Drug & supplement interaction

Coffee + Bacitracin, Neomycin , Polymyxin B

Bacitracin, Neomycin , Polymyxin B brand names: Neosporin Ophthalmic Ointment, Neosporin.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Coffee and Bacitracin, Neomycin , Polymyxin B in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Coffee and Bacitracin, Neomycin , Polymyxin B

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Bacitracin, Neomycin , Polymyxin B and Coffee in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Coffee safety at a glance

Coffee overall Use caution Moderate intake is generally safe for healthy adults, but high amounts can cause side effects.
Pregnancy Possibly Safe When used orally in moderate amounts. Intake of caffeine from coffee and other sources should be monitored during pregnancy. Caffeine crosses the human placenta... Read the full pregnancy detail
Breastfeeding Possibly Safe When used orally. Drinking one or two caffeine-containing beverages daily during lactation is not associated with unacceptable levels of caffeine in human milk. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Bacitracin, Neomycin , Polymyxin B and Coffee? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Bacitracin, Neomycin , Polymyxin B

Interactions in our licensed database are recorded against drug classes, not just single drug names. Bacitracin, Neomycin , Polymyxin B is filed under a single classification — topical drugs. Coffee has documented interactions with 33 drug classes — the most serious being ephedrine (major), adenosine (adenocard) (moderate) and alendronate (fosamax) (moderate) — and none of Bacitracin, Neomycin , Polymyxin B’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Coffee Does Interact With Other Medications

Coffee has 8 major, 467 moderate, 116 minor known drug interactions in our database — Bacitracin, Neomycin , Polymyxin B isn’t one of them. If you take anything else, check it against the full list below.

Major 8 Moderate 467 Minor 116 No known interaction 2,239 (incl. Bacitracin, Neomycin , Polymyxin B)
Taking anything else?

Check Another of Your Medications Against Coffee

Covers the 2,830 medications we’ve checked against Coffee. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Coffee and Bacitracin, Neomycin , Polymyxin B May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • A severe allergic reaction Worth acting on Additional detail

    Coffee

    “Caffeine can cause anaphylaxis in sensitive individuals, although true IgE-mediated caffeine allergy seems to be relatively rare.

    Rectally, coffee enemas have been linked to septicemia leading to death.”

    Coffee · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    5 sources cited
    1. 11315. Infante S, Baeza ML, Calvo M, et al. Anaphylaxis due to caffeine. Allergy 2003;58:681-2. PubMed
    2. 3026. Margolin KA, Green MR. Polymicrobial enteric septicemia from coffee enemas. West J Med 1984;140:460.
    3. 3347. Green S. A critique of the rationale for cancer treatment with coffee enemas and diet. JAMA 1992;268:3224-7. DOI
    4. 3349. Shils ME, Herman MG. Unproved dietary claims in the treatment of patients with cancer. Bull N Y Acad Med 1982;58:323-39.
    5. 6652. Brown BT. Treating cancer with coffee enemas and diet. JAMA 1993;269:1635-6. DOI

    Bacitracin, Neomycin , Polymyxin B

    Listed in the ADVERSE REACTIONS section of the FDA label for Bacitracin, Neomycin , Polymyxin B. Read the label on DailyMed ›

  • Swelling Additional detail

    Coffee

    “Orally, excessive doses of caffeine can cause massive catecholamine release and subsequent metabolic acidosis, hyperglycemia, and ketosis. Other symptoms include hypokalemia and respiratory alkalosis.

    Some evidence shows that caffeine, a constituent of coffee, is associated with fibrocystic breast disease, breast cancer, and endometriosis in females; however, this is controversial since findings are conflicting.”

    Coffee · Natural Medicines adverse-effect record, reported in breast cancer.

    6 sources cited
    1. 13734. Benowitz NL, Osterloh J, Goldschlager N, et al. Massive catecholamine release from caffeine poisoning. JAMA 1982;248:1097-8. DOI
    2. 11832. Institute of Medicine. Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. Washington, DC: National Academy Press, 2001. Available at: http://books.nap.edu/books/0309082587/html/index.html. DOI
    3. 11838. Holmgren P, Norden-Pettersson L, Ahlner J. Caffeine fatalities--four case reports. Forensic Sci Int 2004;139:71-3. PubMed
    4. 13735. Leson CL, McGuigan MA, Bryson SM. Caffeine overdose in an adolescent male. J Toxicol Clin Toxicol 1988;26:407-15. PubMed
    5. 8043. Ferrini RL, Barrett-Connor E. Caffeine intake and endogenous sex steroid levels in postmenopausal women. The Rancho Bernardo Study. Am J Epidemiol 1996:144:642-4. PubMed
    6. 8996. Horner NK, Lampe JW. Potential mechanisms of diet therapy for fibrocystic breast conditions show inadequate evidence of effectiveness. J Am Diet Assoc 2000;100:1368-80. PubMed

    Bacitracin, Neomycin , Polymyxin B

    Listed in the ADVERSE REACTIONS section of the FDA label for Bacitracin, Neomycin , Polymyxin B. Read the label on DailyMed ›

Reported for Coffee but not commonly for Bacitracin, Neomycin , Polymyxin B: trouble concentrating, dependence or withdrawal symptoms, raised blood pressure and fainting.

