JittersAway Ingredients & Drug Interactions
What is this page for?
First and foremost: checking JittersAway against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
JittersAway is a dietary supplement by Pacific BioLogic with 8 active ingredients. Its ingredients are commonly taken for fluid retention and swelling, digestive complaints, sleep and calming support.Based on those ingredients, 1,530 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Fo-Ti, Chinese Salvia, Jujube. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against JittersAway by Pacific BioLogic
Ask about any prescription or over-the-counter medication and we check it for interactions with JittersAway by Pacific BioLogic — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of JittersAway by Pacific BioLogic
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
JittersAway is a capsule blend of 8 ingredients. The active components include Poria (a mushroom), Chinese Salvia (danshen), Fo-Ti, Polygala, Jujube (also called zizyphus), Oyster Shell, and Fossilized Bone, combined in a proprietary blend.
The capsule itself is made from plant material. Poria is traditionally used for its sedative properties, while Chinese Salvia has been studied for effects on blood clotting and the heart.
Fo-Ti is a root used in traditional medicine but has been associated with liver injury in some cases. Jujube is eaten as food in many cultures and is included here for its traditional calming properties.
Does it work?
Not established
The evidence we hold does not establish that any of these ingredients are effective for specific conditions. Poria, Chinese Salvia, Fo-Ti, and Jujube all carry ratings of "Insufficient Reliable Evidence" for the conditions they're traditionally used for—including anxiety, age-related cognitive decline, heart disease, and blood sugar control.
This means the scientific data available is too limited to say whether they work for these purposes. You'd want to talk with your doctor about what this product might (or might not) do for your particular reason for considering it.
How safe is it?
Well-documented data
Poria is generally well tolerated in traditional use, but human safety data are limited, and allergic reactions (including allergic rhinitis and allergic asthma) have been reported rarely. Chinese Salvia may be used short-term by some adults but can affect blood clotting, and product quality varies between manufacturers.
Fo-Ti has been linked to cases of liver injury and should be used carefully under professional guidance; common side effects with unprocessed fo-ti include abdominal pain, diarrhea, nausea, and vomiting. Jujube fruit is widely eaten as food, but concentrated supplements have not been well studied for safety.
None of these ingredients should be used during pregnancy—safety information is not enough to know either way. For breastfeeding, safety data are not reliable for Poria, Chinese Salvia, and Fo-Ti; Jujube at medicinal doses also lacks enough safety information.
Talk with your doctor or pharmacist before taking this product if you are pregnant or breastfeeding.
Meds to double-check
Major interaction found
Before you take JittersAway, double-check with your doctor or pharmacist if you take any blood thinners or antiplatelet drugs (anticoagulants like warfarin or clopidogrel, or antiplatelet agents)—Chinese Salvia and Fo-Ti may increase bleeding risk. Also check if you take digoxin (a heart medication), any blood-pressure lowering drug, any sedative or sleep aid, any diabetes medication, or any drug metabolized by liver enzymes CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2E1, or CYP3A4.
Additionally, if you take diuretics or stimulant laxatives, Fo-Ti may compound their effects on potassium and fluid balance.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.
JittersAway has multiple significant interactions with common medications, especially blood thinners, heart drugs, sedatives, and drugs broken down by the liver. If you take any prescription medication—particularly anything for blood clotting, heart rhythm, or sleep—you need to check your specific drugs against this product before starting.
The effectiveness of its ingredients is not well established in the data we hold. Talk it over with your own doctor or pharmacist before you take it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about JittersAway, straight from the product label.
| Brand | Pacific BioLogic |
|---|---|
| Barcode (UPC) | 065367401327 |
| Net contents | 60 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Apr 23, 2020 |
| DSLD ID | 218478 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for JittersAway by Pacific BioLogic, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 525 mg | -- |
| Poria | 0 NP | -- |
| Chinese Salvia | 0 NP | -- |
| Fo-Ti | 0 NP | -- |
| Polygala | 0 NP | -- |
| Oyster Shell | 0 NP | -- |
| Jujube | 0 NP | -- |
| Fossilized bone | 0 NP | -- |
| Mother-of-Pearl | 0 NP | -- |
Other ingredients: Capsules of plant origin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested dosage: For support of occasional nervous tension, take 1-3 capsules up to 3 times daily.
Precautions
Caution: If pregnant or nursing, consult your healthcare provider before using this, or any other product.
To report a serious adverse event or obtain product information, contact (800) 869-8783
Formulation
JittersAway is manufactured in an FDA compliant facility in the United States of America from imported and domestic ingredients
Storage
Store in a cool, dry place, do not refrigerate.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General Statements
Powerful tools for gentle healing
525 mg
FDA Statement of Identity
Herbal Supplement
Seals/Symbols
Product of USA
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
JittersAway by Pacific BioLogic label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in JittersAway by Pacific BioLogic
These are the 8 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container20 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
- › Poria
- › Chinese Salvia
- › Fo-Ti
- › Polygala
- › Oyster Shell
- › Jujube
- › Fossilized bone
- › Mother-of-Pearl
Other (inactive) ingredients: Capsules of plant origin. These complete the product’s ingredient list but are not active constituents.
