Medication interaction hub

What Supplements Interact with Caffeine , Sodium Benzoate?

Caffeine , Sodium Benzoate brand name: Caffeine and Sodium Benzoate. Every interaction below applies to the brands too.

208 Interactions 7 Major 155 Moderate 46 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Caffeine , Sodium Benzoate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Caffeine , Sodium Benzoate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Caffeine and sodium benzoate is itself a stimulant medication, so the supplements most likely to cause trouble are the ones doing the same job. Seven of the 208 ingredients on file rate major, several of them stimulant herbs such as ephedra that can pile extra blood pressure and heart strain onto a drug already revving the nervous system. This one warrants a careful, unhurried read, beginning with those seven.

Everyday caffeine sources add to that same stimulant load at a moderate level, and many other entries change how the body handles the drug. Echinacea can raise caffeine levels by roughly 30 percent, while some herbs speed its breakdown and weaken it. Activated charcoal, another major-rated entry, can block absorption outright, so space it well apart from your dose. The remaining 155 moderate and 46 minor entries matter less individually, but energy and weight loss blends deserve the closest look.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 155 Minor 46 No known interaction 1,244

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Caffeine , Sodium Benzoate: Top Interactions at a Glance

The Caffeine , Sodium Benzoate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 208 interacting ingredients — plus 1,244 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Caffeine , Sodium Benzoate Combinations Today

The Caffeine , Sodium Benzoate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Dandelion + Caffeine , Sodium Benzoatei

Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.

Read the full interaction Moderate Likelihood Possible Sodium Bicarbonate + Caffeine , Sodium Benzoatei

Theoretically, sodium bicarbonate may increase the risk of hypokalemia in patients taking methylxanthines.

Read the full interaction Moderate Likelihood Possible Boswellia Serrata + Caffeine , Sodium Benzoatei

Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.

Read the full interaction Moderate Likelihood Possible Devil's Claw + Caffeine , Sodium Benzoatei

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Probable Echinacea + Caffeine , Sodium Benzoatei

Echinacea can increase plasma levels of caffeine by inhibiting its metabolism.

Read the full interaction Major Likelihood Likely Grapefruit + Caffeine , Sodium Benzoatei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction
The complete list

Every Supplement Checked Against Caffeine , Sodium Benzoate

All 1,452 ingredients in our database, ranked by severity — 208 with a Caffeine , Sodium Benzoate interaction on file and 1,244 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Caffeine , Sodium Benzoate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Dandelion with Caffeine , Sodium Benzoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.

Full Dandelion + Caffeine , Sodium Benzoate answer

Can you take Sodium Bicarbonate with Caffeine , Sodium Benzoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sodium bicarbonate may increase the risk of hypokalemia in patients taking methylxanthines.

Full Sodium Bicarbonate + Caffeine , Sodium Benzoate answer

Can you take Boswellia Serrata with Caffeine , Sodium Benzoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.

Full Boswellia Serrata + Caffeine , Sodium Benzoate answer

Can you take Devil's Claw with Caffeine , Sodium Benzoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Full Devil's Claw + Caffeine , Sodium Benzoate answer

Can you take Echinacea with Caffeine , Sodium Benzoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Echinacea can increase plasma levels of caffeine by inhibiting its metabolism.

Full Echinacea + Caffeine , Sodium Benzoate answer

Can you take Tangerine with Caffeine , Sodium Benzoate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).

Full Tangerine + Caffeine , Sodium Benzoate answer

Can you take Turpentine Oil with Caffeine , Sodium Benzoate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. There is some concern that turpentine oil can inhibit CYP1A2 enzyme activity by up to 90% via induction of inflammation and subsequent downr...

Full Turpentine Oil + Caffeine , Sodium Benzoate answer

Can you take Grapefruit with Caffeine , Sodium Benzoate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Full Grapefruit + Caffeine , Sodium Benzoate answer

Can you take Activated Charcoal with Caffeine , Sodium Benzoate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Caffeine , Sodium Benzoate answer

Can you take Ephedra with Caffeine , Sodium Benzoate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use might increase the risk for serious adverse effects.

