Ostarine + Nintedanib Esylate
Nintedanib Esylate brand name: Ofev.
We found no known interaction between Ostarine and Nintedanib Esylate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Nintedanib Esylate states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Ostarine and Nintedanib Esylate
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Nintedanib Esylate and Ostarine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Ostarine safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Nintedanib Esylate
Interactions in our licensed database are recorded against drug classes, not just single drug names. Nintedanib Esylate is filed under 5 classifications — including anticoagulant/antiplatelet drugs, p-glycoprotein substrates, cytochrome p450 3a4 (cyp3a4) substrates. Ostarine has documented interactions with 6 drug classes — the most serious being cytochrome p450 3a4 (cyp3a4) inducers (moderate), hepatotoxic drugs (moderate) and probenecid (benemid) (moderate) — and none of Nintedanib Esylate’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Ostarine Does Interact With Other Medications
Ostarine has 442 moderate, 171 minor known drug interactions in our database — Nintedanib Esylate isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Ostarine
We haven’t checked that one against Ostarine yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Ostarine. Pick one to open its full report.
Some Nintedanib Esylate Products Have a Food Rule — Ostarine Should Not Break It
At least one FDA label for a product containing Nintedanib Esylate says to take it with food. If you take Ostarine on an empty stomach out of habit, keep them separate — and take Nintedanib Esylate with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Nintedanib Esylate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
2 DOSAGE AND ADMINISTRATION Recommended dosage: 150 mg taken orally twice daily approximately 12 hours apart taken with food.
From the Dosage and Administration section of the FDA label we read for Nintedanib Esylate — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Nintedanib Esylate
This page covers Ostarine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Nintedanib Esylate page lists 285 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Danshen (major), Grapefruit (major), Piracetam (major) and St. John's Wort (major).
By severity: 5 major · 240 moderate · 40 minor.
From our pharmacist’s overview on the Nintedanib Esylate page
“You take Ofev (nintedanib) to slow lung scarring, and this page deserves a careful read before any supplement joins it. Of the 285 ingredients here, the biggest cluster, over 200, can add to bleeding risk, a real concern since nintedanib itself can make you bleed more easily.”
Reviewed by 2 · Jul 18, 2026
Taking Ostarine as Part of a Dietary Supplement Product? Check It for Interactions
We hold 33 real supplement products containing Ostarine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ostarine. Even though Ostarine itself has no known interaction with Nintedanib Esylate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Ostarine and Nintedanib Esylate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#541 of 1,452 supplements looked up here in the last 7 days
#1,095 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ostarine reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Ostarine and Nintedanib Esylate records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Ostarine
What is Ostarine?
- Muscle building
- Athletic performance
- Fat loss / body recomposition
- Bodybuilding cycles
Ostarine (also called MK-2866 or enobosarm) is an experimental, unapproved drug known as a SARM (selective androgen receptor modulator), not a true dietary supplement. It is not approved by the FDA, is banned in sports, and has been linked to liver injury and other serious harms, so it is not recommended for general use.
Synthetic compound (not from a plant) · Capsules, tablets, liquids, powders sold as research chemicals or 'sports supplements'
An interaction check asks whether these two react with each other — it does not ask whether Ostarine is a good idea for someone in your situation. Here is what our Ostarine record says about it on its own.
Ostarine: dosing
There is no established safe or approved dose of Ostarine, because it is not an approved medicine or a legitimate dietary supplement. Doses used in research studies were given under medical supervision and do not apply to over-the-counter use.We do not recommend using Ostarine. Products sold online may not contain the dose listed on the label and may include other hidden substances.
From our Ostarine monograph — the full record covers uses, side effects and every documented interaction.
About Nintedanib
What Is Nintedanib Used For?
Brand name: Ofev
Nintedanib treats certain scarring lung diseases in adults. All the supported products are indicated for idiopathic pulmonary fibrosis (IPF) and for chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype (scarring lung disease that keeps getting worse).
