Major interaction on record — check this product against your medications before combining. Based on 4 of 10 ingredients. Check your meds →
Dietary supplement

Pyro Stim 7 Ingredients & Drug Interactions

by Metis Nutrition

Pyro Stim 7 label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pyro Stim 7 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Pyro Stim 7 is a dietary supplement by Metis Nutrition with 10 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 1,908 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin B3, Vitamin B6, Chromium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pyro Stim 7 by Metis Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Pyro Stim 7 by Metis Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pyro Stim 7 by Metis Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 7 of its 33 active ingredients.
  • “Energy Complex” is a proprietary blend — the label gives one combined amount (300 mg) without saying how much of each component you get.
  • “Pyro Stim 7 Proprietary Blend” is a proprietary blend — the label gives one combined amount (700 mg) without saying how much of each component you get.
  • “Thermo Stim Blend:” is a proprietary blend — the label doesn't break down how much of each component you get.

Pyro Stim 7 contains 33 active and inactive ingredients. The active components include vitamins (B6, B12, niacin), amino acids (L-tyrosine), stimulants (caffeine anhydrous), minerals (chromium and chromium citrate), herbal extracts (ginkgo biloba, black pepper, dandelion root, yohimbe bark, green tea, ashwagandha, magnolia, reishi mushroom, buchu leaf), phytonutrients (quercetin), and other compounds (GABA, alpha-GPC, alpha-lipoic acid, choline bitartrate).

Inactive ingredients include gelatin, silicon dioxide, vegetable magnesium stearate, microcrystalline cellulose, and titanium dioxide—standard capsule fillers and binders. This is a multi-ingredient energy and cognitive support blend.

The caffeine delivers the primary stimulant effect, while herbs like ginkgo and ashwagandha are included for mental focus, and compounds like GABA and alpha-GPC target brain function. Chromium and niacin address metabolism, and yohimbe provides additional stimulant action.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: weight loss, energy, metabolism, and focus.
  • We looked for evidence on: Attention, Attention deficit-hyperactivity disorder (ADHD), Anxiety, Thermogenesis, Fat loss, Mental clarity.
  • The strongest evidence on file: Ginkgo is rated "Possibly Effective" for Anxiety (Natural Medicines).
  • Also on file: Ashwagandha is rated "Possibly Effective" for Anxiety, Generalized anxiety disorder (GAD).
  • Also on file: Caffeine is rated "Possibly Ineffective" for Attention deficit-hyperactivity disorder (ADHD).

Evidence for this product's effectiveness is mixed and varies by ingredient. Caffeine is effective for mental alertness and athletic performance.

Vitamin B6 is effective for sideroblastic anemia and vitamin B6 deficiency, and possibly effective for pregnancy-related nausea. Ginkgo is possibly effective for hearing loss, stroke recovery, and anxiety.

Ashwagandha is possibly effective for insomnia, anxiety, and stress. Niacin is likely effective for pellagra and possibly effective for certain lipid disorders.

Alpha-lipoic acid is possibly effective for diabetic nerve pain. However, many ingredients lack strong evidence.

Choline, dandelion root, L-tyrosine, GABA, alpha-GPC, chromium, quercetin, reishi mushroom, magnolia, DMAE, and yohimbe either have insufficient evidence or show no meaningful benefit (athletic performance from choline, athletic performance from yohimbe, and cognitive decline from DMAE are rated as ineffective or lacking reliable data). Green tea shows likely effectiveness for human papillomavirus-related conditions and possibly effective for ovarian cancer and cholesterol.

The product as a whole has not been studied as a single formulation.

The evidence, ingredient by ingredient Vitamin B6 Vitamin B12 Niacin Chromium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 28 of the 30 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 29 of 30.
  • General safety write-ups exist for 30 of 30.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients are generally well tolerated at standard doses. However, several carry important cautions.

High-dose vitamin B6 (over 200 mg daily long-term) can cause sensory nerve damage (peripheral neuropathy). Caffeine in high amounts causes jitteriness, insomnia, and anxiety, and is possibly unsafe in pregnancy at high levels.

Yohimbe raises blood pressure and heart rate substantially and should be avoided in pregnancy (possibly unsafe) and while breastfeeding (no data). Ginkgo is possibly unsafe in pregnancy (bleeding risk) and unsafe to use while breastfeeding.

