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Dietary supplement

Chlorophyll Complex 100 mg Ingredients & Drug Interactions

by Puritan's Pride

Chlorophyll Complex 100 mg label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Chlorophyll Complex 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Chlorophyll Complex 100 mg is a dietary supplement by Puritan's Pride with 2 active ingredients. Its ingredients are commonly taken for body and breath odor reduction, wound healing (topical), detoxification.Based on those ingredients, 368 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chlorophyll Complex, Copper. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Chlorophyll Complex 100 mg by Puritan's Pride

Ask about any prescription or over-the-counter medication and we check it for interactions with Chlorophyll Complex 100 mg by Puritan's Pride — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Chlorophyll Complex 100 mg by Puritan's Pride

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients: chlorophyll complex and copper. Chlorophyll is a green pigment from plants that's been studied for various conditions, though the evidence is limited.

Copper is an essential mineral your body needs for several functions, including making red blood cells and supporting bone health. The softgel also contains inactive ingredients — sunflower oil, gelatin, and glycerin — which help deliver the active ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Body and breath odor reduction.
  • We looked for evidence on: Colostomy odor, Halitosis, Body odor, Oral malodor.
  • The closest evidence on file: Chlorophyll is rated "Insufficient Reliable Evidence To Rate" for Colostomy odor (Natural Medicines).
  • Also on file: Chlorophyll is rated "Insufficient Reliable Evidence To Rate" for Halitosis.

The evidence on chlorophyll complex for the conditions it's marketed for — including genital herpes, wound healing, shingles, skin cancer, and pancreatitis — is insufficient to rate it as reliable. That means we don't have enough solid research to say whether it works for these uses.

Copper, on the other hand, is likely effective for treating copper deficiency, but may not help with Alzheimer's disease. For acne, chemotherapy-related anemia, and brain tumors, the evidence for copper is also insufficient to rate.

The evidence, ingredient by ingredient Chlorophyll Copper

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chlorophyll is generally well tolerated in short-term use, but high-quality long-term safety data are limited. The main concern is photosensitization — your skin becomes more sensitive to sun damage — which is the most common side effect when taken by mouth.

Rarely, a condition called pseudoporphyria (painful blisters on your hands and face) has developed after taking chlorophyll. Copper is safe in the amounts found in food and standard supplements, but excess copper can be toxic.

Contact dermatitis from copper is rare. If you have diabetes, be aware that people with diabetes tend to have higher blood copper levels, though it's not clear if elevated copper contributes to diabetes itself.

Side effects, ingredient by ingredient Chlorophyll Copper

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Chlorophyll, Copper.
  • The most serious interaction on file is rated Moderate.
  • For scale: 368 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check your medications with your pharmacist if you use any photosensitizing drugs (which make skin more sun-sensitive), methotrexate (Trexall), penicillamine (Cuprimine, Depen), or oral contraceptive birth control pills. Chlorophyll may increase photosensitivity and slow methotrexate clearance; copper may reduce penicillamine absorption and raise copper levels with birth control use.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Consider this product if you're looking to supplement copper and are interested in chlorophyll, though the evidence for chlorophyll's effectiveness is limited. Be especially careful if you take methotrexate, photosensitizing medications, penicillamine, or birth control pills — check with your pharmacist first.

Pregnant or breastfeeding individuals should avoid this product: chlorophyll safety data are insufficient, and while copper is needed in pregnancy, high-dose supplements aren't recommended without medical guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Chlorophyll Complex 100 mg, straight from the product label.

Brand Puritan's Pride
Barcode (UPC) 025077000555
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 286346
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Chlorophyll Complex 100 mg by Puritan's Pride, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
60
UPC/BARCODE
025077000555
IngredientAmount% DV
Chlorophyll Complex100 mg--
Copper1 mg111%

Other ingredients: Sunflower Oil, Gelatin, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Puritan's Pride supplements are produced from the finest raw materials under the stringent quality control standards. State-of-the-art manufacturing and packaging facilities ensure you the highest quality nutritional supplements money can buy. When it comes to your health...choose the best.

Precautions

Warning: Not intended for use by pregnant or nursing women. If you are taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Storage

Store at room temperature.

