Drug & supplement interaction

Red Clover + Etodolac

Etodolac brand names: Lodine, Lodine XL, Ultradol, Etodolac.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Red Clover and Etodolac in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Red Clover and Etodolac

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Etodolac and Red Clover in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Red Clover safety at a glance

Red Clover overall Use caution Generally well tolerated short-term in healthy adults, but its estrogen-like activity calls for caution in certain people.
Pregnancy Likely Safe When used orally in amounts commonly found in foods. Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in amounts commonly found in foods. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Etodolac and Red Clover? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Etodolac

Interactions in our licensed database are recorded against drug classes, not just single drug names. Etodolac is filed under 6 classifications — including nonsteroidal anti-inflammatory drugs (nsaids), organic anion transporter 3 (oat3) substrates, organic anion transporter 1 (oat1) substrates. Red Clover has documented interactions with 9 drug classes — the most serious being estrogens (moderate), methotrexate (trexall, others) (moderate) and tamoxifen (nolvadex) (moderate) — and none of Etodolac’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Red Clover Does Interact With Other Medications

Red Clover has 44 moderate, 823 minor known drug interactions in our database — Etodolac isn’t one of them. If you take anything else, check it against the full list below.

Moderate 44 Minor 823 No known interaction 1,963 (incl. Etodolac)
Taking anything else?

Check Another of Your Medications Against Red Clover

Covers the 2,830 medications we’ve checked against Red Clover. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Red Clover and Etodolac May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Bleeding or bruising Worth acting on Additional detail

    Red Clover

    “In one case report, a 53-year-old female had a spontaneous subarachnoid hemorrhage associated with the use of an herbal supplement containing red clover, dong quai, and eleuthero. It is not clear if this was due to red clover, another ingredient, the combination of ingredients, or other factors.”

    Red Clover · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    2 sources cited
    1. 70419. Friedman, J. A., Taylor, S. A., McDermott, W., and Alikhani, P. Multifocal and recurrent subarachnoid hemorrhage due to an herbal supplement containing natural coumarins. Neurocrit.Care 2007;7(1):76-80. PubMed
    2. 13155. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed

    Etodolac

    Listed in the ADVERSE REACTIONS section of the FDA label for Etodolac. Read the label on DailyMed ›

  • Muscle pain Additional detail

    Red Clover

    “Orally, red clover has been reported to cause myalgia.”

    Red Clover · Natural Medicines adverse-effect record, reported in myalgia.

    1 source cited
    1. 8194. Tice J, Cummings SR, Ettinger B, et al. Few adverse effects of two red clover extracts rich in phytoestrogens: a multicenter, placebo-controlled trial. Alt Ther 2001;7:S33.

    Etodolac

    Listed in the ADVERSE REACTIONS section of the FDA label for Etodolac. Read the label on DailyMed ›

  • Headache reported in 4.0% of FDA reports for Etodolac Additional detail

    Red Clover

    “Orally, a specific red clover isoflavone product (Medoflavon) has been associated with headache, although with a similar frequency to placebo.”

    Red Clover · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 19545. Hidalgo LA, Chedraui PA, Morocho N, et al. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Gynecol Endocrinol 2005;21(5):257-264. PubMed

    Etodolac

    Listed in the ADVERSE REACTIONS section of the FDA label for Etodolac, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Nausea reported in 4.9% of FDA reports for Etodolac Additional detail

    Red Clover

    “Orally, red clover has been reported to cause nausea.”

    Red Clover · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 8194. Tice J, Cummings SR, Ettinger B, et al. Few adverse effects of two red clover extracts rich in phytoestrogens: a multicenter, placebo-controlled trial. Alt Ther 2001;7:S33.

    Etodolac

    Listed in the ADVERSE REACTIONS section of the FDA label for Etodolac, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Red Clover but not commonly for Etodolac: loss of vision and blood clots.

