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Dietary supplement

TruGlutamine Ingredients & Drug Interactions

by PEScience

TruGlutamine label
See full label image
Powder Category: Amino Acid/protein
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking TruGlutamine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

TruGlutamine is a dietary supplement by PEScience with 1 active ingredient. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 50 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against TruGlutamine by PEScience

Ask about any prescription or over-the-counter medication and we check it for interactions with TruGlutamine by PEScience — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of TruGlutamine by PEScience

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

TruGlutamine is a single-ingredient powder containing L-glutamine, an amino acid your body produces naturally. Glutamine plays roles in immune function, gut health, and muscle metabolism, and your body draws on it especially during stress, illness, or intense exercise.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Muscle recovery and sports performance.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Postoperative recovery, Wound healing, Muscle protein synthesis, Training recovery.
  • The strongest evidence on file: Glutamine is rated "Possibly Effective" for Postoperative recovery (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Glutamine is rated "Insufficient Reliable Evidence To Rate" for Wound healing, Exercise-induced muscle damage.

L-glutamine has solid evidence supporting its use for sickle cell disease. It's considered possibly effective for HIV/AIDS-related wasting, recovery after surgery, and trauma or critical illness.

The research on these conditions continues to evolve, so talk with your doctor about whether it fits your particular situation.

The evidence, ingredient by ingredient Glutamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is generally well tolerated by healthy adults. The most common side effects are gastrointestinal—belching, bloating, gas, constipation, diarrhea, nausea, and stomach pain, especially at higher doses.

A small number of people have reported dizziness or headache, and in rare cases, people with bipolar disorder have experienced mood changes; these resolved when the dose was lowered. If you have kidney or liver disease, use this supplement only under medical supervision.

Safety data during pregnancy and lactation is limited, so talk with your doctor or pharmacist before taking it if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Glutamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glutamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 50 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your anticonvulsant medications (seizure drugs) with your doctor or pharmacist before taking TruGlutamine. Although the interaction is theoretical and hasn't been reported in patients, glutamine breaks down into a brain chemical that might theoretically work against how these medications function.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

TruGlutamine may help with sickle cell disease and possibly support recovery from surgery, trauma, or HIV-related wasting. If you take anticonvulsant medication, check with your doctor or pharmacist first.

People with kidney or liver disease should use it only under medical supervision. Discuss this supplement with your own healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about TruGlutamine, straight from the product label.

Brand PEScience
Barcode (UPC) 040232543302
Net contents 5.3 Ounce(s); 150 Gram(s)
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 297635
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for TruGlutamine by PEScience, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 Gram(s)
Maximum serving Sizes:
5 Gram(s)
Servings per container
30
UPC/BARCODE
040232543302
IngredientAmount% DV
L-Glutamine5 Gram(s)--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Mix 1 scoop into 8-10 oz (300-350 ml) of flavored beverage.

Storage

Use within 3 months of opening to prevent product clumping.

Precautions

Warnings: This product is intended to be consumed by healthy individuals.

Consult with your physician before using this product, especially if you have any medical condition, or take prescription or over the counter medications. Do not use if pregnant or nursing without first consulting a physician.

Discontinue use 2 weeks prior to surgery. Discontinue use and consult your health care professional if you experience any adverse reaction to this product. Do not use if safety seal is broken or missing.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

5 g premium glutamine

Fermented l-glutamine

Formulation

Third party tested

Vegan, fermented l-glutamine

Third-party tested for quality & purity

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Lab Tested Third Party Tested for Quality and Purity pescience.com/difference

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

TruGlutamine by PEScience label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

TruGlutamine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in TruGlutamine by PEScience

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size5 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

L-Glutamine

Interacts with
50 drugs
5 Gram(s) per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

TruGlutamine by PEScience Drug Interactions

Want to check YOUR meds against TruGlutamine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
50Drugs
50 Moderate

Ingredients driving the most interactions

L-Glutamine 50

Individual Drug Interactions

The ingredients in TruGlutamine interact with 50 drugs. Click any drug to see the details.

1 of the 1 ingredient in TruGlutamine interact with drugs. Each result below shows which ingredient is responsible. L-Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in TruGlutamine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for TruGlutamine, from the product label.

PEScience

See all PEScience products
Name
PEScience LLC
Street Address
3665 East Bay Dr #204-155
City
Largo
State
FL
Phone Number
888-885-0195
Web Address
pescience.com
Pharmacist Counseling Corner

TruGlutamine by PEScience: Common Questions

Does TruGlutamine by PEScience interact with any medications?
Yes. Based on its ingredients, TruGlutamine has a known interaction with 50 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
TruGlutamine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What side effects might I get from TruGlutamine?
The most common are gastrointestinal—bloating, gas, diarrhea, constipation, nausea, and stomach pain. Headache and dizziness have been reported less often. These side effects tend to happen at higher doses and often go away if you lower your dose.
Is TruGlutamine safe if I'm pregnant or breastfeeding?
There isn't enough reliable safety data to know either way. Talk with your doctor or pharmacist for personalized advice before taking it during pregnancy or while breastfeeding.
Does TruGlutamine actually work?
It's proven effective for sickle cell disease. For HIV-related wasting, post-surgery recovery, and trauma or critical illness, it's considered possibly effective, meaning the evidence is promising but not yet definitive.
Can I take TruGlutamine if I have kidney or liver disease?
Only under medical supervision. Talk with your doctor before using this supplement if you have either condition.
What is L-glutamine and why is it in this product?
L-glutamine is an amino acid your body makes naturally. It supports immune function, gut health, and muscle metabolism, especially during stress, illness, or intense exercise.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if TruGlutamine is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

TruGlutamine label
Go deeper

The Full Monographs Behind TruGlutamine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph →
Sources

Sources & How We Checked

TruGlutamine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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