Medication interaction hub

What Supplements Interact with Pacritinib?

Pacritinib brand name: Vonjo. Every interaction below applies to the brands too.

158 Interactions 8 Major 110 Moderate 40 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Pacritinib? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Pacritinib against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Someone on pacritinib (Vonjo) is usually fighting myelofibrosis, and the supplements people reach for during cancer treatment, herbal blends, immune boosters, St. John's wort for mood, are where this list gets serious. Eight of the 158 ingredients on record rate major; understand those first. Most of the danger runs through CYP3A4, the liver enzyme that clears pacritinib: St. John's wort revs it up and can drain the drug from your blood, while grapefruit blocks it and lets levels climb.

A cluster of thirteen can stretch the heart's QT interval, the electrical pause between heartbeats, raising the odds of a dangerous rhythm. The 110 moderate and 40 minor entries mostly play variations on the CYP3A4 theme with weaker evidence behind them. And seventeen, activated charcoal at the top, can keep an oral dose from fully absorbing, so keep anything in that group well away from the time you take your pill.

— , Clinical Pharmacist · July 18, 2026

Major 8 Moderate 110 Minor 40 No known interaction 1,294

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Pacritinib: Top Interactions at a Glance

The most significant Pacritinib supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 158 interacting ingredients — plus 1,294 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Pacritinib + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Grapefruit + Pacritinibi

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Probable Activated Charcoal + Pacritinibi

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Arsenic + Pacritinibi

Arsenic trioxide can prolong the QT interval.

Read the full interaction Major Likelihood Probable Cesium + Pacritinibi

Theoretically, taking cesium concomitantly with other drugs that prolong the QT interval may increase the risk of ventricular arrhythmias and death.

Read the full interaction Major Likelihood Probable Ephedra + Pacritinibi

Theoretically, ephedra might have an additive effect with drugs that prolong the QT interval.

Read the full interaction Major Likelihood Probable Sida Cordifolia + Pacritinibi

Theoretically, Sida cordifolia might increase the risk of additive QT interval prolongation when taken with QT interval-prolonging drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Pacritinib

All 1,452 ingredients in our database, ranked by severity — 158 with a Pacritinib interaction on file and 1,294 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Pacritinib?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Hops with Pacritinib?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.

Full Hops + Pacritinib answer

Can you take Oregon Grape with Pacritinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.

Full Oregon Grape + Pacritinib answer

Can you take Gum Arabic with Pacritinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Pacritinib answer

Can you take Higenamine with Pacritinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, higenamine might increase the levels and clinical effects drugs metabolized by CYP3A4.

Full Higenamine + Pacritinib answer

Can you take Horny Goat Weed with Pacritinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.

Full Horny Goat Weed + Pacritinib answer

Can you take Hu Zhang with Pacritinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hu zhang might increase levels of drugs metabolized by CYP3A4.

Full Hu Zhang + Pacritinib answer

Can you take Iboga with Pacritinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, iboga may have an additive effect with drugs that prolong the QT interval.

Full Iboga + Pacritinib answer

Can you take Indian Long Pepper with Pacritinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Indian long pepper might increase the effects and adverse effects of CYP3A4 substrates.

Full Indian Long Pepper + Pacritinib answer

Can you take K2/spice with Pacritinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, K2/spice might have an additive effect with drugs that prolong the QT interval and increase the risk of ventricular arrhythmi...

Full K2/spice + Pacritinib answer

Can you take Kratom with Pacritinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. CYP3A4 inhibitors might increase the concentrations and clinical effects of kratom's primary active alkaloid mitragynine.

Full Kratom + Pacritinib answer

Can you take Lemongrass with Pacritinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lemongrass might decrease the metabolism of CYP3A4 substrates.

Full Lemongrass + Pacritinib answer

Can you take Lentinan with Pacritinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Laboratory research suggests that lentinan might increase the activity of cytochrome P450 3A4 (CYP3A4).

Full Lentinan + Pacritinib answer

Can you take Licorice with Pacritinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.

Full Licorice + Pacritinib answer

Can you take Lime with Pacritinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.

Full Lime + Pacritinib answer

Can you take Methoxylated Flavones with Pacritinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that methoxylated flavones might inhibit cytochrome P450 3A4 (CYP3A4).

Full Methoxylated Flavones + Pacritinib answer

Can you take Moringa with Pacritinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.

Full Moringa + Pacritinib answer

Can you take Neem with Pacritinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem leaf extract might increase the levels and clinical effects of CYP3A4 substrates.

Full Neem + Pacritinib answer

Can you take Oolong Tea with Pacritinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the levels and adverse effects of the caffeine in oolong tea.

Full Oolong Tea + Pacritinib answer

Can you take Padang Cassia with Pacritinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that a methanol extract of Padang cassia inhibits cytochrome P450 3A4 (CYP3A4) activity.

Full Padang Cassia + Pacritinib answer

Can you take Panax Ginseng with Pacritinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Panax ginseng has an additive effect with drugs that prolong the QT interval and potentially increase the risk of ventricular...

Full Panax Ginseng + Pacritinib answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Pacritinib is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Pacritinib, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Pacritinib sits in 5 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Pacritinib through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Pacritinib through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Pacritinib through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Pacritinib through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Pacritinib through this category.

About Pacritinib

Pacritinib is a targeted kinase inhibitor used to treat intermediate or high-risk myelofibrosis (a bone marrow disorder) in adults with very low platelet counts.

Generic name: Pacritinib  ·  Brand name: Vonjo.

See the full Pacritinib drug information
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Take a Supplement Product? Check the Whole Bottle Against Pacritinib

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Pacritinib.

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Pharmacist Counseling Corner

Pacritinib & Supplements: Common Questions

What supplements interact with Pacritinib?
In our interaction database, 158 supplement and herbal ingredients have an interaction with Pacritinib on file — 8 rated major, 110 moderate, and 40 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Activated Charcoal, Arsenic.
Which Pacritinib supplement interactions are the most serious?
Focus on the major group: Grapefruit, Activated Charcoal, Arsenic, Cesium and Ephedra, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Pacritinib?
That depends entirely on which supplement. The honest answer for Pacritinib is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Vonjo have the same supplement interactions as Pacritinib?
Yes — Vonjo all contain Pacritinib, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Pacritinib and my other medications?
This page covers Pacritinib against supplements and herbal ingredients. Checking Pacritinib against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Pacritinib drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.