Drug & supplement interaction

Hordenine + Ketoprofen

Ketoprofen brand names: Orudis, Oruvail Gel, Powergel, Oruvail Injection.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Hordenine and Ketoprofen in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Ketoprofen states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Hordenine and Ketoprofen

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ketoprofen and Hordenine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Hordenine safety at a glance

Hordenine overall Use caution Human safety data is very limited, and it acts as a stimulant.
Pregnancy Avoid No safety data; avoid use during pregnancy.
Breastfeeding Avoid No safety data; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ketoprofen and Hordenine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ketoprofen

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ketoprofen is filed under 8 classifications — including nonsteroidal anti-inflammatory drugs (nsaids), anticoagulant/antiplatelet drugs, organic anion transporter 3 (oat3) substrates. Hordenine has documented interactions with 3 drug classes — the most serious being monoamine oxidase inhibitors (maois) (moderate), stimulant drugs (moderate) and cytochrome p450 2d6 (cyp2d6) substrates (minor) — and none of Ketoprofen’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Hordenine Does Interact With Other Medications

Hordenine has 180 moderate, 149 minor known drug interactions in our database — Ketoprofen isn’t one of them. If you take anything else, check it against the full list below.

Moderate 180 Minor 149 No known interaction 2,501 (incl. Ketoprofen)
Taking anything else?

Check Another of Your Medications Against Hordenine

Covers the 2,830 medications we’ve checked against Hordenine. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Hordenine and Ketoprofen May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Raised blood pressure Worth acting on Additional detail

    Hordenine

    “No clinical studies have evaluated the safety of hordenine in humans. However, hordenine is structurally similar to the stimulants N-methyltyramine and synephrine, which are found in bitter orange. Theoretically, hordenine may cause stimulant-related side effects similar to these compounds, including tachycardia and hypertension.”

    Hordenine · Natural Medicines adverse-effect record, reported in hypertension.

    1 source cited
    1. 29888. Nelson BC, Putzbach K, Sharpless KE, Sander LC. Mass spectrometric determination of the predominant adrenergic protoalkaloids in bitter orange (Citrus aurantium). J Agric Food Chem 2007;55(24):9769-75. PubMed

    “Hordenine is structurally similar to the stimulants N-methyltyramine and synephrine, which are found in bitter orange. Theoretically, hordenine may cause stimulant-related side effects similar to these compounds, including tachycardia and hypertension. However, this has not been assessed or reported in humans.”

    Hordenine · Natural Medicines adverse-effect record, reported in hypertension.

    1 source cited
    1. 29888. Nelson BC, Putzbach K, Sharpless KE, Sander LC. Mass spectrometric determination of the predominant adrenergic protoalkaloids in bitter orange (Citrus aurantium). J Agric Food Chem 2007;55(24):9769-75. PubMed

    Ketoprofen

    Listed in the ADVERSE REACTIONS section of the FDA label for Ketoprofen. Read the label on DailyMed ›

  • A fast or pounding heartbeat Additional detail

    Hordenine

    Recorded for Hordenine in the same Natural Medicines adverse-effect record shown under Raised blood pressure above.

    Ketoprofen

    Listed in the ADVERSE REACTIONS section of the FDA label for Ketoprofen. Read the label on DailyMed ›

Effects for Ketoprofen come from the ADVERSE REACTIONS section of its FDA label; effects for Hordenine come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 13,040 voluntary FDA FAERS reports for Ketoprofen that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Ketoprofen Products Have a Food Rule — Hordenine Should Not Break It

At least one FDA label for a product containing Ketoprofen says to take it with food. If you take Hordenine on an empty stomach out of habit, keep them separate — and take Ketoprofen with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Ketoprofen products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Although food delays the absorption of both formulations (see CLINICAL PHARMACOLOGY ) in most of the clinical trials ketoprofen was taken with food or milk.

From the Dosage and Administration section of the FDA label we read for Ketoprofen — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Ketoprofen

This page covers Hordenine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ketoprofen page lists 252 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

By severity: 7 major · 217 moderate · 28 minor.

From our pharmacist’s overview on the Ketoprofen page

“Bleeding is what worries me most with ketoprofen (Orudis, Oruvail Gel). As an NSAID, it already irritates the stomach lining and slows clotting, and 202 of the 252 supplements and herbs on this page can push that bleeding risk further.”

Reviewed by 2 · Jul 18, 2026

Open the Ketoprofen interaction page

One more smart check

Taking Hordenine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 339 real supplement products containing Hordenine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Hordenine. Even though Hordenine itself has no known interaction with Ketoprofen, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Hordenine and Ketoprofen Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hordenine
Top 25%

#284 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ketoprofen
Top half

#1,183 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hordenine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Hordenine and Ketoprofen records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Hordenine

What is Hordenine?