Effects for Etodolac come from the ADVERSE REACTIONS section of its FDA label; effects for Red Clover come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 5,959 voluntary FDA FAERS reports for Etodolac that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Red Clover in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally in amounts commonly found in foods.

Pregnancy And Lactation Possibly Unsafe

When used orally in medicinal amounts. Red clover has estrogenic activity; avoid using. There is insufficient reliable information available about the safety of the topical use of red clover during pregnancy and lactation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Etodolac Is Prescribed For, and What Red Clover Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Etodolac is a prescription medicine with approved uses on its FDA label. Red Clover is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Etodolac is prescribed for: Etodolac capsules and tablets are used to manage the signs and symptoms of osteoarthritis and rheumatoid arthritis, both short-term and long-term. They are also used for acute pain relief. Etodolac extended-release tablets are indicated for the relief of signs and symptoms of osteoarthritis, rheumatoid arthritis, and juvenile arthritis (in patients aged 6 to 16).

Red Clover has been studied for:

  • Osteoarthritis studied, not established Red Clover has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Red Clover for osteoarthritis

    It is unclear if topical red clover is beneficial in patients with osteoarthritis.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Etodolac on your own; if you are taking Red Clover for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Red Clover or Etodolac

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Red Clover or Etodolac, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Etodolac

This page covers Red Clover only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Etodolac page lists 52 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Siberian Cocklebur (major) and Wine (major).

By severity: 5 major · 35 moderate · 12 minor.

From our pharmacist’s overview on the Etodolac page

“Etodolac (Lodine) is an NSAID for arthritis and other pain, and NSAIDs already stress the stomach lining and the kidneys, so the supplements on this page deserve more than a glance. Five of the 52 entries are rated major, and those five are where I would start reading.”

Reviewed by 2 · Jul 18, 2026

Open the Etodolac interaction page

One more smart check

Taking Red Clover as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,480 real supplement products containing Red Clover, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Red Clover. Even though Red Clover itself has no known interaction with Etodolac, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Red Clover and Etodolac Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Red Clover
Top 25%

#152 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Etodolac
Steady interest

#2,387 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Red Clover reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Red Clover and Etodolac records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Red Clover

What is Red Clover?

Red Clover
  • Menopause symptoms (hot flashes)
  • High cholesterol
  • Bone health/osteoporosis
  • Skin and hair concerns
  • Women's health

Red clover is a plant rich in isoflavones (plant compounds with weak estrogen-like activity) that is most often used for menopause symptoms like hot flashes. The evidence is mixed and generally weak, with some studies showing modest benefit and others showing none. Because of its hormone-like effects, it's not for everyone—talk with your pharmacist or doctor before trying it, especially if you have a hormone-sensitive condition.

Trifolium pratense · Fabaceae · Flowering tops (blossoms) and aerial parts · Capsules, tablets, standardized extracts, tinctures, teas, and topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Red Clover is a good idea for someone in your situation. Here is what our Red Clover record says about it on its own.

Red Clover: dosing

There is no single well-established standard dose for red clover. Products vary widely, and many are standardized to a certain amount of isoflavones, which makes comparison difficult.The safest approach is to follow the directions on the product label and not exceed the recommended amount. They can help you decide whether it's appropriate and what amount is reasonable for you.

From our Red Clover monograph — the full record covers uses, side effects and every documented interaction.

Read the full Red Clover monograph & all interactions
Medication

About Etodolac

What Is Etodolac Used For?

Brand names: Lodine, Lodine XL, Ultradol, Etodolac

Etodolac capsules and tablets are used to manage the signs and symptoms of osteoarthritis and rheumatoid arthritis, both short-term and long-term. They are also used for acute pain relief.

Etodolac extended-release tablets are indicated for the relief of signs and symptoms of osteoarthritis, rheumatoid arthritis, and juvenile arthritis (in patients aged 6 to 16).