JittersAway by Pacific BioLogic Drug Interactions
HelloPharmacist Interaction Report
JittersAway by Pacific BioLogic contains ingredients with documented interactions through its Chinese Salvia, Fo-Ti, Poria, and Jujube content.
The most serious concern is a Major-severity interaction: Chinese Salvia may increase bleeding risk if you take anticoagulant or antiplatelet drugs (blood thinners like warfarin or clopidogrel). Chinese Salvia also carries a Major-severity interaction with digoxin (a heart medication), theoretically raising the risk of adverse effects.
Read the full breakdown — every affected drug type, severity by severity
Fo-Ti presents Moderate-severity interactions with anticoagulant/antiplatelet drugs, and there's a documented case of a patient on warfarin who developed acute liver failure after taking fo-ti for 90 days. Fo-Ti may also interact with warfarin, digoxin, diuretics, and stimulant laxatives.
Poria and Jujube both carry Moderate-severity interactions with sedatives (CNS depressants) and may enhance their effects. Jujube may also theoretically interact with blood-sugar medications (antidiabetes drugs) and drugs broken down by the liver enzyme CYP1A2.
Chinese Salvia interacts with multiple liver enzymes (CYP1A2, CYP2C9, CYP2E1, CYP3A4) and with p-glycoprotein, a protein that affects drug transport—meaning it could alter levels of many prescription medications. Fo-Ti also affects several liver enzymes (CYP2B6, CYP2C8).
Altogether, these interactions span 1,531 individual medications.
We could not check Polygala, Oyster Shell, and Fossilized Bone because we hold no interaction data for them. Before you take JittersAway, check your exact medications with the search tool on this page or review this list with your doctor or pharmacist.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against JittersAway?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in JittersAway interact with 1,530 drugs. Click any drug to see the details.
4 of the 8 ingredients in JittersAway interact with drugs. Each result below shows which ingredient is responsible. Fo-Ti Chinese Salvia Jujube Poria
AbciximabReoPro
How Abciximab interacts with JittersAway — through 2 ingredients. Tap an ingredient for the detail:
Chinese SalviaAnticoagulant/antiplatelet Drugs Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Chinese Salvia + Abciximab interactionFo-tiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Fo-ti has been linked to cases of acute liver failure which can decrease clotting factor production and increase the effects of anticoagulants.
Read the full Fo-ti + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with JittersAway — through 2 ingredients. Tap an ingredient for the detail:
Chinese SalviaCytochrome P450 2c9 (cyp2c9) Substrates, Anticoagulant/antiplatelet Drugs Major
Interaction Summary
Theoretically, danshen may increase the levels and clinical effects of drugs metabolized by CYP2C9.
Read the full Chinese Salvia + Abrocitinib interactionFo-tiCytochrome P450 2c9 (cyp2c9) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, fo-ti may increase the levels and clinical effects of drugs metabolized by CYP2C9.
Read the full Fo-ti + Abrocitinib interactionAcenocoumarolSintrom
How Acenocoumarol interacts with JittersAway — through 2 ingredients. Tap an ingredient for the detail:
Chinese SalviaAnticoagulant/antiplatelet Drugs Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Chinese Salvia + Acenocoumarol interactionFo-tiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Fo-ti has been linked to cases of acute liver failure which can decrease clotting factor production and increase the effects of anticoagulants.
Read the full Fo-ti + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with JittersAway — through 3 ingredients. Tap an ingredient for the detail:
Chinese SalviaAspirin, Glucuronidated Drugs +3 Major
Interaction Summary
Theoretically, danshen may increase the levels of aspirin and the risk of bleeding.
Read the full Chinese Salvia + Acetaminophen, Aspirin interactionFo-tiAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Fo-ti has been linked to cases of acute liver failure which can decrease clotting factor production and increase the effects of anticoagulants.
Read the full Fo-ti + Acetaminophen, Aspirin interactionJujubeCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with JittersAway — through 3 ingredients. Tap an ingredient for the detail:
Chinese SalviaCytochrome P450 1a2 (cyp1a2) Substrates, Aspirin +4 Major
Interaction Summary
Theoretically, danshen may increase the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Chinese Salvia + Acetaminophen, Aspirin, Caffeine interactionFo-tiHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, fo-ti might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Fo-ti + Acetaminophen, Aspirin, Caffeine interactionJujubeCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with JittersAway — through 3 ingredients. Tap an ingredient for the detail:
Chinese SalviaAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +3 Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Chinese Salvia + Acetaminophen, Ibuprofen interactionFo-tiCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates +2 Moderate
Interaction Summary
Theoretically, fo-ti might increase or decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Fo-ti + Acetaminophen, Ibuprofen interactionJujubeCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube + Acetaminophen, Ibuprofen interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with JittersAway — through 2 ingredients. Tap an ingredient for the detail:
Chinese SalviaAspirin, Anticoagulant/antiplatelet Drugs Major
Interaction Summary
Theoretically, danshen may increase the levels of aspirin and the risk of bleeding.
