Medication interaction hub

What Supplements Interact with Codeine Phosphate, Pseudoephedrine, Triprolidine?

Codeine Phosphate, Pseudoephedrine, Triprolidine brand name: CoActifed. Every interaction below applies to the brands too.

176 Interactions 11 Major 142 Moderate 23 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Codeine Phosphate, Pseudoephedrine, Triprolidine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Codeine Phosphate, Pseudoephedrine, Triprolidine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Alcohol is the standout risk here. Beer and wine both carry major ratings against CoActifed (codeine phosphate, pseudoephedrine, and triprolidine), backed by solid human evidence, because drinking deepens the drowsiness and can dangerously slow breathing on a codeine-containing medicine. That same sedative stacking runs through most of the list, with 78 of the 176 ingredients on file adding to it and 11 rated major overall. I would treat this list with real care, starting with those major entries.

The pseudoephedrine pulls the other direction. Forty-four ingredients act as stimulants, so even everyday caffeine can add jitteriness and blood pressure strain on top of the decongestant. Activated charcoal, also rated major, can keep the medicine from absorbing properly, so separate the two by a wide margin. Most of the 142 moderate and 23 minor entries repeat these same sedative or stimulant themes, just at lower intensity.

— , Clinical Pharmacist · July 18, 2026

Major 11 Moderate 142 Minor 23 No known interaction 1,276

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Codeine Phosphate, Pseudoephedrine, Triprolidine: Top Interactions at a Glance

The Codeine Phosphate, Pseudoephedrine, Triprolidine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 176 interacting ingredients — plus 1,276 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Codeine Phosphate, Pseudoephedrine, Triprolidine Combinations Today

The Codeine Phosphate, Pseudoephedrine, Triprolidine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Yohimbe + Codeine Phosphate, Pseudoephedrine, Triprolidinei

Theoretically, yohimbe might increase the levels and adverse effects of CYP2D6 substrates.

Read the full interaction Minor Likelihood Possible Fucus Vesiculosus + Codeine Phosphate, Pseudoephedrine, Triprolidinei

Theoretically, concomitant use of Fucus vesiculosus with CYP2D6 substrates might alter the effects of these substrates.

Read the full interaction Moderate Likelihood Possible Anise + Codeine Phosphate, Pseudoephedrine, Triprolidinei

Theoretically, anise oil might increase the effects and adverse effects of codeine.

Read the full interaction Moderate Likelihood Possible Oregon Grape + Codeine Phosphate, Pseudoephedrine, Triprolidinei

Theoretically, Oregon grape might increase the sedative effects of CNS depressants.

Read the full interaction Moderate Likelihood Possible Cinchona + Codeine Phosphate, Pseudoephedrine, Triprolidinei

Theoretically, taking cinchona might inhibit cytochrome P450 2D6 (CYP2D6) and increase levels of drugs metabolized by this enzyme.

Read the full interaction Major Likelihood Likely Beer + Codeine Phosphate, Pseudoephedrine, Triprolidinei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Codeine Phosphate, Pseudoephedrine, Triprolidine

All 1,452 ingredients in our database, ranked by severity — 176 with a Codeine Phosphate, Pseudoephedrine, Triprolidine interaction on file and 1,276 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Codeine Phosphate, Pseudoephedrine, Triprolidine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Yohimbe with Codeine Phosphate, Pseudoephedrine, Triprolidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, yohimbe might increase the levels and adverse effects of CYP2D6 substrates.

Full Yohimbe + Codeine Phosphate, Pseudoephedrine, Triprolidine answer

Can you take Fucus Vesiculosus with Codeine Phosphate, Pseudoephedrine, Triprolidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of Fucus vesiculosus with CYP2D6 substrates might alter the effects of these substrates.

Full Fucus Vesiculosus + Codeine Phosphate, Pseudoephedrine, Triprolidine answer

Can you take Anise with Codeine Phosphate, Pseudoephedrine, Triprolidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, anise oil might increase the effects and adverse effects of codeine.

Full Anise + Codeine Phosphate, Pseudoephedrine, Triprolidine answer

Can you take Oregon Grape with Codeine Phosphate, Pseudoephedrine, Triprolidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase the sedative effects of CNS depressants.

Full Oregon Grape + Codeine Phosphate, Pseudoephedrine, Triprolidine answer

Can you take Cinchona with Codeine Phosphate, Pseudoephedrine, Triprolidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cinchona might inhibit cytochrome P450 2D6 (CYP2D6) and increase levels of drugs metabolized by this enzyme.

Full Cinchona + Codeine Phosphate, Pseudoephedrine, Triprolidine answer

Can you take Cannabichromene (cbc) with Codeine Phosphate, Pseudoephedrine, Triprolidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Using cannabichromene with drugs that have sedative properties may cause additive therapeutic and adverse effects.

Full Cannabichromene (cbc) + Codeine Phosphate, Pseudoephedrine, Triprolidine answer

Can you take Cannabidiol (cbd) with Codeine Phosphate, Pseudoephedrine, Triprolidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabidiol might have additive effects if used with other CNS depressants.

Full Cannabidiol (cbd) + Codeine Phosphate, Pseudoephedrine, Triprolidine answer

Can you take Cannabis with Codeine Phosphate, Pseudoephedrine, Triprolidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis might have additive effects if used with other CNS depressants.

Full Cannabis + Codeine Phosphate, Pseudoephedrine, Triprolidine answer

Can you take Caraway with Codeine Phosphate, Pseudoephedrine, Triprolidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caraway might increase the effects and adverse effects of CNS depressants.

