Medication interaction hub

What Supplements Interact with Ibrexafungerp Citrate?

Ibrexafungerp Citrate brand name: Brexafemme. Every interaction below applies to the brands too.

138 Interactions 3 Major 94 Moderate 41 Minor
Curated & coded by · Clinical Pharmacist · Updated October 4, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ibrexafungerp Citrate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ibrexafungerp Citrate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Ibrexafungerp (Brexafemme) treats vaginal yeast infections, often in a single day of pills, and even that short course can be thrown off by the wrong supplement, so this list warrants real care. Three of the 138 ingredients on file rate major, and they pull in opposite directions. Grapefruit juice blocks the enzyme (CYP3A4) that clears ibrexafungerp, so levels can climb, while St. John's wort speeds that same enzyme up and can leave too little medicine to cure the infection. Activated charcoal soaks up pills in the gut before they absorb.

Most of the other entries echo those same two problems on a smaller scale. Of the 94 moderate and 41 minor listings, nearly all either nudge that enzyme one way or the other or interfere with how oral doses absorb. Skip grapefruit and St. John's wort during treatment, and space charcoal or thick fiber supplements well apart from your pills.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 94 Minor 41 No known interaction 1,314

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Ibrexafungerp Citrate: Top Interactions at a Glance

The Ibrexafungerp Citrate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 138 interacting ingredients — plus 1,314 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Ibrexafungerp Citrate Combinations Today

The Ibrexafungerp Citrate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Echinacea + Ibrexafungerp Citratei

Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.

Read the full interaction Major Likelihood Likely Grapefruit + Ibrexafungerp Citratei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Minor Likelihood Unlikely Gymnema + Ibrexafungerp Citratei

Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.

Read the full interaction Minor Likelihood Unlikely Pomegranate + Ibrexafungerp Citratei

Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically signif...

Read the full interaction Major Likelihood Probable Activated Charcoal + Ibrexafungerp Citratei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable St. John's Wort + Ibrexafungerp Citratei

St.

Read the full interaction
The complete list

Every Supplement Checked Against Ibrexafungerp Citrate

All 1,452 ingredients in our database, ranked by severity — 138 with a Ibrexafungerp Citrate interaction on file and 1,314 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ibrexafungerp Citrate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Echinacea with Ibrexafungerp Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.

Full Echinacea + Ibrexafungerp Citrate answer

Can you take Grapefruit with Ibrexafungerp Citrate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Full Grapefruit + Ibrexafungerp Citrate answer

Can you take Gymnema with Ibrexafungerp Citrate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.

Full Gymnema + Ibrexafungerp Citrate answer

Can you take Pomegranate with Ibrexafungerp Citrate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to...

Full Pomegranate + Ibrexafungerp Citrate answer

Can you take Kava with Ibrexafungerp Citrate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if kava inhibits CYP3AA; research is conflicting.

Full Kava + Ibrexafungerp Citrate answer

Can you take Milk Thistle with Ibrexafungerp Citrate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if milk thistle inhibits CYP3A4; research is conflicting.

Full Milk Thistle + Ibrexafungerp Citrate answer

Can you take Mommy's Bliss Gripe Water with Ibrexafungerp Citrate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Mommy's Bliss Gripe Water contains fennel seed.

Full Mommy's Bliss Gripe Water + Ibrexafungerp Citrate answer

Can you take Polypodium Leucotomos with Ibrexafungerp Citrate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Polypodium leucotomos might increase levels of drugs metabolized by CYP3A4.

Full Polypodium Leucotomos + Ibrexafungerp Citrate answer

Can you take Red Clover with Ibrexafungerp Citrate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.

Full Red Clover + Ibrexafungerp Citrate answer

Can you take Tangerine with Ibrexafungerp Citrate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).

Full Tangerine + Ibrexafungerp Citrate answer

Can you take Activated Charcoal with Ibrexafungerp Citrate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Ibrexafungerp Citrate answer

Can you take St. John's Wort with Ibrexafungerp Citrate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. St.

Full St. John's Wort + Ibrexafungerp Citrate answer

Can you take Cannabidiol (cbd) with Ibrexafungerp Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cannabidiol may increase levels of drugs that are metabolized by CYP3A4.

Full Cannabidiol (cbd) + Ibrexafungerp Citrate answer

Can you take Coffee Charcoal with Ibrexafungerp Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Ibrexafungerp Citrate answer

Can you take European Mandrake with Ibrexafungerp Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Ibrexafungerp Citrate answer

Can you take Glucomannan with Ibrexafungerp Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Ibrexafungerp Citrate answer

Can you take Guggul with Ibrexafungerp Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, guggul might reduce the effects of CYP3A4 substrates.

Full Guggul + Ibrexafungerp Citrate answer

Can you take Schisandra with Ibrexafungerp Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Schisandra + Ibrexafungerp Citrate answer

Can you take Tree Turmeric with Ibrexafungerp Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.

Full Tree Turmeric + Ibrexafungerp Citrate answer

Can you take Acacia Rigidula with Ibrexafungerp Citrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Acacia rigidula products that are adulterated with beta-methylphenylethylamine (BMPEA) might increase the levels of CYP3A4 su...

Full Acacia Rigidula + Ibrexafungerp Citrate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ibrexafungerp Citrate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ibrexafungerp Citrate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ibrexafungerp Citrate sits in 2 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Ibrexafungerp Citrate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Ibrexafungerp Citrate through this category.

About Ibrexafungerp Citrate

Ibrexafungerp Citrate is a prescription medication also sold under the brand name Brexafemme. Because supplements and herbal products can change how medications work — or how strongly — every ingredient on this page has been checked against it in our interaction database.

Generic name: Ibrexafungerp Citrate  ·  Brand name: Brexafemme.

See the full Ibrexafungerp drug information
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Take a Supplement Product? Check the Whole Bottle Against Ibrexafungerp Citrate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Ibrexafungerp Citrate.

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Pharmacist Counseling Corner

Ibrexafungerp Citrate & Supplements: Common Questions

What supplements interact with Ibrexafungerp Citrate?
In our interaction database, 138 supplement and herbal ingredients have an interaction with Ibrexafungerp Citrate on file — 3 rated major, 94 moderate, and 41 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Activated Charcoal, St. John's Wort.
Which Ibrexafungerp Citrate supplement interactions are the most serious?
The 3 major-rated combinations — led by Grapefruit, Activated Charcoal and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Ibrexafungerp Citrate?
That depends entirely on which supplement. The honest answer for Ibrexafungerp Citrate is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Brexafemme have the same supplement interactions as Ibrexafungerp Citrate?
Yes — Brexafemme all contain Ibrexafungerp Citrate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Ibrexafungerp Citrate and my other medications?
This page covers Ibrexafungerp Citrate against supplements and herbal ingredients. Checking Ibrexafungerp Citrate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Ibrexafungerp drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 4, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.