Medication interaction hub

What Supplements Interact with Ethinyl Estradiol, Desogestrel?

Ethinyl Estradiol, Desogestrel brand names: Linessa, Apri, Reclipsen, Solia, Kariva, and others. Every interaction below applies to the brands too.

246 Interactions 6 Major 201 Moderate 39 Minor
Curated & coded by · Clinical Pharmacist · Updated October 1, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ethinyl Estradiol, Desogestrel? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ethinyl Estradiol, Desogestrel against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

246 supplements and herbal ingredients have interactions with Ethinyl Estradiol, Desogestrel on file in the HelloPharmacist interaction database — 6 rated major, 201 moderate, and 39 minor. The most serious involve Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and St. John's Wort.

Our assessment: with 6 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Ethinyl Estradiol, Desogestrel.

Major 6 Moderate 201 Minor 39 No known interaction 1,206

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Ethinyl Estradiol, Desogestrel: Top Interactions at a Glance

The Ethinyl Estradiol, Desogestrel supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 246 interacting ingredients — plus 1,206 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Ethinyl Estradiol, Desogestrel Combinations Today

The Ethinyl Estradiol, Desogestrel + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Copper + Ethinyl Estradiol, Desogestreli

Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.

Read the full interaction Moderate Likelihood Possible Hemp + Ethinyl Estradiol, Desogestreli

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.

Read the full interaction Minor Likelihood Possible Selenium + Ethinyl Estradiol, Desogestreli

Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.

Read the full interaction Moderate Likelihood Probable Coffee + Ethinyl Estradiol, Desogestreli

Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Read the full interaction Moderate Likelihood Probable Red Clover + Ethinyl Estradiol, Desogestreli

Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.

Read the full interaction Moderate Likelihood Possible Rooibos + Ethinyl Estradiol, Desogestreli

Theoretically, taking rooibos with CYP1A2 substrates may increase the effects of CYP1A2 substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Ethinyl Estradiol, Desogestrel

All 1,452 ingredients in our database, ranked by severity — 246 with a Ethinyl Estradiol, Desogestrel interaction on file and 1,206 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ethinyl Estradiol, Desogestrel?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Copper with Ethinyl Estradiol, Desogestrel?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.

Full Copper + Ethinyl Estradiol, Desogestrel answer

Can you take Hemp with Ethinyl Estradiol, Desogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.

Full Hemp + Ethinyl Estradiol, Desogestrel answer

Can you take Selenium with Ethinyl Estradiol, Desogestrel?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.

Full Selenium + Ethinyl Estradiol, Desogestrel answer

Can you take Coffee with Ethinyl Estradiol, Desogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Full Coffee + Ethinyl Estradiol, Desogestrel answer

Can you take Red Clover with Ethinyl Estradiol, Desogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.

Full Red Clover + Ethinyl Estradiol, Desogestrel answer

Can you take Tangerine with Ethinyl Estradiol, Desogestrel?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).

Full Tangerine + Ethinyl Estradiol, Desogestrel answer

Can you take Turpentine Oil with Ethinyl Estradiol, Desogestrel?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. There is some concern that turpentine oil can inhibit CYP1A2 enzyme activity by up to 90% via induction of inflammation and subsequent downr...

Full Turpentine Oil + Ethinyl Estradiol, Desogestrel answer

Can you take Grapefruit with Ethinyl Estradiol, Desogestrel?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Full Grapefruit + Ethinyl Estradiol, Desogestrel answer

Can you take Siberian Cocklebur with Ethinyl Estradiol, Desogestrel?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Siberian cocklebur can adversely affect the liver.

Full Siberian Cocklebur + Ethinyl Estradiol, Desogestrel answer

Can you take Activated Charcoal with Ethinyl Estradiol, Desogestrel?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Ethinyl Estradiol, Desogestrel answer

Can you take Beer with Ethinyl Estradiol, Desogestrel?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Full Beer + Ethinyl Estradiol, Desogestrel answer

Can you take St. John's Wort with Ethinyl Estradiol, Desogestrel?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. St.