Read the full Chinese Salvia + Acetylsalicylic Acid interactionFo-tiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Fo-ti has been linked to cases of acute liver failure which can decrease clotting factor production and increase the effects of anticoagulants.
Read the full Fo-ti + Acetylsalicylic Acid interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with JittersAway — through 2 ingredients. Tap an ingredient for the detail:
Chinese SalviaAnticoagulant/antiplatelet Drugs Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Chinese Salvia + Alteplase, Tpa interactionFo-tiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Fo-ti has been linked to cases of acute liver failure which can decrease clotting factor production and increase the effects of anticoagulants.
Read the full Fo-ti + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with JittersAway — through 4 ingredients. Tap an ingredient for the detail:
Chinese SalviaAnticoagulant/antiplatelet Drugs, Aspirin Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Chinese Salvia + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionFo-tiAnticoagulant/antiplatelet Drugs, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Fo-ti has been linked to cases of acute liver failure which can decrease clotting factor production and increase the effects of anticoagulants.
Read the full Fo-ti + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionJujubeCns Depressants Moderate
Interaction Summary
Theoretically, zizyphus might cause additive sedative effects when taken with CNS depressants.
Read the full Jujube + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionPoriaCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with JittersAway — through 2 ingredients. Tap an ingredient for the detail:
Chinese SalviaAspirin, Anticoagulant/antiplatelet Drugs Major
Interaction Summary
Theoretically, danshen may increase the levels of aspirin and the risk of bleeding.
Read the full Chinese Salvia + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionFo-tiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Fo-ti has been linked to cases of acute liver failure which can decrease clotting factor production and increase the effects of anticoagulants.
Read the full Fo-ti + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with JittersAway — through 2 ingredients. Tap an ingredient for the detail:
Chinese SalviaAnticoagulant/antiplatelet Drugs Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Chinese Salvia + Anacaulase-bcdb interactionFo-tiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Fo-ti has been linked to cases of acute liver failure which can decrease clotting factor production and increase the effects of anticoagulants.
Read the full Fo-ti + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with JittersAway — through 3 ingredients. Tap an ingredient for the detail:
Chinese SalviaAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Chinese Salvia + Anagrelide interactionFo-tiAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Fo-ti has been linked to cases of acute liver failure which can decrease clotting factor production and increase the effects of anticoagulants.
Read the full Fo-ti + Anagrelide interactionJujubeCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube + Anagrelide interactionAnisindioneMiradon
How Anisindione interacts with JittersAway — through 2 ingredients. Tap an ingredient for the detail:
Chinese SalviaAnticoagulant/antiplatelet Drugs Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Chinese Salvia + Anisindione interactionFo-tiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Fo-ti has been linked to cases of acute liver failure which can decrease clotting factor production and increase the effects of anticoagulants.
Read the full Fo-ti + Anisindione interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with JittersAway — through 2 ingredients. Tap an ingredient for the detail:
Chinese SalviaAnticoagulant/antiplatelet Drugs Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Chinese Salvia + Antithrombin Iii interactionFo-tiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Fo-ti has been linked to cases of acute liver failure which can decrease clotting factor production and increase the effects of anticoagulants.
Read the full Fo-ti + Antithrombin Iii interactionApixabanEliquis
How Apixaban interacts with JittersAway — through 2 ingredients. Tap an ingredient for the detail:
Chinese SalviaCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates +1 Major
Interaction Summary
Danshen might alter the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Chinese Salvia + Apixaban interactionFo-tiCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Fo-ti + Apixaban interactionArgatrobanArgatroban
How Argatroban interacts with JittersAway — through 2 ingredients. Tap an ingredient for the detail:
Chinese SalviaAnticoagulant/antiplatelet Drugs Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Chinese Salvia + Argatroban interactionFo-tiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Fo-ti has been linked to cases of acute liver failure which can decrease clotting factor production and increase the effects of anticoagulants.
Read the full Fo-ti + Argatroban interactionAspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
How Aspirin interacts with JittersAway — through 2 ingredients. Tap an ingredient for the detail:
Chinese SalviaAnticoagulant/antiplatelet Drugs, Aspirin Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Chinese Salvia + Aspirin interactionFo-tiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Fo-ti has been linked to cases of acute liver failure which can decrease clotting factor production and increase the effects of anticoagulants.