Full Caraway + Codeine Phosphate, Pseudoephedrine, Triprolidine answer

Can you take Catnip with Codeine Phosphate, Pseudoephedrine, Triprolidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Full Catnip + Codeine Phosphate, Pseudoephedrine, Triprolidine answer

Can you take Ceylon Leadwort with Codeine Phosphate, Pseudoephedrine, Triprolidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2D6 (CYP2D6) in vitro.

Full Ceylon Leadwort + Codeine Phosphate, Pseudoephedrine, Triprolidine answer

Can you take Clove with Codeine Phosphate, Pseudoephedrine, Triprolidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2D6.

Full Clove + Codeine Phosphate, Pseudoephedrine, Triprolidine answer

Can you take Cnidium with Codeine Phosphate, Pseudoephedrine, Triprolidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In laboratory research, cnidium has been shown to have sedative and hypnotic effects, possibly related to constituent coumarins.

Full Cnidium + Codeine Phosphate, Pseudoephedrine, Triprolidine answer

Can you take Coriander with Codeine Phosphate, Pseudoephedrine, Triprolidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.

Full Coriander + Codeine Phosphate, Pseudoephedrine, Triprolidine answer

Can you take Corn Poppy with Codeine Phosphate, Pseudoephedrine, Triprolidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of corn poppy with CNS depressants might increase the risk of sedation.

Full Corn Poppy + Codeine Phosphate, Pseudoephedrine, Triprolidine answer

Can you take Corydalis Yanhusuo with Codeine Phosphate, Pseudoephedrine, Triprolidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Corydalis yanhusuo might increase the sedative effects of CNS depressants.

Full Corydalis Yanhusuo + Codeine Phosphate, Pseudoephedrine, Triprolidine answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Codeine Phosphate, Pseudoephedrine, Triprolidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, THC might have additive effects if used with other CNS depressants.

Full Delta-9-tetrahydrocannabinol (thc) + Codeine Phosphate, Pseudoephedrine, Triprolidine answer

Can you take Dendrobium with Codeine Phosphate, Pseudoephedrine, Triprolidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. The dendrobium constituent dendrobine is reported to have convulsant effects.

Full Dendrobium + Codeine Phosphate, Pseudoephedrine, Triprolidine answer

Can you take Dimethylhexylamine (dmha) with Codeine Phosphate, Pseudoephedrine, Triprolidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining DMHA with stimulant drugs might increase the risk of adverse cardiovascular effects.

Full Dimethylhexylamine (dmha) + Codeine Phosphate, Pseudoephedrine, Triprolidine answer

Can you take Elecampane with Codeine Phosphate, Pseudoephedrine, Triprolidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.

Full Elecampane + Codeine Phosphate, Pseudoephedrine, Triprolidine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Codeine Phosphate, Pseudoephedrine, Triprolidine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Codeine Phosphate, Pseudoephedrine, Triprolidine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Codeine Phosphate, Pseudoephedrine, Triprolidine sits in 9 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Codeine Phosphate, Pseudoephedrine, Triprolidine through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Codeine Phosphate, Pseudoephedrine, Triprolidine through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Codeine Phosphate, Pseudoephedrine, Triprolidine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Codeine Phosphate, Pseudoephedrine, Triprolidine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Codeine Phosphate, Pseudoephedrine, Triprolidine through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Codeine Phosphate, Pseudoephedrine, Triprolidine through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Codeine Phosphate, Pseudoephedrine, Triprolidine through this category.

Codeine 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Codeine Phosphate, Pseudoephedrine, Triprolidine through this category.

Pseudoephedrine (Sudafed) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Codeine Phosphate, Pseudoephedrine, Triprolidine through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Codeine Phosphate, Pseudoephedrine, Triprolidine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Codeine Phosphate, Pseudoephedrine, Triprolidine.

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Products that contain Codeine Phosphate, Pseudoephedrine, Triprolidine-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Codeine Phosphate, Pseudoephedrine, Triprolidine.

Carda Lean by BS Supplements contains Ephedra Lean 40 by First Choice Supplements contains Ephedra Lipodrene with 25 mg Ephedra Extract by Hi-Tech Pharmaceuticals contains Ephedra Stimerex-ES by HTP Hi-Tech Pharmaceuticals contains Ephedra
Pharmacist Counseling Corner

Codeine Phosphate, Pseudoephedrine, Triprolidine & Supplements: Common Questions

What supplements interact with Codeine Phosphate, Pseudoephedrine, Triprolidine?
In our interaction database, 176 supplement and herbal ingredients have an interaction with Codeine Phosphate, Pseudoephedrine, Triprolidine on file — 11 rated major, 142 moderate, and 23 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Beer, Wine, 1,4-butanediol.
Which Codeine Phosphate, Pseudoephedrine, Triprolidine supplement interactions are the most serious?
The 11 major-rated combinations — led by Beer, Wine, 1,4-butanediol, Activated Charcoal and Ephedra — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Codeine Phosphate, Pseudoephedrine, Triprolidine?
That depends entirely on which supplement. The honest answer for Codeine Phosphate, Pseudoephedrine, Triprolidine is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like CoActifed have the same supplement interactions as Codeine Phosphate, Pseudoephedrine, Triprolidine?
Yes — CoActifed all contain Codeine Phosphate, Pseudoephedrine, Triprolidine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Codeine Phosphate, Pseudoephedrine, Triprolidine and my other medications?
This page covers Codeine Phosphate, Pseudoephedrine, Triprolidine against supplements and herbal ingredients. Checking Codeine Phosphate, Pseudoephedrine, Triprolidine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.