Green tea extracts in high doses have caused rare liver injury. Ashwagandha is likely unsafe in pregnancy (traditional concern about miscarriage risk) and unproven while breastfeeding.

Kelp (not listed as a separate ingredient here but relevant if present) can deliver excess iodine, harming the fetal thyroid. Niacin at high doses causes flushing, liver stress, and high blood sugar.

Dandelion, GABA, and magnolia all lack sufficient pregnancy and breastfeeding safety data. Several ingredients—including chromium, alpha-lipoic acid, and DMAE—have limited long-term safety studies.

Side effects, ingredient by ingredient Vitamin B6 Vitamin B12 Niacin Chromium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 30 of the 30 matched ingredients can interact with medications — Buchu, Magnolia, Quercetin, Ginkgo, Uva Ursi, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; immunosuppressants / transplant drugs; cancer treatments; diabetes medications; heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 1,909 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before using if you take ephedrine or ephedrine-containing products (Major risk with caffeine and green tea), MAOIs (Major risk with yohimbe), or beta blockers like nadolol or talinolol (Major interactions with green tea and ginkgo). Moderate caution is needed with blood pressure drugs (multiple ingredients can lower blood pressure further), antiseizure medications (caffeine and B6 may weaken them), blood thinners like warfarin (ginkgo and other ingredients raise bleeding risk), diabetes drugs (chromium, alpha-lipoic acid, and niacin may lower blood sugar further), thyroid medications (kelp iodine and ashwagandha affect thyroid, chromium reduces levothyroxine absorption), and antidepressants (yohimbe with SSRIs or tricyclics carries risk).

If you take any psychiatric medications, benzodiazepines, or CNS depressants, several ingredients (ashwagandha, magnolia, GABA) can increase sedation. No interactions are documented for the ingredients we could not check in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Pyro Stim 7 is a high-stimulant, multi-targeted supplement aimed at energy and focus. It's geared toward healthy adults without major health conditions or medication use.

If you take any prescription or over-the-counter medications—especially blood pressure drugs, antiseizure drugs, antidepressants, blood thinners, diabetes medications, or thyroid hormones—you must check your specific medications with our tool first. Pregnant or breastfeeding individuals should avoid this product entirely because several of its ingredients are unsafe or unproven in these states.

Talk to your pharmacist or doctor before starting, especially if you have heart, liver, or thyroid issues, or take multiple medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 32 of 33 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pyro Stim 7, straight from the product label.

Brand Metis Nutrition
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 276560
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pyro Stim 7 by Metis Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
IngredientAmount% DV
Vitamin B69 mg529%
L-Tyrosine0 NP--
Caffeine Anhydrous0 NP--
Vitamin B1225 mcg1042%
Choline Bitartrate0 NP--
BioPerine0 NP--
Ginkgo biloba leaf extract0 NP--
Dandelion root powder0 NP--
Niacin0 NP--
Vitamin B31 mg6%
Yohimbe bark extract9 mg--
Kelp0 NP--
Reishi Mushroom powder0 NP--
Ashwagandha root powder0 NP--
Magnolia officinalis bark extract0 NP--
GABA0 NP--
Alpha-GPC0 NP--
Chromium0.75 mcg2%
Chromium Citrate0 NP--
DMAE0 NP--
QU995 Quercetin0 NP--
R-ALA0 NP--
Buchu leaf extract0 NP--
Energy Complex300 mg--
Green Tea Powder0 NP--
Teacrine25 mg--
Uva Ursi, Powder0 NP--
Pyro Stim 7 Proprietary Blend700 mg--
Thermo Stim Blend:0 NP--
Cayenne Pepper25 mg--
Cognitive Focus Blend:0 NP--
Phosphatidyl Serine powder0 NP--
Insul-Thyroid Support Blend:0 NP--
Gum Guggul ext.0 NP--
Hydro Shed Blend:0 NP--
Cortisol-Adrenal Support Blend:0 NP--
Rhodiola rosea root ext.0 NP--
Evodia rutaecarpa Fruit Extract0 NP--
Holy Basil Powder0 NP--
Absorption Agents:0 NP--
White Willow Extract0 NP--

Other ingredients: Gelatin, Silicon Dioxide, Vegetable Magnesium Stearate, Microcrystalline Cellulose, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Contains soy. Product was produced in a facility that may also process ingredients containing milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, and soybeans.

