Interactions on record — worth a quick check against your medications. Based on 3 of 6 ingredients. Check your meds →
Dietary supplement

Restorit Ingredients & Drug Interactions

by Health Direct

Restorit label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Restorit against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Restorit is a dietary supplement by Health Direct with 6 active ingredients. Its ingredients are commonly taken for stress and fatigue, low energy, mental focus and memory.Based on those ingredients, 1,474 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6, Choline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Restorit by Health Direct

Ask about any prescription or over-the-counter medication and we check it for interactions with Restorit by Health Direct — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Restorit by Health Direct

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 13 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1,852 mg) without saying how much of each component you get.
  • “Neurotransmitter-Stimulating Precursors” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Adaptogens And Healthy Cortisol Nutrients” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Restorit contains 13 active ingredients, most of which are amino acids, neurotransmitter precursors, and plant extracts. The amino acids include L-Glutamine, Glycine, L-Arginine, L-Tyrosine, L-Lysine, and L-Theanine — these are building blocks your body uses for protein, neurotransmitters, and other functions.

The product also includes 5-HTP (a serotonin precursor), Vitamin B6, Choline, Pregnenolone (a hormone precursor), and DHEA (another hormone), plus Sensoril Ashwagandha extract. Several of these are grouped into proprietary blends named for their functional roles — neurotransmitter support, cortisol and stress support, serotonin support, and hormone support — though the individual ingredients within those blends are listed separately.

The only inactive ingredient on file is hydroxypropyl methylcellulose, a capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Soothe stress, fight fatigue, restore energy, enhance mood, improve sleep.
  • We looked for evidence on: Anxiety, Chronic fatigue syndrome (CFS), Cognitive function, Cognitive impairment, Age-related cognitive decline, Aging — and 4 related terms.
  • The strongest evidence on file: Dhea is rated "Possibly Effective" for Aging skin (Natural Medicines).
  • Also on file: Ashwagandha is rated "Possibly Effective" for Anxiety, Generalized anxiety disorder (GAD), Stress.
  • Also on file: Tyrosine is rated "Possibly Effective" for Cognitive function.

The evidence for these ingredients is mixed. L-Glutamine is effective for sickle cell disease and possibly effective for HIV/AIDS-related wasting and recovery after surgery or critical illness.

L-Tyrosine is effective for PKU (a genetic condition) and possibly effective for cognitive function and memory, though it was rated possibly ineffective for athletic performance. 5-HTP is possibly effective for depression.

Vitamin B6 is effective for certain types of anemia, B6 deficiency, and a rare seizure disorder, and likely effective for high homocysteine levels. L-Theanine is possibly effective for cognitive function.

Ashwagandha is possibly effective for insomnia, anxiety, and stress. For most other conditions claimed on the label — including L-Lysine for herpes, choline for cognitive decline, pregnenolone for various uses, and DHEA for aging skin — the evidence is either insufficient or rated as possibly effective.

Glycine, L-Arginine, and several other ingredients lack established effectiveness ratings in the data we hold.

The evidence, ingredient by ingredient Adaptogens Vitamin B6 Choline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 12 of the 12 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 12 of 12.
  • General safety write-ups exist for 12 of 12.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients in Restorit are generally well tolerated at typical doses short-term, but several come with important caveats. L-Glutamine, L-Arginine, and L-Theanine should be used under medical supervision if you have kidney or liver disease.

L-Arginine can lower blood pressure and may not be safe for everyone. 5-HTP may cause drowsiness, nausea, diarrhea, headache, and at high doses or in rare cases, mood changes or aggression — severity is dose-dependent.

Vitamin B6 is safe at normal dietary amounts, but high doses over time can damage nerves (neuropathy). Ashwagandha is generally well tolerated but has rare reports of acute liver problems and one case of intracranial bleeding.

DHEA can cause acne, mood changes, insomnia, and in women, unwanted hair growth and voice deepening. Pregnenolone commonly causes acne, agitation, drowsiness, and diarrhea.

