Interactions on record — worth a quick check against your medications. Based on 7 of 16 ingredients. Check your meds →
Dietary supplement

Flora Norm Ingredients & Drug Interactions

by Professional Botanicals

Flora Norm label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Flora Norm against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Flora Norm is a dietary supplement by Professional Botanicals with 16 active ingredients. Its ingredients are commonly taken for constipation and regularity, prebiotic gut health, blood sugar support.Based on those ingredients, 1,617 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus, Bifidobacterium longum infantis, Bifidobacterium bifidum. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Flora Norm by Professional Botanicals

Ask about any prescription or over-the-counter medication and we check it for interactions with Flora Norm by Professional Botanicals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Flora Norm by Professional Botanicals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 24 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (706 mg) without saying how much of each component you get.
  • “AdPT” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “EDS” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Flora Norm contains 24 ingredients that work on digestive support and general wellness. The active components include digestive enzymes—protease, lipase, and amylase—which help break down proteins, fats, and carbohydrates in your food.

It also contains multiple probiotic strains (live beneficial bacteria): Lactobacillus acidophilus, Lactobacillus salivarius, Bifidobacterium longum infantis, Lactobacillus plantarum, Bifidobacterium bifidum, Bifidobacterium longum, Lactobacillus casei, Streptococcus thermophilus, and Lactobacillus helveticus. These support your gut flora balance.

In addition, the formula includes adaptogenic herbs—eleuthero, ashwagandha, cordyceps, rhodiola, and reishi mushroom—along with gynostemma (jiaogulan), inulin (a prebiotic fiber), and apple pectin. The inactive ingredients are cellulose, water, and calcium stearate.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Support maintenance of normal intestinal flora.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Dysbiosis, Microbiome balance, Gastrointestinal health.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Pectin is rated "Insufficient Reliable Evidence To Rate" for Diarrhea.
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Clostridioides difficile infection.

Evidence on Flora Norm's overall effectiveness isn't established in the data we hold, since this is a multi-ingredient formula. However, individual ingredients have varying levels of support.

Lactobacillus acidophilus is possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. Bifidobacterium bifidum is possibly effective for IBS and respiratory tract infections.

Inulin is possibly effective for obesity, constipation, and diabetes. Apple pectin is possibly effective for high cholesterol.

Eleuthero is possibly effective for genital herpes. Ashwagandha is possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder (GAD).

Gynostemma is possibly effective for diabetes. Other ingredients lack reliable evidence—including cordyceps, rhodiola, reishi, lipase, and several probiotics—so their benefits aren't established.

The evidence, ingredient by ingredient Inulin Pectin Lactobacillus Acidophilus Bifidobacterium Longum Bifidobacterium Bifidum Streptococcus Thermophilus Lactobacillus Helveticus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 15 of the 15 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 15 of 15.
  • General safety write-ups exist for 15 of 15.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients are generally well tolerated for short-term use, though some carry cautions. The digestive enzymes (protease and lipase) are generally well tolerated but may cause digestive upset or allergic reactions; protease exposure (especially occupational) has rarely caused allergic rhinitis, conjunctivitis, or asthma.

The probiotic strains are generally well tolerated in healthy people, though rare cases of infection (bacteremia or sepsis) have occurred in critically ill or severely immunocompromised patients. Inulin commonly causes bloating, gas, constipation, or diarrhea, especially at doses over 30 grams, and anaphylaxis is rare but possible.

Eleuthero is generally well tolerated short-term but may cause diarrhea, heartburn, headache, nausea, rash, nervousness, and increased blood pressure (especially in children or those with heart disease). Ashwagandha is generally well tolerated but has rarely been linked to acute hepatitis, liver failure, and hepatic encephalopathy; it also may cause drowsiness, diarrhea, nausea, and vomiting.

Cordyceps, rhodiola, reishi, and gynostemma are generally well tolerated short-term but may cause gastrointestinal upset, dizziness, dry mouth, or nausea. Apple pectin is generally well tolerated but may trigger allergic reactions including anaphylaxis in sensitive individuals.

Side effects, ingredient by ingredient Inulin Pectin Lactobacillus Acidophilus Bifidobacterium Longum Bifidobacterium Bifidum Streptococcus Thermophilus Lactobacillus Helveticus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 12 of the 15 matched ingredients can interact with medications — Jiaogulan, Pectin, Cordyceps, Lactobacillus Acidophilus, Rhodiola, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications.
  • For scale: 1,618 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotics, separate them from this product since the live probiotics may be killed by the drugs. If you're on blood pressure medications, blood thinners (anticoagulants), or blood sugar drugs (antidiabetes medications), ask your pharmacist—eleuthero, ashwagandha, gynostemma, rhodiola, and reishi all interact with these.

