Medication interaction hub

What Supplements Interact with Insulin Glargine, Lixisenatide?

Insulin Glargine, Lixisenatide brand name: Soliqua 100/33. Every interaction below applies to the brands too.

242 Interactions 2 Major 211 Moderate 29 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Insulin Glargine, Lixisenatide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Insulin Glargine, Lixisenatide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Soliqua 100/33 pairs a long-acting insulin, glargine, with lixisenatide, so its whole job is pushing blood sugar down, and that is also what most of the 242 supplements and herbs on this list do. The overlap earns real caution here. The two major-rated entries come first: Siberian cocklebur has caused severe hypoglycemia (dangerously low blood sugar) in humans, worsening over time, and EDTA chelation products can drop glucose sharply while also interfering with the insulin component itself.

Of the rest, 211 rate moderate and 29 minor, and the moderates split into two camps. The larger camp adds its own glucose-lowering effect to the injection, raising the chance of a low. A smaller camp, niacin among them, pushes blood sugar up instead and can blunt the drug. Either way the result shows up on your meter, which is why the full report below matters more with this medication than with most.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 211 Minor 29 No known interaction 1,210

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Insulin Glargine, Lixisenatide: Top Interactions at a Glance

The most significant Insulin Glargine, Lixisenatide supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 242 interacting ingredients — plus 1,210 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Insulin Glargine, Lixisenatide + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Siberian Cocklebur + Insulin Glargine, Lixisenatidei

Siberian cocklebur seedlings and seeds have caused severe hypoglycemia in humans.

Read the full interaction Major Likelihood Probable Chelation Therapy Products + Insulin Glargine, Lixisenatidei

Ethylenediamine tetraacetic acid (EDTA) can decrease the activity of insulin and increase the risk for hypoglycemia.

Read the full interaction
The complete list

Every Supplement Checked Against Insulin Glargine, Lixisenatide

All 1,452 ingredients in our database, ranked by severity — 242 with a Insulin Glargine, Lixisenatide interaction on file and 1,210 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Insulin Glargine, Lixisenatide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Vanadium with Insulin Glargine, Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vanadium might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Vanadium + Insulin Glargine, Lixisenatide answer

Can you take Ilex Guayusa with Insulin Glargine, Lixisenatide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking Ilex guayusa with antidiabetes drugs might increase the risk of hypoglycemia.

Full Ilex Guayusa + Insulin Glargine, Lixisenatide answer

Can you take Inulin with Insulin Glargine, Lixisenatide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, inulin might increase the risk of hypoglycemia with antidiabetes drugs.

Full Inulin + Insulin Glargine, Lixisenatide answer

Can you take Kudzu with Insulin Glargine, Lixisenatide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking kudzu with antidiabetes drugs might increase the risk of hypoglycemia.

Full Kudzu + Insulin Glargine, Lixisenatide answer

Can you take Mommy's Bliss Gripe Water with Insulin Glargine, Lixisenatide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Mommy's Bliss Gripe Water contains ginger.

Full Mommy's Bliss Gripe Water + Insulin Glargine, Lixisenatide answer

Can you take Oolong Tea with Insulin Glargine, Lixisenatide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking oolong tea with antidiabetes drugs might interfere with blood glucose control.

Full Oolong Tea + Insulin Glargine, Lixisenatide answer

Can you take Pu-erh Tea with Insulin Glargine, Lixisenatide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking pu-erh tea with antidiabetes drugs might interfere with blood glucose control.

Full Pu-erh Tea + Insulin Glargine, Lixisenatide answer

Can you take Yerba Mate with Insulin Glargine, Lixisenatide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking yerba mate with antidiabetes drugs might interfere with blood glucose control.

Full Yerba Mate + Insulin Glargine, Lixisenatide answer

Can you take Siberian Cocklebur with Insulin Glargine, Lixisenatide?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Siberian cocklebur seedlings and seeds have caused severe hypoglycemia in humans.