Several ingredients (L-Glutamine, Glycine, L-Tyrosine, L-Lysine, L-Theanine, Choline, Pregnenolone, Ashwagandha, and DHEA) lack enough safety data in pregnancy; some have safety data advising against use while breastfeeding. Talk to your pharmacist or doctor before use if you're pregnant or nursing.

Side effects, ingredient by ingredient Adaptogens Vitamin B6 Choline

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 12 of the 12 matched ingredients can interact with medications — Pregnenolone, Lysine, Dhea, Choline, 5-htp, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; immunosuppressants / transplant drugs; diabetes medications; Parkinson's medications.
  • For scale: 1,475 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Restorit, check with your pharmacist if you take blood pressure medications (especially ACE inhibitors or ARBs), blood thinners or antiplatelet drugs, diabetes medications, anticonvulsants, thyroid hormone, benzodiazepines or other sedatives, serotonergic antidepressants (SSRIs, SNRIs), hormone therapies (estrogen, progesterone, testosterone), cancer medications (tamoxifen, aromatase inhibitors, fulvestrant), levodopa for Parkinson's disease, or any drug that causes sedation. These are the drug types documented to interact with this product's ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Restorit is a complex multi-ingredient supplement targeting neurotransmitter and hormone support. It may be worth considering if you're looking to support mood, stress, or cognitive function — but because it contains multiple ingredients that interact with blood pressure drugs, blood thinners, diabetes medications, thyroid drugs, sedatives, antidepressants, and hormonal therapies, you absolutely must check it against your medications first.

If you take any prescription drugs, especially for heart, blood pressure, mood, seizures, or hormone-related conditions, run those through our interaction checker before you start. Talk to your pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 12 of 13 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Restorit, straight from the product label.

Brand Health Direct
Barcode (UPC) 814599002358
Net contents 112 Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2024
DSLD ID 316683
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Restorit by Health Direct, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
28
UPC/BARCODE
814599002358
IngredientAmount% DV
L-Glutamine0 NP--
Glycine0 NP--
Proprietary Blend1852 mg--
L-Arginine0 NP--
L-Tyrosine0 NP--
L-Lysine0 NP--
5-HTP0 NP--
Vitamin B610 mg588%
L-Theanine0 NP--
L-Pyroglutamate0 NP--
Choline55 mg10%
Pregnenolone, Micronized0 NP--
Neurotransmitter-Stimulating Precursors0 NP--
Adaptogens And Healthy Cortisol Nutrients0 NP--
Serotonin-Stimulating Precursors0 NP--
Hormone-Stimulating Precursors0 NP--
Sensoril Ashwagandha0 NP--
DHEA, Micronized0 NP--

Other ingredients: Hydroxypropyl Methylcellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Feeling burned out, just... not yourself?

Physician formulated

Restorit (528 mg)

Formula

Restorit's fast-acting, doctor-recommended adrenal formula can help. This four-part formula is packed with nutrients clinically shown to soothe stress, fight fatigue, restore your energy, enhance your mood, and improve your sleep.

Suggested/Recommended/Usage/Directions

How to use Take four capsules daily (two at breakfast, two at dinner).

Precautions

Contains DHEA and Pregnenolone.

Warning: Not for use by anyone under the age of 18 years. Keep out of the reach of children.

Do not use if pregnant or nursing. Consult a licensed health care professional before using this product if you have, or have a family history of prostate cancer, prostate enlargement, heart disease, low "good" cholesterol (HDL), estrogen sensitivity, or if you are using any other dietary supplement, prescription drug, or over-the-counter drug.

Do not exceed the recommended serving. Exceeding the recommended serving may cause serious adverse health effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen. Discontinue use and call a licensed health care professional immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms.

Do not use if seal is broken.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Daily support for healthy Daytime energy Stress response Concentration & focus Clinical-strength adrenal care

Zero glandulars Non GMO & Vegan

Non GMO & Vegan

Boosts energy Relieves stress Supports mood

No caffeine, gluten, dairy, soy, or fillers

Made in USA

FDA Statement of Identity

Dietary Supplement

Storage

Important Store in a cool, dry place.

