Medication interaction hub

What Supplements Interact with Isosorbide Dinitrate, Hydralazine?

Isosorbide Dinitrate, Hydralazine brand name: BiDil. Every interaction below applies to the brands too.

137 Interactions 6 Major 110 Moderate 21 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Isosorbide Dinitrate, Hydralazine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Isosorbide Dinitrate, Hydralazine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

BiDil pairs isosorbide dinitrate with hydralazine to relax blood vessels in failing hearts, which is why the 137 supplements on this list deserve genuine care. Nearly all act on blood pressure, either stacking with the drug and dropping it too far or pushing back and undoing the treatment. Six carry a major rating and are the ones to understand first; hawthorn, for instance, widens vessels on its own, on top of two drugs already doing that job.

Even the moderates matter when a heart depends on steady pressure control, and 110 of the 137 sit in that tier (another 21 rate minor), everyday fish oil included. A smaller group of 17, activated charcoal chief among them, can bind the dose in the gut and blunt it, so space those well apart from the medication. Sudden lightheadedness or dizziness is the cue to review what else you took that day.

— , Clinical Pharmacist · July 18, 2026

Major 6 Moderate 110 Minor 21 No known interaction 1,315

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Isosorbide Dinitrate, Hydralazine: Top Interactions at a Glance

The Isosorbide Dinitrate, Hydralazine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 137 interacting ingredients — plus 1,315 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Isosorbide Dinitrate, Hydralazine Combinations Today

The Isosorbide Dinitrate, Hydralazine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Major Likelihood Probable Hawthorn + Isosorbide Dinitrate, Hydralazinei

Theoretically, concomitant use might cause additive coronary vasodilatory effects.

Read the full interaction Major Likelihood Probable Coleus + Isosorbide Dinitrate, Hydralazinei

Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.

Read the full interaction Moderate Likelihood Possible Ashwagandha + Isosorbide Dinitrate, Hydralazinei

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Possible Vitamin B6 + Isosorbide Dinitrate, Hydralazinei

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.

Read the full interaction Moderate Likelihood Possible Niacin + Isosorbide Dinitrate, Hydralazinei

Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.

Read the full interaction Moderate Likelihood Probable L-arginine + Isosorbide Dinitrate, Hydralazinei

Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.

Read the full interaction
The complete list

Every Supplement Checked Against Isosorbide Dinitrate, Hydralazine

All 1,452 ingredients in our database, ranked by severity — 137 with a Isosorbide Dinitrate, Hydralazine interaction on file and 1,315 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Isosorbide Dinitrate, Hydralazine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Hawthorn with Isosorbide Dinitrate, Hydralazine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use might cause additive coronary vasodilatory effects.

Full Hawthorn + Isosorbide Dinitrate, Hydralazine answer

Can you take Coleus with Isosorbide Dinitrate, Hydralazine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.

Full Coleus + Isosorbide Dinitrate, Hydralazine answer

Can you take Ashwagandha with Isosorbide Dinitrate, Hydralazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.

Full Ashwagandha + Isosorbide Dinitrate, Hydralazine answer

Can you take Vitamin B6 with Isosorbide Dinitrate, Hydralazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.

Full Vitamin B6 + Isosorbide Dinitrate, Hydralazine answer

Can you take Niacin with Isosorbide Dinitrate, Hydralazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.

Full Niacin + Isosorbide Dinitrate, Hydralazine answer

Can you take Adrafinil with Isosorbide Dinitrate, Hydralazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, adrafinil might reduce the effects of antihypertensive drugs.

Full Adrafinil + Isosorbide Dinitrate, Hydralazine answer

Can you take Agmatine with Isosorbide Dinitrate, Hydralazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.

Full Agmatine + Isosorbide Dinitrate, Hydralazine answer

Can you take Algal Oil with Isosorbide Dinitrate, Hydralazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking algal oil with antihypertensive drugs might increase the risk of hypotension.

Full Algal Oil + Isosorbide Dinitrate, Hydralazine answer

Can you take Andrographis with Isosorbide Dinitrate, Hydralazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.

Full Andrographis + Isosorbide Dinitrate, Hydralazine answer

Can you take Artichoke with Isosorbide Dinitrate, Hydralazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.

