Drug & supplement interaction

1,3-dmba + Ethosuximide

Ethosuximide brand name: Zarontin.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between 1,3-dmba and Ethosuximide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

1,3-dmba and Ethosuximide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ethosuximide and 1,3-dmba in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

1,3-dmba safety at a glance

1,3-dmba overall Avoid It is an unapproved synthetic stimulant linked to potentially serious heart and blood vessel harm.
Pregnancy Avoid Stimulants like this should not be used during pregnancy.
Breastfeeding Likely Unsafe When used orally. 1,3-DMBA is thought to have stimulant and vasoconstrictive effects which might increase the risk of serious adverse effects. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ethosuximide and 1,3-dmba? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ethosuximide

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ethosuximide is filed under 7 classifications — including anticonvulsants, cytochrome p450 3a4 (cyp3a4) inducers, cns depressants. 1,3-dmba has documented interactions with 2 drug classes — the most serious being stimulant drugs (moderate) and cytochrome p450 2d6 (cyp2d6) substrates (minor) — and none of Ethosuximide’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

1,3-dmba Does Interact With Other Medications

1,3-dmba has 172 moderate, 149 minor known drug interactions in our database — Ethosuximide isn’t one of them. If you take anything else, check it against the full list below.

Moderate 172 Minor 149 No known interaction 2,509 (incl. Ethosuximide)
Taking anything else?

Check Another of Your Medications Against 1,3-dmba

Covers the 2,830 medications we’ve checked against 1,3-dmba. Pick one to open its full report.

What to actually watch for

What 1,3-dmba Itself Has Been Linked To

This is not an interaction — nothing below involves Ethosuximide. It is the side-effect record for 1,3-dmba on its own, from the licensed Natural Medicines monograph. If something new turns up after you add 1,3-dmba, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • A heart attack Worth acting on Additional detail

    “There is currently a limited amount of information available about the adverse effects of 1,3-DMBA. However, the closely related chemical 1,3-DMAA has been linked to serious adverse effects in humans, including lactic acidosis, myocardial infarction, stroke, and death.”

    1,3-dmba · Natural Medicines adverse-effect record, reported in myocardial infarction (mi).

Everything above comes from the Natural Medicines adverse-effect record for 1,3-dmba — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Ethosuximide’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Ethosuximide column appears here.

Special populations

1,3-dmba in Pregnancy & Breastfeeding

Lactation Likely Unsafe

When used orally. 1,3-DMBA is thought to have stimulant and vasoconstrictive effects which might increase the risk of serious adverse effects.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Ethosuximide

This page covers 1,3-dmba only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ethosuximide page lists 226 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 9 major · 179 moderate · 38 minor.

From our pharmacist’s overview on the Ethosuximide page

“Ethosuximide (Zarontin) prevents absence seizures, and a steady blood level is what keeps them away, so I treat this list of 226 interacting supplements and herbs with real care, especially the nine rated major. More than half of the entries can change how the liver clears the drug; grapefruit can raise its level while St.”

Reviewed by 2 · Jul 18, 2026

Open the Ethosuximide interaction page

How much people look this up

Where 1,3-dmba and Ethosuximide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement 1,3-dmba
Steady interest

#957 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ethosuximide
Steady interest

#1,590 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 1,3-dmba reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The 1,3-dmba and Ethosuximide records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About 1,3-dmba

What is 1,3-dmba?

  • Athletic and workout performance
  • Energy and stimulation
  • Weight loss and fat burning
  • Appetite suppression
  • Focus and concentration

1,3-DMBA is a synthetic stimulant chemically similar to the banned stimulant DMAA, and it is not a proven or safe dietary ingredient. The U.S. FDA considers supplements containing it adulterated, and it is banned in sports. Because of serious heart and stroke risks, it is best to avoid products that contain it.