Brand IP Statement(s)

Copyright 2021 Innovative Health Laboratories, LLC. Capros is a trademark of Natreon, Inc. Vitacholine is a trademark of Balchem Corporation. Restorit is a trademark of Inspired Health Products, LLC.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Restorit by Health Direct label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Restorit label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Restorit by Health Direct

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container28 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

1852 mg per serving

Vitamin B6

Interacts with
210 drugs
10 mg per serving Form: Pyridoxal 5-Phosphate

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Choline

Interacts with
16 drugs
55 mg per serving Form: Vitacholine

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Restorit by Health Direct Drug Interactions

Want to check YOUR meds against Restorit?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,474Drugs
1,454 Moderate 20 Minor

Ingredients driving the most interactions

Vitamin B6 210
Choline 16

Individual Drug Interactions

The ingredients in Restorit interact with 1,474 drugs. Click any drug to see the details.

2 of the 6 ingredients in Restorit interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6 Choline

Each ingredient & the kinds of drugs it affects

For each ingredient in Restorit with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Choline1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Restorit, from the product label.

Health Direct

See all Health Direct products
Name
HD Nutrition, Inc.
City
Irvine
State
CA
ZipCode
92606
Phone Number
1-800-414-4496
Pharmacist Counseling Corner

Restorit by Health Direct: Common Questions

Does Restorit by Health Direct interact with any medications?
Yes. Based on its ingredients, Restorit has a known interaction with 1,474 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Restorit contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Restorit safe to take while I'm pregnant or breastfeeding?
Several ingredients — L-Glutamine, Glycine, L-Tyrosine, L-Lysine, L-Theanine, Choline, Pregnenolone, Ashwagandha, and DHEA — don't have enough safety data in pregnancy or while breastfeeding. Two ingredients (5-HTP and Ashwagandha) have safety data advising against use in pregnancy; 5-HTP and several others should be avoided while breastfeeding. Talk to your doctor or pharmacist before using this product if you're pregnant or nursing — they can help you decide what's right for your situation.
Can Restorit help with depression or anxiety?
5-HTP is rated possibly effective for depression, and Ashwagandha is possibly effective for both anxiety and stress. However, 5-HTP carries a risk of serotonin syndrome if combined with antidepressants, and both ingredients can cause side effects. If you have depression or anxiety, talk to your doctor first — they may want to monitor you if you add this to your care.
What are the most common side effects I might notice?
The most commonly reported side effects across the ingredients are gastrointestinal: nausea, diarrhea, abdominal pain, bloating, and constipation. You might also experience headache, dizziness, or drowsiness. 5-HTP and ashwagandha are more likely to cause sedation. If side effects are dose-dependent (as many are here), lowering your dose may help. Stop and talk to your pharmacist if effects are bothersome or don't settle.
Does Restorit help with memory and thinking?
L-Tyrosine and L-Theanine are both rated possibly effective for cognitive function. However, the evidence is preliminary, and we don't have strong proof that this specific product will noticeably sharpen your memory or focus. If that's your main goal, talk to your doctor about whether it's worth trying, especially if you're taking other medications.
Is there anything in Restorit I should know about before I start?
Yes — several ingredients are hormone precursors (Pregnenolone and DHEA), which means they can affect your body's hormone levels. These are best used under medical guidance. If you have a history of hormone-sensitive cancer, liver disease, or take medications for thyroid, blood pressure, or mood, definitely check with your pharmacist first. Also, L-Arginine can lower blood pressure, so it's not right for everyone.
I couldn't find one of the ingredients listed — is that a problem?
One ingredient, L-Pyroglutamate, isn't in our monograph system, so we couldn't check it for interactions with medications. For questions about that specific ingredient, ask your pharmacist or contact the product maker. For all the other ingredients, we've checked the data — just make sure to verify your own medications against them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Restorit is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Restorit label
Go deeper

The Full Monographs Behind Restorit’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Adaptogens

Adaptogens are a group of herbs and roots—such as ashwagandha, rhodiola, eleuthero, and Asian ginseng—that people use to help the body handle stress and fatigue. Some have early supportive r...

