Drug & supplement interaction

Red Clover + Oxazepam

Oxazepam brand name: Serax.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Red Clover and Oxazepam in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Red Clover and Oxazepam

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Oxazepam and Red Clover in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Red Clover safety at a glance

Red Clover overall Use caution Generally well tolerated short-term in healthy adults, but its estrogen-like activity calls for caution in certain people.
Pregnancy Likely Safe When used orally in amounts commonly found in foods. Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in amounts commonly found in foods. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Oxazepam and Red Clover? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Oxazepam

Interactions in our licensed database are recorded against drug classes, not just single drug names. Oxazepam is filed under 6 classifications — including benzodiazepines, anticonvulsants, glucuronidated drugs. Red Clover has documented interactions with 9 drug classes — the most serious being estrogens (moderate), methotrexate (trexall, others) (moderate) and tamoxifen (nolvadex) (moderate) — and none of Oxazepam’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Red Clover Does Interact With Other Medications

Red Clover has 44 moderate, 823 minor known drug interactions in our database — Oxazepam isn’t one of them. If you take anything else, check it against the full list below.

Moderate 44 Minor 823 No known interaction 1,963 (incl. Oxazepam)
Taking anything else?

Check Another of Your Medications Against Red Clover

Covers the 2,830 medications we’ve checked against Red Clover. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Red Clover and Oxazepam May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Headache Additional detail

    Red Clover

    “Orally, a specific red clover isoflavone product (Medoflavon) has been associated with headache, although with a similar frequency to placebo.”

    Red Clover · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 19545. Hidalgo LA, Chedraui PA, Morocho N, et al. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Gynecol Endocrinol 2005;21(5):257-264. PubMed

    Oxazepam

    Listed in the ADVERSE REACTIONS section of the FDA label for Oxazepam. Read the label on DailyMed ›

  • Nausea Additional detail

    Red Clover

    “Orally, red clover has been reported to cause nausea.”

    Red Clover · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 8194. Tice J, Cummings SR, Ettinger B, et al. Few adverse effects of two red clover extracts rich in phytoestrogens: a multicenter, placebo-controlled trial. Alt Ther 2001;7:S33.

    Oxazepam

    Listed in the ADVERSE REACTIONS section of the FDA label for Oxazepam. Read the label on DailyMed ›

Reported for Red Clover but not commonly for Oxazepam: loss of vision, blood clots, bleeding or bruising and muscle pain.

Effects for Oxazepam come from the ADVERSE REACTIONS section of its FDA label; effects for Red Clover come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Red Clover in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally in amounts commonly found in foods.

Pregnancy And Lactation Possibly Unsafe

When used orally in medicinal amounts. Red clover has estrogenic activity; avoid using. There is insufficient reliable information available about the safety of the topical use of red clover during pregnancy and lactation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Oxazepam

This page covers Red Clover only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Oxazepam page lists 119 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 8 major · 94 moderate · 17 minor.

From our pharmacist’s overview on the Oxazepam page

“The single biggest hazard with oxazepam (Serax), a benzodiazepine prescribed for anxiety and alcohol withdrawal, is stacked sedation, and this is a list to treat with genuine respect. Nearly two thirds of the supplements and foods on this page add their own drowsiness on top of the drug's, and the worst of them can depress breathing it…”

Reviewed by 2 · Jul 18, 2026

Open the Oxazepam interaction page

One more smart check

Taking Red Clover as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,480 real supplement products containing Red Clover, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Red Clover. Even though Red Clover itself has no known interaction with Oxazepam, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Red Clover and Oxazepam Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Red Clover
Top 25%

#153 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Oxazepam
Steady interest

#2,002 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Red Clover reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Red Clover and Oxazepam records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Red Clover

What is Red Clover?

Red Clover
  • Menopause symptoms (hot flashes)
  • High cholesterol
  • Bone health/osteoporosis
  • Skin and hair concerns
  • Women's health

Red clover is a plant rich in isoflavones (plant compounds with weak estrogen-like activity) that is most often used for menopause symptoms like hot flashes. The evidence is mixed and generally weak, with some studies showing modest benefit and others showing none. Because of its hormone-like effects, it's not for everyone—talk with your pharmacist or doctor before trying it, especially if you have a hormone-sensitive condition.

Trifolium pratense · Fabaceae · Flowering tops (blossoms) and aerial parts · Capsules, tablets, standardized extracts, tinctures, teas, and topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Red Clover is a good idea for someone in your situation. Here is what our Red Clover record says about it on its own.

Red Clover: dosing

There is no single well-established standard dose for red clover. Products vary widely, and many are standardized to a certain amount of isoflavones, which makes comparison difficult.The safest approach is to follow the directions on the product label and not exceed the recommended amount. They can help you decide whether it's appropriate and what amount is reasonable for you.

