Drug & supplement interaction

Hordenine + Medroxyprogesterone Acetate

Medroxyprogesterone Acetate brand names: Proclim, Cycrin, Curretab, Depo-Provera CI.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Hordenine and Medroxyprogesterone Acetate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Hordenine and Medroxyprogesterone Acetate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Medroxyprogesterone Acetate and Hordenine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Hordenine safety at a glance

Hordenine overall Use caution Human safety data is very limited, and it acts as a stimulant.
Pregnancy Avoid No safety data; avoid use during pregnancy.
Breastfeeding Avoid No safety data; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Medroxyprogesterone Acetate and Hordenine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Medroxyprogesterone Acetate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Medroxyprogesterone Acetate is filed under 3 classifications — progestin, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Hordenine has documented interactions with 3 drug classes — the most serious being monoamine oxidase inhibitors (maois) (moderate), stimulant drugs (moderate) and cytochrome p450 2d6 (cyp2d6) substrates (minor) — and none of Medroxyprogesterone Acetate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Hordenine Does Interact With Other Medications

Hordenine has 180 moderate, 149 minor known drug interactions in our database — Medroxyprogesterone Acetate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 180 Minor 149 No known interaction 2,501 (incl. Medroxyprogesterone Acetate)
Taking anything else?

Check Another of Your Medications Against Hordenine

Covers the 2,830 medications we’ve checked against Hordenine. Pick one to open its full report.

What to actually watch for

What Hordenine Itself Has Been Linked To

This is not an interaction — nothing below involves Medroxyprogesterone Acetate. It is the side-effect record for Hordenine on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Hordenine, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Raised blood pressure Worth acting on Additional detail

    “No clinical studies have evaluated the safety of hordenine in humans. However, hordenine is structurally similar to the stimulants N-methyltyramine and synephrine, which are found in bitter orange. Theoretically, hordenine may cause stimulant-related side effects similar to these compounds, including tachycardia and hypertension.”

    Hordenine · Natural Medicines adverse-effect record, reported in hypertension.

    1 source cited
    1. 29888. Nelson BC, Putzbach K, Sharpless KE, Sander LC. Mass spectrometric determination of the predominant adrenergic protoalkaloids in bitter orange (Citrus aurantium). J Agric Food Chem 2007;55(24):9769-75. PubMed

    “Hordenine is structurally similar to the stimulants N-methyltyramine and synephrine, which are found in bitter orange. Theoretically, hordenine may cause stimulant-related side effects similar to these compounds, including tachycardia and hypertension. However, this has not been assessed or reported in humans.”

    Hordenine · Natural Medicines adverse-effect record, reported in hypertension.

    1 source cited
    1. 29888. Nelson BC, Putzbach K, Sharpless KE, Sander LC. Mass spectrometric determination of the predominant adrenergic protoalkaloids in bitter orange (Citrus aurantium). J Agric Food Chem 2007;55(24):9769-75. PubMed
  • A fast or pounding heartbeat Additional detail

    Recorded for Hordenine in the same Natural Medicines adverse-effect record shown under Raised blood pressure above.

Everything above comes from the Natural Medicines adverse-effect record for Hordenine — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Medroxyprogesterone Acetate’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Medroxyprogesterone Acetate column appears here.

From our Q&A

Questions About Hordenine or Medroxyprogesterone Acetate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Hordenine or Medroxyprogesterone Acetate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Medroxyprogesterone Acetate

This page covers Hordenine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Medroxyprogesterone Acetate page lists 139 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

Open the Medroxyprogesterone Acetate interaction page

One more smart check

Taking Hordenine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 339 real supplement products containing Hordenine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Hordenine. Even though Hordenine itself has no known interaction with Medroxyprogesterone Acetate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Hordenine and Medroxyprogesterone Acetate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hordenine
Top 25%

#307 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Medroxyprogesterone Acetate
Steady interest

#2,005 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hordenine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Hordenine and Medroxyprogesterone Acetate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Hordenine

What is Hordenine?

Hordenine
  • Energy and stimulation
  • Athletic and workout performance
  • Weight loss/fat burning
  • Focus and mood
  • Appetite control

Hordenine is a natural alkaloid found in barley and some cacti that is marketed as a stimulant for energy, focus, and fat loss, but solid human evidence for these benefits is lacking. Its safety in people has not been well studied, so caution is warranted, and it should be avoided in pregnancy, breastfeeding, and by people with heart conditions.