Hordenine
  • Energy and stimulation
  • Athletic and workout performance
  • Weight loss/fat burning
  • Focus and mood
  • Appetite control

Hordenine is a natural alkaloid found in barley and some cacti that is marketed as a stimulant for energy, focus, and fat loss, but solid human evidence for these benefits is lacking. Its safety in people has not been well studied, so caution is warranted, and it should be avoided in pregnancy, breastfeeding, and by people with heart conditions.

Alkaloid isolated from plants such as barley sprouts and certain cacti · Capsules, tablets, powders (often in pre-workout and 'fat burner' blends)

An interaction check asks whether these two react with each other — it does not ask whether Hordenine is a good idea for someone in your situation. Here is what our Hordenine record says about it on its own.

Hordenine: dosing

There is no established, well-studied dose for hordenine. The amounts found in supplements vary widely, and they have not been tested for safety or effectiveness in proper human trials.If you choose to use a product containing hordenine, follow the label instructions and do not exceed them. Be aware that it is often mixed with caffeine and other stimulants, so the total stimulant load may be higher than it appears.

From our Hordenine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Hordenine monograph & all interactions
Medication

About Ketoprofen

What Is Ketoprofen Used For?

Brand names: Orudis, Oruvail Gel, Powergel, Oruvail Injection

Ketoprofen capsules (including the brand Orudis) are used to manage the signs and symptoms of rheumatoid arthritis and osteoarthritis, to treat pain, and to treat primary dysmenorrhea (painful menstrual periods).

Ketoprofen extended-release capsules are approved for rheumatoid arthritis and osteoarthritis only. Because of the way they slowly release the drug, ketoprofen extended-release capsules are not recommended for treating acute (sudden) pain.

Most-Reported Side Effects for Ketoprofen

From FAERS, the FDA’s public side-effect reporting system (13,040 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Headache 1,232 reports
Fatigue 932 reports
Nausea 799 reports
Infusion site pain 764 reports
Fever 756 reports
See full Ketoprofen drug information
Keep checking

Other Drugs & Hordenine

Browse every other medication we’ve checked against Hordenine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
180Moderate
149Minor
2,500No known interaction
180 Moderate 149 Minor 2,500 No interaction
Moderate

180 interactions

Showing 60 of 180 moderate interactions — see all 180 on the Hordenine page.

Minor

149 interactions

Showing 60 of 149 minor interactions — see all 149 on the Hordenine page.

No interaction 2,500 drugs checked — show the list

We also checked Hordenine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,500 medications checked with no known interaction — see the full Hordenine list.

See the full Hordenine interactions page
See every supplement checked against Ketoprofen, ranked by severity
Evidence & sources

Hordenine References

The 3 references that drive our Hordenine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Barwell CJ, Basma AN, Lafi MA, Leake LD. Deamination of hordenine by monoamine oxidase and its action on vasa deferentia of the rat. J Pharm Pharmacol 1989;41(6):421-3. PubMed
  2. Nelson BC, Putzbach K, Sharpless KE, Sander LC. Mass spectrometric determination of the predominant adrenergic protoalkaloids in bitter orange (Citrus aurantium). J Agric Food Chem 2007;55(24):9769-75. PubMed
  3. Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Hordenine and Ketoprofen Together: Common Questions

Is it safe to take Hordenine with Ketoprofen?
We do not list a known interaction between Hordenine and Ketoprofen. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Hordenine and Ketoprofen have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Hordenine and Ketoprofen at the same time of day?
At least one FDA label for a product containing Ketoprofen says to take it with food. If you take Hordenine on an empty stomach out of habit, keep them separate and take Ketoprofen with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Ketoprofen products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Hordenine and Ketoprofen combination checked?
Interactions in our licensed database are recorded against drug classes. Ketoprofen is filed under 8 classifications, and Hordenine has documented interactions with 3 drug classes — none of Ketoprofen's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Hordenine interact with any other medications?
Yes. Hordenine has 329 documented drug interactions in our database — Ketoprofen is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ketoprofen interact with any supplements?
Yes. Ketoprofen has documented interactions with 252 supplements in our database — Hordenine is not one of them. The Ketoprofen interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Hordenine monograph Uses, safety profile, and every drug interaction in one place Ketoprofen drug information The full plain-English guide to this medication Ketoprofen supplement interactions Every supplement checked against Ketoprofen, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ketoprofen and Hordenine?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.