Ofev, nintedanib capsules (100 mg and 150 mg) and one other nintedanib capsule product are also indicated to slow the decline in lung function in systemic sclerosis-associated interstitial lung disease (SSc-ILD). The nintedanib esylate capsule label lists only IPF and progressive chronic fibrosing ILDs.
Other Drugs & Ostarine
Browse every other medication we’ve checked against Ostarine — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
442 interactions
- Diclofenac Sodium ›
- Nifedipine ›
- Doxycycline ›
- Minocycline ›
- Tetracycline ›
- Amoxicillin ›
- Testosterone ›
- Verapamil ›
- Fenofibrate ›
- Levonorgestrel ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Glyburide ›
- Methyltestosterone ›
- Ciprofloxacin ›
- Phenytoin ›
- Allopurinol ›
- Carbamazepine ›
- Diclofenac Potassium ›
- Acetaminophen ›
- Griseofulvin ›
- Methotrexate ›
- Nitrofurantoin ›
- Ofloxacin ›
- Propoxyphene ›
- Rifampin ›
- Testosterone Undecanoate ›
- Acarbose ›
- Dapsone ›
- Doxycycline Hyclate ›
- Duloxetine ›
- Eltrombopag ›
- Interferon Alfa-2b ›
- Interferon Beta-1b ›
- Isoniazid ›
- Itraconazole ›
- Levofloxacin ›
- Modafinil ›
- Naltrexone ›
- Phenobarbital ›
- Probenecid ›
- Riluzole ›
- Valproic Acid ›
- Abiraterone Acetate ›
- Acebutolol ›
- Ambrisentan ›
- Amiodarone ›
- Aprepitant ›
- Azathioprine ›
- Chlorpropamide ›
- Choline Magnesium Trisalicylate ›
- Cyclophosphamide ›
- Daclizumab ›
- Dantrolene ›
- Deferasirox ›
- Diclofenac Epolamine ›
- Fingolimod ›
- Fluconazole ›
- Fluvastatin ›
Showing 60 of 442 moderate interactions — see all 442 on the Ostarine page.
171 interactions
- Diltiazem ›
- Ibuprofen ›
- Metronidazole ›
- Naproxen ›
- Erythromycin ›
- Estradiol ›
- Norethindrone ›
- Prednisone ›
- Flurbiprofen ›
- Formoterol ›
- Indomethacin ›
- Miconazole ›
- Trimipramine ›
- Diazepam ›
- Everolimus ›
- Meloxicam ›
- Cimetidine ›
- Erythromycin Ethylsuccinate ›
- Erythromycin Stearate ›
- Nicardipine ›
- Omeprazole ›
- Warfarin Sodium ›
- Carvedilol ›
- Celecoxib ›
- Clarithromycin ›
- Clomipramine ›
- Danazol ›
- Dronabinol ›
- Fluoxetine ›
- Fosamprenavir ›
- Glipizide ›
- Imipramine ›
- Irbesartan ›
- Lacosamide ›
- Methylprednisolone ›
- Mifepristone ›
- Octreotide ›
- Piroxicam ›
- Quinine Sulfate ›
- Saquinavir ›
- Tapentadol ›
- Torsemide ›
- Valsartan ›
- Abametapir ›
- Abrocitinib ›
- Acitretin ›
- Agomelatine ›
- Amitriptyline ›
- Amprenavir ›
- Asciminib ›
- Atazanavir ›
- Avatrombopag Maleate ›
- Azilsartan ›
- Berotralstat Hydrochloride ›
- Boceprevir ›
- Brigatinib ›
- Clopidogrel ›
- Cobicistat ›
- Crizotinib ›
- Darunavir ›
Showing 60 of 171 minor interactions — see all 171 on the Ostarine page.