Read the full Fo-ti + Aspirin interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with JittersAway — through 2 ingredients. Tap an ingredient for the detail:
Chinese SalviaAspirin, Anticoagulant/antiplatelet Drugs Major
Interaction Summary
Theoretically, danshen may increase the levels of aspirin and the risk of bleeding.
Read the full Chinese Salvia + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionFo-tiAnticoagulant/antiplatelet Drugs, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Fo-ti has been linked to cases of acute liver failure which can decrease clotting factor production and increase the effects of anticoagulants.
Read the full Fo-ti + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAspirin, ButalbitalAxotal
How Aspirin, Butalbital interacts with JittersAway — through 2 ingredients. Tap an ingredient for the detail:
Chinese SalviaAnticoagulant/antiplatelet Drugs, Aspirin Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Chinese Salvia + Aspirin, Butalbital interactionFo-tiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Fo-ti has been linked to cases of acute liver failure which can decrease clotting factor production and increase the effects of anticoagulants.
Read the full Fo-ti + Aspirin, Butalbital interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with JittersAway — through 3 ingredients. Tap an ingredient for the detail:
Chinese SalviaAspirin, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Major
Interaction Summary
Theoretically, danshen may increase the levels of aspirin and the risk of bleeding.
Read the full Chinese Salvia + Aspirin, Butalbital, Caffeine interactionFo-tiAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Fo-ti has been linked to cases of acute liver failure which can decrease clotting factor production and increase the effects of anticoagulants.
Read the full Fo-ti + Aspirin, Butalbital, Caffeine interactionJujubeCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with JittersAway — through 4 ingredients. Tap an ingredient for the detail:
Chinese SalviaCytochrome P450 1a2 (cyp1a2) Substrates, Aspirin +2 Major
Interaction Summary
Theoretically, danshen may increase the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Chinese Salvia + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionFo-tiCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs +2 Moderate
Interaction Summary
Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Fo-ti + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionPoriaCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionJujubeCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with JittersAway — through 3 ingredients. Tap an ingredient for the detail:
Chinese SalviaCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Major
Interaction Summary
Danshen might alter the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Chinese Salvia + Aspirin, Butalbital, Caffeine, Phenacetin interactionFo-tiCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, fo-ti might increase or decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Fo-ti + Aspirin, Butalbital, Caffeine, Phenacetin interactionJujubeCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with JittersAway — through 3 ingredients. Tap an ingredient for the detail:
Chinese SalviaAspirin, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Major
Interaction Summary
Theoretically, danshen may increase the levels of aspirin and the risk of bleeding.
Read the full Chinese Salvia + Aspirin, Caffeine interactionFo-tiCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Fo-ti + Aspirin, Caffeine interactionJujubeCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube + Aspirin, Caffeine interactionAspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
How Aspirin, Caffeine, Codeine Phosphate interacts with JittersAway — through 4 ingredients. Tap an ingredient for the detail:
Chinese SalviaCytochrome P450 1a2 (cyp1a2) Substrates, Aspirin +2 Major
Interaction Summary
Theoretically, danshen may increase the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Chinese Salvia + Aspirin, Caffeine, Codeine Phosphate interactionFo-tiAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Fo-ti has been linked to cases of acute liver failure which can decrease clotting factor production and increase the effects of anticoagulants.
Read the full Fo-ti + Aspirin, Caffeine, Codeine Phosphate interactionJujubeCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube + Aspirin, Caffeine, Codeine Phosphate interactionPoriaCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria + Aspirin, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC
How Aspirin, Caffeine, Dihydrocodeine Bitartrate interacts with JittersAway — through 4 ingredients. Tap an ingredient for the detail:
Chinese SalviaCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Major
Interaction Summary
Danshen might alter the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Chinese Salvia + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionJujubeCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might cause additive sedative effects when taken with CNS depressants.
Read the full Jujube + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionFo-tiCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, fo-ti might increase or decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Fo-ti + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionPoriaCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionAspirin, Caffeine, Dover's PwdAcedoval, Dovacet
How Aspirin, Caffeine, Dover's Pwd interacts with JittersAway — through 3 ingredients. Tap an ingredient for the detail:
Chinese SalviaAspirin, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Major
Interaction Summary
Theoretically, danshen may increase the levels of aspirin and the risk of bleeding.
Read the full Chinese Salvia + Aspirin, Caffeine, Dover's Pwd interactionFo-tiAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Fo-ti has been linked to cases of acute liver failure which can decrease clotting factor production and increase the effects of anticoagulants.