Alkaloid isolated from plants such as barley sprouts and certain cacti · Capsules, tablets, powders (often in pre-workout and 'fat burner' blends)

An interaction check asks whether these two react with each other — it does not ask whether Hordenine is a good idea for someone in your situation. Here is what our Hordenine record says about it on its own.

Hordenine: dosing

There is no established, well-studied dose for hordenine. The amounts found in supplements vary widely, and they have not been tested for safety or effectiveness in proper human trials.If you choose to use a product containing hordenine, follow the label instructions and do not exceed them. Be aware that it is often mixed with caffeine and other stimulants, so the total stimulant load may be higher than it appears.

From our Hordenine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Hordenine monograph & all interactions
Medication

About Medroxyprogesterone

What Is Medroxyprogesterone Used For?

Brand names: Proclim, Cycrin, Curretab, Depo-Provera CI

Medroxyprogesterone is a progestin (a form of the hormone progesterone). The injections and tablets are used for different things.

  • Injections (Depo-Provera CI and medroxyprogesterone acetate injectable suspension): prevent pregnancy in females of reproductive potential.
  • Depo-SubQ Provera 104 (subcutaneous): prevents pregnancy and manages endometriosis-associated pain in females of reproductive age.
  • Tablets (Provera and medroxyprogesterone acetate tablets): treat secondary amenorrhea (missed periods) and abnormal uterine bleeding due to hormonal imbalance when there is no underlying problem such as fibroids or uterine cancer. They also help prevent endometrial hyperplasia (overgrowth of the uterine lining) in postmenopausal women with a uterus who take daily oral conjugated estrogens.

The injections are not recommended for more than 2 years unless other options are considered inadequate.

See full Medroxyprogesterone drug information
Keep checking

Other Drugs & Hordenine

Browse every other medication we’ve checked against Hordenine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
180Moderate
149Minor
2,500No known interaction
180 Moderate 149 Minor 2,500 No interaction
Moderate

180 interactions

Showing 60 of 180 moderate interactions — see all 180 on the Hordenine page.

Minor

149 interactions

Showing 60 of 149 minor interactions — see all 149 on the Hordenine page.

No interaction 2,500 drugs checked — show the list

We also checked Hordenine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,500 medications checked with no known interaction — see the full Hordenine list.

See the full Hordenine interactions page
See every supplement checked against Medroxyprogesterone Acetate, ranked by severity
Evidence & sources

Hordenine References

The 3 references that drive our Hordenine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Barwell CJ, Basma AN, Lafi MA, Leake LD. Deamination of hordenine by monoamine oxidase and its action on vasa deferentia of the rat. J Pharm Pharmacol 1989;41(6):421-3. PubMed
  2. Nelson BC, Putzbach K, Sharpless KE, Sander LC. Mass spectrometric determination of the predominant adrenergic protoalkaloids in bitter orange (Citrus aurantium). J Agric Food Chem 2007;55(24):9769-75. PubMed
  3. Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Hordenine and Medroxyprogesterone Acetate Together: Common Questions

Is it safe to take Hordenine with Medroxyprogesterone Acetate?
We do not list a known interaction between Hordenine and Medroxyprogesterone Acetate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Hordenine and Medroxyprogesterone Acetate combination checked?
Interactions in our licensed database are recorded against drug classes. Medroxyprogesterone Acetate is filed under 3 classifications, and Hordenine has documented interactions with 3 drug classes — none of Medroxyprogesterone Acetate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Hordenine interact with any other medications?
Yes. Hordenine has 329 documented drug interactions in our database — Medroxyprogesterone Acetate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Medroxyprogesterone Acetate interact with any supplements?
Yes. Medroxyprogesterone Acetate has documented interactions with 139 supplements in our database — Hordenine is not one of them. The Medroxyprogesterone Acetate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Hordenine monograph Uses, safety profile, and every drug interaction in one place Medroxyprogesterone drug information The full plain-English guide to this medication Medroxyprogesterone Acetate supplement interactions Every supplement checked against Medroxyprogesterone Acetate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Medroxyprogesterone Acetate and Hordenine?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.