Warning: Keep out of reach of children.

For use by healthy adults only. Not for use by those under the age of 18. Do not exceed recommended dose or daily intake.

Do not use if you are pregnant, nursing, or allergic or contraindicated to aspirin.

Do not use if you are pregnant, nursing, or allergic or contraindicated to aspirin.

Before consuming, seek advice from a health care professional if you are unaware of your current health condition.

Contains caffeine. Do not consume caffeine from other sources, including but not limited to, coffee, tea, soda and other dietary supplements or medications containing caffeine.

Consult with your physician prior to use if you were taking medication, including but not limited to MAOI inhibitors, antidepressants, aspirin, blood thinning, non steroidal anti-inflammatory drugs or products containing phylephrine, ephedrine, pseudoephedrine, or other stimulants.

Do not use if you have blood pressure or heart conditions. Consult your physician prior to use if you have a medical condition, including but not limited to, liver, kidney, or thyroid disease, psychiatric or epileptic disorders, difficulty urinating, diabetes, cardiac arrhythmia, recurrent headaches, enlarged prostate or glaucoma. Do not use if you are prone to dehydration or exposed to excessive heat.

Warning for California residents only: This product contains a chemical known in the state of California to cause birth defects or other reproductive harm.

Discontinue use two weeks prior to surgery or if you experience rapid heartbeat, dizziness, severe headache, shortness of breath, or upset stomach. Do not use if tamper resistant seal is broken.

General Statements

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60 day supply

Consumer notice: FitLife Brands can only confirm product purity when our brands are purchased from authorized retailers, on gnc.com, or on metisnutrition.com. For an approved list of retailers, go to metisnutrition.com.

1. Snitker S, et al. (2009). Effects of capsinoid treatment on fatness and energy metabolism in humans: Possible pharmacogenetic implications. Am J Cin Nutr. 89(1): 45-50. 2. Leung, FW. (2008). Capsaicin-sensitive intestinal mucosal afferent mechanism and body fat distribution. Life Sci. 83(1-2): 1-5. 3. Lejeune MP, et al. (2003). Effects of capsaicin on substrate oxidation and weight maintenance after modest body-weight loss in human subjects. Br J Nutr. 90(3): 651-59. 4. Reinbach H, et al. (2009). Effects of capsaicin, green tea and CH-19 sweet pepper on appetite and energy intake in humans in negative and positive energy balance. Clin Nut. (3): 260-5. 5. Janssens PL, et al. (2014). Capsaicin increases sensation of fullness in energy balance, and decreases desire to eat after dinner in negative energy balance. Appetite. 77: 44-49. 6. Habowski SM, et al. (2014). The effect of TeaCrine on subjective measures of cognitive function, psychometric and hemodynamic indices in healthy humans: a randomized, double-blind crossover pilot trial. JISSN 11(Suppl 1): 49. 7. Taylor L, et al. (2016). Safety of TeaCrine, a non-habituating, naturally-occurring purine alkaloid over eight weeks of continuous use. JISSN 13:2.

Formulation

Clinically studied ingredients

7 N 1 Support for Metabolism Toning Energy Focus Appetite control Mood Recharge

Pyro Stim 7 offers a dynamic 7 N 1 weight loss thermogenic with the university studied ingredients necessary to deliver powerful results. This cutting edge stimulant-based thermogenic is intended to help promote fat loss, deliver energy and focus, suppress appetite, and support healthy mood. Featuring clinically studied compounds, alongside a comprehensive set of energy, cognitive and thyroid support blends, Pyro Stim 7 is designed to provide a successful multi-dimensional approach toward weight loss.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Proven science Powerful results

TeaCrine is a registered trademark and protected by Patents Pending, Serial No. 61/903,362; under exclusive global distribution by Compound Solutions, Inc. Capsi-Cuts is a registerd trademark of FitLife Brands, Inc. QU995 is a trademark of Quercegen Pharmaceuticals. BioPerine is a registered trademark and patented product of Sabinsa Corp.

Suggested/Recommended/Usage/Directions

Suggested use: Take 1 capsule daily, preferably with a meal and with 6-8 oz. of water. To avoid sleeplessness, avoid taking within 6 hours of bedtime. To be used as part of a healthy lifestyle consisting of regular physical activity and a proper diet.

