Drug & supplement interaction

Cola Nut + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine

Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine brand names: De Con, Naldecon, Tri Phen Mine Sr, West-Decon, Uni Decon, and others.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine falls into 2 drug categories that Cola Nut can interact with; the most serious is rated moderate. Theoretically, concomitant use might increase stimulant adverse effects.

Read the full interaction report
SeverityModerate
LikelihoodProbable
Interactions2
EvidenceC
What do Severity, Likelihood & Evidence mean?
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Interaction report

Cola Nut and Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Cola Nut interacts with whole categories of medication. Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine falls into 2 of those categories, so it can interact with Cola Nut in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

STIMULANT DRUGS

1 of 2

Why this applies to Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine

Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine falls under STIMULANT DRUGS — the group Cola Nut interacts with.

Theoretically, concomitant use might increase stimulant adverse effects.
Cola nut contains caffeine. Due to the central nervous system (CNS) stimulant effects of caffeine, concomitant use with stimulant drugs can increase the risk of adverse effects.
Severity Moderate Likelihood Probable Evidence C

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

This combination cold and allergy product contains phenylephrine and phenylpropanolamine, two decongestants that already have a stimulant-like push on your body. Cola nut adds caffeine on top of that. Stacking these stimulant effects together can make side effects more noticeable, things like a racing or pounding heart, jitteriness, feeling wired, trouble sleeping, and a bump in blood pressure.

Keep in mind this is mostly a theoretical, expert-opinion concern rather than something proven in strong studies, so it is not a reason to panic. Still, if you have high blood pressure, a heart condition, or you are sensitive to caffeine, it is worth being careful. A casual cola drink is unlikely to matter much, but concentrated cola nut supplements give a bigger caffeine dose. Check with your pharmacist or doctor before pairing them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Institute of Medicine. Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. Washington, DC: National Academy Press, 2001. Available at: http://books.nap.edu/books/0309082587/html/index.html. DOI
Moderate

PHENYLPROPANOLAMINE

2 of 2

Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine also falls under PHENYLPROPANOLAMINE.

Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of the caffeine in cola nut.
Cola nut contains caffeine. Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.
Severity Moderate Likelihood Probable Evidence B

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

This combination product contains phenylpropanolamine and phenylephrine, two decongestants that can mildly raise your blood pressure and heart rate on their own. Cola nut adds caffeine into the mix, and that creates a two-way problem: the two stimulants together can push your blood pressure up more than either alone, and phenylpropanolamine also appears to slow how fast you clear caffeine, so the caffeine sticks around longer.

In real life that might mean a faster or pounding heartbeat, jitteriness, restlessness, trouble sleeping, or a headache. The blood pressure concern is the main reason to be careful, especially if you already have heart issues or high blood pressure. A casual cola drink probably won't matter much, but concentrated cola nut supplements are a different story. Please check with your pharmacist or doctor before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Brown NJ, Ryder D, Branch RA. A pharmacodynamic interaction between caffeine and phenylpropanolamine. Clin Pharmacol Ther 1991;50:363-71. PubMed
  2. Lake CR, Rosenberg DB, Gallant S, et al. Phenylpropanolamine increases plasma caffeine levels. Clin Pharmacol Ther 1990;47:675-85. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Cola Nut Also Interacts With Other Medications

Cola Nut has 546 moderate, 108 minor known drug interactions in our database — the Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine one above is among them. If you take anything else, check it against the full list below.

Moderate 546 Minor 108 No known interaction 2,176 (incl. Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine)
Taking anything else?

Check Another of Your Medications Against Cola Nut

Covers the 2,830 medications we’ve checked against Cola Nut. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine

This page covers Cola Nut only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine page lists 229 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Grapefruit (major), Henbane (major) and Lithium (major).

By severity: 10 major · 175 moderate · 44 minor.

From our pharmacist’s overview on the Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine page

“Ephedra worries me most on this list. This four-ingredient cold medicine, which pairs the antihistamines chlorpheniramine and phenyltoloxamine with the decongestants phenylephrine and phenylpropanolamine (Naldecon, Decongest), already pushes blood pressure and heart rate upward, and the 44 stimulant supplements on file, everyday caffei…”

Reviewed by 2 · Jul 18, 2026

Open the Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine interaction page

One more smart check

Taking Cola Nut as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2 real supplement products containing Cola Nut, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cola Nut. Your product may carry other ingredients that interact with Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine too, on top of Cola Nut — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Cola Nut and Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cola Nut
Top half

#649 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine
Top 10%

#197 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Cola Nut

What is Cola Nut?

Cola Nut
  • Energy and alertness
  • Mental focus
  • Physical performance
  • Weight loss support
  • Traditional digestive aid

Cola nut is a caffeine-containing seed from West Africa used mainly as a natural stimulant for energy and alertness. Most of its effects come from caffeine, and strong human evidence for specific health benefits is limited. Because of its caffeine content, people sensitive to stimulants and those who are pregnant or have heart conditions should be cautious.

Read the full Cola Nut monograph & all interactions
Keep checking

Other Drugs & Cola Nut

Browse every other medication we’ve checked against Cola Nut — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
546Moderate
108Minor
2,175No known interaction
546 Moderate 108 Minor 2,175 No interaction
Moderate

546 interactions

Showing 60 of 546 moderate interactions — see all 546 on the Cola Nut page.

Minor

108 interactions

Showing 60 of 108 minor interactions — see all 108 on the Cola Nut page.

No interaction 2,175 drugs checked — show the list

We also checked Cola Nut against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,175 medications checked with no known interaction — see the full Cola Nut list.

See the full Cola Nut interactions page
See every supplement checked against Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Cola Nut monograph › Uses, safety, and every drug interaction in one place Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine supplement interactions › Every supplement checked against Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Cola Nut and Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine Together: Common Questions

Can you take Cola Nut with Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Cola Nut and Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine?
Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine belongs to more than one drug category, and Cola Nut interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Cola Nut and Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine and Cola Nut?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.