Seals/Symbols

QA Quality Assured

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) softgel daily, preferably with a meal.

Formulation

No artificial color, flavor or sweetener, no sugar, no starch, no milk, no lactose, no soy, no gluten, no wheat, no yeast, no fish. Sodium free.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Chlorophyll Complex 100 mg by Puritan's Pride label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Chlorophyll Complex 100 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Chlorophyll Complex 100 mg by Puritan's Pride

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Chlorophyll Complex

Interacts with
337 drugs
100 mg per serving

Chlorophyll is the green pigment found in plants and algae, and supplements often use a stable form called chlorophyllin. It is most studied for reduc...

Chlorophyll Complex monograph & interactions

Copper

Interacts with
31 drugs
1 mg per serving Form: Chlorophyll Complex

Copper is an essential trace mineral your body needs in small amounts for making red blood cells, supporting nerves and bones, and helping enzymes wor...

Copper monograph & interactions

Other (inactive) ingredients: Sunflower Oil, Gelatin, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Chlorophyll Complex 100 mg by Puritan's Pride Drug Interactions

Want to check YOUR meds against Chlorophyll Complex 100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
368Drugs
338 Moderate 30 Minor

Ingredients driving the most interactions

Chlorophyll Complex 337
Copper 31

Individual Drug Interactions

The ingredients in Chlorophyll Complex 100 mg interact with 368 drugs. Click any drug to see the details.

2 of the 2 ingredients in Chlorophyll Complex 100 mg interact with drugs. Each result below shows which ingredient is responsible. Chlorophyll Complex Copper

Each ingredient & the kinds of drugs it affects

For each ingredient in Chlorophyll Complex 100 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Chlorophyll Complex2 drug types · 337 drugs

Methotrexate (Trexall, Others)

Theoretically, chlorophyll may reduce the clearance of methotrexate.
In one case report, a 54-year-old male developed delayed clearance of intravenous high-dose methotrexate with concomitant use of chlorophyll. When chlorophyll was stopped 2 days prior to methotrexate treatment, methotrexate clearance was unaffected.

Likelihood Possible Evidence B
Photosensitizing Drugs

Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Chlorophyll has been reported to cause photosensitization. In two case reports, pseudoporphyria developed after oral intake of chlorophyll. Theoretically, concomitant use with other photosensitizing drugs may exacerbate this effect.

Likelihood Probable Evidence B
Chlorophyll Complex full monograph & interactions

Copper2 drug types · 31 drugs

Penicillamine (Cuprimine, Depen)

Theoretically, taking copper with penicillamine might decrease the absorption of penicillamine; separate dosing by at least 2 hours.
Copper chelates penicillamine, which decreases its absorption and may reduce its clinical effects.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.
A meta-analysis of clinical studies suggests that chronic use of oral contraceptives increases serum copper levels by a mean of 57 mcg/dL. In most people, this resulted in levels above the normal reference range for copper.

Likelihood Possible Evidence D
Copper full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Chlorophyll Complex 100 mg, from the product label.

Puritan's Pride

See all Puritan's Pride products
Name
Puritan's Pride, Inc.
City
Ronkonkoma
State
NY
ZipCode
11779
Phone Number
1-800-645-1030
Web Address
www.puritan.com
Pharmacist Counseling Corner

Chlorophyll Complex 100 mg by Puritan's Pride: Common Questions

Does Chlorophyll Complex 100 mg by Puritan's Pride interact with any medications?
Yes. Based on its ingredients, Chlorophyll Complex 100 mg has a known interaction with 368 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Chlorophyll Complex 100 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Not recommended. There isn't enough reliable safety information for chlorophyll during pregnancy, so it's best avoided. For breastfeeding, safety is unknown, so avoid it unless your doctor advises otherwise. While copper itself is needed in pregnancy, high-dose supplements aren't recommended without medical guidance — stick to the amounts in food and prenatal vitamins.
What's the most common side effect?
Photosensitization — meaning your skin becomes more sensitive to sun damage and burns more easily. Rarely, a painful blistering condition called pseudoporphyria has developed after taking chlorophyll by mouth.
Does chlorophyll actually work for herpes, wound healing, or skin cancer?
The evidence isn't established enough to say. For genital herpes, shingles, wound healing, skin cancer, and pancreatitis, we don't have reliable research to rate chlorophyll as effective for those uses.
What is copper doing in this product?
Copper is an essential mineral your body needs to make red blood cells and support bone health. This product is likely effective for treating copper deficiency, but may not help with Alzheimer's disease or other conditions it's sometimes promoted for.
Is this product safe for long-term use?
Chlorophyll is generally well tolerated in short-term use, but high-quality safety data for long-term use are limited. Copper is safe in standard supplement amounts, but excess copper can be toxic, so stick to recommended doses.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Chlorophyll Complex 100 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Chlorophyll Complex 100 mg label
Go deeper

