Drug & supplement interaction

Red Clover + Doxycycline

Doxycycline brand names: Vibra-Tabs, Vibramycin, Doryx, Monodox, Doxycin, and others.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Red Clover and Doxycycline in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Doxycycline states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Red Clover and Doxycycline

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Doxycycline and Red Clover in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Red Clover safety at a glance

Red Clover overall Use caution Generally well tolerated short-term in healthy adults, but its estrogen-like activity calls for caution in certain people.

Pregnancy Likely Safe When used orally in amounts commonly found in foods. Read the full pregnancy detail

Breastfeeding Likely Safe When used orally in amounts commonly found in foods. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Doxycycline and Red Clover? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Doxycycline

Interactions in our licensed database are recorded against drug classes, not just single drug names. Doxycycline is filed under 9 classifications — including tetracycline antibiotics, antibiotic drugs, p-glycoprotein substrates. Red Clover has documented interactions with 9 drug classes — the most serious being estrogens (moderate), methotrexate (trexall, others) (moderate) and tamoxifen (nolvadex) (moderate) — and none of Doxycycline’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Red Clover Does Interact With Other Medications

Red Clover has 44 moderate, 823 minor known drug interactions in our database — Doxycycline isn’t one of them. If you take anything else, check it against the full list below.

Moderate 44 Minor 823 No known interaction 1,963 (incl. Doxycycline)

Taking anything else?

Check Another of Your Medications Against Red Clover

Covers the 2,830 medications we’ve checked against Red Clover. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Red Clover and Doxycycline May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

Bleeding or bruising Worth acting on Additional detail
Red Clover
“In one case report, a 53-year-old female had a spontaneous subarachnoid hemorrhage associated with the use of an herbal supplement containing red clover, dong quai, and eleuthero. It is not clear if this was due to red clover, another ingredient, the combination of ingredients, or other factors.”

Red Clover · Natural Medicines adverse-effect record, reported in myasthenia gravis.
2 sources cited

70419. Friedman, J. A., Taylor, S. A., McDermott, W., and Alikhani, P. Multifocal and recurrent subarachnoid hemorrhage due to an herbal supplement containing natural coumarins. Neurocrit.Care 2007;7(1):76-80. PubMed

13155. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
Doxycycline

Listed in the ADVERSE REACTIONS section of the FDA label for Doxycycline. Read the label on DailyMed ›
Headache Additional detail
Red Clover
“Orally, a specific red clover isoflavone product (Medoflavon) has been associated with headache, although with a similar frequency to placebo.”

Red Clover · Natural Medicines adverse-effect record, reported in cluster headache.
1 source cited

19545. Hidalgo LA, Chedraui PA, Morocho N, et al. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Gynecol Endocrinol 2005;21(5):257-264. PubMed
Doxycycline

Listed in the ADVERSE REACTIONS section of the FDA label for Doxycycline. Read the label on DailyMed ›
Nausea Additional detail
Red Clover
“Orally, red clover has been reported to cause nausea.”

Red Clover · Natural Medicines adverse-effect record, reported in nausea and vomiting.
1 source cited

8194. Tice J, Cummings SR, Ettinger B, et al. Few adverse effects of two red clover extracts rich in phytoestrogens: a multicenter, placebo-controlled trial. Alt Ther 2001;7:S33.
Doxycycline

Listed in the ADVERSE REACTIONS section of the FDA label for Doxycycline. Read the label on DailyMed ›

Reported for Red Clover but not commonly for Doxycycline: loss of vision, blood clots and muscle pain.

Effects for Doxycycline come from the ADVERSE REACTIONS section of its FDA label; effects for Red Clover come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Red Clover in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally in amounts commonly found in foods.

Pregnancy And Lactation Possibly Unsafe

When used orally in medicinal amounts. Red clover has estrogenic activity; avoid using. There is insufficient reliable information available about the safety of the topical use of red clover during pregnancy and lactation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Doxycycline Products Have a Food Rule — Red Clover Should Not Break It

At least one FDA label for a product containing Doxycycline says to take it on an empty stomach. Most supplements — Red Clover included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Doxycycline on its own and move Red Clover to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Doxycycline products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Take one Doxycycline capsule (40 mg) once daily in the morning on an empty stomach, preferably at least one hour prior to or two hours after meals.

From the Dosage and Administration section of the FDA label we read for Doxycycline — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Red Clover or Doxycycline

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Red Clover or Doxycycline, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Doxycycline

This page covers Red Clover only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Doxycycline page lists 166 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Oleander (major) and Siberian Cocklebur (major).