Full Siberian Cocklebur + Insulin Glargine, Lixisenatide answer

Can you take Chelation Therapy Products with Insulin Glargine, Lixisenatide?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Ethylenediamine tetraacetic acid (EDTA) can decrease the activity of insulin and increase the risk for hypoglycemia.

Full Chelation Therapy Products + Insulin Glargine, Lixisenatide answer

Can you take American Ginseng with Insulin Glargine, Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.

Full American Ginseng + Insulin Glargine, Lixisenatide answer

Can you take Apple Polyphenols with Insulin Glargine, Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In healthy adults, taking 900-1800 mg of a polyphenol-rich apple extract prior to a meal delays the time to peak postprandial blood glucose...

Full Apple Polyphenols + Insulin Glargine, Lixisenatide answer

Can you take Astragalus with Insulin Glargine, Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.

Full Astragalus + Insulin Glargine, Lixisenatide answer

Can you take Banaba with Insulin Glargine, Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of banaba and hypoglycemic drugs might have additive effects.

Full Banaba + Insulin Glargine, Lixisenatide answer

Can you take Beer with Insulin Glargine, Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use may interfere with blood glucose control.

Full Beer + Insulin Glargine, Lixisenatide answer

Can you take Bitter Melon with Insulin Glargine, Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.

Full Bitter Melon + Insulin Glargine, Lixisenatide answer

Can you take Branched-chain Amino Acids (bcaa) with Insulin Glargine, Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, BCAAs might alter the effects of antidiabetes medications.

Full Branched-chain Amino Acids (bcaa) + Insulin Glargine, Lixisenatide answer

Can you take Cumin with Insulin Glargine, Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cumin might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Cumin + Insulin Glargine, Lixisenatide answer

Can you take Ephedra with Insulin Glargine, Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ephedra with antidiabetes drugs might interfere with blood glucose control.

Full Ephedra + Insulin Glargine, Lixisenatide answer

Can you take Fasting with Insulin Glargine, Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Fasting might increase the risk of hypoglycemia if used with insulin.

Full Fasting + Insulin Glargine, Lixisenatide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Insulin Glargine, Lixisenatide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Insulin Glargine, Lixisenatide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Insulin Glargine, Lixisenatide sits in 2 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Insulin Glargine, Lixisenatide through this category.

Insulin 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Insulin Glargine, Lixisenatide through this category.

Related: does Insulin Glargine, Lixisenatide deplete any nutrients?

Insulin Glargine, Lixisenatide has 2 reported nutrient associations in the research literature — see the Insulin Glargine, Lixisenatide nutrient depletion report.

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Take a Supplement Product? Check the Whole Bottle Against Insulin Glargine, Lixisenatide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Insulin Glargine, Lixisenatide.

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Pharmacist Counseling Corner

Insulin Glargine, Lixisenatide & Supplements: Common Questions

What supplements interact with Insulin Glargine, Lixisenatide?
Our database currently documents 242 ingredients with a known Insulin Glargine, Lixisenatide interaction (2 major, 211 moderate, 29 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 242. The highest-ranked right now: Siberian Cocklebur, Chelation Therapy Products, American Ginseng.
Which Insulin Glargine, Lixisenatide supplement interactions are the most serious?
The 2 major-rated combinations — led by Siberian Cocklebur and Chelation Therapy Products — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Insulin Glargine, Lixisenatide?
Plenty of supplements coexist fine with Insulin Glargine, Lixisenatide; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Soliqua 100/33 have the same supplement interactions as Insulin Glargine, Lixisenatide?
Yes — Soliqua 100/33 all contain Insulin Glargine, Lixisenatide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Insulin Glargine, Lixisenatide deplete any vitamins or nutrients?
It might — Insulin Glargine, Lixisenatide has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Insulin Glargine, Lixisenatide nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Insulin Glargine, Lixisenatide and my other medications?
This page covers Insulin Glargine, Lixisenatide against supplements and herbal ingredients. Checking Insulin Glargine, Lixisenatide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.