Full St. John's Wort + Ethinyl Estradiol, Desogestrel answer

Can you take Wine with Ethinyl Estradiol, Desogestrel?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Full Wine + Ethinyl Estradiol, Desogestrel answer

Can you take Black Tea with Ethinyl Estradiol, Desogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Full Black Tea + Ethinyl Estradiol, Desogestrel answer

Can you take Caffeine with Ethinyl Estradiol, Desogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Full Caffeine + Ethinyl Estradiol, Desogestrel answer

Can you take Cannabidiol (cbd) with Ethinyl Estradiol, Desogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cannabidiol may increase levels of drugs metabolized by CYP1A2.

Full Cannabidiol (cbd) + Ethinyl Estradiol, Desogestrel answer

Can you take Cocoa with Ethinyl Estradiol, Desogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Full Cocoa + Ethinyl Estradiol, Desogestrel answer

Can you take Coffee Charcoal with Ethinyl Estradiol, Desogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Ethinyl Estradiol, Desogestrel answer

Can you take Cola Nut with Ethinyl Estradiol, Desogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, estrogens might increase the levels and adverse effects of the caffeine in cola nut.

Full Cola Nut + Ethinyl Estradiol, Desogestrel answer

Can you take European Mandrake with Ethinyl Estradiol, Desogestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Ethinyl Estradiol, Desogestrel answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ethinyl Estradiol, Desogestrel is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ethinyl Estradiol, Desogestrel, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ethinyl Estradiol, Desogestrel sits in 12 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Ethinyl Estradiol, Desogestrel through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Ethinyl Estradiol, Desogestrel through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Ethinyl Estradiol, Desogestrel through this category.

Estrogens 60 ingredients

Hormone-related medications. Supplements with hormone-like activity can add to or interfere with them.

60 of the supplement ingredients on this page reach Ethinyl Estradiol, Desogestrel through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Ethinyl Estradiol, Desogestrel through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Ethinyl Estradiol, Desogestrel through this category.

Contraceptive Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Ethinyl Estradiol, Desogestrel through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Ethinyl Estradiol, Desogestrel through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Ethinyl Estradiol, Desogestrel through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Ethinyl Estradiol, Desogestrel through this category.

Ethinyl Estradiol 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Ethinyl Estradiol, Desogestrel through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Ethinyl Estradiol, Desogestrel through this category.

Related: does Ethinyl Estradiol, Desogestrel deplete any nutrients?

Ethinyl Estradiol, Desogestrel has 70 reported nutrient associations in the research literature — see the Ethinyl Estradiol, Desogestrel nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Ethinyl Estradiol, Desogestrel

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Ethinyl Estradiol, Desogestrel.

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Pharmacist Counseling Corner

Ethinyl Estradiol, Desogestrel & Supplements: Common Questions

What supplements interact with Ethinyl Estradiol, Desogestrel?
In our interaction database, 246 supplement and herbal ingredients have an interaction with Ethinyl Estradiol, Desogestrel on file — 6 rated major, 201 moderate, and 39 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Ethinyl Estradiol, Desogestrel supplement interactions are the most serious?
The 6 major-rated combinations — led by Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Ethinyl Estradiol, Desogestrel?
That depends entirely on which supplement. The honest answer for Ethinyl Estradiol, Desogestrel is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Linessa have the same supplement interactions as Ethinyl Estradiol, Desogestrel?
Yes — Linessa, Apri, Reclipsen, Solia, Kariva and other brands all contain Ethinyl Estradiol, Desogestrel, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Ethinyl Estradiol, Desogestrel deplete any vitamins or nutrients?
It might — Ethinyl Estradiol, Desogestrel has 70 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Ethinyl Estradiol, Desogestrel nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Ethinyl Estradiol, Desogestrel and my other medications?
This page covers Ethinyl Estradiol, Desogestrel against supplements and herbal ingredients. Checking Ethinyl Estradiol, Desogestrel against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 1, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.