Medication interaction hub

What Supplements Interact with Fosamprenavir?

Fosamprenavir brand names: Lexiva, Telzir. Every interaction below applies to the brands too.

143 Interactions 3 Major 100 Moderate 40 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Fosamprenavir? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Fosamprenavir against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Fosamprenavir (Lexiva, Telzir) keeps HIV suppressed only if its blood level stays where it belongs, so the 143 supplement interactions on file deserve real attention, not a shrug. Three are rated major and those are the ones to understand first. St. John's wort can drive levels down enough to risk treatment failure and viral resistance, grapefruit juice pushes levels of drugs handled by the CYP3A4 enzyme upward, and activated charcoal can soak up an oral dose before it ever absorbs.

Most of the remaining 100 moderate and 40 minor entries work through that same CYP3A4 pathway, some raising drug levels (schisandra, CBD among them), others lowering them, plus a smaller group that interferes with how oral doses absorb. With an HIV medicine, a dip in level is not just a weaker effect, it gives the virus room to adapt. Run any supplement past your pharmacist first.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 100 Minor 40 No known interaction 1,309

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Fosamprenavir: Top Interactions at a Glance

The Fosamprenavir supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 143 interacting ingredients — plus 1,309 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Fosamprenavir Combinations Today

The Fosamprenavir + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Hops + Fosamprenaviri

Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.

Read the full interaction Moderate Likelihood Possible Sweet Annie + Fosamprenaviri

Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.

Read the full interaction Minor Likelihood Possible Hibiscus Sabdariffa + Fosamprenaviri

Theoretically, Hibiscus sabdariffa extract might reduce the metabolism of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Adrafinil + Fosamprenaviri

Theoretically, drugs that inhibit CYP3A4 might increase the levels and clinical effects of adrafinil.

Read the full interaction Minor Likelihood Unlikely Milk Thistle + Fosamprenaviri

It is unclear if milk thistle inhibits CYP3A4; research is conflicting.

Read the full interaction Major Likelihood Likely Grapefruit + Fosamprenaviri

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction
The complete list

Every Supplement Checked Against Fosamprenavir

All 1,452 ingredients in our database, ranked by severity — 143 with a Fosamprenavir interaction on file and 1,309 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Fosamprenavir?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Hops with Fosamprenavir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.

Full Hops + Fosamprenavir answer

Can you take Sweet Annie with Fosamprenavir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.

Full Sweet Annie + Fosamprenavir answer

Can you take Hibiscus Sabdariffa with Fosamprenavir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Hibiscus sabdariffa extract might reduce the metabolism of CYP3A4 substrates.

Full Hibiscus Sabdariffa + Fosamprenavir answer

Can you take Adrafinil with Fosamprenavir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, drugs that inhibit CYP3A4 might increase the levels and clinical effects of adrafinil.

Full Adrafinil + Fosamprenavir answer

Can you take Milk Thistle with Fosamprenavir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if milk thistle inhibits CYP3A4; research is conflicting.

Full Milk Thistle + Fosamprenavir answer

Can you take Vitamin E with Fosamprenavir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.

Full Vitamin E + Fosamprenavir answer

Can you take White Pepper with Fosamprenavir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that piperine, a constituent of white pepper, inhibits cytochrome P450 3A4 (CYP3A4).

Full White Pepper + Fosamprenavir answer

Can you take Wild Cherry with Fosamprenavir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that wild cherry can inhibit cytochrome P450 3A4 (CYP3A4) enzymes.

Full Wild Cherry + Fosamprenavir answer

Can you take Yohimbe with Fosamprenavir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inhibitors might increase the levels and adverse effects of yohimbine, a constituent of yohimbe bark.

Full Yohimbe + Fosamprenavir answer

Can you take Zedoary with Fosamprenavir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zedoary might increase levels of drugs metabolized by CYP3A4.

Full Zedoary + Fosamprenavir answer

Can you take Thyroid Extract with Fosamprenavir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Fosamprenavir answer

Can you take Aegeline with Fosamprenavir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Aegeline inhibits cytochrome P450 3A4 (CYP3A4) activity in vitro.

Full Aegeline + Fosamprenavir answer

Can you take Agar with Fosamprenavir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Fosamprenavir answer

Can you take Algin with Fosamprenavir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Fosamprenavir answer

Can you take Ashwagandha with Fosamprenavir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.

Full Ashwagandha + Fosamprenavir answer

Can you take Atractylodes with Fosamprenavir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, atractylodes might increase the levels of CYP3A4 substrates.

Full Atractylodes + Fosamprenavir answer

Can you take Bael with Fosamprenavir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Bael and its constituents marmelosin and marmesinin inhibited cytochrome P450 3A4 (CYP3A4) activity in vitro.

Full Bael + Fosamprenavir answer

Can you take Black Psyllium with Fosamprenavir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Fosamprenavir answer

Can you take Blond Psyllium with Fosamprenavir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Fosamprenavir answer

Can you take Breadfruit with Fosamprenavir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, breadfruit might inhibit cytochrome P450 3A4 (CYP3A4) and increase levels of drugs metabolized by these enzymes; until more i...

Full Breadfruit + Fosamprenavir answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Fosamprenavir is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Fosamprenavir, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Fosamprenavir sits in 4 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Fosamprenavir through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Fosamprenavir through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Fosamprenavir through this category.

Protease Inhibitors (Pis) 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Fosamprenavir through this category.

About Fosamprenavir

Fosamprenavir is an HIV protease inhibitor used in combination with other antiretroviral medicines to treat HIV-1 infection.

Generic name: Fosamprenavir  ·  Brand names: Lexiva, Telzir.

See the full Fosamprenavir drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Fosamprenavir

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Fosamprenavir.

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Pharmacist Counseling Corner

Fosamprenavir & Supplements: Common Questions

What supplements interact with Fosamprenavir?
In our interaction database, 143 supplement and herbal ingredients have an interaction with Fosamprenavir on file — 3 rated major, 100 moderate, and 40 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, St. John's Wort, Activated Charcoal.
Which Fosamprenavir supplement interactions are the most serious?
The 3 major-rated combinations — led by Grapefruit, St. John's Wort and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Fosamprenavir?
That depends entirely on which supplement. The honest answer for Fosamprenavir is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Lexiva have the same supplement interactions as Fosamprenavir?
Yes — Lexiva, Telzir all contain Fosamprenavir, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Fosamprenavir and my other medications?
This page covers Fosamprenavir against supplements and herbal ingredients. Checking Fosamprenavir against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Fosamprenavir drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.