Medication interaction hub

What Supplements Interact with Sofosbuvir, Velpatasvir?

Sofosbuvir, Velpatasvir brand name: Epclusa. Every interaction below applies to the brands too.

147 Interactions 3 Major 108 Moderate 36 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Sofosbuvir, Velpatasvir? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Sofosbuvir, Velpatasvir against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Epclusa (the sofosbuvir and velpatasvir combination) is a finite course meant to cure hepatitis C, so I treat its supplement interactions with genuine seriousness, since anything that lowers the drug's level can undermine the cure itself. St. John's wort is the clearest threat, speeding up the liver enzyme (CYP3A4) that processes velpatasvir and potentially leaving too little medicine to work. Grapefruit pushes the other direction, raising levels and side effect risk, and activated charcoal can soak up the dose before it ever absorbs.

Most of the 147 ingredients on this page act through those same channels, either the CYP3A4 enzyme or the P-glycoprotein transporter, nudging drug levels up or down by varying degrees. A smaller cluster, mostly charcoals and bulky fibers like glucomannan, can blunt absorption of any pill, so space them well apart from your dose. Only the three named above are rated major; 108 sit at moderate and 36 at minor.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 108 Minor 36 No known interaction 1,305

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Sofosbuvir, Velpatasvir: Top Interactions at a Glance

The most significant Sofosbuvir, Velpatasvir supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 147 interacting ingredients — plus 1,305 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Sofosbuvir, Velpatasvir + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Grapefruit + Sofosbuvir, Velpatasviri

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Probable Activated Charcoal + Sofosbuvir, Velpatasviri

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable St. John's Wort + Sofosbuvir, Velpatasviri

St.

Read the full interaction
The complete list

Every Supplement Checked Against Sofosbuvir, Velpatasvir

All 1,452 ingredients in our database, ranked by severity — 147 with a Sofosbuvir, Velpatasvir interaction on file and 1,305 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Sofosbuvir, Velpatasvir?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Goldthread with Sofosbuvir, Velpatasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme.

Full Goldthread + Sofosbuvir, Velpatasvir answer

Can you take Resveratrol with Sofosbuvir, Velpatasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.

Full Resveratrol + Sofosbuvir, Velpatasvir answer

Can you take Rhodiola with Sofosbuvir, Velpatasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rhodiola might increase levels of P-glycoprotein substrates.

Full Rhodiola + Sofosbuvir, Velpatasvir answer

Can you take Rooibos with Sofosbuvir, Velpatasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rooibos with CYP3A4 substrates may increase the effects of CYP3A4 substrates.

Full Rooibos + Sofosbuvir, Velpatasvir answer

Can you take Sage with Sofosbuvir, Velpatasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Sage + Sofosbuvir, Velpatasvir answer

Can you take Schizonepeta with Sofosbuvir, Velpatasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, induces cytochrome P450 (CYP) 3A4.

Full Schizonepeta + Sofosbuvir, Velpatasvir answer

Can you take Slippery Elm with Sofosbuvir, Velpatasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Sofosbuvir, Velpatasvir answer

Can you take Strawberry with Sofosbuvir, Velpatasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that strawberry extract can inhibit p-glycoprotein efflux.

Full Strawberry + Sofosbuvir, Velpatasvir answer

Can you take Sulforaphane with Sofosbuvir, Velpatasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sulforaphane might increase the levels and effects of CYP3A4 substrates.

Full Sulforaphane + Sofosbuvir, Velpatasvir answer

Can you take Sweet Annie with Sofosbuvir, Velpatasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.

Full Sweet Annie + Sofosbuvir, Velpatasvir answer

Can you take Sweet Orange with Sofosbuvir, Velpatasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.

Full Sweet Orange + Sofosbuvir, Velpatasvir answer

Can you take Syrian Rue with Sofosbuvir, Velpatasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Syrian rue might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Syrian Rue + Sofosbuvir, Velpatasvir answer

Can you take Terminalia with Sofosbuvir, Velpatasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.

Full Terminalia + Sofosbuvir, Velpatasvir answer

Can you take Thunder God Vine with Sofosbuvir, Velpatasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, thunder god vine might increase the levels and clinical effects of CYP3A4 substrates.

Full Thunder God Vine + Sofosbuvir, Velpatasvir answer

Can you take Tragacanth with Sofosbuvir, Velpatasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Sofosbuvir, Velpatasvir answer

Can you take Turmeric with Sofosbuvir, Velpatasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Turmeric might increase or decrease levels of drugs metabolized by CYP3A4.

Full Turmeric + Sofosbuvir, Velpatasvir answer

Can you take Uva Ursi with Sofosbuvir, Velpatasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.

Full Uva Ursi + Sofosbuvir, Velpatasvir answer

Can you take Vitamin E with Sofosbuvir, Velpatasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.

Full Vitamin E + Sofosbuvir, Velpatasvir answer

Can you take White Pepper with Sofosbuvir, Velpatasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that piperine, a constituent of white pepper, inhibits cytochrome P450 3A4 (CYP3A4).

Full White Pepper + Sofosbuvir, Velpatasvir answer

Can you take Wild Cherry with Sofosbuvir, Velpatasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that wild cherry can inhibit cytochrome P450 3A4 (CYP3A4) enzymes.

Full Wild Cherry + Sofosbuvir, Velpatasvir answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Sofosbuvir, Velpatasvir is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Sofosbuvir, Velpatasvir, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Sofosbuvir, Velpatasvir sits in 7 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Sofosbuvir, Velpatasvir through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Sofosbuvir, Velpatasvir through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Sofosbuvir, Velpatasvir through this category.

Cytochrome P450 2B6 (Cyp2B6) Substrates 15 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

15 of the supplement ingredients on this page reach Sofosbuvir, Velpatasvir through this category.

Cytochrome P450 2C8 (Cyp2C8) Substrates 11 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

11 of the supplement ingredients on this page reach Sofosbuvir, Velpatasvir through this category.

Sofosbuvir (Sovaldi) 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Sofosbuvir, Velpatasvir through this category.

Sofosbuvir (Solvaldi) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Sofosbuvir, Velpatasvir through this category.

About Sofosbuvir, Velpatasvir

Sofosbuvir and velpatasvir is a two-drug antiviral combination used to treat chronic hepatitis C virus (HCV) infection across all major genotypes in adults and children as young as 3 years old.

Generic name: Sofosbuvir, Velpatasvir  ·  Brand name: Epclusa.

See the full Sofosbuvir and Velpatasvir drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Sofosbuvir, Velpatasvir

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Sofosbuvir, Velpatasvir.

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Pharmacist Counseling Corner

Sofosbuvir, Velpatasvir & Supplements: Common Questions

What supplements interact with Sofosbuvir, Velpatasvir?
Our database currently documents 147 ingredients with a known Sofosbuvir, Velpatasvir interaction (3 major, 108 moderate, 36 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 147. The highest-ranked right now: Grapefruit, Activated Charcoal, St. John's Wort.
Which Sofosbuvir, Velpatasvir supplement interactions are the most serious?
Focus on the major group: Grapefruit, Activated Charcoal and St. John's Wort. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Sofosbuvir, Velpatasvir?
Plenty of supplements coexist fine with Sofosbuvir, Velpatasvir; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Epclusa have the same supplement interactions as Sofosbuvir, Velpatasvir?
Yes — Epclusa all contain Sofosbuvir, Velpatasvir, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Sofosbuvir, Velpatasvir and my other medications?
This page covers Sofosbuvir, Velpatasvir against supplements and herbal ingredients. Checking Sofosbuvir, Velpatasvir against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Sofosbuvir and Velpatasvir drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.