Storage

Store in a cool, dry place. Avoid excessive heat.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Clinically studied CAPSAICIN CAPSAICIN is the naturally occurring active compound in cayenne pepper, associated with many of the health benefits of cayenne pepper use. Clinical research supports the function of capsaicin and associated capsinoids as weight management agents. Capsinoid ingestion increases energy expenditure and is associated with both increased and sustained fat oxidation. Both oral and gastrointestinal exposure to capsaicin increases satiety (feeling of fullness). Capsinoids role in weight management has been well researched as the center of more than 90 clinical studies.

Clinically studied TEACRINE TEACRINE is a dynamic patent-pending compound derived naturally from certain teas, exotic fruits and various coffee beans. TeaCrine's strong efficacy has been proven to facilitate a wide range of healthy benefits for thermogenic supplementation. TeaCrine works with the body's natural metabolic processes to deliver improvement in energy and fatigue reduction. By offering a smooth energy lift without irritability, the jitters, or a crash, it can be used advantageously to help break through plateaus and support stronger results. TeaCrine has also been shown to heighten positive effects on mental focus and concentration, increase motivation, and support a positive mood. TeaCrine's effectiveness has been researched in preclinical and human clinical studies.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pyro Stim 7 by Metis Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pyro Stim 7 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pyro Stim 7 by Metis Nutrition

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
9 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Vitamin B12

Interacts with
20 drugs
25 mcg per serving Form: Methylcobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Vitamin B3

Interacts with
727 drugs
1 mg per serving Form: Niacin

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescr...

Vitamin B3 monograph & interactions

Chromium

Interacts with
178 drugs
0.75 mcg per serving Form: Chromium Citrate

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...

Chromium monograph & interactions

Pyro Stim 7 Proprietary Blend

700 mg per serving
  • › Thermo Stim Blend:
  • › Cognitive Focus Blend:
  • › Insul-Thyroid Support Blend:
  • › Hydro Shed Blend:
  • › Cortisol-Adrenal Support Blend:
  • › Absorption Agents:

Other (inactive) ingredients: Gelatin, Silicon Dioxide, Vegetable Magnesium Stearate, Microcrystalline Cellulose, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pyro Stim 7 by Metis Nutrition Drug Interactions

Want to check YOUR meds against Pyro Stim 7?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,908Drugs
23 Major 1,870 Moderate 15 Minor

Ingredients driving the most interactions

Vitamin B3 727
Vitamin B6 210
Chromium 178
Vitamin B12 20

Individual Drug Interactions

The ingredients in Pyro Stim 7 interact with 1,908 drugs. Click any drug to see the details.

4 of the 10 ingredients in Pyro Stim 7 interact with drugs. Each result below shows which ingredient is responsible. Vitamin B3 Vitamin B6 Chromium Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in Pyro Stim 7 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B315 drug types · 727 drugs

Alcohol (Ethanol)

Concomitant use of alcohol and niacin might increase the risk of flushing and hepatotoxicity.
Alcohol can exacerbate the flushing and pruritus associated with niacin. Large doses of niacin might also exacerbate liver dysfunction associated with chronic alcohol use. A case report describes delirium and lactic acidosis in a patient taking niacin 3 grams daily who ingested 1 liter of wine. Advise patients to avoid large amounts of alcohol while taking niacin.

Likelihood Probable Evidence D
Allopurinol (Zyloprim)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as allopurinol.
Large doses of niacin can reduce urinary excretion of uric acid, potentially resulting in hyperuricemia. Doses of uricosurics such as allopurinol might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Anticoagulant/Antiplatelet Drugs

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.
Several cases of clotting factor synthesis deficiency and coagulopathy have been reported in patients taking sustained-release niacin. Also, thrombocytopenia has been reported in patients treated with niacin or niacin plus lovastatin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Niacin can increase blood glucose levels and may diminish the effects of antidiabetes drugs.
Niacin impairs glucose tolerance in a dose-dependent manner, probably by causing or aggravating insulin resistance and increasing hepatic production of glucose. In diabetes patients, niacin 4.5 grams daily for 5 weeks can increase plasma glucose by an average of 16% and glycated hemoglobin (HbA1c) by 21%. However, lower doses of 1.5 grams daily or less appear to have minimal effects on blood glucose. In some patients, glucose levels increase when niacin is started, but then return to baseline when a stable dose is reached. Up to 35% of patients with diabetes may need adjustments in hypoglycemic therapy when niacin is added.

