Mirtazapine

78 interactions 5 explained in plain English

Also sold as: Mirataz Remeron

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Ketoconazole Topical Palonosetron Injection Metronidazole Midazolam Injection Metronidazole Topical

2 Contraindicated 76 Major

All (78) Contraindicated (2) Major (76)

Contraindicated

Mirtazapine Ketoconazole Topical Extina® Foam Increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation Details Mirtazapine Linezolid Injection Zyvox Increased risk of serotonin syndrome (hyperthermia, hyperreflexia, myoclonus, mental status changes) Details

Major

Mirtazapine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Mirtazapine Amitriptyline Elavil Explained Increased risk of serotonin syndrome, an increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Mirtazapine Sertraline Explained Increased risk of serotonin syndrome, an increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Mirtazapine Buprenorphine Belbuca Explained Increased risk of serotonin syndrome, an increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Mirtazapine Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Mirtazapine Amisulpride Injection Barhemsys Increased risk of QT interval prolongation and torsades de pointes Details Mirtazapine Arsenic Trioxide Trisenox Increased risk of QT interval prolongation and torsades de pointes Details Mirtazapine Aripiprazole Injection Abilify Increased risk of QT interval prolongation and torsades de pointes Details Mirtazapine Arsenic Trioxide Injection Trisenox Increased risk of QT interval prolongation and torsades de pointes Details Mirtazapine Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation and torsades de pointes Details Mirtazapine Azithromycin AzaSite Increased risk of QT interval prolongation and torsades de pointes Details Mirtazapine Alfuzosin UroXatral Increased risk of QT interval prolongation and torsades de pointes Details Mirtazapine Anagrelide Agrylin Increased risk of QT interval prolongation and torsades de pointes Details Mirtazapine Bedaquiline Sirturo Increased risk of QT interval prolongation and torsades de pointes Details Mirtazapine Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Mirtazapine Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Mirtazapine Chloroquine Aralen® Increased risk of QT interval prolongation and torsades de pointes Details Mirtazapine Clonidine Transdermal Patch Catapres Hypertension, decreased antihypertensive effectiveness Details Mirtazapine Dasatinib Phyrago Increased risk of QT interval prolongation and torsades de pointes Details Mirtazapine Degarelix Injection Firmagon Increased risk of QT interval prolongation and torsades de pointes Details Mirtazapine Deutetrabenazine Austedo Increased risk of QT interval prolongation and torsades de pointes Details Mirtazapine Diazepam Nasal Spray Valtoco Increased risk of somnolence Details Mirtazapine Diazepam Rectal Diastat Increased risk of somnolence Details Mirtazapine Disopyramide Norpace Increased risk of QT interval prolongation and torsades de pointes Details Mirtazapine Dofetilide Tikosyn Increased risk of QT interval prolongation and torsades de pointes Details Mirtazapine Dolasetron Anzemet Increased risk of serotonin syndrome, an increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Mirtazapine Dolasetron Injection Anzemet Increased risk of serotonin syndrome, an increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Mirtazapine Encorafenib Braftovi Increased risk of QT interval prolongation and torsades de pointes Details Mirtazapine Entrectinib Rozlytrek Increased risk of QT interval prolongation and torsades de pointes Details Mirtazapine Eribulin Injection Halaven Increased risk of QT interval prolongation and torsades de pointes Details Mirtazapine Famotidine Calmicid Increased risk of QT interval prolongation and torsades de pointes Details Mirtazapine Famotidine Injection Calmicid Increased risk of QT interval prolongation and torsades de pointes Details Mirtazapine Felbamate Felbatol Increased risk of QT interval prolongation and torsades de pointes Details Mirtazapine Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome Details Mirtazapine Flecainide Tambocor® Increased risk of QT interval prolongation and torsades de pointes Details Mirtazapine Foscarnet Injection Foscavir Increased risk of QT interval prolongation and torsades de pointes Details Mirtazapine Galantamine Razadyne Increased risk of QT interval prolongation and torsades de pointes Details Mirtazapine Gatifloxacin Ophthalmic Zymar® Increased risk of QT interval prolongation and torsades de pointes Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.