Medication interaction hub

What Supplements Interact with Fluticasone Proprionate, Salmeterol?

Fluticasone Proprionate, Salmeterol brand name: Airduo Respiclick. Every interaction below applies to the brands too.

144 Interactions 7 Major 107 Moderate 30 Minor
Curated & coded by · Clinical Pharmacist · Updated September 25, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Fluticasone Proprionate, Salmeterol? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Fluticasone Proprionate, Salmeterol against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Airduo Respiclick pairs fluticasone propionate with salmeterol to control asthma, and salmeterol is the half that makes supplement choices matter. It is cleared by the CYP3A4 enzyme and can affect heart rhythm when its levels climb, and seven of the 144 interacting ingredients carry a major rating, enough that I read this page as a genuine warning. Grapefruit blocks that enzyme so salmeterol builds up; St. John's wort speeds it and can blunt the medication.

Most of the other majors are herbs, ephedra among them, that lengthen the QT interval, the heart's electrical recovery time, stacking with salmeterol's own effect. A smaller cluster of caffeine sources can amplify the drug's stimulant push on the heart in large amounts. The 107 moderate and 30 minor entries mostly echo these enzyme and heart themes, but on a drug that touches the heart, weaker evidence is not the same as no risk.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 107 Minor 30 No known interaction 1,308

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Fluticasone Proprionate, Salmeterol: Top Interactions at a Glance

The most significant Fluticasone Proprionate, Salmeterol supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 144 interacting ingredients — plus 1,308 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Fluticasone Proprionate, Salmeterol + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Grapefruit + Fluticasone Proprionate, Salmeteroli

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Probable Arsenic + Fluticasone Proprionate, Salmeteroli

Arsenic trioxide can prolong the QT interval.

Read the full interaction Major Likelihood Probable Cesium + Fluticasone Proprionate, Salmeteroli

Theoretically, taking cesium concomitantly with other drugs that prolong the QT interval may increase the risk of ventricular arrhythmias and death.

Read the full interaction Major Likelihood Probable Ephedra + Fluticasone Proprionate, Salmeteroli

Theoretically, ephedra might have an additive effect with drugs that prolong the QT interval.

Read the full interaction Major Likelihood Probable Sida Cordifolia + Fluticasone Proprionate, Salmeteroli

Theoretically, Sida cordifolia might increase the risk of additive QT interval prolongation when taken with QT interval-prolonging drugs.

Read the full interaction Major Likelihood Probable St. John's Wort + Fluticasone Proprionate, Salmeteroli

St.

Read the full interaction
The complete list

Every Supplement Checked Against Fluticasone Proprionate, Salmeterol

All 1,452 ingredients in our database, ranked by severity — 144 with a Fluticasone Proprionate, Salmeterol interaction on file and 1,308 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Fluticasone Proprionate, Salmeterol?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Cinchona with Fluticasone Proprionate, Salmeterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cinchona with other QT interval-prolonging drugs might cause an additive effect and increase the risk of ventricular a...

Full Cinchona + Fluticasone Proprionate, Salmeterol answer

Can you take Rabdosia Rubescens with Fluticasone Proprionate, Salmeterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that oridonin, a constituent of Rabdosia rubescens, induces cytochrome P450 3A4 (CYP3A4) enzyme.

Full Rabdosia Rubescens + Fluticasone Proprionate, Salmeterol answer

Can you take Hemp with Fluticasone Proprionate, Salmeterol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.

Full Hemp + Fluticasone Proprionate, Salmeterol answer

Can you take Hibiscus Sabdariffa with Fluticasone Proprionate, Salmeterol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Hibiscus sabdariffa extract might reduce the metabolism of CYP3A4 substrates.

Full Hibiscus Sabdariffa + Fluticasone Proprionate, Salmeterol answer

Can you take Honey with Fluticasone Proprionate, Salmeterol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.

Full Honey + Fluticasone Proprionate, Salmeterol answer

Can you take Hops with Fluticasone Proprionate, Salmeterol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.

Full Hops + Fluticasone Proprionate, Salmeterol answer

Can you take Melatonin with Fluticasone Proprionate, Salmeterol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, melatonin might increase levels of drugs metabolized by CYP3A4.

Full Melatonin + Fluticasone Proprionate, Salmeterol answer

Can you take Passion Flower with Fluticasone Proprionate, Salmeterol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, passion flower might decrease the effects of CYP3A4 substrates.