Full Artichoke + Isosorbide Dinitrate, Hydralazine answer

Can you take Asafoetida with Isosorbide Dinitrate, Hydralazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that asafoetida has hypotensive effects.

Full Asafoetida + Isosorbide Dinitrate, Hydralazine answer

Can you take Ash with Isosorbide Dinitrate, Hydralazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of ash seed with antihypertensive drugs might have additive blood pressure lowering effects.

Full Ash + Isosorbide Dinitrate, Hydralazine answer

Can you take Baikal Skullcap with Isosorbide Dinitrate, Hydralazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Baikal skullcap with antihypertensive drugs might have additive effects and increase the risk of hypotensi...

Full Baikal Skullcap + Isosorbide Dinitrate, Hydralazine answer

Can you take Basil with Isosorbide Dinitrate, Hydralazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, basil might increase the risk of hypotension when taken with antihypertensive drugs.

Full Basil + Isosorbide Dinitrate, Hydralazine answer

Can you take Berberine with Isosorbide Dinitrate, Hydralazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might have additive effects with antihypertensive drugs.

Full Berberine + Isosorbide Dinitrate, Hydralazine answer

Can you take Beta-glucans with Isosorbide Dinitrate, Hydralazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.

Full Beta-glucans + Isosorbide Dinitrate, Hydralazine answer

Can you take Betony with Isosorbide Dinitrate, Hydralazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, betony might have additive effects with blood pressure lowering drugs due to hypotensive activity of the glycosides found in...

Full Betony + Isosorbide Dinitrate, Hydralazine answer

Can you take Black Seed with Isosorbide Dinitrate, Hydralazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.

Full Black Seed + Isosorbide Dinitrate, Hydralazine answer

Can you take Blue Cohosh with Isosorbide Dinitrate, Hydralazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Constituents in blue cohosh might increase blood pressure by causing coronary vasoconstriction.

Full Blue Cohosh + Isosorbide Dinitrate, Hydralazine answer

Can you take Breadfruit with Isosorbide Dinitrate, Hydralazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with antihypertensive drugs might increase the risk of hypotension.

Full Breadfruit + Isosorbide Dinitrate, Hydralazine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Isosorbide Dinitrate, Hydralazine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Isosorbide Dinitrate, Hydralazine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Isosorbide Dinitrate, Hydralazine sits in 4 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Isosorbide Dinitrate, Hydralazine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Isosorbide Dinitrate, Hydralazine through this category.

Vasodilators 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Isosorbide Dinitrate, Hydralazine through this category.

Nitrates 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Isosorbide Dinitrate, Hydralazine through this category.

Related: does Isosorbide Dinitrate, Hydralazine deplete any nutrients?

Isosorbide Dinitrate, Hydralazine has 2 reported nutrient associations in the research literature — see the Isosorbide Dinitrate, Hydralazine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Isosorbide Dinitrate, Hydralazine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Isosorbide Dinitrate, Hydralazine.

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Pharmacist Counseling Corner

Isosorbide Dinitrate, Hydralazine & Supplements: Common Questions

What supplements interact with Isosorbide Dinitrate, Hydralazine?
Our database currently documents 137 ingredients with a known Isosorbide Dinitrate, Hydralazine interaction (6 major, 110 moderate, 21 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 137. The highest-ranked right now: American Hellebore, Tyramine, Activated Charcoal.
Which Isosorbide Dinitrate, Hydralazine supplement interactions are the most serious?
The 6 major-rated combinations — led by American Hellebore, Tyramine, Activated Charcoal, American Mistletoe and Coleus — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Isosorbide Dinitrate, Hydralazine?
Plenty of supplements coexist fine with Isosorbide Dinitrate, Hydralazine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like BiDil have the same supplement interactions as Isosorbide Dinitrate, Hydralazine?
Yes — BiDil all contain Isosorbide Dinitrate, Hydralazine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Isosorbide Dinitrate, Hydralazine deplete any vitamins or nutrients?
It might — Isosorbide Dinitrate, Hydralazine has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Isosorbide Dinitrate, Hydralazine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Isosorbide Dinitrate, Hydralazine and my other medications?
This page covers Isosorbide Dinitrate, Hydralazine against supplements and herbal ingredients. Checking Isosorbide Dinitrate, Hydralazine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.