Lofepramine
51 interactions 4 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Diclofenac Ophthalmic
Dolasetron
Ibuprofen
Diclofenac Topical (Actinic Keratosis)
Mefenamic Acid
Palonosetron Injection
Major
Lofepramine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Lofepramine Sertraline Explained Modest elevations in lofepramine exposure and an increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, ment... Details Lofepramine Albuterol Oral Inhalation Accuneb® Explained An increased risk of cardiovascular system effects Details Lofepramine Buprenorphine Belbuca Explained An increased risk of serotonin syndrome Details Lofepramine Aspirin Acuprin® An increased risk of bleeding Details Lofepramine Aspirin Rectal Aspirin An increased risk of bleeding Details Lofepramine Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Lofepramine Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Lofepramine Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Lofepramine Clonidine Transdermal Patch Catapres Reduced antihypertensive effects and may counteract the hypotensive effects of cloNIDine Details Lofepramine Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Lofepramine Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Lofepramine Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Lofepramine Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Lofepramine Dolasetron Anzemet Increased risk of serotonin syndrome Details Lofepramine Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Lofepramine Etodolac Lodine An increased risk of bleeding Details Lofepramine Fenoprofen Fenopron An increased risk of bleeding Details Lofepramine Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome Details Lofepramine Flurbiprofen Ansaid An increased risk of bleeding Details Lofepramine Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Lofepramine Gatifloxacin Ophthalmic Zymar® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Lofepramine Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Lofepramine Granisetron Injection Granisol Increased risk of serotonin syndrome Details Lofepramine Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome Details Lofepramine Hydromorphone Rectal available generically Increased risk of serotonin syndrome Details Lofepramine Hydroxychloroquine Plaquenil An increased risk of seizures Details Lofepramine Ibuprofen Addaprin An increased risk of bleeding Details Lofepramine Ketoprofen Actron® An increased risk of bleeding Details Lofepramine Ketorolac Acular An increased risk of bleeding Details Lofepramine Ketorolac Injection Acular An increased risk of bleeding Details Lofepramine Ketorolac Nasal Spray Sprix An increased risk of bleeding Details Lofepramine Ketorolac Ophthalmic Acular An increased risk of bleeding Details Lofepramine Linezolid Injection Zyvox An increased risk of serotonin syndrome Details Lofepramine Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Lofepramine Meclofenamate Meclodium® An increased risk of bleeding Details Lofepramine Mefenamic Acid Ponstel® An increased risk of bleeding Details Lofepramine Meloxicam Alloxate An increased risk of bleeding Details Lofepramine Meloxicam Injection Alloxate An increased risk of bleeding Details Lofepramine Morphine Injection Astramorph® PF Increased risk of serotonin syndrome DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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