Drug & supplement interaction

Cola Nut + Insulin Glargine, Lixisenatide

Insulin Glargine, Lixisenatide brand name: Soliqua 100/33.

Minor Interaction
Medically reviewed by · Updated September 2026
The bottom line Minor

Cola Nut has a minor interaction with Insulin Glargine, Lixisenatide. Theoretically, taking cola nut with antidiabetes drugs might interfere with blood glucose control.

Read the full interaction report
SeverityMinor
LikelihoodUnlikely
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Cola Nut and Insulin Glargine, Lixisenatide

Here is the interaction we found between these two, with the evidence behind it.

Minor

ANTIDIABETES DRUGS

Why this applies to Insulin Glargine, Lixisenatide

Insulin Glargine, Lixisenatide falls under ANTIDIABETES DRUGS — the group Cola Nut interacts with.

Theoretically, taking cola nut with antidiabetes drugs might interfere with blood glucose control.
Cola nut contains caffeine. Some conflicting reports claim that caffeine might increase or decrease blood sugar.
Severity Minor Likelihood Unlikely Evidence B

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Soliqua combines two diabetes medicines: insulin glargine, a long-acting insulin, plus lixisenatide, which helps lower blood sugar after meals. Both work to bring your glucose down. The concern with cola nut comes from its caffeine, which in some reports nudges blood sugar slightly up and in others slightly down. The picture is genuinely mixed and the evidence here is weak, so this is more of a theoretical possibility than something most people will notice.

In real life, an occasional cola nut drink or supplement is unlikely to throw off your numbers in a meaningful way. Still, since Soliqua already pulls your blood sugar down, I'd watch for signs of a low, like shakiness, sweating, or feeling lightheaded, especially with larger or daily caffeine doses. If you use cola nut regularly, mention it to your pharmacist or doctor so they can help you keep an eye on your readings.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Watson JM, Jenkins EJ, Hamilton P, et al. Influence of caffeine on the frequency and perception of hypoglycemia in free-living patients with type 1 diabetes. Diabetes Care 2000;23:455-9. PubMed
  2. Bell DG, Jacobs I, Ellerington K. Effect of caffeine and ephedrine ingestion on anaerobic exercise performance. Med Sci Sports Exerc 2001;33:1399-403. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Cola Nut Also Interacts With Other Medications

Cola Nut has 547 moderate, 107 minor known drug interactions in our database — the Insulin Glargine, Lixisenatide one above is one of them. If you take anything else, check it against the full list below.

Moderate 547 Minor 107 No known interaction 2,176 (incl. Insulin Glargine, Lixisenatide)
Taking anything else?

Check Another of Your Medications Against Cola Nut

Covers the 2,830 medications we’ve checked against Cola Nut. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Insulin Glargine, Lixisenatide

This page covers Cola Nut only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Insulin Glargine, Lixisenatide page lists 242 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Chelation Therapy Products (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 211 moderate · 29 minor.

From our pharmacist’s overview on the Insulin Glargine, Lixisenatide page

“Soliqua 100/33 pairs a long-acting insulin, glargine, with lixisenatide, so its whole job is pushing blood sugar down, and that is also what most of the 242 supplements and herbs on this list do. The overlap earns real caution here.”

Reviewed by 2 · Jul 18, 2026

Open the Insulin Glargine, Lixisenatide interaction page

One more smart check

Taking Cola Nut as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2 real supplement products containing Cola Nut, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cola Nut. Your product may carry other ingredients that interact with Insulin Glargine, Lixisenatide too, on top of Cola Nut — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Cola Nut and Insulin Glargine, Lixisenatide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cola Nut
Steady interest

#972 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Insulin Glargine, Lixisenatide
Steady interest

#1,631 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Cola Nut

What is Cola Nut?

Cola Nut
  • Energy and alertness
  • Mental focus
  • Physical performance
  • Weight loss support
  • Traditional digestive aid

Cola nut is a caffeine-containing seed from West Africa used mainly as a natural stimulant for energy and alertness. Most of its effects come from caffeine, and strong human evidence for specific health benefits is limited. Because of its caffeine content, people sensitive to stimulants and those who are pregnant or have heart conditions should be cautious.

Read the full Cola Nut monograph & all interactions
Keep checking

Other Drugs & Cola Nut

Browse every other medication we’ve checked against Cola Nut — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
547Moderate
107Minor
2,175No known interaction
547 Moderate 107 Minor 2,175 No interaction
Moderate

547 interactions

Showing 60 of 547 moderate interactions — see all 547 on the Cola Nut page.

Minor

107 interactions

Showing 60 of 107 minor interactions — see all 107 on the Cola Nut page.

No interaction 2,175 drugs checked — show the list

We also checked Cola Nut against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,175 medications checked with no known interaction — see the full Cola Nut list.

See the full Cola Nut interactions page
See every supplement checked against Insulin Glargine, Lixisenatide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Cola Nut monograph › Uses, safety, and every drug interaction in one place Insulin Glargine, Lixisenatide supplement interactions › Every supplement checked against Insulin Glargine, Lixisenatide, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Cola Nut and Insulin Glargine, Lixisenatide Together: Common Questions

Can you take Cola Nut with Insulin Glargine, Lixisenatide?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Cola Nut and Insulin Glargine, Lixisenatide interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Insulin Glargine, Lixisenatide and Cola Nut?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.