From our Red Clover monograph — the full record covers uses, side effects and every documented interaction.

Read the full Red Clover monograph & all interactions
Medication

About Oxazepam

What Is Oxazepam Used For?

Brand name: Serax

Oxazepam capsules are used to manage anxiety disorders and for short-term relief of anxiety symptoms. They are also helpful for anxiety that occurs alongside depression.

Oxazepam is particularly useful for older adults experiencing anxiety, tension, agitation, or irritability. It is also used for people going through alcohol withdrawal who have tremors, agitation, or anxiety.

Most-Reported Side Effects for Oxazepam

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Toxicity to various agents 2,858 reports
Drug abuse 1,522 reports
Fall 1,520 reports
Hypotension 1,402 reports
Coma 1,108 reports
See full Oxazepam drug information
Keep checking

Other Drugs & Red Clover

Browse every other medication we’ve checked against Red Clover — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
44Moderate
823Minor
1,962No known interaction
44 Moderate 823 Minor 1,962 No interaction
Moderate

44 interactions

Minor

823 interactions

Showing 60 of 823 minor interactions — see all 823 on the Red Clover page.

No interaction 1,962 drugs checked — show the list

We also checked Red Clover against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,962 medications checked with no known interaction — see the full Red Clover list.

See the full Red Clover interactions page
See every supplement checked against Oxazepam, ranked by severity
Evidence & sources

Red Clover References

The 24 references that drive our Red Clover monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kurzer MS, Xu X. Dietary phytoestrogens. Annu Rev Nutr 1997;17:353-81. PubMed
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
  4. This P, De La Rochefordiere A, Clough K, et al. Phytoestrogens after breast cancer. Endocr Relat Cancer 2001;8:129-34. PubMed
  5. Tice J, Cummings SR, Ettinger B, et al. Few adverse effects of two red clover extracts rich in phytoestrogens: a multicenter, placebo-controlled trial. Alt Ther 2001;7:S33.
  6. Ingram DM, Hickling C, West L, et al. A double-blind randomized controlled trial of isoflavones in the treatment of cyclical mastalgia. The Breast 2002;11:170-4. PubMed
  7. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  8. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
  9. Geller SE, Shulman LP, van Breemen RB, et al. Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial. Menopause 2009;16:1156-66. PubMed
  10. Hidalgo LA, Chedraui PA, Morocho N, et al. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Gynecol Endocrinol 2005;21(5):257-264. PubMed
  11. Campbell MJ, Woodside JV, Honour JW, et al. Effect of red clover-derived isoflavone supplementation on insulin-like growth factor, lipid and antioxidant status in healthy female volunteers: a pilot study. Eur J Clin Nutr 2004;58(1):173-179. PubMed
  12. Guerrero JA, Lozano ML, Castillo J, et al. Flavonoids inhibit platelet function through binding to the thromboxane A2 receptor. J Thromb Haemost 2005;3(2):369-376. PubMed
  13. Kondo K, Suzuki Y, Ikeda Y, Umemura K. Genistein, an isoflavone included in soy, inhibits thrombotic vessel occlusion in the mouse femoral artery and in vitro platelet aggregation. Eur J Pharmacol 2002;455(1):53-57. PubMed
  14. Polini N, Rauschemberger MB, Mendiberri J, et al. Effect of genistein and raloxifene on vascular dependent platelet aggregation. Mol Cell Endocrinol 2007;267(1-2):55-62. PubMed
  15. Wuttke W, Jarry H, Seidlova-Wuttke D. Plant-derived alternative treatments for the aging male: facts and myths. Aging Male 2010;13(2):75-81. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Red Clover and Oxazepam Together: Common Questions

Is it safe to take Red Clover with Oxazepam?
We do not list a known interaction between Red Clover and Oxazepam. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Red Clover and Oxazepam have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Red Clover and Oxazepam combination checked?
Interactions in our licensed database are recorded against drug classes. Oxazepam is filed under 6 classifications, and Red Clover has documented interactions with 9 drug classes — none of Oxazepam's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Red Clover interact with any other medications?
Yes. Red Clover has 867 documented drug interactions in our database — Oxazepam is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Oxazepam interact with any supplements?
Yes. Oxazepam has documented interactions with 119 supplements in our database — Red Clover is not one of them. The Oxazepam interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Red Clover monograph Uses, safety profile, and every drug interaction in one place Oxazepam drug information The full plain-English guide to this medication Oxazepam supplement interactions Every supplement checked against Oxazepam, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 24 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Oxazepam and Red Clover?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.