Medication interaction hub

What Supplements Interact with Suvorexant?

Suvorexant brand name: Belsomra. Every interaction below applies to the brands too.

195 Interactions 9 Major 147 Moderate 39 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Suvorexant? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Suvorexant against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

People take suvorexant (Belsomra) to fall asleep, and the supplements they reach for often promise the same thing, which is exactly the trouble. Of the 195 ingredients with an interaction on file, 78 add their own sedation on top of the drug's, and that theme dominates the 9 rated major, alcohol in any form among them. This is a list that deserves genuine care, because stacking one sedative on another can go past next-day grogginess and, with a few of these, into dangerously slowed breathing.

The largest group, 121 ingredients, works differently. Suvorexant is cleared by a liver enzyme called CYP3A4, and these entries speed it up or slow it down, so grapefruit can push levels higher while St. John's wort can quietly drain the drug's effect. Learn the nine major entries first, then read the rest of the page with a clear head.

— , Clinical Pharmacist · July 18, 2026

Major 9 Moderate 147 Minor 39 No known interaction 1,257

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Suvorexant: Top Interactions at a Glance

The Suvorexant supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 195 interacting ingredients — plus 1,257 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Suvorexant Combinations Today

The Suvorexant + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Black Pepper + Suvorexanti

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Gotu Kola + Suvorexanti

Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.

Read the full interaction Moderate Likelihood Possible Zizyphus + Suvorexanti

Theoretically, zizyphus might cause additive sedative effects when taken with CNS depressants.

Read the full interaction Moderate Likelihood Possible Shepherd's Purse + Suvorexanti

Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Read the full interaction Moderate Likelihood Probable Schisandra + Suvorexanti

Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Cannabichromene (cbc) + Suvorexanti

Using cannabichromene with drugs that have sedative properties may cause additive therapeutic and adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Suvorexant

All 1,452 ingredients in our database, ranked by severity — 195 with a Suvorexant interaction on file and 1,257 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Suvorexant?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Black Pepper with Suvorexant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Full Black Pepper + Suvorexant answer

Can you take Gotu Kola with Suvorexant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.

Full Gotu Kola + Suvorexant answer

Can you take Zizyphus with Suvorexant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zizyphus might cause additive sedative effects when taken with CNS depressants.

Full Zizyphus + Suvorexant answer

Can you take Shepherd's Purse with Suvorexant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Full Shepherd's Purse + Suvorexant answer

Can you take Schisandra with Suvorexant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Schisandra + Suvorexant answer

Can you take Beer with Suvorexant?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may increase sedative and other adverse effects.

Full Beer + Suvorexant answer

Can you take Grapefruit with Suvorexant?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Full Grapefruit + Suvorexant answer

Can you take Wine with Suvorexant?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may increase sedative and other adverse effects.

Full Wine + Suvorexant answer

Can you take 1,4-butanediol with Suvorexant?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Full 1,4-butanediol + Suvorexant answer

Can you take Activated Charcoal with Suvorexant?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Suvorexant answer

Can you take Gamma-hydroxybutyrate (ghb) with Suvorexant?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. GHB may increase the risk of serious CNS and respiratory depression.

Full Gamma-hydroxybutyrate (ghb) + Suvorexant answer

Can you take Kava with Suvorexant?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Combining kava with CNS depressants can have additive sedative effects.

Full Kava + Suvorexant answer

Can you take L-tryptophan with Suvorexant?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.

Full L-tryptophan + Suvorexant answer

Can you take St. John's Wort with Suvorexant?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. St.

Full St. John's Wort + Suvorexant answer

Can you take Cannabidiol (cbd) with Suvorexant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cannabidiol may increase levels of drugs that are metabolized by CYP3A4.

Full Cannabidiol (cbd) + Suvorexant answer

Can you take Coffee Charcoal with Suvorexant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Suvorexant answer

Can you take European Mandrake with Suvorexant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Suvorexant answer

Can you take Glucomannan with Suvorexant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Suvorexant answer

Can you take Guggul with Suvorexant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, guggul might reduce the effects of CYP3A4 substrates.

Full Guggul + Suvorexant answer

Can you take Tree Turmeric with Suvorexant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.

Full Tree Turmeric + Suvorexant answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Suvorexant is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Suvorexant, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Suvorexant sits in 3 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Suvorexant through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Suvorexant through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Suvorexant through this category.

About Suvorexant

Suvorexant is an orexin receptor antagonist used to treat insomnia, a condition where people have difficulty falling or staying asleep.

Generic name: Suvorexant  ·  Brand name: Belsomra.

See the full Suvorexant drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Suvorexant

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Suvorexant.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Products that contain Suvorexant-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Suvorexant.

Yeast-Cleanse by Solaray contains Grapefruit Ultimate GCB by M3 Supplement Company contains Grapefruit Neuro Health by Nature’s Craft contains Grapefruit NDF Happy Peach by Bioray Kids contains Grapefruit
Pharmacist Counseling Corner

Suvorexant & Supplements: Common Questions

What supplements interact with Suvorexant?
Our database currently documents 195 ingredients with a known Suvorexant interaction (9 major, 147 moderate, 39 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 195. The highest-ranked right now: Beer, Grapefruit, Wine.
Which Suvorexant supplement interactions are the most serious?
Focus on the major group: Beer, Grapefruit, Wine, 1,4-butanediol and Activated Charcoal, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Suvorexant?
Plenty of supplements coexist fine with Suvorexant; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Belsomra have the same supplement interactions as Suvorexant?
Yes — Belsomra all contain Suvorexant, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Suvorexant and my other medications?
This page covers Suvorexant against supplements and herbal ingredients. Checking Suvorexant against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Suvorexant drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.