Drug & supplement interaction

Tiratricol + Metformin, Rosiglitazone

Metformin, Rosiglitazone brand name: Avandamet.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Tiratricol has a moderate interaction with Metformin, Rosiglitazone. Theoretically, tiratricol might interfere with blood glucose control.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Tiratricol and Metformin, Rosiglitazone

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Metformin, Rosiglitazone

Metformin, Rosiglitazone falls under ANTIDIABETES DRUGS — the group Tiratricol interacts with.

Theoretically, tiratricol might interfere with blood glucose control.
Tiratricol is related to thyroid hormones, such as levothyroxine, which can interfere with blood glucose control and necessitate adjustment of diabetes drug therapy. It is not known if tiratricol has these effects.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to know about Avandamet (metformin plus rosiglitazone): it works to lower your blood sugar. Tiratricol acts like a strong thyroid hormone, and hormones in that family can shift how your body handles sugar, often pushing blood sugar levels around. The worry is that tiratricol could work against your diabetes medicine, making it harder to keep your numbers steady.

Honestly, this concern is theoretical. We know thyroid hormones can affect blood sugar, but nobody has proven tiratricol does the same thing. My bigger concern is tiratricol itself, since the FDA has warned it can cause serious heart and thyroid trouble. I'd steer clear of it and talk with your doctor or pharmacist before using any product containing it.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Tiratricol Also Interacts With Other Medications

Tiratricol has 16 major, 208 moderate known drug interactions in our database — the Metformin, Rosiglitazone one above is one of them. If you take anything else, check it against the full list below.

Major 16 Moderate 208 No known interaction 2,606 (incl. Metformin, Rosiglitazone)
Taking anything else?

Check Another of Your Medications Against Tiratricol

Covers the 2,830 medications we’ve checked against Tiratricol. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Metformin, Rosiglitazone

This page covers Tiratricol only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Metformin, Rosiglitazone page lists 315 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Acai (moderate).

By severity: 4 major · 268 moderate · 43 minor.

From our pharmacist’s overview on the Metformin, Rosiglitazone page

“Avandamet pairs metformin with rosiglitazone to manage type 2 diabetes, and its supplement list calls for genuine care rather than a quick skim. Start with the four major-rated entries: alcohol and the herb Siberian cocklebur can each stress the liver, a serious concern with rosiglitazone on board, while activated charcoal can soak up…”

Reviewed by 2 · Jul 18, 2026

Open the Metformin, Rosiglitazone interaction page

How much people look this up

Where Tiratricol and Metformin, Rosiglitazone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tiratricol
Top half

#447 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Metformin, Rosiglitazone
Top 25%

#470 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Tiratricol

What is Tiratricol?

  • Weight loss
  • Fat burning
  • Boosting metabolism
  • Bodybuilding and cutting
  • Thyroid-related supplementation

Tiratricol (also called TRIAC) is a powerful synthetic thyroid hormone metabolite, not a natural herb, and it has been illegally added to some weight-loss and bodybuilding supplements. It can cause serious heart and thyroid problems, and the U.S. FDA has warned consumers not to use products containing it. It is not a safe or approved dietary supplement, and you should avoid it.

Read the full Tiratricol monograph & all interactions
Keep checking

Other Drugs & Tiratricol

Browse every other medication we’ve checked against Tiratricol — both the ones with a known interaction and the ones without. Select any drug for the full detail.

16Major
208Moderate
0Minor
2,605No known interaction
16 Major 208 Moderate 2,605 No interaction
Major

16 interactions

Moderate

208 interactions

Showing 60 of 208 moderate interactions — see all 208 on the Tiratricol page.

No interaction 2,605 drugs checked — show the list

We also checked Tiratricol against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,605 medications checked with no known interaction — see the full Tiratricol list.

See the full Tiratricol interactions page
See every supplement checked against Metformin, Rosiglitazone, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Tiratricol monograph › Uses, safety, and every drug interaction in one place Metformin, Rosiglitazone supplement interactions › Every supplement checked against Metformin, Rosiglitazone, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Tiratricol and Metformin, Rosiglitazone Together: Common Questions

Can you take Tiratricol with Metformin, Rosiglitazone?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Tiratricol and Metformin, Rosiglitazone interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Metformin, Rosiglitazone and Tiratricol?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.