Synthetic chemical (sometimes claimed to come from plants such as Coreopsis tinctoria or pouchong tea) · Capsules, tablets, and powders (pre-workout, fat-burner, and weight-loss products)

An interaction check asks whether these two react with each other — it does not ask whether 1,3-dmba is a good idea for someone in your situation. Here is what our 1,3-dmba record says about it on its own.

1,3-dmba: dosing

There is no safe or established dose of 1,3-DMBA. It is not an approved supplement ingredient, and the amounts in products are unregulated and may vary widely.Because of the real risk of serious harm, no recommended dose can be given. The safest amount is none.

From our 1,3-dmba monograph — the full record covers uses, side effects and every documented interaction.

Read the full 1,3-dmba monograph & all interactions
Medication

About Ethosuximide

What Is Ethosuximide Used For?

Brand name: Zarontin

Ethosuximide — sold as Zarontin and also available as generic Ethosuximide — is used to control absence (petit mal) epilepsy. Absence seizures are brief episodes where a person loses awareness for a few seconds, often mistaken for daydreaming.

Both Zarontin and Ethosuximide products (capsule and oral solution forms) are approved for this use. Either may also be used alongside other seizure medicines when a patient has absence seizures together with other types of epilepsy.

Most-Reported Side Effects for Ethosuximide

From FAERS, the FDA’s public side-effect reporting system (2,490 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Seizure 367 reports
Somnolence 157 reports
Generalised tonic-clonic seizure 149 reports
Petit mal epilepsy 118 reports
Treatment failure 116 reports
See full Ethosuximide drug information
Keep checking

Other Drugs & 1,3-dmba

Browse every other medication we’ve checked against 1,3-dmba — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
172Moderate
149Minor
2,508No known interaction
172 Moderate 149 Minor 2,508 No interaction
Moderate

172 interactions

Showing 60 of 172 moderate interactions — see all 172 on the 1,3-dmba page.

Minor

149 interactions

Showing 60 of 149 minor interactions — see all 149 on the 1,3-dmba page.

No interaction 2,508 drugs checked — show the list

We also checked 1,3-dmba against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,508 medications checked with no known interaction — see the full 1,3-dmba list.

See the full 1,3-dmba interactions page
See every supplement checked against Ethosuximide, ranked by severity
Evidence & sources

1,3-dmba References

The 4 references that drive our 1,3-dmba monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. SWANSON EE, CHEN KK. Comparison of pressor action of alicyclic derivatives of aliphatic amines. J Pharmacol Exp Ther. 1948 Aug;93(4):423-9.
  2. Cohen PA, Travis JC, and Venhuis BJ. A synthetic stimulant never tested in humans, 1,3-dimethylbutylamine (DMBA), is identified in multiple dietary supplements. Drug Test Analysis.,10-8-2014. PubMed
  3. Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10. PubMed
  4. Cohen PA, Travis JC, Keizers PHJ, Deuster P, Venhuis BJ. Four experimental stimulants found in sports and weight loss supplements: 2-amino-6-methylheptane (octodrine), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylamylamine (1,3-DMAA) and 1,3-dimethylbuty

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking 1,3-dmba and Ethosuximide Together: Common Questions

Is it safe to take 1,3-dmba with Ethosuximide?
We do not list a known interaction between 1,3-dmba and Ethosuximide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the 1,3-dmba and Ethosuximide combination checked?
Interactions in our licensed database are recorded against drug classes. Ethosuximide is filed under 7 classifications, and 1,3-dmba has documented interactions with 2 drug classes — none of Ethosuximide's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does 1,3-dmba interact with any other medications?
Yes. 1,3-dmba has 321 documented drug interactions in our database — Ethosuximide is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ethosuximide interact with any supplements?
Yes. Ethosuximide has documented interactions with 226 supplements in our database — 1,3-dmba is not one of them. The Ethosuximide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

1,3-dmba monograph Uses, safety profile, and every drug interaction in one place Ethosuximide drug information The full plain-English guide to this medication Ethosuximide supplement interactions Every supplement checked against Ethosuximide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ethosuximide and 1,3-dmba?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.