The Full Monographs Behind Chlorophyll Complex 100 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chlorophyll

Interacts with 337 drugs

Chlorophyll is the green pigment found in plants and algae, and supplements often use a stable form called chlorophyllin. It is most studied for reducing body and fecal odor and as a topical...

Read the full Chlorophyll monograph → Herb & supplement monograph

Copper

Interacts with 31 drugs

Copper is an essential trace mineral your body needs in small amounts for making red blood cells, supporting nerves and bones, and helping enzymes work. Most people get enough copper from fo...

Read the full Copper monograph →
Sources

Sources & How We Checked

Chlorophyll Complex 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chlorophyll 5 references
  1. Mathews-Roth MM. Carotenoids in erythropoietic protoporphyria and other photosensitivity diseases. Ann N Y Acad Sci, 1993; 691:127-38. PubMed
  2. Belen'kii, G. B. and Krikun, B. L. [Treatment of herpes simplex and herpes zoster by chlorophyll preparations]. Sov.Med. 1971;34(1):151-152.
  3. Brooks SL, Sanders J, Seymour JF, Mellor JD. A case of delayed methotrexate clearance following administration of a complementary medication containing chlorophyll. J Oncol Pharm Pract. 2014 Jun;20(3):225-8. PubMed
  4. Rossi E, Borchard K, Cole JM. Pseudoporphyria following self-medication with chlorophyll. Australas J Dermatol. 2015 Feb;56(1):47-8. PubMed
  5. Zhao CY, Frew JW, Muhaidat J, et al. Chlorophyll-induced pseudoporphyria with ongoing photosensitivity after cessation - a case series of four patients. J Eur Acad Dermatol Venereol 2016;30(7):1239-42. PubMed

See these in context on the Chlorophyll monograph →

Copper 11 references
  1. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  2. Campbell IA, Elmes PC. Ethambutol and the eye: zinc and copper (letter). Lancet 1975;2:711. DOI
  3. Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
  4. Kozak SF, Inderlied CB, Hsu HY, et al. The role of copper on ethambutol's antimicrobial action and implications for ethambutol-induced optic neuropathy. Diag Microbiol Infect Dis 1998;30:83-7. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  6. Cantilena LR, Klaassen CD. The effect of chelating agents on the excretion of endogenous metals. Toxicol Appl Pharmacol 1982;63:344-50.
  7. Babic Z, Tariba B, Kovacic J, Pizent A, Varnai VM, Macan J. Relevance of serum copper elevation induced by oral contraceptives: a meta-analysis. Contraception. 2013 Jun;87(6):790-800. PubMed
  8. Qui Q, Zhang F, Zhu W, Wu J, Liang M. Copper in diabetes mellitus: a meta-analysis and systematic review of plasma and serum studies. Biol Trace Elem Res 2017;177(1):53-63.
  9. Walker-Smith PK, Keith DJ, Kennedy CT, Sansom JE. Allergic contact dermatitis caused by copper. Contact Dermatitis 2016;75(3):186-7. PubMed
  10. Gallentine A. Third-degree burn on the neuropathic lower extremity in a patient with diabetes while wearing a copper-containing compression sock: a case report. Wound Manag Prev 2021;67(12):26-29. DOI
  11. Chung KJ, Chin YM, Wong MS, Sanmugam A, Singaravel S, Nah SA. Effectiveness of table salt versus copper sulphate in treating umbilical granuloma: A pilot randomized controlled trial. J Pediatr Surg 2022;57(2):261-265. PubMed

See these in context on the Copper monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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