By severity: 7 major · 139 moderate · 20 minor.

From our pharmacist’s overview on the Doxycycline page

“St. John's wort is the supplement I would flag first for anyone on doxycycline (Vibramycin, Doryx), because it can speed the antibiotic out of the body and leave an infection undertreated.”

Reviewed by 2 · Jul 18, 2026

Open the Doxycycline interaction page

One more smart check

Taking Red Clover as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,480 real supplement products containing Red Clover, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Red Clover. Even though Red Clover itself has no known interaction with Doxycycline, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Red Clover and Doxycycline Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Red Clover

Top 25%

#162 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Doxycycline

Top 5%

#41 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Red Clover reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Red Clover and Doxycycline records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Red Clover

What is Red Clover?

Menopause symptoms (hot flashes)
High cholesterol
Bone health/osteoporosis
Skin and hair concerns
Women's health

Red clover is a plant rich in isoflavones (plant compounds with weak estrogen-like activity) that is most often used for menopause symptoms like hot flashes. The evidence is mixed and generally weak, with some studies showing modest benefit and others showing none. Because of its hormone-like effects, it's not for everyone—talk with your pharmacist or doctor before trying it, especially if you have a hormone-sensitive condition.

Trifolium pratense · Fabaceae · Flowering tops (blossoms) and aerial parts · Capsules, tablets, standardized extracts, tinctures, teas, and topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Red Clover is a good idea for someone in your situation. Here is what our Red Clover record says about it on its own.

Red Clover: dosing

There is no single well-established standard dose for red clover. Products vary widely, and many are standardized to a certain amount of isoflavones, which makes comparison difficult.The safest approach is to follow the directions on the product label and not exceed the recommended amount. They can help you decide whether it's appropriate and what amount is reasonable for you.

From our Red Clover monograph — the full record covers uses, side effects and every documented interaction.

Read the full Red Clover monograph & all interactions

Medication

About Doxycycline

What Is Doxycycline Used For?

Brand names: Vibra-Tabs, Vibramycin, Doryx, Monodox, Doxycin, Doxy, Doxylin, Doxy-D, Periostat, Doxycycline Injection, Oracea, Xyrosa

Doxycycline belongs to the tetracycline family of antibiotics. It's prescribed for many types of bacterial infections, including respiratory tract infections, sexually transmitted infections (STIs), tick-borne illnesses like Rocky Mountain spotted fever, and eye infections. It's also used to help prevent malaria and, in some cases, as a helper treatment for severe acne.

In situations where penicillin-type antibiotics can't be used — due to allergy, for example — doxycycline can step in as an alternative. It should only be used for infections that are proven or strongly suspected to be caused by bacteria.

See full Doxycycline drug information

Keep checking

Other Drugs & Red Clover

Browse every other medication we’ve checked against Red Clover — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

44Moderate

823Minor

1,962No known interaction

44 Moderate 823 Minor 1,962 No interaction

Moderate

44 interactions

Minor

823 interactions

Showing 60 of 823 minor interactions — see all 823 on the Red Clover page.

No interaction 1,962 drugs checked — show the list

We also checked Red Clover against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,962 medications checked with no known interaction — see the full Red Clover list.