Full Ephedra + Caffeine , Sodium Benzoate answer

Can you take Peyote with Caffeine , Sodium Benzoate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of peyote with stimulant drugs may increase the risk of adverse CNS effects.

Full Peyote + Caffeine , Sodium Benzoate answer

Can you take Rauvolfia Vomitoria with Caffeine , Sodium Benzoate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use might cause additive effects.

Full Rauvolfia Vomitoria + Caffeine , Sodium Benzoate answer

Can you take Sida Cordifolia with Caffeine , Sodium Benzoate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, Sida cordifolia might increase the risk of adverse cardiovascular effects when taken with stimulant drugs.

Full Sida Cordifolia + Caffeine , Sodium Benzoate answer

Can you take St. John's Wort with Caffeine , Sodium Benzoate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. St.

Full St. John's Wort + Caffeine , Sodium Benzoate answer

Can you take Black Tea with Caffeine , Sodium Benzoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Black Tea + Caffeine , Sodium Benzoate answer

Can you take Caffeine with Caffeine , Sodium Benzoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Caffeine + Caffeine , Sodium Benzoate answer

Can you take Cannabidiol (cbd) with Caffeine , Sodium Benzoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cannabidiol may increase levels of drugs metabolized by CYP1A2.

Full Cannabidiol (cbd) + Caffeine , Sodium Benzoate answer

Can you take Cocoa with Caffeine , Sodium Benzoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Cocoa + Caffeine , Sodium Benzoate answer

Can you take Coffee with Caffeine , Sodium Benzoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Coffee + Caffeine , Sodium Benzoate answer

Can you take Coffee Charcoal with Caffeine , Sodium Benzoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Caffeine , Sodium Benzoate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Caffeine , Sodium Benzoate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Caffeine , Sodium Benzoate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Caffeine , Sodium Benzoate sits in 7 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Caffeine , Sodium Benzoate through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Caffeine , Sodium Benzoate through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Caffeine , Sodium Benzoate through this category.

Caffeine 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Caffeine , Sodium Benzoate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Caffeine , Sodium Benzoate through this category.

Methylxanthines 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Caffeine , Sodium Benzoate through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Caffeine , Sodium Benzoate through this category.

Related: does Caffeine , Sodium Benzoate deplete any nutrients?

Caffeine , Sodium Benzoate has 1 reported nutrient association in the research literature — see the Caffeine , Sodium Benzoate nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Caffeine , Sodium Benzoate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Caffeine , Sodium Benzoate.

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Pharmacist Counseling Corner

Caffeine , Sodium Benzoate & Supplements: Common Questions

What supplements interact with Caffeine , Sodium Benzoate?
More than you might expect — 208 in total, though they are far from equal: 7 are rated major, 155 moderate, and 46 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Activated Charcoal, Ephedra.
Which Caffeine , Sodium Benzoate supplement interactions are the most serious?
The 7 major-rated combinations — led by Grapefruit, Activated Charcoal, Ephedra, Peyote and Rauvolfia Vomitoria — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Caffeine , Sodium Benzoate?
Usually yes — most people on Caffeine , Sodium Benzoate can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Caffeine and Sodium Benzoate have the same supplement interactions as Caffeine , Sodium Benzoate?
Yes — Caffeine and Sodium Benzoate all contain Caffeine , Sodium Benzoate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Caffeine , Sodium Benzoate deplete any vitamins or nutrients?
It might — Caffeine , Sodium Benzoate has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Caffeine , Sodium Benzoate nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Caffeine , Sodium Benzoate and my other medications?
This page covers Caffeine , Sodium Benzoate against supplements and herbal ingredients. Checking Caffeine , Sodium Benzoate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.