Medication interaction hub

What Supplements Interact with Acetaminophen, Pentazocine?

Acetaminophen, Pentazocine brand name: Talacen. Every interaction below applies to the brands too.

216 Interactions 9 Major 169 Moderate 38 Minor
Curated & coded by · Clinical Pharmacist · Updated September 20, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Acetaminophen, Pentazocine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Acetaminophen, Pentazocine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Talacen combines acetaminophen with pentazocine, an opioid pain reliever, and the opioid is exactly why I treat this page as a serious one. Nine of its 216 supplement interactions are rated major. The largest group, 78 ingredients, adds sedation on top of pentazocine. Alcohol (beer and wine both carry well-documented major ratings) and kava lead that group, and a few entries such as GHB can suppress breathing, not merely cause grogginess. Another 38 ingredients can strain the same liver that acetaminophen already works through.

Most of the rest is moderate, largely herbs and foods that speed up or slow how the liver clears one of the two drugs, so pain relief or side effects can drift without warning. A small handful can stress the kidneys. And activated charcoal blocks absorption of oral medicines outright, so it needs to be taken well apart from any dose.

— , Clinical Pharmacist · July 18, 2026

Major 9 Moderate 169 Minor 38 No known interaction 1,236

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Acetaminophen, Pentazocine: Top Interactions at a Glance

The Acetaminophen, Pentazocine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 216 interacting ingredients — plus 1,236 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Acetaminophen, Pentazocine Combinations Today

The Acetaminophen, Pentazocine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Baikal Skullcap + Acetaminophen, Pentazocinei

Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.

Read the full interaction Moderate Likelihood Possible Hops + Acetaminophen, Pentazocinei

Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.

Read the full interaction Minor Likelihood Possible Ginger + Acetaminophen, Pentazocinei

Theoretically, ginger might increase the levels of CYP1A2 substrates.

Read the full interaction Major Likelihood Probable Kava + Acetaminophen, Pentazocinei

Combining kava with CNS depressants can have additive sedative effects.

Read the full interaction Moderate Likelihood Possible Saffron + Acetaminophen, Pentazocinei

Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.

Read the full interaction Moderate Likelihood Possible Catnip + Acetaminophen, Pentazocinei

Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Read the full interaction
The complete list

Every Supplement Checked Against Acetaminophen, Pentazocine

All 1,452 ingredients in our database, ranked by severity — 216 with a Acetaminophen, Pentazocine interaction on file and 1,236 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Acetaminophen, Pentazocine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Baikal Skullcap with Acetaminophen, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.

Full Baikal Skullcap + Acetaminophen, Pentazocine answer

Can you take Hops with Acetaminophen, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.

Full Hops + Acetaminophen, Pentazocine answer

Can you take Ginger with Acetaminophen, Pentazocine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, ginger might increase the levels of CYP1A2 substrates.

Full Ginger + Acetaminophen, Pentazocine answer

Can you take Kava with Acetaminophen, Pentazocine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Combining kava with CNS depressants can have additive sedative effects.

Full Kava + Acetaminophen, Pentazocine answer

Can you take Saffron with Acetaminophen, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.

Full Saffron + Acetaminophen, Pentazocine answer

Can you take Pinellia Ternata with Acetaminophen, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research shows that a Pinellia ternata preparation decreases activity and increases sleeping time.

Full Pinellia Ternata + Acetaminophen, Pentazocine answer

Can you take Poria Mushroom with Acetaminophen, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.

Full Poria Mushroom + Acetaminophen, Pentazocine answer

Can you take Propolis with Acetaminophen, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.

Full Propolis + Acetaminophen, Pentazocine answer

Can you take Rauvolfia Vomitoria with Acetaminophen, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Rauvolfia vomitoria might cause additive sedative effects.

Full Rauvolfia Vomitoria + Acetaminophen, Pentazocine answer

Can you take Rauwolscine with Acetaminophen, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.

Full Rauwolscine + Acetaminophen, Pentazocine answer

Can you take Red Yeast Rice with Acetaminophen, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of liver damage.

Full Red Yeast Rice + Acetaminophen, Pentazocine answer

Can you take Rhubarb with Acetaminophen, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.