Read the full Fo-ti + Aspirin, Caffeine, Dover's Pwd interactionJujubeCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube + Aspirin, Caffeine, Dover's Pwd interactionAspirin, Caffeine, HydrocodoneDamason-P
How Aspirin, Caffeine, Hydrocodone interacts with JittersAway — through 4 ingredients. Tap an ingredient for the detail:
Chinese SalviaCytochrome P450 1a2 (cyp1a2) Substrates, Aspirin +2 Major
Interaction Summary
Theoretically, danshen may increase the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Chinese Salvia + Aspirin, Caffeine, Hydrocodone interactionFo-tiCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs +2 Moderate
Interaction Summary
Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Fo-ti + Aspirin, Caffeine, Hydrocodone interactionJujubeCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might cause additive sedative effects when taken with CNS depressants.
Read the full Jujube + Aspirin, Caffeine, Hydrocodone interactionPoriaCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria + Aspirin, Caffeine, Hydrocodone interactionAspirin, Caffeine, Isobutylallylbarbituric Acid, PhenacetinLanorinal
How Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interacts with JittersAway — through 3 ingredients. Tap an ingredient for the detail:
Chinese SalviaAnticoagulant/antiplatelet Drugs, Aspirin +2 Major
Interaction Summary
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Chinese Salvia + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionJujubeCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionFo-tiCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, fo-ti might increase or decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Fo-ti + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionAspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte
How Aspirin, Caffeine, Orphenadrine interacts with JittersAway — through 3 ingredients. Tap an ingredient for the detail:
Chinese SalviaAspirin, Anticoagulant/antiplatelet Drugs +2 Major
Interaction Summary
Theoretically, danshen may increase the levels of aspirin and the risk of bleeding.
Read the full Chinese Salvia + Aspirin, Caffeine, Orphenadrine interactionFo-tiCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs +2 Moderate
Interaction Summary
Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Fo-ti + Aspirin, Caffeine, Orphenadrine interactionJujubeCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube + Aspirin, Caffeine, Orphenadrine interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
How Aspirin, Caffeine, Phenacetin, Propoxyphene interacts with JittersAway — through 4 ingredients. Tap an ingredient for the detail:
Chinese SalviaAspirin, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Major
Interaction Summary
Theoretically, danshen may increase the levels of aspirin and the risk of bleeding.
Read the full Chinese Salvia + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionFo-tiCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs +3 Moderate
Interaction Summary
Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Fo-ti + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionJujubeCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Jujube + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionPoriaCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionEach ingredient & the kinds of drugs it affects
For each ingredient in JittersAway with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Fo-Ti
Anticoagulant/Antiplatelet Drugs
Fo-ti has been linked to cases of acute liver failure which can decrease clotting factor production and increase the effects of anticoagulants. In one case, a patient who had been stable on warfarin presented with acute hepatitis and an INR elevated to 14.98. The patient had been taking fo-ti for 90 days prior to admission. Discontinuation of warfarin and fo-ti lead to a decrease in the INR and full recovery. Theoretically, concomitant use of fo-ti with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients. Until more is known, monitor patients taking fo-ti and drugs that affect bleeding.
Some of these drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), dipyridamole (Persantine), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.
Antidiabetes Drugs
Theoretically, fo-ti might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Fo-ti reportedly has hypoglycemic effects.
Contraceptive Drugs
Theoretically, taking large amounts of fo-ti might interfere with contraceptive drugs due to competition for estrogen receptors.
In vitro research suggests that fo-ti extract has estrogenic activity.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, fo-ti might increase or decrease the levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research suggests that fo-ti might inhibit CYP1A2. Additionally, in vitro research suggests that the degree of CYP1A2 inhibition depends on the type of fo-ti extract (i.e., the raw plant leads to greater inhibition than extensively processed extracts). However, in an animal study, an aqueous extract of fo-ti inhibited CYP1A2 while an alcoholic extract of fo-ti induced CYP1A2. Induction or inhibition of CYP1A2 by fo-ti has not been reported in humans.
Cytochrome P450 2B6 (Cyp2B6) Substrates
Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP2B6.
Animal research suggests that fo-ti might inhibit CYP2B6. One in vitro study suggests that the degree of CYP2B6 inhibition may depend on the type of fo-ti extract (i.e., the raw plant leads to greater inhibition than extensively processed extracts). However, this interaction has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, fo-ti may increase the levels and clinical effects of drugs metabolized by CYP2C19.
Animal and in vitro research suggests that fo-ti may inhibit CYP2C19. An in vitro study suggests that the degree of CYP2C19 inhibition may depend on the type of fo-ti extract (i.e., the raw plant leads to greater inhibition than extensively processed extracts). However, this interaction has not been reported in humans.
Cytochrome P450 2C8 (Cyp2C8) Substrates
Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP2C8.
In vitro research suggests that fo-ti might inhibit CYP2C8. However, this interaction has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, fo-ti may increase the levels and clinical effects of drugs metabolized by CYP2C9.