If you take digoxin or lovastatin, check before using; apple pectin and eleuthero can affect how your body handles them. If you're on benzodiazepines, sedatives, thyroid hormone, or immune-suppressing drugs, run this product by your pharmacist first.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Flora Norm is a multi-ingredient digestive and adaptogenic formula that may appeal to you if you're seeking probiotic and enzyme support for digestion. If you take any prescription medications—especially antibiotics, blood pressure or blood sugar drugs, blood thinners, benzodiazepines, thyroid hormone, or immunosuppressants—you should check with your pharmacist before starting.

Short-term use is generally well tolerated, though digestive upset and bloating are common, and quality varies widely across supplement brands.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 16 of 24 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Flora Norm, straight from the product label.

Brand Professional Botanicals
Barcode (UPC) 898175001386
Net contents 90 Veg. Capsule(s)
Market status On market
Date entered into DSLD Jun 20, 2024
DSLD ID 308954
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Flora Norm by Professional Botanicals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
45
UPC/BARCODE
898175001386
IngredientAmount% DV
Proprietary Blend706 mg--
Amylase0 NP--
Protease0 NP--
Lipase0 NP--
Cellulase0 NP--
Lactobacillus acidophilus0 NP--
Lactobacillus salivarius0 NP--
Bifidobacterium longum infantis0 NP--
Lactobacillus plantarum0 NP--
Bifidobacterium bifidum0 NP--
Lactobacillus paracasei0 NP--
Bifidobacterium longum0 NP--
Eleuthero0 NP--
Lactobacillus casei0 NP--
Ashwagandha0 NP--
Inulin0 NP--
Apple Pectin0 NP--
Streptococcus thermophilus0 NP--
AdPT0 NP--
Gynostemma0 NP--
EDS0 NP--
Lactobacillus helveticus0 NP--
Cordyceps0 NP--
Rhodiola0 NP--
Reishi0 NP--
Lactobacillus rhamnosus0 NP--
Pediococcus acidilactici0 NP--
12 Strain Probiotic Blend400 mg--

Other ingredients: Cellulose, Water, Calcium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Made in USA

General Statements

2 Please recycle

Formula

Contains powerful blend of probiotics and prebiotics known to support maintenance of normal flora in the intestinal tract.

EDS: Added enzymes for better absorption & breakdown. AdPT: Adaptogenic herbs for energy production & adaptation.

Suggested/Recommended/Usage/Directions

Dosage: Two capsules two to four times a day, or as

Formulation

Gluten free Non GMO No fillers 3x tested

Premium quality

Brand IP Statement(s)

Professional Botanicals EST. 1980

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Flora Norm by Professional Botanicals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Flora Norm label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Flora Norm by Professional Botanicals

These are the 16 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

706 mg per serving

12 Strain Probiotic Blend

400 mg per serving

Other (inactive) ingredients: Cellulose, Water, Calcium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Flora Norm by Professional Botanicals Drug Interactions

Want to check YOUR meds against Flora Norm?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,617Drugs
1,308 Moderate 309 Minor

Ingredients driving the most interactions

Lactobacillus acidophilus 182
Bifidobacterium longum infantis 182
Bifidobacterium bifidum 182
Lactobacillus helveticus 182
Inulin 86

Individual Drug Interactions

The ingredients in Flora Norm interact with 1,617 drugs. Click any drug to see the details.

6 of the 16 ingredients in Flora Norm interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus Bifidobacterium longum infantis Bifidobacterium bifidum Lactobacillus helveticus Inulin Apple Pectin

Each ingredient & the kinds of drugs it affects

For each ingredient in Flora Norm with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus full monograph & interactions

Bifidobacterium longum infantis1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum infantis full monograph & interactions

Bifidobacterium bifidum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium bifidum full monograph & interactions

Lactobacillus helveticus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus helveticus with antibiotic drugs might decrease the effectiveness of L. helveticus.
Lactobacillus helveticus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. helveticus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus helveticus full monograph & interactions

Inulin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, inulin might increase the risk of hypoglycemia with antidiabetes drugs.
Some clinical research shows that inulin improves glycemic control in patients with diabetes; however, it is unclear if it has hypoglycemic effects.