Likelihood Probable Evidence B
Antihypertensive Drugs

Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.
The vasodilating effects of niacin can cause hypotension. Furthermore, some clinical evidence suggests that a one-hour infusion of niacin can reduce systolic, diastolic, and mean blood pressure in hypertensive patients. This effect is not observed in normotensive patients.

Likelihood Possible Evidence B
Bile Acid Sequestrants

Bile acid sequestrants can bind niacin and decrease absorption. Separate administration by 4-6 hours to avoid an interaction.
In vitro studies show that colestipol (Colestid) binds about 98% of available niacin and cholestyramine (Questran) binds 10% to 30%.

Likelihood Possible Evidence D
Gemfibrozil (Lopid)

Theoretically, concomitant use of niacin and gemfibrozil might increase the risk of myopathy in some patients.
A case of myopathy from concomitant use of niacin and gemfibrozil has been reported. Niacin alone has also been associated with cases of myopathy. Using gemfibrozil with niacin might further increase the risk of developing myopathy.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Niacin has been associated with cases of liver toxicity, especially when used in pharmacologic doses. Sustained-release niacin preparations appear to be associated with a higher risk of hepatotoxicity than immediate-release niacin.

Likelihood Possible Evidence D
Hmg-Coa Reductase Inhibitors ("Statins")

Theoretically, concomitant use of niacin and statins might increase the risk of myopathy and rhabdomyolysis in some patients.
Some case reports have raised concerns that niacin might increase the risk of myopathy and rhabdomyolysis when combined with statins. However, a significantly increased risk of myopathy has not been demonstrated in clinical trials, including those using an FDA-approved combination of lovastatin and niacin (Advicor).

Likelihood Possible Evidence D
Probenecid (Benemid)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as probenecid.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as probenecid might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Sulfinpyrazone (Anturane)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as sulfinpyrazone.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as sulfinpyrazone might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Thyroid Hormone

Theoretically, niacin might antagonize the therapeutic effects of thyroid hormones.
Clinical research and case reports suggests that taking niacin can reduce serum levels of thyroxine-binding globulin by up to 25% and moderately reduce levels of thyroxine (T4). Patients taking thyroid hormone for hypothyroidism might need dose adjustments when using niacin.

Likelihood Probable Evidence D
Transdermal Nicotine (Nicoderm)

Theoretically, concomitant use of niacin and transdermal nicotine might increase the risk of flushing and dizziness.
Niacin and nicotine can both cause flushing and dizziness.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that niacin may increase the anticoagulant effects of warfarin.
In a case report, a patient on warfarin developed an elevated international normalized ratio (INR) of 3.9 after taking niacin for two weeks. The patient's INR was previously stable, ranging between 2 and 3 in recent months, and no other medication changes were identified. The elevated INR returned to therapeutic range within 4 days following the discontinuation of niacin.

Likelihood Possible Evidence D
Aspirin

Large doses of aspirin might alter the clearance of niacin.
Aspirin is often used with niacin to reduce niacin-induced flushing. Doses of 80-975 mg aspirin have been used, but 325 mg appears to be optimal. Aspirin also seems to reduce the clearance of niacin by competing for glycine conjugation. Taking aspirin 1 gram seems to reduce niacin clearance by 45%. This is probably a dose-related effect and not clinically significant with the more common aspirin dose of 325 mg.

Likelihood Likely Evidence B
Vitamin B3 full monograph & interactions

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Chromium5 drug types · 178 drugs

Antidiabetes Drugs

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.

Likelihood Possible Evidence A
Insulin

Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,

Likelihood Possible Evidence B
Levothyroxine (Synthroid, Others)

Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.

Likelihood Probable Evidence B
Aspirin

Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.

Likelihood Possible Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.

Likelihood Possible Evidence D
Chromium full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pyro Stim 7, from the product label.

