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Dietary supplement

Glutamine Ingredients & Drug Interactions

by Prolab

Glutamine label
See full label image
Powder Category: Amino Acid/protein
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Glutamine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Glutamine is a dietary supplement by Prolab with 1 active ingredient. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 50 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Glutamine by Prolab

Ask about any prescription or over-the-counter medication and we check it for interactions with Glutamine by Prolab — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Glutamine by Prolab

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Prolab Glutamine is a single-ingredient supplement: L-glutamine, an amino acid your body makes naturally and uses for gut health, immune function, and muscle recovery. It comes as a powder with no other active ingredients listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: muscle recovery and athletic performance support.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Postoperative recovery, Critical illness (trauma), Wound healing, Burns — and 3 related terms.
  • The strongest evidence on file: Glutamine is rated "Possibly Effective" for Critical illness (trauma) (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Effective" for Postoperative recovery.
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance, Burns.

L-glutamine is effective for sickle cell disease. The evidence is possibly effective for HIV/AIDS-related wasting, postoperative recovery, and critical illness from trauma.

We hold no effectiveness data for other uses.

The evidence, ingredient by ingredient Glutamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is generally well tolerated in healthy adults. The most common side effects are digestive — belching, bloating, constipation, diarrhea, flatulence, nausea, and vomiting — especially at higher doses (10–30 grams daily).

Headache and musculoskeletal pain have also been reported. Two people with bipolar disorder experienced mania or hypomania while taking glutamine up to 4 grams daily, though this is rare.

If you have kidney or liver disease, use it only under medical supervision. There isn't enough safety data to recommend supplemental doses during pregnancy or breastfeeding — talk with your doctor or pharmacist for personalized guidance.

Dizziness has been reported but improved when the dose was lowered.

Side effects, ingredient by ingredient Glutamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glutamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 50 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take anticonvulsant medications (drugs to prevent seizures), check your exact medications with your doctor or pharmacist before adding this supplement. The interaction is moderate and theoretical but hasn't been studied in patients yet.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Prolab Glutamine may help with sickle cell disease and possibly aids recovery after surgery or in critical illness. If you take anticonvulsant medications, check with your doctor or pharmacist before starting — the interaction is theoretical but documented.

Otherwise, it's generally well tolerated, though digestive upset is common at higher doses.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Glutamine, straight from the product label.

Brand Prolab
Barcode (UPC) 750902104299
Net contents 14.1 Ounce(s); 400 Gram(s)
Market status On market
Date entered into DSLD May 22, 2021
DSLD ID 250485
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Glutamine by Prolab, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4.5 Gram(s)
Maximum serving Sizes:
4.5 Gram(s)
Servings per container
88
UPC/BARCODE
750902104299
IngredientAmount% DV
L-Glutamine4.5 Gram(s)--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Prolab Glutamine is a flavorless, easy-mixing powder and an extremely versatile free form amino acid formula. Glutamine is the most abundant, naturally occurring amino acid in muscle tissue, but it can depleted during prolong training. Supplementing with Prolab Glutamine replenishes depleted stores, to help build new lean muscle and protect hard-earned gains by supporting protein synthesis - the manufacturing of new muscle proteins. L-Glutamine also supports acid base homeostasis. Prolab Glutamine supports post-workout muscle energy repletion, volumization and repair. This "conditionally essential" amino acid functions as a critical factor in muscle form and function.

Helps maximize recovery Supports a healthy immune system

Repair Growth Preservation Lean muscle support

Made in USA with globally sourced ingredients.

No: Milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat, soybeans, yeast, artificial colors or flavors, added sugar or preservatives.

General Statements

You do your part. We'll do ours. Join the Prolab Nation: www.prolab.com

Performance Simplified

Product does not completely fill container. Settling occurs in shipping.

Suggested/Recommended/Usage/Directions

This product is to be used in conjunction with a healthy diet and exercise regimen.

Directions: As a dietary supplement, take one rounded teaspoon per day. This product is flavorless and dissolves in water or your favorite beverage.

Precautions

Consult your healthcare professional prior to use if you have or suspect a medical condition, are taking prescription drugs, or are pregnant or lactating.

Keep out of reach of children.

Formula

Anti-catabolic amino acid

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Prolab Quality Assurance

Brand IP Statement(s)

2017 Prolab Nutrition LLC

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Glutamine by Prolab label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Glutamine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Glutamine by Prolab

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size4.5 Gram(s) Dosage formPowder Servings per container88 Amounts shown are per serving.

L-Glutamine

Interacts with
50 drugs
4.5 Gram(s) per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Glutamine by Prolab Drug Interactions

Want to check YOUR meds against Glutamine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
50Drugs
50 Moderate

Ingredients driving the most interactions

L-Glutamine 50

Individual Drug Interactions

The ingredients in Glutamine interact with 50 drugs. Click any drug to see the details.

1 of the 1 ingredient in Glutamine interact with drugs. Each result below shows which ingredient is responsible. L-Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Glutamine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Glutamine, from the product label.

Prolab

See all Prolab products
Name
Prolab Nutrition LLC
City
Chatsworth
State
CA
ZipCode
91311
Phone Number
1-800-7765221
Web Address
www.prolab.com
Pharmacist Counseling Corner

Glutamine by Prolab: Common Questions

Does Glutamine by Prolab interact with any medications?
Yes. Based on its ingredients, Glutamine has a known interaction with 50 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Glutamine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is glutamine safe during pregnancy or while breastfeeding?
We don't have enough safety data on supplemental glutamine in pregnancy or breastfeeding to say either way. Talk with your doctor or pharmacist — they can give you personalized advice based on your situation.
What are the most common side effects?
Digestive upset is the main issue: bloating, constipation, diarrhea, nausea, flatulence, and stomach pain. These happen especially at higher doses. Headache and muscle pain have been reported too.
Can I take this if I have kidney or liver disease?
Not without medical supervision. If you have either condition, check with your doctor or pharmacist before using this supplement.
Does glutamine actually work?
It's effective for sickle cell disease. For HIV-related wasting, postoperative recovery, and critical illness, the evidence is possibly effective — meaning some research supports it, but we need more proof.
What does glutamine do in my body?
L-glutamine is an amino acid your body naturally produces. It supports gut health, immune function, and muscle recovery. When you digest glutamine, your body breaks it down into glutamate and ammonia — both of which have effects in your nervous system.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Glutamine is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Glutamine label
Go deeper

The Full Monographs Behind Glutamine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph →
Sources

Sources & How We Checked

Glutamine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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