Cola Nut - Brompheniramine, Pseudoephedrine Interaction
Herbal: Cola Nut
Also Known As: Cola acuminata, Bissey Nut, Bissy Nut, Bitter Kola, Guru Nut, Gworo, Kola Nut, Kolatier, Noix de Cola, Noix de Kola, Noix du Soudan, Nuez de Cola, Soudan Coffee
Drug: Brompheniramine, Pseudoephedrine
Brand names:
Bromfenex, Bromfenex PD, Bromfed, BPM PSEH 08, Allent, Ultrabrom, Nasal Decongestant, Rondec Chewable, Touro Allergy, Respahist, Iofed PD, Nalfed PD, Iofed, Bromfed PD, Ultrabrom PD, Lodrane LD, Endafed, Lodrane 12 D

Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
Brompheniramine, Pseudoephedrine is classified as belonging to the following category: Stimulant Drugs
Theoretically, concomitant use might increase stimulant adverse effects.
Cola nut contains caffeine. Due to the central nervous system (CNS) stimulant effects of caffeine, concomitant use with stimulant drugs can increase the risk of adverse effects.
Interaction Rating
Likelihood of Occurrence
ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
References
- Institute of Medicine. Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. Washington, DC: National Academy Press, 2001. Available at: http://books.nap.edu/books/0309082587/html/index.html.
Cola Nut Overview

Cola Nut - More Interactions
Cola Nut interacts with 647 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
Return to the main supplement interaction checker page
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.