Medication interaction hub

What Supplements Interact with Omeprazole, Sodium Bicarbonate?

Omeprazole, Sodium Bicarbonate brand name: Konvomep. Every interaction below applies to the brands too.

174 Interactions 3 Major 121 Moderate 50 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Omeprazole, Sodium Bicarbonate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Omeprazole, Sodium Bicarbonate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Omeprazole with sodium bicarbonate (Konvomep) is a heartburn and ulcer treatment, a proton pump inhibitor paired with an antacid, and its supplement list warrants real vigilance because three of the 174 ingredients on file rate major. St. John's wort speeds the liver's clearance of omeprazole enough to drain its effect, grapefruit does the opposite by blocking a key liver enzyme and raising drug levels, and activated charcoal can soak up the dose in the gut before it ever reaches the bloodstream.

Beyond those three, most of the 121 moderate entries share liver enzyme pathways with omeprazole and tend to nudge levels up or down rather than cause sudden harm; the 50 minor entries carry less weight still. A few fibers and absorbents can also blunt absorption of anything swallowed, so keep them spaced well apart from your dose. Learn the majors first, since they can truly change whether this medicine works.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 121 Minor 50 No known interaction 1,278

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Omeprazole, Sodium Bicarbonate: Top Interactions at a Glance

The Omeprazole, Sodium Bicarbonate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 174 interacting ingredients — plus 1,278 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Omeprazole, Sodium Bicarbonate Combinations Today

The Omeprazole, Sodium Bicarbonate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Betaine Hydrochloride + Omeprazole, Sodium Bicarbonatei

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.

Read the full interaction Moderate Likelihood Probable Ginkgo + Omeprazole, Sodium Bicarbonatei

Theoretically, ginkgo might decrease levels of drugs metabolized by CYP2C19.

Read the full interaction Moderate Likelihood Possible Kava + Omeprazole, Sodium Bicarbonatei

Theoretically, kava might increase levels of CYP2C19 substrates.

Read the full interaction Minor Likelihood Possible Algin + Omeprazole, Sodium Bicarbonatei

Theoretically, algin can alter the absorption of oral drugs.

Read the full interaction Minor Likelihood Possible Hemp + Omeprazole, Sodium Bicarbonatei

Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.

Read the full interaction Minor Likelihood Likely Thyroid Extract + Omeprazole, Sodium Bicarbonatei

Food and medications can interfere with thyroid hormone absorption.

Read the full interaction
The complete list

Every Supplement Checked Against Omeprazole, Sodium Bicarbonate

All 1,452 ingredients in our database, ranked by severity — 174 with a Omeprazole, Sodium Bicarbonate interaction on file and 1,278 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Omeprazole, Sodium Bicarbonate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Betaine Hydrochloride with Omeprazole, Sodium Bicarbonate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.

Full Betaine Hydrochloride + Omeprazole, Sodium Bicarbonate answer

Can you take Ginkgo with Omeprazole, Sodium Bicarbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ginkgo might decrease levels of drugs metabolized by CYP2C19.

Full Ginkgo + Omeprazole, Sodium Bicarbonate answer

Can you take Kava with Omeprazole, Sodium Bicarbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, kava might increase levels of CYP2C19 substrates.

Full Kava + Omeprazole, Sodium Bicarbonate answer

Can you take Algin with Omeprazole, Sodium Bicarbonate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Omeprazole, Sodium Bicarbonate answer

Can you take Hemp with Omeprazole, Sodium Bicarbonate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.

Full Hemp + Omeprazole, Sodium Bicarbonate answer

Can you take Oregon Grape with Omeprazole, Sodium Bicarbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP2C9.

Full Oregon Grape + Omeprazole, Sodium Bicarbonate answer

Can you take Padang Cassia with Omeprazole, Sodium Bicarbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that a methanol extract of Padang cassia inhibits cytochrome P450 3A4 (CYP3A4) activity.

Full Padang Cassia + Omeprazole, Sodium Bicarbonate answer

Can you take Panax Ginseng with Omeprazole, Sodium Bicarbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Panax ginseng might increase or decrease levels of drugs metabolized by CYP3A4.

Full Panax Ginseng + Omeprazole, Sodium Bicarbonate answer

Can you take Peony with Omeprazole, Sodium Bicarbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Peony + Omeprazole, Sodium Bicarbonate answer

Can you take Peppermint with Omeprazole, Sodium Bicarbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, peppermint might increase the levels of CYP2C19 substrates.

Full Peppermint + Omeprazole, Sodium Bicarbonate answer

Can you take Phellodendron with Omeprazole, Sodium Bicarbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP2C9.

