Levorphanol

37 interactions 4 explained in plain English
Also sold as: Xyvona
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Levorphanol Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Levorphanol Amitriptyline Elavil Explained An increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Levorphanol Sertraline Explained An increased risk of serotonin syndrome Details Levorphanol Buprenorphine Belbuca Explained Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Levorphanol Aripiprazole Injection Abilify An increased risk of respiratory and CNS depression Details Levorphanol Asenapine Transdermal Patch Secuado An increased risk of respiratory and CNS depression Details Levorphanol Butorphanol Injection Butorphic Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Levorphanol Butorphanol Nasal Spray Stadol® NS Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Levorphanol Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Levorphanol Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Levorphanol Clopidogrel Plavix Reduced efficacy of clopidogrel Details Levorphanol Diazepam Nasal Spray Valtoco An increased risk of respiratory and CNS depression Details Levorphanol Diazepam Rectal Diastat An increased risk of respiratory and CNS depression Details Levorphanol Diphenhydramine Injection Banophen An increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Levorphanol Diphenhydramine Topical Afterbite with Antihistamine An increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Levorphanol Dolasetron Anzemet An increased risk of serotonin syndrome Details Levorphanol Dolasetron Injection Anzemet An increased risk of serotonin syndrome Details Levorphanol Esketamine Nasal Spray Spravato Increased risk of sedation Details Levorphanol Fentanyl Transdermal Patch Duragesic® Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Levorphanol Granisetron Transdermal Patch Sancuso An increased risk of serotonin syndrome Details Levorphanol Granisetron Injection Granisol An increased risk of serotonin syndrome Details Levorphanol Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Levorphanol Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Levorphanol Hydroxychloroquine Plaquenil An increased risk of seizures Details Levorphanol Lacosamide Injection Motpoly An increased risk of CNS depression Details Levorphanol Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Levorphanol Linezolid Injection Zyvox An increased risk of serotonin syndrome Details Levorphanol Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Levorphanol Metoclopramide Injection Gimoti Increased risk of CNS depression Details Levorphanol Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Levorphanol Midazolam Nasal Spray Nayzilam An increased risk of respiratory and CNS depression Details Levorphanol Midazolam Injection Nayzilam An increased risk of respiratory and CNS depression Details Levorphanol Morphine Injection Astramorph® PF Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Levorphanol Nalbuphine Injection Nubain® Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Levorphanol Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.