Full Passion Flower + Fluticasone Proprionate, Salmeterol answer

Can you take Rhodiola with Fluticasone Proprionate, Salmeterol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.

Full Rhodiola + Fluticasone Proprionate, Salmeterol answer

Can you take Valerian with Fluticasone Proprionate, Salmeterol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.

Full Valerian + Fluticasone Proprionate, Salmeterol answer

Can you take Vitamin D with Fluticasone Proprionate, Salmeterol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Full Vitamin D + Fluticasone Proprionate, Salmeterol answer

Can you take Yohimbe with Fluticasone Proprionate, Salmeterol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.

Full Yohimbe + Fluticasone Proprionate, Salmeterol answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Fluticasone Proprionate, Salmeterol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, THC may increase the levels and clinical effects of CYP3A4 substrates.

Full Delta-9-tetrahydrocannabinol (thc) + Fluticasone Proprionate, Salmeterol answer

Can you take Eleuthero with Fluticasone Proprionate, Salmeterol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.

Full Eleuthero + Fluticasone Proprionate, Salmeterol answer

Can you take Gymnema with Fluticasone Proprionate, Salmeterol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.

Full Gymnema + Fluticasone Proprionate, Salmeterol answer

Can you take Humann Superbeets Heart Chews with Fluticasone Proprionate, Salmeterol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Full Humann Superbeets Heart Chews + Fluticasone Proprionate, Salmeterol answer

Can you take Jequirity with Fluticasone Proprionate, Salmeterol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro research shows that jequirity extract inhibits CYP3A4 enzymes.

Full Jequirity + Fluticasone Proprionate, Salmeterol answer

Can you take Kava with Fluticasone Proprionate, Salmeterol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if kava inhibits CYP3AA; research is conflicting.

Full Kava + Fluticasone Proprionate, Salmeterol answer

Can you take Milk Thistle with Fluticasone Proprionate, Salmeterol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if milk thistle inhibits CYP3A4; research is conflicting.

Full Milk Thistle + Fluticasone Proprionate, Salmeterol answer

Can you take Mommy's Bliss Gripe Water with Fluticasone Proprionate, Salmeterol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Mommy's Bliss Gripe Water contains fennel seed.

Full Mommy's Bliss Gripe Water + Fluticasone Proprionate, Salmeterol answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Fluticasone Proprionate, Salmeterol is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Fluticasone Proprionate, Salmeterol, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Fluticasone Proprionate, Salmeterol sits in 4 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Fluticasone Proprionate, Salmeterol through this category.

Beta-Adrenergic Agonists 15 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

15 of the supplement ingredients on this page reach Fluticasone Proprionate, Salmeterol through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Fluticasone Proprionate, Salmeterol through this category.

Topical Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Fluticasone Proprionate, Salmeterol through this category.

Related: does Fluticasone Proprionate, Salmeterol deplete any nutrients?

Fluticasone Proprionate, Salmeterol has 2 reported nutrient associations in the research literature — see the Fluticasone Proprionate, Salmeterol nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Fluticasone Proprionate, Salmeterol

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Fluticasone Proprionate, Salmeterol.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

Fluticasone Proprionate, Salmeterol & Supplements: Common Questions

What supplements interact with Fluticasone Proprionate, Salmeterol?
In our interaction database, 144 supplement and herbal ingredients have an interaction with Fluticasone Proprionate, Salmeterol on file — 7 rated major, 107 moderate, and 30 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Arsenic, Cesium.
Which Fluticasone Proprionate, Salmeterol supplement interactions are the most serious?
The 7 major-rated combinations — led by Grapefruit, Arsenic, Cesium, Ephedra and Sida Cordifolia — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Fluticasone Proprionate, Salmeterol?
That depends entirely on which supplement. The honest answer for Fluticasone Proprionate, Salmeterol is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Airduo Respiclick have the same supplement interactions as Fluticasone Proprionate, Salmeterol?
Yes — Airduo Respiclick all contain Fluticasone Proprionate, Salmeterol, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Fluticasone Proprionate, Salmeterol deplete any vitamins or nutrients?
It might — Fluticasone Proprionate, Salmeterol has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Fluticasone Proprionate, Salmeterol nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Fluticasone Proprionate, Salmeterol and my other medications?
This page covers Fluticasone Proprionate, Salmeterol against supplements and herbal ingredients. Checking Fluticasone Proprionate, Salmeterol against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 25, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.