Bedaquiline

320 interactions 402 cited references

Also sold as: Sirturo Sirturo®

About Bedaquiline

Bedaquiline is used along with at least three other medications to treat multi-drug resistant tuberculosis (MDR-TB; a serious infection that affects the lungs and other parts of the body and that cannot be treated with other medications that are usually used to treat the condition) in adults and children 5 years and ol… Read the full Bedaquiline drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Fluconazole Piperaquine Mesoridazine Pimozide Levoketoconazole Ketoconazole

17 Contraindicated 299 Major 4 Moderate

All (320) Contraindicated (17) Major (299) Moderate (4)

Contraindicated

Bedaquiline Bepridil An increased risk of QT interval prolongation Details Bedaquiline Cisapride Propulsid® Increased risk of QT interval prolongation Details Bedaquiline Dronedarone Multaq Increased risk of QT interval prolongation Details Bedaquiline Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Bedaquiline Fluconazole Diflucan Increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation Details Bedaquiline Ketoconazole Extina Increased bedaquiline exposure and an increased risk for QT interval prolongation Details Bedaquiline Levoketoconazole Recorlev An increased risk of QT interval prolongation and torsades pointes, an increased CYP3A4 substrate exposure and an increased risk o... Details Bedaquiline Mesoridazine An increased risk of QT interval prolongation Details Bedaquiline Pimozide An increased risk of QT interval prolongation Details Bedaquiline Piperaquine An increased risk of QT interval prolongation Details Bedaquiline Posaconazole Noxafil Increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation Details Bedaquiline Saquinavir Increased bedaquiline exposure and an increased risk of QT interval prolongation Details Bedaquiline Sparfloxacin An increased risk of QT interval prolongation Details Bedaquiline Terfenadine An increased risk of QT interval prolongation Details Bedaquiline Thioridazine An increased risk of QT interval prolongation Details Bedaquiline Ziprasidone Geodon An increased risk of QT interval prolongation Details Bedaquiline Ketoconazole Topical Extina® Foam Increased bedaquiline exposure and an increased risk for QT interval prolongation Details

Major

Bedaquiline Abametapir Increased exposure of CYP3A4 substrate Details Bedaquiline Amitriptyline Elavil Increased risk of QT interval prolongation Details Bedaquiline Sertraline An increased risk of QT interval prolongation Details Bedaquiline Buprenorphine Belbuca An increased risk of QT interval prolongation Details Bedaquiline Relugolix Orgovyx Increased risk of QT interval prolongation Details Bedaquiline Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Bedaquiline Arsenic Trioxide Trisenox Increased risk of QT interval prolongation Details Bedaquiline Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Bedaquiline Arsenic Trioxide Injection Trisenox Increased risk of QT interval prolongation Details Bedaquiline Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Bedaquiline Azithromycin AzaSite An increased risk of QT interval prolongation and torsade de pointes Details Bedaquiline Alfuzosin UroXatral Increased risk of QT interval prolongation Details Bedaquiline Anagrelide Agrylin Increased risk of QT interval prolongation Details Bedaquiline Adagrasib Krazati An increased risk of QT interval prolongation, torsade de pointes, polymorphic ventricular tachycardia, other serious arrhythmias Details Bedaquiline Amiodarone Nexterone Increased bedaquiline exposure and an increased risk of QT interval prolongation Details Bedaquiline Amisulpride Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Bedaquiline Amprenavir Increased bedaquiline exposure Details Bedaquiline Apalutamide Erleada Reduced bedaquiline exposure and reduced efficacy of bedaquiline Details Bedaquiline Apomorphine Apokyn Increased risk of QT interval prolongation Details Bedaquiline Aprepitant Aponvie Increased bedaquiline exposure Details Bedaquiline Aripiprazole Abilify An increased risk of QT interval prolongation Details Bedaquiline Aripiprazole Lauroxil Aristada An increased risk of QT interval prolongation Details Bedaquiline Artemether An increased risk of QT interval prolongation, reduced CYP3A4 substrates exposure and reduced efficacy of CYP3A4 substrates Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.