Read the full Adaptogens monograph → Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph →
Sources

Sources & How We Checked

Restorit's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 317 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Glycine 5 references
  1. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
  2. Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
  3. Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
  4. Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
  5. Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed

See these in context on the Glycine monograph →

L-arginine 66 references
  1. Sapienza MA, Kharitonov SA, Horvath I, et al. Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. Thorax 1998;53:172-5.
  2. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996;97:1989-94. PubMed
  3. Tenenbaum A, Fisman EZ, Motro M. L-arginine: Rediscovery in progress. Cardiology 1998;90:153-9.
  4. Brittenden J, Park KGM, Heys SD, et al. L-Arginine stimulates host defenses in patients with breast cancer. Surgery 1994;115:205-12.
  5. Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol 1999;161:558-65. DOI
  6. Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation 1996;93:2135-41.
  7. Siani A, Pagano E, Iacone R, et al. Blood pressure and metabolic changes during dietary L-arginine supplementation in humans. Am J Hypertens 2000;13:547-51. PubMed
  8. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  9. Wallace AW, Tom WL. Interaction of L-arginine and phosphodiesterase inhibitors in vasodilation of the porcine internal mammary artery. Anesth Analg 2000;90:840-6. DOI
  10. Huynh NT, Tayek JA. Oral arginine reduces systemic blood pressure in type 2 diabetes: its potential role in nitric oxide generation. J Am Coll Nutr 2002;21:422-7.. PubMed
  11. Staff AC, Berge L, Haugen G, et al. Dietary supplementation with L-arginine or placebo in women with pre-eclampsia. Acta Obstet Gynecol Scand 2004;83:103-7.
  12. Resnick DJ, Softness B, Murphy AR, et al. Case report of an anaphylactoid reaction to arginine. Ann Allergy Asthma Immunol 2002;88:67-8. PubMed
  13. Anon. Arginine hydrochloride injection (marketed as R-Gene 10). FDA Drug Safety Newsletter 2009;2(2):16-18. Available at: www.fda.gov/Drugs/DrugSafety/DrugSafetyNewsletter/default.htm.
  14. Higashi Y, Oshima T, Sasaki S, et. al. Angiotensin-converting enzyme inhibition, but not calcium antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension. Hypertension. 1998 Jul;32(1):16-24.
  15. Facchinetti, F., Longo, M., Piccinini, F., Neri, I., and Volpe, A. L-arginine infusion reduces blood pressure in preeclamptic women through nitric oxide release. J Soc Gynecol.Investig. 1999;6(4):202-207. DOI
  16. de Gouw, H. W., Verbruggen, M. B., Twiss, I. M., and Sterk, P. J. Effect of oral L-arginine on airway hyperresponsiveness to histamine in asthma. Thorax 1999;54(11):1033-1035. PubMed
  17. Komers, R., Komersova, K., Kazdova, L., Ruzickova, J., and Pelikanova, T. Effect of ACE inhibition and angiotensin AT1 receptor blockade on renal and blood pressure response to L-arginine in humans. J Hypertens. 2000;18(1):51-59. PubMed
  18. Cartledge, J. J., Davies, A. M., and Eardley, I. A randomized double-blind placebo-controlled crossover trial of the efficacy of L-arginine in the treatment of interstitial cystitis. BJU.Int. 2000;85(4):421-426.
  19. Sozykin, A. V., Noeva, E. A., Balakhonova, T. V., Pogorelova, O. A., and Men'shikov, M. I. [Effect of L-arginine on platelet aggregation, endothelial function adn exercise tolerance in patients with stable angina pectoris]. Ter.Arkh. 2000;72(8):24-27.
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Adaptogens 4 references
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