Drug & supplement interaction

Cesium + Phenylephrine

Phenylephrine brand names: Gilchew, AH Chew D, Gilchew IR, Sudafed PE, Biorphen.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Cesium and Phenylephrine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Cesium and Phenylephrine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Phenylephrine and Cesium in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cesium safety at a glance

Cesium overall Avoid Cesium chloride can cause life-threatening heart rhythm problems and has no proven benefit.
Pregnancy Avoid Not safe; avoid during pregnancy due to serious toxicity risks.
Breastfeeding Avoid Not safe; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Phenylephrine and Cesium? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Phenylephrine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Phenylephrine is filed under 5 classifications — including alpha-adrenergic agonists, stimulant drugs, serotonergic drugs. Cesium has documented interactions with 3 drug classes — the most serious being qt interval-prolonging drugs (major), corticosteroids (moderate) and diuretic drugs (moderate) — and none of Phenylephrine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Cesium Does Interact With Other Medications

Cesium has 161 major, 94 moderate known drug interactions in our database — Phenylephrine isn’t one of them. If you take anything else, check it against the full list below.

Major 161 Moderate 94 No known interaction 2,575 (incl. Phenylephrine)
Taking anything else?

Check Another of Your Medications Against Cesium

Covers the 2,830 medications we’ve checked against Cesium. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Cesium and Phenylephrine May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Nausea reported in 7.6% of FDA reports for Phenylephrine Additional detail

    Cesium

    “Orally, cesium can cause nausea, diarrhea, and anorexia.”

    Cesium · Natural Medicines adverse-effect record, reported in anorexia.

    1 source cited
    1. 7671. Neulieb R. Effect of oral intake of cesium chloride: a single case report. Pharmacol Biochem Behav 1984;21:15-6.

    Phenylephrine

    Listed in the ADVERSE REACTIONS section of the FDA label for Phenylephrine, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Cesium but not commonly for Phenylephrine: an irregular heartbeat, fainting, a fast or pounding heartbeat and low potassium.

Effects for Phenylephrine come from the ADVERSE REACTIONS section of its FDA label; effects for Cesium come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 221,388 voluntary FDA FAERS reports for Phenylephrine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Cesium or Phenylephrine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Cesium or Phenylephrine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Phenylephrine

This page covers Cesium only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Phenylephrine page lists 81 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Lithium (major), Peyote (major) and Rauvolfia Vomitoria (major).

By severity: 6 major · 60 moderate · 15 minor.

From our pharmacist’s overview on the Phenylephrine page

“If you take phenylephrine (Sudafed PE, Biorphen) for congestion, treat this list as one that needs real attention, since six of its 81 entries carry a major rating. Phenylephrine tightens blood vessels to clear your nose, and more than half of the interactions here come from stimulant ingredients, ephedra above all, that can push blood…”

Reviewed by 2 · Jul 18, 2026

Open the Phenylephrine interaction page

One more smart check

Taking Cesium as Part of a Dietary Supplement Product? Check It for Interactions

We hold 51 real supplement products containing Cesium, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cesium. Even though Cesium itself has no known interaction with Phenylephrine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Cesium and Phenylephrine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cesium
Top half

#596 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Phenylephrine
Top 25%

#668 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cesium reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Cesium and Phenylephrine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Cesium

What is Cesium?

  • Marketed as an alternative cancer treatment ('high pH therapy')
  • Claimed to alter tumor pH
  • General 'alkaline' health claims

Cesium chloride is a mineral salt sold as an alternative cancer therapy ('high pH therapy'), but there is no reliable scientific evidence that it treats cancer or any other disease. It can cause dangerous heart rhythm problems and even death, so it should not be used. Talk to your doctor or pharmacist before taking any supplement, and never use cesium in place of proven medical care.

Mineral element (cesium chloride salt) · Capsules, powders, liquid solutions (often as cesium chloride)

An interaction check asks whether these two react with each other — it does not ask whether Cesium is a good idea for someone in your situation. Here is what our Cesium record says about it on its own.

Cesium: dosing

There is no safe or established dose for cesium chloride, and it is not approved as a medicine. Because it can cause life-threatening harm, no dosing recommendation can be given.We strongly advise against taking cesium chloride.

From our Cesium monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cesium monograph & all interactions
Medication

About Phenylephrine

What Is Phenylephrine Used For?