Animal and in vitro research suggests that fo-ti may inhibit CYP2C9. However, this interaction has not been reported in humans.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, fo-ti may increase the levels and clinical effects of drugs metabolized by CYP2D6.
Animal research suggests that fo-ti might inhibit CYP2D6. Additionally, an in vitro study suggests that the degree of CYP2D6 inhibition may depend on the type of fo-ti extract (i.e., the raw plant leads to greater inhibition than extensively processed extracts). However, this interaction has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.
In vitro research suggests that fo-ti might inhibit CYP3A4. One in vitro study suggests that the degree of CYP3A4 inhibition may depend on the type of fo-ti extract (i.e., the raw plant leads to greater inhibition than extensively processed extracts). However, this evidence conflicts with animal research suggesting that fo-ti does not inhibit CYP3A4. This interaction has not been reported in humans.
Digoxin (Lanoxin)
Theoretically, fo-ti, particularly raw fo-ti root, might increase the risk of hypokalemia and cardiotoxicity when taken with digoxin.
Raw fo-ti root contains anthraquinone derivatives, which might have stimulant laxative effects. In vitro research shows that fermented and processed fo-ti root have reduced laxative effects compared with raw fo-ti root.
Diuretic Drugs
Theoretically, fo-ti, particularly raw fo-ti root, might increase the risk of hypokalemia when taken with diuretic drugs.
Raw fo-ti root contains anthraquinone derivatives, which might have stimulant laxative effects and compound diuretic-induced potassium loss. In vitro research shows that fermented and processed fo-ti root have reduced laxative effects compared with raw fo-ti root.
Estrogens
Theoretically, taking large amounts of fo-ti might interfere with hormone replacement therapy through competition for estrogen receptors.
In vitro research suggests that fo-ti extract has estrogenic activity.
Hepatotoxic Drugs
Theoretically, fo-ti might increase the risk of liver damage when taken with hepatotoxic drugs.
Fo-ti has been linked to liver damage in many reports.
Stimulant Laxatives
Theoretically, fo-ti, particularly raw fo-ti root, might increase the risk of fluid and electrolyte depletion when taken with stimulant laxatives.
Raw fo-ti root contains anthraquinone derivatives, which might have stimulant laxative effects. However, in vitro research shows that fermented and processed fo-ti root have reduced laxative effects compared with raw fo-ti root.
Sulindac (Clinoril)
Theoretically, fo-ti might increase or decrease the levels and clinical effects of sulindac.
Animal research suggests that the type of fo-ti extract might affect the levels of sulindac differently; the raw plant may increase levels, but processed parts may decrease levels. Induction or inhibition of CYP1A2 by fo-ti has not been reported in humans.
Warfarin (Coumadin)
Theoretically, fo-ti might increase the effects and adverse effects of warfarin.
Fo-ti may have stimulant laxative effects and cause diarrhea, especially when the raw or unprocessed fo-ti root is used. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Also, fo-ti has been linked to cases of acute liver failure which can decrease clotting factor production and increase the effects of warfarin. In one case, a patient who had been stable on warfarin presented with acute hepatitis and an INR elevated to 14.98. The patient had been taking fo-ti for 90 days prior to admission. Discontinuation of warfarin and fo-ti lead to a decrease in the INR and full recovery.
Chinese Salvia
Anticoagulant/Antiplatelet Drugs
Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Danshen has been reported to have antithrombotic effects. Animal research also suggests that taking a danshen combination formula with clopidogrel exhibits a synergistic increase in antiplatelet aggregation and prolongation of coagulation time when compared with either taken alone.
Digoxin (Lanoxin)
Theoretically, using danshen with digoxin might increase the risk of adverse effects.
Danshen has structural and pharmacological similarities to cardiac glycosides.
Amlodipine (Norvasc)
Theoretically, taking danshen in combination with amlodipine may decrease the clinical effects of amlodipine.
In animal research, taking danshen orally in combination with amlodipine reduced blood levels of amlodipine by about 52%. This may have been due to induction of cytochrome P450 3A4 (CYP3A4) by danshen, which has been demonstrated in vitro. So far, this interaction has not been reported in humans.
Antihypertensive Drugs
Theoretically, taking danshen with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that danshen can produce dose-dependent hypotensive effects. Furthermore, concomitant use with captopril appears to potentiate this effect.
Aspirin
Theoretically, danshen may increase the levels of aspirin and the risk of bleeding.
Research in healthy adult males shows that taking a combination of danshen and kudzu with aspirin increases plasma aspirin area under the curve by approximately 3.4-fold. Animal research also shows that taking a combination of danshen and kudzu (danshen-gegen formula) with aspirin increases maximal blood levels of aspirin and salicylic acid by approximately 4-fold and 3.7-fold, respectively, without impacting blood loss. Taking danshen increases the antiplatelet activity of aspirin and might increase the side effects of aspirin.