Effects for Bacitracin, Neomycin , Polymyxin B come from the ADVERSE REACTIONS section of its FDA label; effects for Coffee come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Coffee in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When used orally in moderate amounts. Intake of caffeine from coffee and other sources should be monitored during pregnancy. Caffeine crosses the human placenta, but is not considered a teratogen. Fetal blood and tissue levels are similar to maternal concentrations. The use of caffeine during pregnancy is controversial; however, moderate consumption has not been associated with clinically important adverse fetal effects. However, some research has also found that intrauterine exposure to even modest amounts of caffeine, based on maternal blood levels during the first trimester, is associated with a shorter stature in children ages 4-8 years. In some studies, consuming amounts over 200 mg daily has been associated with a significantly increased risk of miscarriage. This increased risk may be most likely to occur in people with genotypes that confer a slow rate of caffeine metabolism. According to a review by Health Canada, and a subsequent large meta-analysis conducted in the US, most healthy pregnant patients can safely consume caffeine in doses up to 300 mg daily without an increased risk of spontaneous abortion, stillbirth, preterm birth, fetal growth retardation, or congenital malformations. Advise patients to keep caffeine consumption below 300 mg daily during pregnancy. This is similar to the amount of caffeine in about 3 cups of coffee. Keep in mind that only the amount of ADDED caffeine must be stated on product labels. The amount of caffeine found in ingredients such as coffee, which naturally contains caffeine, does not need to be provided. This can make it difficult to determine the total amount of caffeine in a given product.

Pregnancy Possibly Unsafe

When caffeinated coffee providing more than 300 mg of caffeine daily is consumed orally. Caffeine from coffee crosses the placenta, producing fetal blood concentrations similar to maternal levels. Consumption of caffeine in amounts over 300 mg daily is associated with a significantly increased risk of miscarriage in some studies. Advise patients to keep caffeine consumption from all sources below 300 mg daily during pregnancy. This is similar to the amount of caffeine in about 3 cups of coffee. High doses of caffeine throughout pregnancy have resulted in symptoms of caffeine withdrawal in newborn infants. High doses of caffeine have also been associated with spontaneous abortion, premature delivery, and low birth weight. Drinking more than 6 cups of coffee daily increases the risk of spontaneous abortion. Drinking 8 or more cups of coffee daily doubles the risk of stillbirth when compared with those who do not drink coffee during pregnancy.

Lactation Possibly Safe

When used orally. Drinking one or two caffeine-containing beverages daily during lactation is not associated with unacceptable levels of caffeine in human milk.

Lactation Possibly Unsafe

When used orally in large amounts. Caffeine from coffee can cause wakefulness or irritability in breast-fed infants. Caffeine can also cause feeding intolerance and gastrointestinal irritation in infants.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Bacitracin, Neomycin , Polymyxin B

This page covers Coffee only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bacitracin, Neomycin , Polymyxin B page lists 3 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Turpentine Oil (moderate) and Alchemilla (minor).

By severity: 2 moderate · 1 minor.

From our pharmacist’s overview on the Bacitracin, Neomycin , Polymyxin B page

“Neosporin (bacitracin, neomycin, and polymyxin B) is a first-aid antibiotic ointment meant to sit on the skin surface, not travel into the bloodstream, and that is exactly what its short interaction list is about. Only three supplement ingredients are on file, none rated major, and the theme is shared by all of them: other things appli…”

Reviewed by 2 · Jul 18, 2026

Open the Bacitracin, Neomycin , Polymyxin B interaction page

One more smart check

Taking Coffee as Part of a Dietary Supplement Product? Check It for Interactions

We hold 716 real supplement products containing Coffee, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Coffee. Even though Coffee itself has no known interaction with Bacitracin, Neomycin , Polymyxin B, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Coffee and Bacitracin, Neomycin , Polymyxin B Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Coffee
Top 5%

#70 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Bacitracin, Neomycin , Polymyxin B
Steady interest

#1,508 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Coffee reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Coffee and Bacitracin, Neomycin , Polymyxin B records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Coffee

What is Coffee?

  • Alertness and reducing fatigue
  • Mental focus and concentration
  • Athletic performance
  • Headache relief
  • Weight management

Coffee is a widely consumed beverage made from roasted coffee beans, valued mainly for its caffeine, which boosts alertness and energy. For most healthy adults, moderate coffee intake is generally safe and may have some health benefits, but too much can cause jitteriness, poor sleep, and a faster heartbeat. People who are pregnant, breastfeeding, or sensitive to caffeine should limit their intake and check with a doctor or pharmacist.

Coffea arabica · Rubiaceae · Roasted seeds (beans) of the coffee fruit · Brewed coffee, instant coffee, espresso, capsules, green coffee bean extract, decaffeinated coffee

An interaction check asks whether these two react with each other — it does not ask whether Coffee is a good idea for someone in your situation. Here is what our Coffee record says about it on its own.