Full Phellodendron + Omeprazole, Sodium Bicarbonate answer

Can you take Propolis with Omeprazole, Sodium Bicarbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C19.

Full Propolis + Omeprazole, Sodium Bicarbonate answer

Can you take Pu-erh Tea with Omeprazole, Sodium Bicarbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Full Pu-erh Tea + Omeprazole, Sodium Bicarbonate answer

Can you take Puravive with Omeprazole, Sodium Bicarbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Puravive contains quercetin, which has been shown in studies to mildly inhibit the CYP2C9 metabolizing enzyme.

Full Puravive + Omeprazole, Sodium Bicarbonate answer

Can you take Quercetin with Omeprazole, Sodium Bicarbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the levels and adverse effects of CYP2C9 substrates.

Full Quercetin + Omeprazole, Sodium Bicarbonate answer

Can you take Rabdosia Rubescens with Omeprazole, Sodium Bicarbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that oridonin, a constituent of Rabdosia rubescens, induces cytochrome P450 3A4 (CYP3A4) enzyme.

Full Rabdosia Rubescens + Omeprazole, Sodium Bicarbonate answer

Can you take Resveratrol with Omeprazole, Sodium Bicarbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, resveratrol might increase levels of drugs metabolized by CYP2C19.

Full Resveratrol + Omeprazole, Sodium Bicarbonate answer

Can you take Rhodiola with Omeprazole, Sodium Bicarbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.

Full Rhodiola + Omeprazole, Sodium Bicarbonate answer

Can you take Rooibos with Omeprazole, Sodium Bicarbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rooibos with CYP2C19 substrates may increase the effects of CYP2C19 substrates.

Full Rooibos + Omeprazole, Sodium Bicarbonate answer

Can you take Sage with Omeprazole, Sodium Bicarbonate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2C19.

Full Sage + Omeprazole, Sodium Bicarbonate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Omeprazole, Sodium Bicarbonate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Omeprazole, Sodium Bicarbonate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Omeprazole, Sodium Bicarbonate sits in 10 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Omeprazole, Sodium Bicarbonate through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Omeprazole, Sodium Bicarbonate through this category.

Cytochrome P450 2C19 (Cyp2C19) Substrates 33 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

33 of the supplement ingredients on this page reach Omeprazole, Sodium Bicarbonate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Omeprazole, Sodium Bicarbonate through this category.

Proton Pump Inhibitors (Ppis) 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Omeprazole, Sodium Bicarbonate through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Omeprazole, Sodium Bicarbonate through this category.

Omeprazole (Prilosec) 7 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

7 of the supplement ingredients on this page reach Omeprazole, Sodium Bicarbonate through this category.

Cytochrome P450 2C9 (Cyp2C9) Inhibitors 4 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

4 of the supplement ingredients on this page reach Omeprazole, Sodium Bicarbonate through this category.

Cytochrome P450 2C19 (Cyp2C19) Inhibitors 2 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

2 of the supplement ingredients on this page reach Omeprazole, Sodium Bicarbonate through this category.

Cytochrome P450 1A2 (Cyp1A2) Inducers 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Omeprazole, Sodium Bicarbonate through this category.

Related: does Omeprazole, Sodium Bicarbonate deplete any nutrients?

Omeprazole, Sodium Bicarbonate has 9 reported nutrient associations in the research literature — see the Omeprazole, Sodium Bicarbonate nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Omeprazole, Sodium Bicarbonate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Omeprazole, Sodium Bicarbonate.

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Pharmacist Counseling Corner

Omeprazole, Sodium Bicarbonate & Supplements: Common Questions

What supplements interact with Omeprazole, Sodium Bicarbonate?
In our interaction database, 174 supplement and herbal ingredients have an interaction with Omeprazole, Sodium Bicarbonate on file — 3 rated major, 121 moderate, and 50 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, St. John's Wort, Activated Charcoal.
Which Omeprazole, Sodium Bicarbonate supplement interactions are the most serious?
The 3 major-rated combinations — led by Grapefruit, St. John's Wort and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Omeprazole, Sodium Bicarbonate?
That depends entirely on which supplement. The honest answer for Omeprazole, Sodium Bicarbonate is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Konvomep have the same supplement interactions as Omeprazole, Sodium Bicarbonate?
Yes — Konvomep all contain Omeprazole, Sodium Bicarbonate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Omeprazole, Sodium Bicarbonate deplete any vitamins or nutrients?
It might — Omeprazole, Sodium Bicarbonate has 9 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Omeprazole, Sodium Bicarbonate nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Omeprazole, Sodium Bicarbonate and my other medications?
This page covers Omeprazole, Sodium Bicarbonate against supplements and herbal ingredients. Checking Omeprazole, Sodium Bicarbonate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.