Metis Nutrition

See all Metis Nutrition products
Name
Metis Nutrition
Pharmacist Counseling Corner

Pyro Stim 7 by Metis Nutrition: Common Questions

Does Pyro Stim 7 by Metis Nutrition interact with any medications?
Yes. Based on its ingredients, Pyro Stim 7 has a known interaction with 1,908 medications, including 23 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pyro Stim 7 contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product have caffeine, and how much?
Yes, Pyro Stim 7 contains caffeine anhydrous, which is a concentrated form of caffeine used in energy supplements. The facts don't specify the exact dose per capsule, so you'll need to check the supplement label or contact the manufacturer for the precise amount.
Can I take this if I'm pregnant or breastfeeding?
No, you should avoid this product during pregnancy and breastfeeding. Several ingredients—including yohimbe, ginkgo, and ashwagandha—are unsafe or unproven during these times. Even caffeine at high levels in pregnancy is possibly unsafe. Talk to your doctor before considering any supplement while pregnant or nursing.
Will this help me lose weight or burn fat?
The product contains multiple ingredients marketed for energy and metabolism, but the data shows limited evidence. Caffeine is effective for mental alertness and athletic performance. Chromium is possibly effective for diabetes control but not for weight loss. Most other weight-loss claims lack reliable evidence in our data. Weight loss depends primarily on diet and exercise.
Is it safe to take this with my blood pressure medication?
No—you must check with your pharmacist first. At least six ingredients in this product (yohimbe, caffeine, green tea, ashwagandha, magnolia, GABA, niacin, and vitamin B6) can lower blood pressure or have effects that interact with blood pressure drugs. Combining them without monitoring could cause dangerously low blood pressure.
What are the most common side effects?
Caffeine is the primary active ingredient, so expect stimulant effects: jitteriness, insomnia, headache, rapid heartbeat, and anxiety. Niacin causes flushing (hot, burning face and skin). Yohimbe raises blood pressure and heart rate and can cause tremor, sweating, and agitation. Other ingredients may cause nausea, diarrhea, or dizziness at higher doses.
Can I take this with my antidepressant?
It depends on which antidepressant and which ingredient. Yohimbe in this product poses a serious risk with tricyclic antidepressants and MAOIs. Ashwagandha and magnolia may increase sedation if you take certain antidepressants. Ask your pharmacist to check your specific medication against each ingredient in this product before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pyro Stim 7 label
Go deeper

The Full Monographs Behind Pyro Stim 7’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Niacin

Interacts with 727 drugs

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescription-strength niacin has been used to...

Read the full Niacin monograph → Herb & supplement monograph

Chromium

Interacts with 178 drugs

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, b...

Read the full Chromium monograph →
Sources

Sources & How We Checked

Pyro Stim 7's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 1,210 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
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  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
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  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
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  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
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  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
  22. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
  23. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
  24. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
  25. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
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  28. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
  29. Gupta M, Gallante B, Bamberger JN, et al. Prospective randomized evaluation of idiopathic hyperoxaluria treatments. J Endourol 2021;35(12):1844-1851. PubMed
  30. Li H, Chen M, Liang S, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clin Nutr 2021;40(4):2293-2300. PubMed
  31. Tanigawa J, Nabatame S, Tominaga K, et al. High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. Brain Dev 2021;43(6):680-687. PubMed
  32. Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy. Obstet Gynecol. 2018;131(1):e15-e30. PubMed

See these in context on the Vitamin B6 monograph →

Tyrosine 4 references
  1. Meyer JS, Welch KM, Deshmukh VD, et al. Neurotransmitter precursor amino acids in the treatment of multi-infarct dementia and Alzheimer's disease. J Amer Geriat Soc 1977;25:289-98.
  2. DiPiro JT, Talbert RL, Yee GC, et al; eds. Pharmacotherapy: A pathophysiologic approach. 4th ed. Stamford, CT: Appleton & Lange, 1999.
  3. Wood DR, Reimherr FW, Wender PH. Amino acid precursors for the treatment of attention deficit disorder, residual type. Psychopharmacol Bull 1985;21:146-9.
  4. van Spronsen FJ, van Rijn M, Bekhof J. Phenylketonuria: tyrosine supplementation in phenylalanine-restricted diets. Am J Clin Nutr 2001;73:153-7. PubMed

See these in context on the Tyrosine monograph →

Caffeine 236 references
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Ashwagandha 32 references
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See these in context on the Rhodiola monograph →

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See these in context on the Evodia monograph →

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See these in context on the Holy Basil monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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