Coffee: dosing

There is no single official dose for coffee as a supplement. Many health authorities suggest that up to about 400 milligrams of caffeine per day is moderate for most healthy adults, which is roughly a few cups of brewed coffee, but individual tolerance varies a lot.If you use coffee capsules or extracts, follow the directions on the product label, since caffeine content can differ widely between products.

From our Coffee monograph — the full record covers uses, side effects and every documented interaction.

Read the full Coffee monograph & all interactions
Keep checking

Other Drugs & Coffee

Browse every other medication we’ve checked against Coffee — both the ones with a known interaction and the ones without. Select any drug for the full detail.

8Major
467Moderate
116Minor
2,238No known interaction
8 Major 467 Moderate 116 Minor 2,238 No interaction
Major

8 interactions

Moderate

467 interactions

Showing 60 of 467 moderate interactions — see all 467 on the Coffee page.

Minor

116 interactions

Showing 60 of 116 minor interactions — see all 116 on the Coffee page.

No interaction 2,238 drugs checked — show the list

We also checked Coffee against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,238 medications checked with no known interaction — see the full Coffee list.

See the full Coffee interactions page
See every supplement checked against Bacitracin, Neomycin , Polymyxin B, ranked by severity
Evidence & sources

Coffee References

The 175 references that drive our Coffee monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Harder S, Fuhr U, Staib AH, Wolff T. Ciprofloxacin-caffeine: a drug interaction established using in vivo and in vitro investigations. Am J Med 1989;87:89S-91S. PubMed
  3. Carbo M, Segura J, De la Torre R, et al. Effect of quinolones on caffeine disposition. Clin Pharmacol Ther 1989;45:234-40. PubMed
  4. Healy DP, Polk RE, Kanawati L, et al. Interaction between oral ciprofloxacin and caffeine in normal volunteers. Antimicrob Agents Chemother 1989;33:474-8. PubMed
  5. Mester R, Toren P, Mizrachi I, et al. Caffeine withdrawal increases lithium blood levels. Biol Psychiatry 1995;37:348-50. PubMed
  6. Jefferson JW. Lithium tremor and caffeine intake: two cases of drinking less and shaking more. J Clin Psychiatry 1988;49:72-3.
  7. Lasswell WL Jr, Weber SS, Wilkins JM. In vitro interaction of neuroleptics and tricylic antidepressants with coffee, tea, and gallotannic acid. J Pharm Sci 1984;73:1056-8. PubMed
  8. Kulhanek F, Linde OK, Meisenberg G. Precipitation of antipsychotic drugs in interaction with coffee or tea. Lancet 1979;2:1130.
  9. Joeres R, Klinker H, Heusler H, et al. Influence of mexiletine on caffeine elimination. Pharmacol Ther 1987;33:163-9. PubMed
  10. Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3.
  11. Grubben MJ, Boers GH, Blom HJ, et al. Unfiltered coffee increases plasma homocysteine concentrations in healthy volunteers: a randomized trial. Am J Clin Nutr 2000;71:480-4. PubMed
  12. Wakabayashi K, Kono S, Shinchi K, et al. Habitual coffee consumption and blood pressure: A study of self-defense officials in Japan. Eur J Epidemiol 1998;14:669-73. PubMed
  13. Hodgson JM, Puddey IB, Burke V, et al. Effects on blood pressure of drinking green and black tea. J Hypertens 1999;17:457-63. PubMed
  14. Rapuri PB, Gallagher JC, Kinyamu HK, Ryschon KL. Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes. Am J Clin Nutr 2001;74:694-700. PubMed
  15. The National Toxicology Program (NTP). Caffeine. Center for the Evaluation of Risks to Human Reproduction (CERHR). Available at: http://cerhr.niehs.nih.gov/common/caffeine.html.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Coffee and Bacitracin, Neomycin , Polymyxin B Together: Common Questions

Is it safe to take Coffee with Bacitracin, Neomycin , Polymyxin B?
We do not list a known interaction between Coffee and Bacitracin, Neomycin , Polymyxin B. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Coffee and Bacitracin, Neomycin , Polymyxin B have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Coffee and Bacitracin, Neomycin , Polymyxin B combination checked?
Interactions in our licensed database are recorded against drug classes. Bacitracin, Neomycin , Polymyxin B is filed under 1 classification, and Coffee has documented interactions with 33 drug classes — none of Bacitracin, Neomycin , Polymyxin B's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Coffee interact with any other medications?
Yes. Coffee has 591 documented drug interactions in our database — Bacitracin, Neomycin , Polymyxin B is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Bacitracin, Neomycin , Polymyxin B interact with any supplements?
Yes. Bacitracin, Neomycin , Polymyxin B has documented interactions with 3 supplements in our database — Coffee is not one of them. The Bacitracin, Neomycin , Polymyxin B interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Coffee monograph Uses, safety profile, and every drug interaction in one place Bacitracin, Neomycin , Polymyxin B supplement interactions Every supplement checked against Bacitracin, Neomycin , Polymyxin B, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 175 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Bacitracin, Neomycin , Polymyxin B and Coffee?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.