Clopidogrel (Plavix)
Theoretically, danshen may increase the risk of bleeding if taken with clopidogrel.
Clopidogrel is an antiplatelet prodrug that is metabolized by carboxyl esterase 1 (CES1) to an inactive metabolite. Animal research shows that a danshen combination formula decreases the activity of CES1, decreasing levels of the inactive metabolite in the blood and possibly increasing levels of the active metabolite. Animal research also suggests that taking a danshen combination formula with clopidogrel exhibits a synergistic increase in antiplatelet aggregation and prolongation of coagulation time when compared with either taken alone.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, danshen may increase the levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research shows that danshen tincture and various constituents of danshen inhibit the activity of CYP1A2. However, this activity has not been shown in humans when theophylline, a CYP1A2 substrate, was used as a target drug.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, danshen may increase the levels and clinical effects of drugs metabolized by CYP2C9.
In vitro research shows that various constituents of danshen inhibit the activity of CYP2C9. So far, this interaction has not been reported in humans.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Theoretically, danshen may increase the levels and clinical effects of drugs metabolized by CYP2E1.
In vitro research shows that various constituents of danshen inhibit the activity of CYP2E1. So far, this interaction has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Danshen might alter the levels and clinical effects of drugs metabolized by CYP3A4.
Preliminary clinical research in healthy males shows that the administration of danshen for 10-14 days induces intestinal CYP3A4 and increases the clearance of midazolam, a CYP3A4 substrate. The maximum concentration of midazolam was decreased by 31% to 67%, and drug levels were decreased by 27% to 80%. However, a single dose of danshen has the opposite effect, increasing maximum concentrations of midazolam by 87%.
Fexofenadine (Allegra)
Danshen might increase the levels and clinical effects of fexofenadine.
Pharmacokinetic research in healthy volunteers shows that taking danshen extract 1 gram three times daily for 10 days prior to receiving fexofenadine 60 mg increases peak levels of fexofenadine, a p-glycoprotein substrate, by 27.4% and area under the curve (AUC) by 37.2%.
Glucuronidated Drugs
Theoretically, danshen might affect the levels and clinical effects of drugs requiring glucuronidation.
In vitro research shows that danshen induces the expression of glucuronosyltransferases. However, it also inhibits the activity of glucuronosyltransferases, including various members of the 1A and 2B families. The extent of inhibition of a specific glucuronosyltransferase seems to be dependent on whether or not the danshen is processed via 'sweating'. This type of processing may affect the levels of constituents in danshen that alter glucuronosyltransferase activity. So far, this interaction has not been reported in humans.
Midazolam (Versed)
Danshen might alter the levels and clinical effects of midazolam.
Preliminary clinical research in healthy males shows that the administration of danshen for 10-14 days induces intestinal CYP3A4 and increases midazolam clearance. The maximum concentration was decreased by 31% to 67%, and drug levels were decreased by 27% to 80%. However, a single dose of danshen has the opposite effect, increasing maximum concentrations of midazolam by 87%.
P-Glycoprotein Substrates
Danshen might alter the levels of drugs cleared by p-glycoprotein.
Pharmacokinetic research in healthy volunteers suggests that danshen might affect p-glycoprotein activity. Taking danshen extract 1 gram three times daily for 10 days prior to receiving fexofenadine 60 mg increases peak levels of fexofenadine, a p-glycoprotein substrate, by 27.4% and area under the curve (AUC) by 37.2%.
Rosuvastatin (Crestor)
Theoretically, danshen might increase the levels and clinical effects of rosuvastatin.
Animal research shows that a single dose of danshen increases levels of rosuvastatin at least 2-fold, possibly by increasing absorption and/or decreasing elimination. So far, this interaction has not been reported in humans.
Warfarin (Coumadin)
Theoretically, danshen may increase the risk of bleeding if used with warfarin.
There have been several case reports of increased international normalized ratio (INR) after concomitant use of danshen and warfarin. Elevations in INR have occurred as early as 3-5 days after start of danshen. However, a clinical trial in adults taking warfarin with stable INR found that the addition of compound danshen dripping pills, containing danshen extract, Panax notoginseng, and borneol, 270 mg three times daily for 4 weeks did not alter INR levels or the average required warfarin dose when compared to baseline. These findings are consistent with animal research, which found no change in warfarin pharmacokinetics with the use of danshen. Other research in healthy adult males also shows that taking a combination of danshen and kudzu with warfarin does not increases plasma warfarin area under the curve, but may reduce plasma soluble thrombomodulin levels. However, other research shows that danshen might increase the rate of absorption and decrease the elimination rate of warfarin. Also, research in healthy adult males shows that taking a combination of danshen and kudzu with warfarin increases plasma area under the curve of danshensu, a constituent of danshen, by approximately 29.5-fold. Danshen should be used cautiously in patients taking warfarin.
