycardia and/or hypotension.

Full Indian Snakeroot + Dorzolamide, Timolol answer

Can you take Ayahuasca with Dorzolamide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ayahuasca might increase plasma concentrations of CYP2D6 substrates.

Full Ayahuasca + Dorzolamide, Timolol answer

Can you take Goldenseal with Dorzolamide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Goldenseal might increase serum levels of drugs metabolized by CYP2D6.

Full Goldenseal + Dorzolamide, Timolol answer

Can you take Octacosanol with Dorzolamide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of octacosanol with beta-blockers might result in additive hypotensive effects.

Full Octacosanol + Dorzolamide, Timolol answer

Can you take Policosanol with Dorzolamide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of policosanol with beta-blockers can cause additive blood pressure-lowering effects.

Full Policosanol + Dorzolamide, Timolol answer

Can you take Syrian Rue with Dorzolamide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Syrian rue might increase the levels and clinical effects of drugs metabolized by CYP2D6.

Full Syrian Rue + Dorzolamide, Timolol answer

Can you take Acacia Rigidula with Dorzolamide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Acacia rigidula products that are adulterated with beta-methylphenylethylamine (BMPEA) might increase the levels of CYP2D6 su...

Full Acacia Rigidula + Dorzolamide, Timolol answer

Can you take Berberine with Dorzolamide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase serum levels of drugs metabolized by CYP2D6.

Full Berberine + Dorzolamide, Timolol answer

Can you take Beta-methylphenethylamine (bmpea) with Dorzolamide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, BMPEA might increase the levels and clinical effects of CYP2D6 substrates.

Full Beta-methylphenethylamine (bmpea) + Dorzolamide, Timolol answer

Can you take Biofeedback with Dorzolamide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that electroencephalogram (EEG) biofeedback might lower the seizure threshold in some patients.

Full Biofeedback + Dorzolamide, Timolol answer

Can you take Black Cohosh with Dorzolamide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some research suggests that black cohosh might inhibit CYP2D6, but there is conflicting evidence.

Full Black Cohosh + Dorzolamide, Timolol answer

Can you take Black Pepper with Dorzolamide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.

Full Black Pepper + Dorzolamide, Timolol answer

Can you take Boswellia Serrata with Dorzolamide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.

Full Boswellia Serrata + Dorzolamide, Timolol answer

Can you take Cajeput Oil with Dorzolamide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that cajeput leaf extract can inhibit cytochrome P450 2D6 (CYP2D6) by approximately 30%.

Full Cajeput Oil + Dorzolamide, Timolol answer

Can you take Calamus with Dorzolamide, Timolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking calamus with drugs metabolized by CYP2D6 might increase drug levels and potentially increase the risk of adverse effec...

Full Calamus + Dorzolamide, Timolol answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Dorzolamide, Timolol is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Dorzolamide, Timolol, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Dorzolamide, Timolol sits in 4 interaction categories. Open any one to see what the group means:

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Dorzolamide, Timolol through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Dorzolamide, Timolol through this category.

Beta-Blockers 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Dorzolamide, Timolol through this category.

Topical Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Dorzolamide, Timolol through this category.

About Dorzolamide, Timolol

Dorzolamide and timolol ophthalmic is a combination eye drop used to lower elevated eye pressure in adults and children with open-angle glaucoma or ocular hypertension.

Generic name: Dorzolamide, Timolol  ·  Brand name: Cosopt.

See the full Dorzolamide and Timolol Ophthalmic drug information

Related: does Dorzolamide, Timolol deplete any nutrients?

Dorzolamide, Timolol has 1 reported nutrient association in the research literature — see the Dorzolamide, Timolol nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Dorzolamide, Timolol

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Dorzolamide, Timolol.

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Pharmacist Counseling Corner

Dorzolamide, Timolol & Supplements: Common Questions

What supplements interact with Dorzolamide, Timolol?
Our database currently documents 71 ingredients with a known Dorzolamide, Timolol interaction (1 major, 59 moderate, 11 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 71. The highest-ranked right now: Indian Snakeroot, Ayahuasca, Goldenseal.
Which Dorzolamide, Timolol supplement interactions are the most serious?
Focus on the major group: Indian Snakeroot. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Dorzolamide, Timolol?
Plenty of supplements coexist fine with Dorzolamide, Timolol; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Cosopt have the same supplement interactions as Dorzolamide, Timolol?
Yes — Cosopt all contain Dorzolamide, Timolol, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Dorzolamide, Timolol deplete any vitamins or nutrients?
It might — Dorzolamide, Timolol has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Dorzolamide, Timolol nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Dorzolamide, Timolol and my other medications?
This page covers Dorzolamide, Timolol against supplements and herbal ingredients. Checking Dorzolamide, Timolol against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Dorzolamide and Timolol Ophthalmic drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.