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Dietary supplement

Mulberry Leaf Extract Ingredients & Drug Interactions

by Earthborn Elements

Mulberry Leaf Extract label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mulberry Leaf Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Mulberry Leaf Extract is a dietary supplement by Earthborn Elements with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, high cholesterol, weight management.Based on those ingredients, 87 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Morus alba Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Mulberry Leaf Extract by Earthborn Elements

Ask about any prescription or over-the-counter medication and we check it for interactions with Mulberry Leaf Extract by Earthborn Elements — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Mulberry Leaf Extract by Earthborn Elements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: white mulberry leaf extract. Mulberry leaf has been used traditionally to support blood sugar regulation and overall health.

The capsules also contain gelatin as an inactive ingredient to hold the powder together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient White Mulberry product and its label doesn't state a use — see White Mulberry's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold doesn't establish that white mulberry leaf works for any specific condition. We don't have reliable data on its effectiveness for androgenic alopecia (hair loss), osteoporosis, common cold, diabetes, or high cholesterol — all rated insufficient evidence to rate in our sources.

That doesn't mean it won't help, just that solid clinical proof isn't available yet.

The evidence, ingredient by ingredient White Mulberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

White mulberry leaf is generally well tolerated when taken orally. The most common side effects are mild digestive issues: bloating, flatulence, loose stools, and constipation.

In one study, about half of participants experienced bloating or gas, a quarter had loose stools, and one in five had constipation over 4 weeks — but these effects often lessened over time for some people. Because concentrated supplements haven't been as thoroughly studied as whole food mulberry, the data advises caution.

There isn't enough safety information to know whether medicinal amounts are safe during pregnancy or while breastfeeding — talk with your doctor or pharmacist for personalized guidance if either applies to you.

Side effects, ingredient by ingredient White Mulberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — White Mulberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 87 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against our interaction tool below if you take antidiabetes drugs or any OCT2 substrates (particularly metformin). These are Moderate-severity interactions — your doctor or pharmacist needs to weigh the benefit against the risk of low blood sugar or slowed drug elimination.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're managing blood sugar with medication or taking drugs eliminated through the kidney (like metformin), run this supplement past your pharmacist first — the interaction potential is real. For everyone else without those medications, mulberry leaf is generally well tolerated, though digestive side effects like bloating are common, especially at first.

Its effectiveness for any specific health goal isn't established in the data we hold.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mulberry Leaf Extract, straight from the product label.

Brand Earthborn Elements
Net contents 200 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 319628
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mulberry Leaf Extract by Earthborn Elements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
200
IngredientAmount% DV
Morus alba Leaf Extract600 mg--

Other ingredients: Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take 1 capsule 1 to 2 times daily, preferably with meals, or as directed by a physician. Take with at least 8 oz of liquid.

Precautions

If you are pregnant, nursing, or taking medication, consult your healthcare professional before taking this or any dietary supplement.

For adults only.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure or prevent any disease or health condition.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mulberry Leaf Extract by Earthborn Elements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mulberry Leaf Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mulberry Leaf Extract by Earthborn Elements

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container200 Amounts shown are per serving.

Morus alba Leaf Extract

Interacts with
87 drugs
600 mg per serving

White mulberry leaf is most studied for helping blunt the rise in blood sugar after meals, but the human evidence is limited and not strong. It is gen...

Morus alba Leaf Extract monograph & interactions

Other (inactive) ingredients: Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mulberry Leaf Extract by Earthborn Elements Drug Interactions

Want to check YOUR meds against Mulberry Leaf Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
87Drugs
87 Moderate

Ingredients driving the most interactions

Morus alba Leaf Extract 87

Individual Drug Interactions

The ingredients in Mulberry Leaf Extract interact with 87 drugs. Click any drug to see the details.

1 of the 1 ingredient in Mulberry Leaf Extract interact with drugs. Each result below shows which ingredient is responsible. Morus alba Leaf Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Mulberry Leaf Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Morus alba Leaf Extract2 drug types · 87 drugs

Antidiabetes Drugs

Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research shows that white mulberry leaf can lower blood glucose levels. Advise patients to monitor glucose levels closely.

