Drug & supplement interaction

Red Clover + Hethylphenidate HCl

Hethylphenidate HCl brand name: Hethylphenidate HCl.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Red Clover and Hethylphenidate HCl in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Red Clover and Hethylphenidate HCl

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Hethylphenidate HCl and Red Clover in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Red Clover safety at a glance

Red Clover overall Use caution Generally well tolerated short-term in healthy adults, but its estrogen-like activity calls for caution in certain people.
Pregnancy Likely Safe When used orally in amounts commonly found in foods. Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in amounts commonly found in foods. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Hethylphenidate HCl and Red Clover? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Hethylphenidate HCl

Interactions in our licensed database are recorded against drug classes, not just single drug names. Hethylphenidate HCl is filed under 3 classifications — amphetamines, stimulant drugs, oral drugs. Red Clover has documented interactions with 9 drug classes — the most serious being estrogens (moderate), methotrexate (trexall, others) (moderate) and tamoxifen (nolvadex) (moderate) — and none of Hethylphenidate HCl’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Red Clover Does Interact With Other Medications

Red Clover has 44 moderate, 823 minor known drug interactions in our database — Hethylphenidate HCl isn’t one of them. If you take anything else, check it against the full list below.

Moderate 44 Minor 823 No known interaction 1,963 (incl. Hethylphenidate HCl)
Taking anything else?

Check Another of Your Medications Against Red Clover

Covers the 2,830 medications we’ve checked against Red Clover. Pick one to open its full report.

What to actually watch for

What Red Clover Itself Has Been Linked To

This is not an interaction — nothing below involves Hethylphenidate HCl. It is the side-effect record for Red Clover on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Red Clover, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Loss of vision / Blood clots / Bleeding or bruising Worth acting on Additional detail

    “In one case report, a 53-year-old female had a spontaneous subarachnoid hemorrhage associated with the use of an herbal supplement containing red clover, dong quai, and eleuthero. It is not clear if this was due to red clover, another ingredient, the combination of ingredients, or other factors.”

    Red Clover · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    2 sources cited
    1. 70419. Friedman, J. A., Taylor, S. A., McDermott, W., and Alikhani, P. Multifocal and recurrent subarachnoid hemorrhage due to an herbal supplement containing natural coumarins. Neurocrit.Care 2007;7(1):76-80. PubMed
    2. 13155. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
  • Muscle pain Additional detail

    “Orally, red clover has been reported to cause myalgia.”

    Red Clover · Natural Medicines adverse-effect record, reported in myalgia.

    1 source cited
    1. 8194. Tice J, Cummings SR, Ettinger B, et al. Few adverse effects of two red clover extracts rich in phytoestrogens: a multicenter, placebo-controlled trial. Alt Ther 2001;7:S33.
  • Headache Additional detail

    “Orally, a specific red clover isoflavone product (Medoflavon) has been associated with headache, although with a similar frequency to placebo.”

    Red Clover · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 19545. Hidalgo LA, Chedraui PA, Morocho N, et al. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Gynecol Endocrinol 2005;21(5):257-264. PubMed
  • Nausea Additional detail

    “Orally, red clover has been reported to cause nausea.”

    Red Clover · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 8194. Tice J, Cummings SR, Ettinger B, et al. Few adverse effects of two red clover extracts rich in phytoestrogens: a multicenter, placebo-controlled trial. Alt Ther 2001;7:S33.

Everything above comes from the Natural Medicines adverse-effect record for Red Clover — expand a row for the licensed statement it rests on. We haven’t matched Hethylphenidate HCl to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Hethylphenidate HCl.

Special populations

Red Clover in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally in amounts commonly found in foods.

Pregnancy And Lactation Possibly Unsafe

When used orally in medicinal amounts. Red clover has estrogenic activity; avoid using. There is insufficient reliable information available about the safety of the topical use of red clover during pregnancy and lactation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Hethylphenidate HCl

This page covers Red Clover only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hethylphenidate HCl page lists 65 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Peyote (major), Rauvolfia Vomitoria (major) and Sida Cordifolia (major).

By severity: 5 major · 47 moderate · 13 minor.

From our pharmacist’s overview on the Hethylphenidate HCl page

“Hethylphenidate HCl is a stimulant medication, which is exactly why this list deserves genuine care rather than a quick skim. Of the 65 supplement and herbal ingredients with an interaction on file, 44 pile more stimulant effect on top of the drug, raising blood pressure, heart rate, and cardiovascular risk.”

Reviewed by 2 · Jul 18, 2026

Open the Hethylphenidate HCl interaction page

One more smart check

Taking Red Clover as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,480 real supplement products containing Red Clover, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Red Clover. Even though Red Clover itself has no known interaction with Hethylphenidate HCl, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Red Clover and Hethylphenidate HCl Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Red Clover
Top 25%

#163 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Hethylphenidate HCl
Top 5%

#95 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Red Clover reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Red Clover and Hethylphenidate HCl records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Red Clover

What is Red Clover?