No interaction 2,216 drugs checked — show the list
We also checked Ostarine against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Metoprolol ›
- Escitalopram ›
- Rivaroxaban ›
- Isotretinoin ›
- Tirzepatide ›
- Levothyroxine, Liothyronine ›
- Amlodipine Besylate ›
- Docusate ›
- Methamphetamine ›
- Metformin ›
- Lisdexamfetamine ›
- Tadalafil ›
- Semaglutide ›
- Hydroxyurea ›
- Valacyclovir ›
- Amphetamine ›
- Sumatriptan ›
- Propranolol ›
- Lisinopril ›
- Bupropion ›
- Azithromycin ›
- Pregabalin ›
- Gabapentin ›
- Dextroamphetamine ›
- Lamotrigine ›
- Bendamustine ›
- Quetiapine ›
- Clonazepam ›
- Acyclovir ›
- Buspirone ›
- Letrozole ›
- Citalopram ›
- Methylene Blue ›
- Candesartan Cilexetil ›
- Acetylsalicylic Acid ›
- Amlodipine Besylate, Benazepril ›
- Aluminum Hydroxide, Aspirin, Magnesium Hydroxide ›
- Perindopril Arginine, Amlodipine ›
- Insulin Degludec, Liraglutide ›
- Bisoprolol ›
- Amlodipine Besilate ›
- Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate ›
- Aspirin, Caffeine, Orphenadrine ›
- Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate ›
- Aminophylline, Amobarbital, Ephedrine ›
- Aspirin, Butalbital ›
- Atenolol, Chlorthalidone ›
- Enalapril Maleate ›
- Bendroflumethiazide, Rauwolfia Serpentina ›
- Ado-trastuzumab Emtansine ›
- Bismuth Subcarbonate, Calcium Carbonate, Opium ›
- Ezetimibe ›
- Cephalexin ›
Showing the 60 most looked-up of 2,216 medications checked with no known interaction — see the full Ostarine list.
Ostarine References
The 10 references that drive our Ostarine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Warning Letter: Ironmag Labs 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582464.htm Accessed: November 1, 2017
- Warning Letter: Panther Sports Nutrition 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm581630.htm. Accessed: November 1, 2017
- Warning Letter: Infantry Labs LLC 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582685.htm. Accessed: November 1, 2017
- Dobs AS, Boccia RV, Croot CC, et al. Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial. Lancet Oncol 2013;14(4):335-45. PubMed
- Dalton JT, Barnette KG, Bohl CE, et al. The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II tri
- Coss CC, Jones A, Dalton JT. Pharmacokinetic drug interactions of the selective androgen receptor modulator GTx-024 (enobosarm) with itraconazole, rifampin, probenecid, celecoxib and rosuvastatin. Invest New Drugs 2016;34(4):458-67. PubMed
- FDA. FDA Warns against using SARMs in body building products. October 2017. Available at: https://www.fda.gov/newsevents/newsroom/fdainbrief/ucm583021.htm.
- Bedi H, Hammond C, Sanders D, Yang HM, Yoshida EM. Drug-induced liver injury from enobosarm (ostarine), a selective androgen receptor modulator. ACG Case Rep J 2021;8(1):e00518. PubMed
- Kintz P, Gheddar L, Paradis C, et al. Peroxisome Proliferator-Activated Receptor Delta Agonist (PPAR- d) and Selective Androgen Receptor Modulator (SARM) Abuse: Clinical, Analytical and Biological Data in a Case Involving a Poisonous Combination of GW1516
- Weinblatt D, Roy S. Drug-Induced Liver Injury Secondary to Enobosarm: A Selective Androgen Receptor Modulator. J Med Cases 2022;13(5):244-248. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Ostarine and Nintedanib Esylate Together: Common Questions
Is it safe to take Ostarine with Nintedanib Esylate?
Do Ostarine and Nintedanib Esylate have any of the same side effects?
Should I take Ostarine and Nintedanib Esylate at the same time of day?
How was the Ostarine and Nintedanib Esylate combination checked?
Does Ostarine interact with any other medications?
Does Nintedanib Esylate interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.