Likelihood Unlikely Evidence D
Inulin full monograph & interactions

Apple Pectin3 drug types · 23 drugs

Digoxin (Lanoxin)

Theoretically, pectin might reduce the absorption of digoxin, potentially decreasing its effectiveness.
A small clinical study shows that taking digoxin with a kaolin-pectin suspension reduces the absorption of digoxin by about 62%. It is unclear if these effects are due to pectin, kaolin, or the combination.

Likelihood Possible Evidence B
Lovastatin (Mevacor)

Theoretically, pectin might reduce the absorption of lovastatin, potentially decreasing its effectiveness.
Case reports suggest that concomitant use of pectin and lovastatin might reduce the cholesterol-lowering effect of lovastatin, possibly due to reduced intestinal absorption of lovastatin.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
A small clinical study shows that taking tetracycline with bismuth subsalicylate in a kaolin-pectin suspension reduces the absorption of tetracycline by about 34%. It is unclear if these effects are due to pectin, kaolin, bismuth subsalicylate, or the combination.

Likelihood Possible Evidence B
Apple Pectin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Flora Norm, from the product label.

Professional Botanicals

See all Professional Botanicals products
Name
Professional Botanicals
City
Ogden
State
UT
ZipCode
84404
Phone Number
877-745-0850
Web Address
ProfessionalBotanicals.com
Pharmacist Counseling Corner

Flora Norm by Professional Botanicals: Common Questions

Does Flora Norm by Professional Botanicals interact with any medications?
Yes. Based on its ingredients, Flora Norm has a known interaction with 1,617 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Flora Norm contains 16 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Flora Norm if I'm pregnant or breastfeeding?
The data vary by ingredient. Eleuthero, ashwagandha, cordyceps, rhodiola, reishi, and gynostemma should be avoided in pregnancy and breastfeeding because safety hasn't been established. Bifidobacterium longum infantis and Bifidobacterium longum are possibly safe in pregnancy. Lactobacillus helveticus, inulin, and apple pectin have limited safety data in pregnancy and breastfeeding—talk to your doctor or pharmacist for personalized guidance. For other probiotics and enzymes, safety data aren't on file, so check with your healthcare provider.
What are the enzymes in this product for?
The enzymes—protease, lipase, and amylase—help break down different parts of your food. Protease breaks down proteins, lipase breaks down fats, and amylase breaks down carbohydrates. They're meant to support your digestive system.
Will this cause bloating or gas?
Yes, it's common. Inulin (a prebiotic fiber in the formula) often causes bloating, gas, constipation, or diarrhea, especially at higher doses. The probiotics may also cause mild gastrointestinal upset when you first start. These effects usually settle down with time.
Is there evidence that Flora Norm actually works?
We don't have effectiveness data for the complete formula. However, some individual ingredients—like Lactobacillus acidophilus for IBS, inulin for constipation, and ashwagandha for stress—have research showing they may be helpful. Others, like cordyceps and rhodiola, lack reliable evidence. The overall benefit depends on your specific health goal.
What if I'm allergic to eggs or dairy?
The product facts don't specify allergen information beyond the ingredients listed. If you have egg or dairy allergies, contact the manufacturer or check the label for allergen statements, since some probiotic strains are cultured on dairy-containing media.
Can I take this with other supplements?
That depends on what you're taking. If your other supplements contain ingredients that affect blood pressure, blood sugar, immune function, or how your liver processes drugs, there could be an interaction. It's safest to run all your supplements and medications by your pharmacist at once.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Flora Norm is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Flora Norm label
Go deeper

The Full Monographs Behind Flora Norm’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Inulin

Interacts with 86 drugs

Inulin is a type of plant fiber (a prebiotic) found naturally in foods like chicory root, onions, and garlic, and it is widely added to supplements and processed foods. It may help with regu...

Read the full Inulin monograph → Herb & supplement monograph

Pectin

Interacts with 23 drugs

Pectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly help with cholesterol, blood sugar, and di...

Read the full Pectin monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Streptococcus Thermophilus

Streptococcus thermophilus is a friendly bacterium used as a probiotic, often combined with other strains in yogurt and supplements. It is generally well tolerated in healthy people and may...

Read the full Streptococcus Thermophilus monograph → Herb & supplement monograph

Lactobacillus Helveticus

Interacts with 182 drugs

Lactobacillus helveticus is a lactic acid bacterium used as a probiotic, often combined with other strains in mood, gut, and general wellness products. Early research is interesting—especial...

Read the full Lactobacillus Helveticus monograph →
Sources

Sources & How We Checked

Flora Norm's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 206 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
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Eleuthero 24 references
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Ashwagandha 32 references
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Inulin 17 references
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Pectin 11 references
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Streptococcus Thermophilus 21 references
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Jiaogulan 8 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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