Glucagon

24 interactions 3 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Amitriptyline Trospium / Xanomeline Ipratropium Oral Inhalation Atropine Ophthalmic Cyclopentolate Ophthalmic Diphenhydramine Injection

10 Major 14 Moderate

All (24) Major (10) Moderate (14)

Major

Glucagon Amitriptyline Elavil Explained Increased risk of gastrointestinal side effects Details Glucagon Trospium / Xanomeline Cobenfy Explained Increased risk of gastrointestinal side effects Details Glucagon Aclidinium Oral Inhalation Tudorza Increased risk of gastrointestinal side effects Details Glucagon Atropine Ophthalmic Atropine Care 1% Increased risk of gastrointestinal side effects Details Glucagon Cyclopentolate Ophthalmic Akpentolate® Increased risk of gastrointestinal side effects Details Glucagon Diphenhydramine Injection Banophen Increased risk of gastrointestinal side effects Details Glucagon Diphenhydramine Topical Afterbite with Antihistamine Increased risk of gastrointestinal side effects Details Glucagon Glycopyrronium Topical Cuvposa® Increased risk of gastrointestinal side effects Details Glucagon Ipratropium Nasal Spray Atrovent Nasal Spray® Increased risk of gastrointestinal side effects Details Glucagon Ipratropium Oral Inhalation Atrovent® HFA Increased risk of gastrointestinal side effects Details

Moderate

Glucagon Atenolol Tenormin Explained A transient increase in pulse and blood pressure Details Glucagon Acebutolol Sectral® A transient increase in pulse and blood pressure Details Glucagon Betaxolol Betoptic S A transient increase in pulse and blood pressure Details Glucagon Betaxolol Ophthalmic Betoptic® A transient increase in pulse and blood pressure Details Glucagon Bisoprolol Zebeta® A transient increase in pulse and blood pressure Details Glucagon Esmolol Brevibloc A transient increase in pulse and blood pressure Details Glucagon Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Decreased blood glucose-lowering effects; interference with glucagon action Details Glucagon Insulin Detemir (Rdna Origin) Injection Levemir Decreased blood glucose-lowering effects; interference with glucagon action Details Glucagon Insulin Glulisine (Rdna Origin) Injection Apidra Decreased blood glucose-lowering effects; interference with glucagon action Details Glucagon Labetalol Normodyne® A transient increase in pulse and blood pressure Details Glucagon Levobunolol Ophthalmic AKBeta® A transient increase in pulse and blood pressure Details Glucagon Nadolol Corgard A transient increase in pulse and blood pressure Details Glucagon Nebivolol Bystolic A transient increase in pulse and blood pressure Details Glucagon Penbutolol Levatol® A transient increase in pulse and blood pressure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.