Jujube
Antidiabetes Drugs
Theoretically, zizyphus might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that zizyphus has hypoglycemic activity. However, a small clinical study shows that zizyphus fruit powder does not reduce fasting blood glucose levels in patients with type 2 diabetes.
Cns Depressants
Theoretically, zizyphus might cause additive sedative effects when taken with CNS depressants.
Some animal research has found that various parts of zizyphus have sedative effects. However, other animal research shows that zizyphus plant extract does not alter sleep parameters when used in combination with pentobarbital.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Animal research shows that zizyphus induces CYP1A2 enzymes. However, this effect has not been reported in humans.
Poria
Anticholinergic Drugs
Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.
Cholinergic Drugs
Theoretically, poria mushroom might have additive effects when used with cholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.
Cns Depressants
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Animal research shows that poria mushroom extract has sedative properties. This interaction has not been shown in humans.
Brand information
Manufacturer and brand details for JittersAway, from the product label.
Pacific BioLogic
See all Pacific BioLogic products- Name
- Pacific BioLogic Co.
- City
- Concord
- State
- CA
- ZipCode
- 94521
- Phone Number
- 800 869-8783
- Web Address
- www.pacificbiologic.com
JittersAway by Pacific BioLogic: Common Questions
Does JittersAway by Pacific BioLogic interact with any medications?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind JittersAway’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Poria Mushroom
Interacts with 417 drugsPoria mushroom (Fu Ling) is a fungus long used in Traditional Chinese Medicine, mainly as a mild diuretic and digestive and calming aid. Modern scientific evidence in humans is very limited,...
Read the full Poria Mushroom monograph → Herb & supplement monographDanshen
Interacts with 1,059 drugsDanshen is a root used in traditional Chinese medicine, mainly for heart and circulation problems. Some early research is promising, but the evidence is not strong enough to confirm it works...
Read the full Danshen monograph → Herb & supplement monographFo-ti
Interacts with 1,257 drugsFo-ti (He Shou Wu) is a root used in traditional Chinese medicine, often promoted for healthy aging and hair. High-quality human evidence for these benefits is limited, and processed Fo-ti h...
Read the full Fo-ti monograph → Herb & supplement monographZizyphus
Interacts with 469 drugsZizyphus (jujube) is an edible fruit and traditional remedy used mainly for sleep, anxiety, and digestion. The fruit is a nutritious food, but human evidence for its medicinal benefits is li...
Read the full Zizyphus monograph →Sources & How We Checked
JittersAway's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 74 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Poria Mushroom 3 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Kim H, Park I, Park K, Park S, Kim YI, Park BG. The positive effects of Poria cocos extract on quality of sleep in insomnia rat models. Int J Environ Res Public Health 2022;19(11):6629. PubMed
- Lv Q, Di X, Bian B, Li K, Guo J. Neuroprotective effects of Poria cocos (Agaricomycetes) essential oil on Aß1-40-induced learning and memory deficit in rats. Int J Med Mushrooms 2022;24(10):73-82.
Danshen 28 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Yu CM, Chan JC, Sanderson JE. Chinese herbs and warfarin potentiation by danshen. J Intern Med 1997;241:337-9. PubMed
- Tam LS, et al. Warfarin interacions with Chinese traditional medicines: danshen and methyl salicylate medicated oil. Aust N Z J Med 1995;25:258.
- Chan TY. Interaction between warfarin and danshen (Salvia miltiorrhiza). Ann Pharmacother 2001;35:501-4. DOI
- Chan TY. Drug interactions as a cause of overanticoagulation and bleedings in Chinese patients receiving warfarin. Int J Clin Pharmacol Ther 1998;36:403-5.
- Izzat MB, Yim APC, El-Zufari MH. A taste of Chinese medicine! Ann Thorac Surg 1998;66:941-2. PubMed
- Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7. DOI
- Wahed A, Dasgupta A. Positive and negative in vitro interference of Chinese medicine dan shen in serum digoxin measurement. Elimination of interference by monitoring free digoxin concentration. Am J Clin Pathol 2001;116:403-408. PubMed
- Wu B, Liu M, Zhang S. Dan Shen agents for acute ischaemic stroke. Cochrane Database Syst Rev 2007;(2):CD004295. PubMed
- Qiu F, Wang G, Zhang R, Sun J, et al. Effect of danshen extract on the activity of CYP3A4 in healthy volunteers. Br J Clin Pharmacol 2010;69:656-62. PubMed
- Li CP, Yung KH, and Chiu KW. Hypotensive action of Salvia miltiorrhiza cell culture extract. American Journal of Chinese Medicine 1990;18(3-4):157-166.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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