Full Rhubarb + Acetaminophen, Pentazocine answer

Can you take Rooibos with Acetaminophen, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rooibos with CYP1A2 substrates may increase the effects of CYP1A2 substrates.

Full Rooibos + Acetaminophen, Pentazocine answer

Can you take Sage with Acetaminophen, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.

Full Sage + Acetaminophen, Pentazocine answer

Can you take Saigon Cinnamon with Acetaminophen, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Saigon cinnamon might cause additive effects when used with hepatotoxic drugs.

Full Saigon Cinnamon + Acetaminophen, Pentazocine answer

Can you take Sassafras with Acetaminophen, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.

Full Sassafras + Acetaminophen, Pentazocine answer

Can you take Sceletium with Acetaminophen, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sceletium and CNS depressants might result in additive sedative effects.

Full Sceletium + Acetaminophen, Pentazocine answer

Can you take Schizonepeta with Acetaminophen, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, inhibits cytochrome P450 (CYP) 1A2.

Full Schizonepeta + Acetaminophen, Pentazocine answer

Can you take Shepherd's Purse with Acetaminophen, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Full Shepherd's Purse + Acetaminophen, Pentazocine answer

Can you take Skullcap with Acetaminophen, Pentazocine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, skullcap can have additive effects when used with other CNS depressants.

Full Skullcap + Acetaminophen, Pentazocine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Acetaminophen, Pentazocine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Acetaminophen, Pentazocine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Acetaminophen, Pentazocine sits in 12 interaction categories. Open any one to see what the group means:

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Acetaminophen, Pentazocine through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Acetaminophen, Pentazocine through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Acetaminophen, Pentazocine through this category.

Cytochrome P450 2E1 (Cyp2E1) Substrates 24 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

24 of the supplement ingredients on this page reach Acetaminophen, Pentazocine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Acetaminophen, Pentazocine through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Acetaminophen, Pentazocine through this category.

Acetaminophen (Tylenol, Others) 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Acetaminophen, Pentazocine through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetaminophen, Pentazocine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetaminophen, Pentazocine through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Acetaminophen, Pentazocine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Acetaminophen, Pentazocine through this category.

Pentazocine (Talwin) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Acetaminophen, Pentazocine through this category.

Related: does Acetaminophen, Pentazocine deplete any nutrients?

Acetaminophen, Pentazocine has 1 reported nutrient association in the research literature — see the Acetaminophen, Pentazocine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Acetaminophen, Pentazocine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Acetaminophen, Pentazocine.

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Products that contain Acetaminophen, Pentazocine-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Acetaminophen, Pentazocine.

Zi Sheng Teapills by Plum Flower contains Siberian Cocklebur Cold Away by Health Concerns contains Siberian Cocklebur Sugar Coated Bi Yan Pian by Plum Flower contains Siberian Cocklebur Pe Min Kan Wan by Plum Flower contains Siberian Cocklebur
Pharmacist Counseling Corner

Acetaminophen, Pentazocine & Supplements: Common Questions

What supplements interact with Acetaminophen, Pentazocine?
Our database currently documents 216 ingredients with a known Acetaminophen, Pentazocine interaction (9 major, 169 moderate, 38 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 216. The highest-ranked right now: Beer, Siberian Cocklebur, Wine.
Which Acetaminophen, Pentazocine supplement interactions are the most serious?
The 9 major-rated combinations — led by Beer, Siberian Cocklebur, Wine, 1,4-butanediol and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Acetaminophen, Pentazocine?
Plenty of supplements coexist fine with Acetaminophen, Pentazocine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Talacen have the same supplement interactions as Acetaminophen, Pentazocine?
Yes — Talacen all contain Acetaminophen, Pentazocine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Acetaminophen, Pentazocine deplete any vitamins or nutrients?
It might — Acetaminophen, Pentazocine has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Acetaminophen, Pentazocine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Acetaminophen, Pentazocine and my other medications?
This page covers Acetaminophen, Pentazocine against supplements and herbal ingredients. Checking Acetaminophen, Pentazocine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 20, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.