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Dietary supplement

Natural Astaxanthin Ingredients & Drug Interactions

by NewtonEverett

Natural Astaxanthin label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Natural Astaxanthin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Natural Astaxanthin is a dietary supplement by NewtonEverett with 1 active ingredient. Its ingredients are commonly taken for antioxidant support, skin health and aging, eye health.Based on those ingredients, 671 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Natural Astaxanthin by NewtonEverett

Ask about any prescription or over-the-counter medication and we check it for interactions with Natural Astaxanthin by NewtonEverett — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Natural Astaxanthin by NewtonEverett

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This softgel contains one active ingredient: astaxanthin, a carotenoid (a type of plant pigment) sometimes used in supplements for aging and eye health. The rest of the capsule is made up of inactive ingredients — safflower oil, gelatin, vegetable glycerin, yellow beeswax, and soy lecithin — which help deliver and protect the active ingredient.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Astaxanthin product and its label doesn't state a use — see Astaxanthin's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold on astaxanthin's effectiveness is not established. We rate it insufficient reliable evidence for age-related cognitive decline, age-related macular degeneration (AMD), aging skin, Alzheimer disease, athletic performance, and carpal tunnel syndrome — meaning studies so far haven't shown enough consistent benefit to back any of these uses.

If you're considering it for a specific reason, your pharmacist or doctor can help you sort through what's available.

The evidence, ingredient by ingredient Astaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Astaxanthin is generally well tolerated in studies, though long-term safety data are limited. The most common side effects are mild — abdominal pain, diarrhea, and red fecal color — though at a higher dose (40 mg daily), one formulation caused severe stomach pain in a small number of patients.

The safety data advises against using astaxanthin during pregnancy or while breastfeeding, since there isn't enough information to know it's safe in those situations.

Side effects, ingredient by ingredient Astaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Astaxanthin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 672 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against this product if you take any drugs metabolized by your liver's CYP3A4 or CYP2B6 enzyme systems — astaxanthin may theoretically lower their levels (both Moderate severity). Common drugs that use these pathways include certain statins, some blood pressure medications, and immunosuppressants, but there are many others.

Use the search tool on this page to verify your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Natural Astaxanthin may be worth considering if you're interested in a carotenoid supplement for aging skin or eye health, though the evidence for those uses isn't strong yet. If you take any prescription medications — especially those processed by your liver — check your exact drugs with the tool below before starting.

Talk to your pharmacist if you're pregnant, breastfeeding, or uncertain whether it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Natural Astaxanthin, straight from the product label.

Brand NewtonEverett
Barcode (UPC) 689076031561
Net contents 120 Softgel(s); 4 mg
Market status On market
Date entered into DSLD Jun 25, 2014
DSLD ID 34800
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Natural Astaxanthin by NewtonEverett, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
120
UPC/BARCODE
689076031561
IngredientAmount% DV
Astaxanthin4 mg--

Other ingredients: Safflower Oil, Gelatin, Vegetable Glycerin, yellow Beeswax, Soy Lecithin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Made in USA

Not suitable for vegetarians.

Pure - Potent - Bioavailable We are driven to deliver highly potent, ultra-pure nutritional products with uncompromised quality. Our premium-grade liquid softgels are designed to provide an ideal delivery vehicle for maximum absorption and enhanced bioavailability.

Formulation

No artificial color, flavor or sweetener, preservatives, sugar, starch, milk, lactose, gluten, wheat, yeast, fish. Sodium free.

Seals/Symbols

newtoneverett(R)

FDA Statement of Identity

dietary supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) softgel daily, preferably with a meal.

Precautions

Warning: If you are pregnant, nursing, taking any medications or planning a medical procedure, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

KEEP OUT OF REACH OF CHILDREN.

Storage

Store at room temperature.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Natural Astaxanthin by NewtonEverett label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Natural Astaxanthin label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Natural Astaxanthin by NewtonEverett

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container120 Amounts shown are per serving.

Astaxanthin

Interacts with
671 drugs
4 mg per serving

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin monograph & interactions

Other (inactive) ingredients: Safflower Oil, Gelatin, Vegetable Glycerin, Yellow Beeswax, Soy Lecithin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Natural Astaxanthin by NewtonEverett Drug Interactions

Want to check YOUR meds against Natural Astaxanthin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
671Drugs
671 Moderate

Ingredients driving the most interactions

Astaxanthin 671

Individual Drug Interactions

The ingredients in Natural Astaxanthin interact with 671 drugs. Click any drug to see the details.

1 of the 1 ingredient in Natural Astaxanthin interact with drugs. Each result below shows which ingredient is responsible. Astaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Natural Astaxanthin with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Natural Astaxanthin, from the product label.

NewtonEverett

See all NewtonEverett products
Name
Newton-Everett Biotech
Web Address
www.newton-everett.com
Pharmacist Counseling Corner

Natural Astaxanthin by NewtonEverett: Common Questions

Does Natural Astaxanthin by NewtonEverett interact with any medications?
Yes. Based on its ingredients, Natural Astaxanthin has a known interaction with 671 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Natural Astaxanthin contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is astaxanthin safe to take if I'm pregnant or breastfeeding?
The safety data advise against it. There isn't enough information to know whether astaxanthin is safe during pregnancy or while breastfeeding, so it's best to avoid it in those situations. Talk to your doctor or pharmacist for personalized guidance.
What are the side effects I should expect?
Most people tolerate it well. The most common side effects are mild — abdominal pain, diarrhea, and red fecal color. At higher doses, some people have experienced more severe stomach pain, but that's rare. Long-term safety data are limited.
Does astaxanthin actually work for aging skin or eye health?
The evidence isn't established in our data. We rate astaxanthin insufficient reliable evidence for age-related skin or eye conditions like macular degeneration. If you want to know whether it might help your specific situation, ask your pharmacist or doctor.
Why is my stool red after taking this?
Red fecal color is one of the documented side effects of astaxanthin and is generally harmless — it's just the pigment from the supplement coming through. If it bothers you or doesn't go away, talk to your pharmacist.
How many active ingredients does this product have?
One — astaxanthin. The rest of the softgel is made up of inactive ingredients that deliver and protect the active one.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Natural Astaxanthin is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Natural Astaxanthin label
Go deeper

The Full Monographs Behind Natural Astaxanthin’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph →
Sources

Sources & How We Checked

Natural Astaxanthin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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