Drug & supplement interaction

Tiratricol + Selumetinib Sulfate

Selumetinib Sulfate brand name: Koselugo.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Tiratricol has a moderate interaction with Selumetinib Sulfate. Theoretically, tiratricol might increase the hypoprothrombinemic effects of oral anticoagulants.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Tiratricol and Selumetinib Sulfate

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Selumetinib Sulfate

Selumetinib Sulfate falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Tiratricol interacts with.

Theoretically, tiratricol might increase the hypoprothrombinemic effects of oral anticoagulants.
Tiratricol is related to thyroid hormones such as levothyroxine. The hypoprothrombinemic effects of oral anticoagulants, including warfarin (Coumadin), are increased by levothyroxine due to increased catabolism of vitamin K-dependent clotting factors. It is not known if tiratricol has a similar effect.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the honest catch with this one: the interaction we have on file is about blood thinners like warfarin, and selumetinib (Koselugo) isn't a blood thinner or antiplatelet drug. It's a kinase inhibitor that slows the growth of nerve tumors in NF1. So this particular tiratricol warning doesn't really line up with how selumetinib works, and I wouldn't apply it directly here.

The bigger concern, frankly, is tiratricol itself. It's a synthetic thyroid-like compound the FDA has warned people not to use, and it can cause fast heart rate, palpitations, and other heart and thyroid trouble. With a child on cancer-type therapy, please don't add this. Talk with your pharmacist or your child's specialist before combining anything new.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Tiratricol Also Interacts With Other Medications

Tiratricol has 16 major, 208 moderate known drug interactions in our database — the Selumetinib Sulfate one above is one of them. If you take anything else, check it against the full list below.

Major 16 Moderate 208 No known interaction 2,606 (incl. Selumetinib Sulfate)
Taking anything else?

Check Another of Your Medications Against Tiratricol

Covers the 2,830 medications we’ve checked against Tiratricol. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Selumetinib Sulfate

This page covers Tiratricol only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Selumetinib Sulfate page lists 282 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Danshen (major), Grapefruit (major), Piracetam (major) and St. John's Wort (major).

By severity: 5 major · 236 moderate · 41 minor.

Open the Selumetinib Sulfate interaction page

How much people look this up

Where Tiratricol and Selumetinib Sulfate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tiratricol
Top half

#447 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Selumetinib Sulfate
Top half

#1,022 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Tiratricol

What is Tiratricol?

  • Weight loss
  • Fat burning
  • Boosting metabolism
  • Bodybuilding and cutting
  • Thyroid-related supplementation

Tiratricol (also called TRIAC) is a powerful synthetic thyroid hormone metabolite, not a natural herb, and it has been illegally added to some weight-loss and bodybuilding supplements. It can cause serious heart and thyroid problems, and the U.S. FDA has warned consumers not to use products containing it. It is not a safe or approved dietary supplement, and you should avoid it.

Read the full Tiratricol monograph & all interactions
Medication

About Selumetinib

What Is Selumetinib Used For?

Brand name: Koselugo

Selumetinib, sold as Koselugo, treats neurofibromatosis type 1 (NF1) in adults and children 1 year of age and older. It is for people whose plexiform neurofibromas (nerve sheath tumors) cause symptoms and cannot be removed by surgery.

Koselugo comes as capsules and as oral granules. Both are used for this same condition.

See full Selumetinib drug information
Keep checking

Other Drugs & Tiratricol

Browse every other medication we’ve checked against Tiratricol — both the ones with a known interaction and the ones without. Select any drug for the full detail.

16Major
208Moderate
0Minor
2,605No known interaction
16 Major 208 Moderate 2,605 No interaction
Major

16 interactions

Moderate

208 interactions

Showing 60 of 208 moderate interactions — see all 208 on the Tiratricol page.

No interaction 2,605 drugs checked — show the list

We also checked Tiratricol against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,605 medications checked with no known interaction — see the full Tiratricol list.

See the full Tiratricol interactions page
See every supplement checked against Selumetinib Sulfate, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Tiratricol monograph › Uses, safety, and every drug interaction in one place Selumetinib Sulfate supplement interactions › Every supplement checked against Selumetinib Sulfate, ranked by severity Selumetinib drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Tiratricol and Selumetinib Sulfate Together: Common Questions

Can you take Tiratricol with Selumetinib Sulfate?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Tiratricol and Selumetinib Sulfate interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Selumetinib Sulfate and Tiratricol?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.