Brand names: Gilchew, AH Chew D, Gilchew IR, Sudafed PE, Biorphen

Phenylephrine is used in several different products, and each one has its own use.

Injection (IV): raises blood pressure in adults with clinically important hypotension (low blood pressure) caused mainly by widened blood vessels. Some injections are labeled for anesthesia only. Others are labeled for anesthesia and septic shock.

Eye drops: Phenylephrine Hydrochloride Ophthalmic Solution is used to dilate the pupil.

Nasal products: temporarily relieve nasal and sinus congestion from the common cold, hay fever or other upper respiratory allergies.

Rectal suppositories: relieve itching, burning and discomfort from hemorrhoids and temporarily shrink hemorrhoidal tissue.

Most-Reported Side Effects for Phenylephrine

From FAERS, the FDA’s public side-effect reporting system (221,388 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 20,609 reports
Headache 17,301 reports
Nausea 16,925 reports
Diarrhea 14,221 reports
Dyspnea 13,719 reports
See full Phenylephrine drug information
Keep checking

Other Drugs & Cesium

Browse every other medication we’ve checked against Cesium — both the ones with a known interaction and the ones without. Select any drug for the full detail.

161Major
94Moderate
0Minor
2,574No known interaction
161 Major 94 Moderate 2,574 No interaction
Major

161 interactions

Showing 60 of 161 major interactions — see all 161 on the Cesium page.

Moderate

94 interactions

Showing 60 of 94 moderate interactions — see all 94 on the Cesium page.

No interaction 2,574 drugs checked — show the list

We also checked Cesium against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,574 medications checked with no known interaction — see the full Cesium list.

See the full Cesium interactions page
See every supplement checked against Phenylephrine, ranked by severity
Evidence & sources

Cesium References

The 9 references that drive our Cesium monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Sartori HE. Nutrients and cancer: an introduction to cesium therapy. Pharmacol Biochem Behav 1984;21:7-10. PubMed
  2. Neulieb R. Effect of oral intake of cesium chloride: a single case report. Pharmacol Biochem Behav 1984;21:15-6.
  3. Lyon AW, Mayhew WJ. Cesium toxicity: A case of self-treatment by alternate therapy gone awry. Ther Drug Monit 2003;25:114-6. PubMed
  4. Vyas H, Johnson K, Houlihan R, et al. Acquired long QT syndrome secondary to cesium chloride supplement. J Altern Complement Med 2006;12:1011-4. PubMed
  5. Cesium chloride and ventricular arrhythmias. Canadian Adverse Reaction Newsletter 2008;18:3-4.
  6. Pinter A, Dorian P, Newman D. Cesium-induced torsades de pointes. N Engl J Med 2002;346:383-4. PubMed
  7. O'Brien CE, Harik N, James LP, et al. Cesium-induced QT-interval prolongation in an adolescent. Pharmacotherapy 2008;28:1059-65. PubMed
  8. FDA alerts health care professionals of significant safety risks associated with cesium chloride. FDA: Human Drug Compounding. July 23,2018. Available at: https://www.fda.gov/drugs/human-drug-compounding/fda-alerts-health-care-professionals-significant-sa
  9. Public Health Alert Concerning Dietary Supplements Containing Cesium Salts. FDA Dietary Supplement Products & Ingredients. February 5, 2020. Available at: https://www.fda.gov/food/dietary-supplement-products-ingredients/public-health-alert-concerning-diet

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cesium and Phenylephrine Together: Common Questions

Is it safe to take Cesium with Phenylephrine?
We do not list a known interaction between Cesium and Phenylephrine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Cesium and Phenylephrine have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Cesium and Phenylephrine combination checked?
Interactions in our licensed database are recorded against drug classes. Phenylephrine is filed under 5 classifications, and Cesium has documented interactions with 3 drug classes — none of Phenylephrine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Cesium interact with any other medications?
Yes. Cesium has 255 documented drug interactions in our database — Phenylephrine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Phenylephrine interact with any supplements?
Yes. Phenylephrine has documented interactions with 81 supplements in our database — Cesium is not one of them. The Phenylephrine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Cesium monograph Uses, safety profile, and every drug interaction in one place Phenylephrine drug information The full plain-English guide to this medication Phenylephrine supplement interactions Every supplement checked against Phenylephrine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Phenylephrine and Cesium?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.