Red Clover
  • Menopause symptoms (hot flashes)
  • High cholesterol
  • Bone health/osteoporosis
  • Skin and hair concerns
  • Women's health

Red clover is a plant rich in isoflavones (plant compounds with weak estrogen-like activity) that is most often used for menopause symptoms like hot flashes. The evidence is mixed and generally weak, with some studies showing modest benefit and others showing none. Because of its hormone-like effects, it's not for everyone—talk with your pharmacist or doctor before trying it, especially if you have a hormone-sensitive condition.

Trifolium pratense · Fabaceae · Flowering tops (blossoms) and aerial parts · Capsules, tablets, standardized extracts, tinctures, teas, and topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Red Clover is a good idea for someone in your situation. Here is what our Red Clover record says about it on its own.

Red Clover: dosing

There is no single well-established standard dose for red clover. Products vary widely, and many are standardized to a certain amount of isoflavones, which makes comparison difficult.The safest approach is to follow the directions on the product label and not exceed the recommended amount. They can help you decide whether it's appropriate and what amount is reasonable for you.

From our Red Clover monograph — the full record covers uses, side effects and every documented interaction.

Read the full Red Clover monograph & all interactions
Keep checking

Other Drugs & Red Clover

Browse every other medication we’ve checked against Red Clover — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
44Moderate
823Minor
1,962No known interaction
44 Moderate 823 Minor 1,962 No interaction
Moderate

44 interactions

Minor

823 interactions

Showing 60 of 823 minor interactions — see all 823 on the Red Clover page.

No interaction 1,962 drugs checked — show the list

We also checked Red Clover against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,962 medications checked with no known interaction — see the full Red Clover list.

See the full Red Clover interactions page
See every supplement checked against Hethylphenidate HCl, ranked by severity
Evidence & sources

Red Clover References

The 24 references that drive our Red Clover monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kurzer MS, Xu X. Dietary phytoestrogens. Annu Rev Nutr 1997;17:353-81. PubMed
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
  4. This P, De La Rochefordiere A, Clough K, et al. Phytoestrogens after breast cancer. Endocr Relat Cancer 2001;8:129-34. PubMed
  5. Tice J, Cummings SR, Ettinger B, et al. Few adverse effects of two red clover extracts rich in phytoestrogens: a multicenter, placebo-controlled trial. Alt Ther 2001;7:S33.
  6. Ingram DM, Hickling C, West L, et al. A double-blind randomized controlled trial of isoflavones in the treatment of cyclical mastalgia. The Breast 2002;11:170-4. PubMed
  7. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  8. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
  9. Geller SE, Shulman LP, van Breemen RB, et al. Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial. Menopause 2009;16:1156-66. PubMed
  10. Hidalgo LA, Chedraui PA, Morocho N, et al. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Gynecol Endocrinol 2005;21(5):257-264. PubMed
  11. Campbell MJ, Woodside JV, Honour JW, et al. Effect of red clover-derived isoflavone supplementation on insulin-like growth factor, lipid and antioxidant status in healthy female volunteers: a pilot study. Eur J Clin Nutr 2004;58(1):173-179. PubMed
  12. Guerrero JA, Lozano ML, Castillo J, et al. Flavonoids inhibit platelet function through binding to the thromboxane A2 receptor. J Thromb Haemost 2005;3(2):369-376. PubMed
  13. Kondo K, Suzuki Y, Ikeda Y, Umemura K. Genistein, an isoflavone included in soy, inhibits thrombotic vessel occlusion in the mouse femoral artery and in vitro platelet aggregation. Eur J Pharmacol 2002;455(1):53-57. PubMed
  14. Polini N, Rauschemberger MB, Mendiberri J, et al. Effect of genistein and raloxifene on vascular dependent platelet aggregation. Mol Cell Endocrinol 2007;267(1-2):55-62. PubMed
  15. Wuttke W, Jarry H, Seidlova-Wuttke D. Plant-derived alternative treatments for the aging male: facts and myths. Aging Male 2010;13(2):75-81. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Red Clover and Hethylphenidate HCl Together: Common Questions

Is it safe to take Red Clover with Hethylphenidate HCl?
We do not list a known interaction between Red Clover and Hethylphenidate HCl. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Red Clover and Hethylphenidate HCl combination checked?
Interactions in our licensed database are recorded against drug classes. Hethylphenidate HCl is filed under 3 classifications, and Red Clover has documented interactions with 9 drug classes — none of Hethylphenidate HCl's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Red Clover interact with any other medications?
Yes. Red Clover has 867 documented drug interactions in our database — Hethylphenidate HCl is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Hethylphenidate HCl interact with any supplements?
Yes. Hethylphenidate HCl has documented interactions with 65 supplements in our database — Red Clover is not one of them. The Hethylphenidate HCl interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Red Clover monograph Uses, safety profile, and every drug interaction in one place Hethylphenidate HCl supplement interactions Every supplement checked against Hethylphenidate HCl, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 24 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Hethylphenidate HCl and Red Clover?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.