Most-Reported Side Effects for Etodolac

From FAERS, the FDA’s public side-effect reporting system (5,959 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 292 reports
Arthralgia 285 reports
Fatigue 279 reports
Headache 240 reports
Diarrhea 235 reports
See full Etodolac drug information
Keep checking

Other Drugs & Red Clover

Browse every other medication we’ve checked against Red Clover — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
44Moderate
823Minor
1,962No known interaction
44 Moderate 823 Minor 1,962 No interaction
Moderate

44 interactions

Minor

823 interactions

Showing 60 of 823 minor interactions — see all 823 on the Red Clover page.

No interaction 1,962 drugs checked — show the list

We also checked Red Clover against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,962 medications checked with no known interaction — see the full Red Clover list.

See the full Red Clover interactions page
See every supplement checked against Etodolac, ranked by severity
Evidence & sources

Red Clover References

The 24 references that drive our Red Clover monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kurzer MS, Xu X. Dietary phytoestrogens. Annu Rev Nutr 1997;17:353-81. PubMed
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
  4. This P, De La Rochefordiere A, Clough K, et al. Phytoestrogens after breast cancer. Endocr Relat Cancer 2001;8:129-34. PubMed
  5. Tice J, Cummings SR, Ettinger B, et al. Few adverse effects of two red clover extracts rich in phytoestrogens: a multicenter, placebo-controlled trial. Alt Ther 2001;7:S33.
  6. Ingram DM, Hickling C, West L, et al. A double-blind randomized controlled trial of isoflavones in the treatment of cyclical mastalgia. The Breast 2002;11:170-4. PubMed
  7. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  8. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
  9. Geller SE, Shulman LP, van Breemen RB, et al. Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial. Menopause 2009;16:1156-66. PubMed
  10. Hidalgo LA, Chedraui PA, Morocho N, et al. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Gynecol Endocrinol 2005;21(5):257-264. PubMed
  11. Campbell MJ, Woodside JV, Honour JW, et al. Effect of red clover-derived isoflavone supplementation on insulin-like growth factor, lipid and antioxidant status in healthy female volunteers: a pilot study. Eur J Clin Nutr 2004;58(1):173-179. PubMed
  12. Guerrero JA, Lozano ML, Castillo J, et al. Flavonoids inhibit platelet function through binding to the thromboxane A2 receptor. J Thromb Haemost 2005;3(2):369-376. PubMed
  13. Kondo K, Suzuki Y, Ikeda Y, Umemura K. Genistein, an isoflavone included in soy, inhibits thrombotic vessel occlusion in the mouse femoral artery and in vitro platelet aggregation. Eur J Pharmacol 2002;455(1):53-57. PubMed
  14. Polini N, Rauschemberger MB, Mendiberri J, et al. Effect of genistein and raloxifene on vascular dependent platelet aggregation. Mol Cell Endocrinol 2007;267(1-2):55-62. PubMed
  15. Wuttke W, Jarry H, Seidlova-Wuttke D. Plant-derived alternative treatments for the aging male: facts and myths. Aging Male 2010;13(2):75-81. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Red Clover and Etodolac Together: Common Questions

Is it safe to take Red Clover with Etodolac?
We do not list a known interaction between Red Clover and Etodolac. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Red Clover and Etodolac have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Red Clover and Etodolac used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Red Clover in each. That is a conversation for your prescriber, especially if Etodolac is being adjusted to a target.
How was the Red Clover and Etodolac combination checked?
Interactions in our licensed database are recorded against drug classes. Etodolac is filed under 6 classifications, and Red Clover has documented interactions with 9 drug classes — none of Etodolac's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Red Clover interact with any other medications?
Yes. Red Clover has 867 documented drug interactions in our database — Etodolac is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Etodolac interact with any supplements?
Yes. Etodolac has documented interactions with 52 supplements in our database — Red Clover is not one of them. The Etodolac interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Red Clover monograph Uses, safety profile, and every drug interaction in one place Etodolac drug information The full plain-English guide to this medication Etodolac supplement interactions Every supplement checked against Etodolac, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 24 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Etodolac and Red Clover?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.