Likelihood Possible Evidence D
Organic Cation Transporter 2 (Oct2) Substrates

Theoretically, white mulberry leaf might slow the elimination and increase the adverse effects of drugs which are OCT2 substrates.
Animal research shows that coadministration of white mulberry leaf extract with metformin, an OCT2 substrate, slows the renal elimination of metformin via inhibition of OCT2 activity. OCT2 is expressed in the kidneys and is responsible for transporting cationic drugs into tubular epithelial cells in order to be excreted in the urine.

Likelihood Possible Evidence D
Morus alba Leaf Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mulberry Leaf Extract, from the product label.

Earthborn Elements

See all Earthborn Elements products
Name
Earthborn Elements
Street Address
9450 SW Gemini Dr #49936
City
Beaverton
State
Oregon
ZipCode
97008
Web Address
Earthbornelements.com
Pharmacist Counseling Corner

Mulberry Leaf Extract by Earthborn Elements: Common Questions

Does Mulberry Leaf Extract by Earthborn Elements interact with any medications?
Yes. Based on its ingredients, Mulberry Leaf Extract has a known interaction with 87 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mulberry Leaf Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this lower my blood sugar if I'm diabetic?
Clinical research shows white mulberry leaf can lower blood glucose levels. If you take diabetes medication, the combination could push your blood sugar too low. Don't start this without talking to your doctor or pharmacist — they'll help you monitor and adjust if needed.
What side effects should I expect?
The most common are mild digestive ones: bloating, gas, loose stools, or constipation. In one study, about half of people had bloating or gas, a quarter had loose stools, and one in five had constipation — but for many, these effects lessened over the course of treatment.
Can I take this while pregnant or breastfeeding?
There isn't enough safety data to know either way with medicinal amounts. The safety notes advise against it. Talk with your doctor or pharmacist to decide what's right for your situation.
Does it actually work for diabetes or high cholesterol?
We don't have reliable evidence that it's effective for either. It may help lower blood glucose in theory, but proof for treating diabetes, high cholesterol, hair loss, osteoporosis, or colds isn't established in the data we hold.
What's in each capsule besides the mulberry extract?
Just gelatin, which is the capsule material itself — a binder that holds the powder. No other fillers or additives.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Mulberry Leaf Extract is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mulberry Leaf Extract label
Go deeper

The Full Monographs Behind Mulberry Leaf Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

White Mulberry

Interacts with 87 drugs

White mulberry leaf is most studied for helping blunt the rise in blood sugar after meals, but the human evidence is limited and not strong. It is generally well tolerated as a food and tea,...

Read the full White Mulberry monograph →
Sources

Sources & How We Checked

Mulberry Leaf Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

White Mulberry 6 references
  1. Andallu B, Suryakantham V, Lakshmi Srikanthi B, Reddy GK. Effect of mulberry (Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes. Clin Chim Acta 2001;314:47-53. PubMed
  2. Mudra M, Ercan-Fang N, Zhong L, et al. Influence of mulberry leaf extract on the blood glucose and breath hydrogen response to ingestion of 75 g sucrose by type 2 diabetic and control subjects. Diabetes Care 2007;30:1272-4. PubMed
  3. Kimura T, Nakagawa K, Kubota H, et al. Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. J Agric Food Chem 2007;55:5869-74. PubMed
  4. Huh HW, Na YG, Bang KH, et al. Extended intake of mulberry leaf extract delayed metformin elimination via inhibiting the organic cation transporter 2. Pharmaceutics. 2020;12(1):49. PubMed
  5. Thaipitakwong T, Supasyndh O, Rasmi Y, Aramwit P. A randomized controlled study of dose-finding, efficacy, and safety of mulberry leaves on glycemic profiles in obese persons with borderline diabetes. Complement Ther Med. 2020;49:102292. PubMed
  6. Thondre PS, Lightowler H, Ahlstrom L, Gallagher A. Mulberry leaf extract improves glycaemic response and insulaemic response to sucrose in healthy subjects: results of a randomized, double blind, placebo-controlled study. Nutr Metab (Lond) 2021;18(1):41. PubMed

See these in context on the White Mulberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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