Herb & supplement monograph

Boneset Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Boneset interacts with medications. The heart of this page is the interaction list — every drug Boneset is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Boneset is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Boneset Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Boneset drug interaction appears low for most people, since every listed concern is theoretical rather than proven in humans. None of the interactions are rated major, and all of them rest on lab-based reasoning rather than documented human harm.

Interactions deserving the most attention

The one concern worth knowing about involves medications that speed up a liver enzyme called CYP3A4. Boneset comes from a plant family that can contain compounds called pyrrolizidine alkaloids, and in theory, enzyme-inducing drugs could convert more of these compounds into forms that stress the liver. The clearest examples are the seizure medicines carbamazepine and phenytoin, along with the antibiotic rifampin and phenobarbital. This has not been shown to happen in people, but because the possible harm involves the liver, it deserves the most caution.

What the rest of the list means

Although the number of listed medications looks large, every one of them traces back to this single theoretical mechanism. No human studies have confirmed that combining boneset with these drugs actually causes harm, so the long list reflects one shared prediction rather than dozens of separate proven problems.

Check your medications against Boneset

Based on HelloPharmacist’s Boneset interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Boneset

87 medications have a known interaction with Boneset, graded by severity. Select any drug for the full evidence-based detail.

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AI summaries are generated from our Boneset interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

AminoglutethimideCytadren

Moderate Cytochrome P450 3a4 (cyp3a4) Inducers