See the full Red Clover interactions page

See every supplement checked against Doxycycline, ranked by severity

Evidence & sources

Red Clover References

The 24 references that drive our Red Clover monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Kurzer MS, Xu X. Dietary phytoestrogens. Annu Rev Nutr 1997;17:353-81. PubMed
Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
This P, De La Rochefordiere A, Clough K, et al. Phytoestrogens after breast cancer. Endocr Relat Cancer 2001;8:129-34. PubMed
Tice J, Cummings SR, Ettinger B, et al. Few adverse effects of two red clover extracts rich in phytoestrogens: a multicenter, placebo-controlled trial. Alt Ther 2001;7:S33.
Ingram DM, Hickling C, West L, et al. A double-blind randomized controlled trial of isoflavones in the treatment of cyclical mastalgia. The Breast 2002;11:170-4. PubMed
Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
Geller SE, Shulman LP, van Breemen RB, et al. Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial. Menopause 2009;16:1156-66. PubMed
Hidalgo LA, Chedraui PA, Morocho N, et al. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Gynecol Endocrinol 2005;21(5):257-264. PubMed
Campbell MJ, Woodside JV, Honour JW, et al. Effect of red clover-derived isoflavone supplementation on insulin-like growth factor, lipid and antioxidant status in healthy female volunteers: a pilot study. Eur J Clin Nutr 2004;58(1):173-179. PubMed
Guerrero JA, Lozano ML, Castillo J, et al. Flavonoids inhibit platelet function through binding to the thromboxane A2 receptor. J Thromb Haemost 2005;3(2):369-376. PubMed
Kondo K, Suzuki Y, Ikeda Y, Umemura K. Genistein, an isoflavone included in soy, inhibits thrombotic vessel occlusion in the mouse femoral artery and in vitro platelet aggregation. Eur J Pharmacol 2002;455(1):53-57. PubMed
Polini N, Rauschemberger MB, Mendiberri J, et al. Effect of genistein and raloxifene on vascular dependent platelet aggregation. Mol Cell Endocrinol 2007;267(1-2):55-62. PubMed
Wuttke W, Jarry H, Seidlova-Wuttke D. Plant-derived alternative treatments for the aging male: facts and myths. Aging Male 2010;13(2):75-81. PubMed
Villaseca P. Non-estrogen conventional and phytochemical treatments for vasomotor symptoms: what needs to be known for practice. Climacteric 2012;15(2):115-124. PubMed
Chen, Y., Xiao, C. Q., He, Y. J., Chen, B. L., Wang, G., Zhou, G., Zhang, W., Tan, Z. R., Cao, S., Wang, L. P., and Zhou, H. H. Genistein alters caffeine exposure in healthy female volunteers. Eur.J Clin.Pharmacol. 2011;67(4):347-353. PubMed
Friedman, J. A., Taylor, S. A., McDermott, W., and Alikhani, P. Multifocal and recurrent subarachnoid hemorrhage due to an herbal supplement containing natural coumarins. Neurocrit.Care 2007;7(1):76-80. PubMed
Hooper, L., Madhavan, G., Tice, J. A., Leinster, S. J., and Cassidy, A. Effects of isoflavones on breast density in pre- and post-menopausal women: a systematic review and meta-analysis of randomized controlled trials. Hum.Reprod.Update. 2010;16(6):745-7 PubMed
Orr A and Parker R. Red clover causing symptoms suggestive of methotrexate toxicity in a patient on high-dose methotrexate. Menopause Int. 2013;19(3):133-134. PubMed
Clifton-Bligh PB, et al. Red cover isoflavones enriched with formononetin lower serum LDL cholesterol- a randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr. 2015;69(1):134-142.
Risk assessment for peri- and post-menopausal women taking food supplements containing isolated isoflavones. EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS). 2015. DOI
Ferraris C, Ballestra B, Listorti C, et al. Red clover and lifestyle changes to contrast menopausal symptoms in premenopausal patients with hormone-sensitive breast cancer receiving tamoxifen. Breast Cancer Res Treat 2020;180(1):157-65. doi: 10.1007/s1054 PubMed
Chen L, Choi J, Leonard SW, et al. No Clinically Relevant Pharmacokinetic Interactions of a Red Clover Dietary Supplement with Cytochrome P450 Enzymes in Women. J Agric Food Chem. 2020;68(47):13929-13939. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Related: nutrient depletion

Doxycycline Is Linked to Lower Levels of 7 Nutrients

Natural Medicines records Doxycycline as a medicine that can lower these. This is not an interaction with Red Clover — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:

Read the full Doxycycline nutrient depletion report ›

Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.

Pharmacist Counseling Corner

Taking Red Clover and Doxycycline Together: Common Questions

Is it safe to take Red Clover with Doxycycline?

We do not list a known interaction between Red Clover and Doxycycline. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Red Clover and Doxycycline have any of the same side effects?

Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

Should I take Red Clover and Doxycycline at the same time of day?

At least one FDA label for a product containing Doxycycline says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Doxycycline on its own and move Red Clover to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.

How was the Red Clover and Doxycycline combination checked?

Interactions in our licensed database are recorded against drug classes. Doxycycline is filed under 9 classifications, and Red Clover has documented interactions with 9 drug classes — none of Doxycycline's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Red Clover interact with any other medications?

Yes. Red Clover has 867 documented drug interactions in our database — Doxycycline is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Doxycycline interact with any supplements?

Yes. Doxycycline has documented interactions with 166 supplements in our database — Red Clover is not one of them. The Doxycycline interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Red Clover monograph Uses, safety profile, and every drug interaction in one place Doxycycline drug information The full plain-English guide to this medication Doxycycline supplement interactions Every supplement checked against Doxycycline, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 24 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Doxycycline and Red Clover?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.